메뉴 건너뛰기




Volumn 7, Issue 6, 2012, Pages

Down-regulation of HtrA1 activates the Epithelial-Mesenchymal transition and ATM DNA damage response pathways

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; HTRA1 PROTEIN; MICRORNA 200; SERINE PROTEINASE; UNCLASSIFIED DRUG;

EID: 84862751215     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039446     Document Type: Article
Times cited : (37)

References (89)
  • 1
    • 0030566837 scopus 로고    scopus 로고
    • Primary structure of a putative serine protease specific for IGF-binding proteins
    • Zumbrunn J, Trueb B, (1996) Primary structure of a putative serine protease specific for IGF-binding proteins. FEBS Lett 398: 187-192.
    • (1996) FEBS Lett , vol.398 , pp. 187-192
    • Zumbrunn, J.1    Trueb, B.2
  • 2
    • 51849099386 scopus 로고    scopus 로고
    • Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins
    • Clawson GA, Bui V, Xin P, Wang N, Pan W, (2008) Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins. J Cellular Biochem 105: 81-88.
    • (2008) J Cellular Biochem , vol.105 , pp. 81-88
    • Clawson, G.A.1    Bui, V.2    Xin, P.3    Wang, N.4    Pan, W.5
  • 4
    • 33751004690 scopus 로고    scopus 로고
    • A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration
    • Yang Z, Camp N, Sun H, Tong Z, Gibbs D, et al. (2006) A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science 314: 992-993.
    • (2006) Science , vol.314 , pp. 992-993
    • Yang, Z.1    Camp, N.2    Sun, H.3    Tong, Z.4    Gibbs, D.5
  • 5
    • 79951865527 scopus 로고    scopus 로고
    • Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): from discovery to gene identification
    • Fukutake T, (2011) Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): from discovery to gene identification. J Stroke Cerebrovasc Dis 20: 85-93.
    • (2011) J Stroke Cerebrovasc Dis , vol.20 , pp. 85-93
    • Fukutake, T.1
  • 6
    • 1542742098 scopus 로고    scopus 로고
    • A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer
    • Chien J, Staub J, Hu S, Erickson-Johnson M, Couch F, et al. (2004) A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene 23: 1636-1644.
    • (2004) Oncogene , vol.23 , pp. 1636-1644
    • Chien, J.1    Staub, J.2    Hu, S.3    Erickson-Johnson, M.4    Couch, F.5
  • 9
    • 50149115769 scopus 로고    scopus 로고
    • The serine protease HtrA1 is a novel prognostic factor for human mesothelioma
    • Baldi A, Mottolese M, Vincenzi B, Campioni M, Mellone P, et al. (2008) The serine protease HtrA1 is a novel prognostic factor for human mesothelioma. Pharmacogenomics 9: 1069-1077.
    • (2008) Pharmacogenomics , vol.9 , pp. 1069-1077
    • Baldi, A.1    Mottolese, M.2    Vincenzi, B.3    Campioni, M.4    Mellone, P.5
  • 10
    • 0037179864 scopus 로고    scopus 로고
    • The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells
    • Baldi A, De Luca A, Morini M, Battista T, Felsani A, et al. (2002) The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells. Oncogene 21: 6684-6688.
    • (2002) Oncogene , vol.21 , pp. 6684-6688
    • Baldi, A.1    de Luca, A.2    Morini, M.3    Battista, T.4    Felsani, A.5
  • 11
    • 33745855832 scopus 로고    scopus 로고
    • Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity
    • Chien J, Aletti G, Baldi A, Catalano V, Muretto P, et al. (2006) Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J Clin Invest 116: 1994-2004.
    • (2006) J Clin Invest , vol.116 , pp. 1994-2004
    • Chien, J.1    Aletti, G.2    Baldi, A.3    Catalano, V.4    Muretto, P.5
  • 15
    • 41549123979 scopus 로고    scopus 로고
    • Changes in expression of serin eproteases HtrA1 and HtrA2 during estrogen-induced oxidative strress and nephrocarcinogenesis in male Syrian hamster
    • Zurawa-Janicka D, Kobiela J, Stefaniak T, Wozniak A, Narkiewicz J, et al. (2008) Changes in expression of serin eproteases HtrA1 and HtrA2 during estrogen-induced oxidative strress and nephrocarcinogenesis in male Syrian hamster. Acta Biochim Pol 55: 9-19.
    • (2008) Acta Biochim Pol , vol.55 , pp. 9-19
    • Zurawa-Janicka, D.1    Kobiela, J.2    Stefaniak, T.3    Wozniak, A.4    Narkiewicz, J.5
  • 17
    • 33748539093 scopus 로고    scopus 로고
    • Serine protease HTRA1 and HTRA3 are down-regualted with increasing grades of human endometrial cancer
