Transforming growth factor-betas: Smad signaling and roles in physiopathology;Transforming growth factor-βs: Signalisation et rôles physiopathologiques

Pathologie Biologie

Volumn 52, Issue 1, 2004, Pages 50-54

  Javelaud, D ^a   Mauviel, A ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

Cancer; Fibrosis; Signal transduction; Smad; TGF beta

Indexed keywords

SCLEROPROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; DNA BINDING PROTEIN; TRANSACTIVATOR PROTEIN;

CANCER INHIBITION; CARCINOGENESIS; CARCINOGENICITY; CELL DIFFERENTIATION; CELL GROWTH; CELL MIGRATION; CELL NUCLEUS; CELL SURFACE; EMBRYO DEVELOPMENT; FIBROSIS; HUMAN; INFLAMMATION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR; ANIMAL; GENETICS; MOUSE; PHYSIOLOGY; TRANSGENIC MOUSE; WOUND HEALING;

ANIMALS; DNA-BINDING PROTEINS; HUMANS; INFLAMMATION; MICE; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 0842305071     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.patbio.2003.10.002     Document Type: Article

References (24)

1. Roberts A.B. Molecular and cell biology of TGF-beta. Miner Electrolyte Metab. 24:1998;111-119.
2. Barcellos-Hoff M.-H. Latency and activation in the control of TGF-beta. J. Mammary Gland. Biol. Neoplasia. 1:1996;353-363.
3. Massague J., Chen Y.G. Controlling TGF-beta signaling. Genes Dev. 14:2000;627-644.
4. Attisano L., Wrana J.L. Signal transduction by TGF-beta superfamily. Curr. Opin. Cell. Biol. 10:1998;188-194.
5. Miyazono K., Ten Dijke P., Heldin C.H. TGF-beta signaling by Smad proteins. Adv. Immunol. 75:2000;115-157.
6. Moustakas A., Souchelnytskyi S., Heldin C.H. Smad regulation in TGF-beta signal transduction. J. Cell. Sci. 114:2001;4359-4369.
7. Fink S.P., Mikkola D., Willson J.K., Markowitz S. TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. Oncogene. 22:2003;1317-1323.
8. Kurisaki K., Kurisaki A., Valcourt U., Terentiev A.A., Pardali K., Ten Dijke P., et al. Nuclear factor YY1 inhibits transforming growth factor: beta- and bone morphogenetic protein-induced cell differentiation. Mol. Cell. Biol. 23:2003;4494-4510.
9. Liu X., Sun Y., Weinberg R.A., Lodish H.F. Ski/SnoN and TGF-beta signaling. Cytokine Growth Factor Rev. 12:2001;1-8.
10. Miyazono K. TGF-beta signaling by Smad proteins. Cytokine Growth Factor Rev. 11:2000;15-22.
11. Datta P.K., Chytil A., Gorska A.E., Moses H.L. Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J. Biol. Chem. 273:1998;34671-34674.
12. Ferrigno O., Lallemand F., Verrecchia F., L'Hoste S., Camonis J., Atfi A., et al. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene. 21:2002;4879-4884.
13. De Caestecker M.P., Piek E., Roberts A.B. Role of transforming growth factor-beta signaling in cancer. J. Natl. Cancer Inst. 92:2000;1388-1402.
14. Mulder K.M. Role of ras and Mapks in TGF-beta signaling. Cytokine growth factor. Rev. 11:2000;23-35.
15. Ten Dijke P., Goumans M.J., Itoh F., Itoh S. Regulation of cell proliferation by Smad proteins. J. Cell. Physiol. 191:2002;1-16.
16. Kang Y., Chen C.R., Massague J. A self-enabling TGF-beta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell. 1:2003;915-926.
17. Ruzinova M.B., Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell. Biol. 13:2003;410-418.
18. Ling M.T., Wang X., Tsao S.W., Wong Y.C. Down-regulation of Id-1 expression is associated with TGF-beta 1-induced growth arrest in prostate epithelial cells. Biochim. Biophys. Acta. 1570:2002;145-152.
19. Verrecchia F., Mauviel A. Transforming growth factor-Beta signaling through the smad pathway: role in extracellular matrix gene expression and regulation. J. Invest. Dermatol. 118:2002;211-215.
20. O'Kane S., Ferguson M.W. Transforming growth factors-betas and wound healing. Int. J. Biochem. Cell. Biol. 29:1997;63-78.
21. Chen W., Wahl S.M. TGF-beta: receptors, signaling pathways and autoimmunity. Curr. Dir. Autoimmun. 5:2002;62-91.
22. Varga J. Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis. Arthritis Rheum. 46:2002;1703-1713.
23. Reiss M. TGF-beta and cancer. Microbes Infect. 1:1999;1327-1347.
24. Akhurst R.J. TGF-beta antagonists: why suppress a tumor suppressor? J. Clin. Invest. 109:2002;1533-1536.