    • Bowden M, Di Nezza-Cossens L, Jobling T, Salamonsen L, Nie G, (2006) Serine protease HTRA1 and HTRA3 are down-regualted with increasing grades of human endometrial cancer. Gynecol Oncol 103: 253-260.
    • (2006) Gynecol Oncol , vol.103 , pp. 253-260
    • Bowden, M.1    Di Nezza-Cossens, L.2    Jobling, T.3    Salamonsen, L.4    Nie, G.5
  • 18
    • 79954591707 scopus 로고    scopus 로고
    • HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer
    • Catalona V, Pasquale M, d-Avino A, Shridhar V, Staccioli MP, et al. (2011) HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer. Histopathology 58: 669-678.
    • (2011) Histopathology , vol.58 , pp. 669-678
    • Catalona, V.1    Pasquale, M.2    d-Avino, A.3    Shridhar, V.4    Staccioli, M.P.5
  • 19
    • 27144459430 scopus 로고    scopus 로고
    • Gene expression profile associated with response to doxorubicin-based therapy in breast cancer
    • Folgueira M, Carraro D, Brentani H, Patrao D, Barbosa E, et al. (2005) Gene expression profile associated with response to doxorubicin-based therapy in breast cancer. Clin Cancer Res 11: 7434-7443.
    • (2005) Clin Cancer Res , vol.11 , pp. 7434-7443
    • Folgueira, M.1    Carraro, D.2    Brentani, H.3    Patrao, D.4    Barbosa, E.5
  • 20
    • 77951075728 scopus 로고    scopus 로고
    • Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells
    • EPub Apr 13
    • He X, Ota T, Liu P, Chien J, Shridhar V, (2010) Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells. Cancer Res 70: ePub Apr 13.
    • (2010) Cancer Res , vol.70
    • He, X.1    Ota, T.2    Liu, P.3    Chien, J.4    Shridhar, V.5
  • 21
    • 67651225288 scopus 로고    scopus 로고
    • Serine protease HtrA1 associates with microtubules and inhibits cell migration
    • Chien J, Ota T, Aletti G, Shridhar R, Boccellino M, et al. (2009) Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol 29: 4177-4187.
    • (2009) Mol Cell Biol , vol.29 , pp. 4177-4187
    • Chien, J.1    Ota, T.2    Aletti, G.3    Shridhar, R.4    Boccellino, M.5
  • 22
    • 66149085161 scopus 로고    scopus 로고
    • Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening
    • Chien J, He X, Shridhar V, (2009) Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening. J Cell Biochem 107: 253-263.
    • (2009) J Cell Biochem , vol.107 , pp. 253-263
    • Chien, J.1    He, X.2    Shridhar, V.3
  • 23
    • 44149110574 scopus 로고    scopus 로고
    • Intermediate filament cytoskeleton of the liver in health and disease
    • Strnad P, Stumptner C, Zatloukal K, Denk H, (2008) Intermediate filament cytoskeleton of the liver in health and disease. Histochem Cell Biol 129: 735-749.
    • (2008) Histochem Cell Biol , vol.129 , pp. 735-749
    • Strnad, P.1    Stumptner, C.2    Zatloukal, K.3    Denk, H.4
  • 25
    • 77949381018 scopus 로고    scopus 로고
    • Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression
    • Wang Z, Li Y, Sarkar FH, (2010) Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression. Curr Stem Cell Res Ther 5: 74-80.
    • (2010) Curr Stem Cell Res Ther , vol.5 , pp. 74-80
    • Wang, Z.1    Li, Y.2    Sarkar, F.H.3
  • 26
    • 77952855239 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer
    • Ahmed N, Abubaker K, Findlay J, Quinn M, (2010) Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer. Curr Cancer Drug Targets 10: 268-278.
    • (2010) Curr Cancer Drug Targets , vol.10 , pp. 268-278
    • Ahmed, N.1    Abubaker, K.2    Findlay, J.3    Quinn, M.4
  • 27
    • 77957969261 scopus 로고    scopus 로고
    • Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance
    • Wang Z, Li Y, Ahmad A, Azmi AS, Kong D, et al. (2010) Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance. Drug Resist Updat 13: 109-118.
    • (2010) Drug Resist Updat , vol.13 , pp. 109-118
    • Wang, Z.1    Li, Y.2    Ahmad, A.3    Azmi, A.S.4    Kong, D.5
  • 28
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki M, Mimori K, Yokobori T, Ishi H, Beppu T, et al. (2010) Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 101: 293-299.
    • (2010) Cancer Sci , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3    Ishi, H.4    Beppu, T.5
  • 29
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic
    • Voulgari A, Pintzas A, (2009) Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 1796: 75-90.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 30
    • 31544452076 scopus 로고    scopus 로고
    • Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
    • Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, et al. (2006) Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 66: 944-950.
    • (2006) Cancer Res , vol.66 , pp. 944-950
    • Witta, S.E.1    Gemmill, R.M.2    Hirsch, F.R.3    Coldren, C.D.4    Hedman, K.5
  • 31
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    • Singh A, Settleman J, (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29: 4741-4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 32
    • 43049103824 scopus 로고    scopus 로고
    • The iR-200 family and miR-205 regulate epithelial to mesenchymal transition by argeting ZEB1 and SIP1/
    • Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, et al. (2008) The iR-200 family and miR-205 regulate epithelial to mesenchymal transition by argeting ZEB1 and SIP1/. Nature Cell Biol 10: 593-601.
    • (2008) Nature Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3    Barry, S.C.4    Tsykin, A.5
  • 33
    • 73349099030 scopus 로고    scopus 로고
    • MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells
    • Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, et al. (2009) MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal 2: ra62.
    • (2009) Sci Signal , vol.2
    • Iliopoulos, D.1    Polytarchou, C.2    Hatziapostolou, M.3    Kottakis, F.4    Maroulakou, I.G.5
  • 34
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA, (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 35
    • 84856692524 scopus 로고    scopus 로고
    • Identification of mammary epithelial cells subject to chronic oxidative stress in mammary epithelium of young women and teenagers living in USA
    • Weisz J, Shearer DA, Murata E, Patrick SD, Han B, et al. (2012) Identification of mammary epithelial cells subject to chronic oxidative stress in mammary epithelium of young women and teenagers living in USA. Cancer Biol Therapy 13: 1-13.
    • (2012) Cancer Biol Therapy , vol.13 , pp. 1-13
    • Weisz, J.1    Shearer, D.A.2    Murata, E.3    Patrick, S.D.4    Han, B.5
  • 36
    • 33750324764 scopus 로고    scopus 로고
    • Negative and positive regulation of gene expression by mouse histone deacetylase 1
    • Zupkovitz G, Tischler J, Posch M, Sadzak I, Ramsauer K, et al. (2006) Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol 26: 7913-7928.
    • (2006) Mol Cell Biol , vol.26 , pp. 7913-7928
    • Zupkovitz, G.1    Tischler, J.2    Posch, M.3    Sadzak, I.4    Ramsauer, K.5
  • 37
    • 74949135078 scopus 로고    scopus 로고
    • MicroRNAs align with accessible sites in target mRNAs
    • Pan W, Xin P, Clawson GA, (2010) MicroRNAs align with accessible sites in target mRNAs. J Cell Biochem 109: 509-518.
    • (2010) J Cell Biochem , vol.109 , pp. 509-518
    • Pan, W.1    Xin, P.2    Clawson, G.A.3
  • 38
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypiclly diverse progeny and survive chemotherapy
    • Fillmore CM, Kuperwasser C, (2008) Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypiclly diverse progeny and survive chemotherapy. Breast Can Res 10: R25.
    • (2008) Breast Can Res , vol.10
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 39
    • 0347993932 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention
    • Liu Y, (2004) Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15: 1-12.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1-12
    • Liu, Y.1
  • 40
    • 57349116972 scopus 로고    scopus 로고
    • Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells
    • Holian J, Qi W, Kelly DJ, Zhang Y, Mreich E, et al. (2008) Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells. Am J Physiol Renal Physiol 295: F1388-1396.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Holian, J.1    Qi, W.2    Kelly, D.J.3    Zhang, Y.4    Mreich, E.5
  • 43
    • 79958023043 scopus 로고    scopus 로고
    • MCM proteins are negative regulators of hypoxia-inducible factor 1
    • Hubbi ME, Luo W, Baek JH, Semenza GL, (2011) MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell 42: 700-712.
    • (2011) Mol Cell , vol.42 , pp. 700-712
    • Hubbi, M.E.1    Luo, W.2    Baek, J.H.3    Semenza, G.L.4
  • 44
    • 44149115749 scopus 로고    scopus 로고
    • The potential role of AKT phosphorylation in human cancers
    • Cicenas J, (2008) The potential role of AKT phosphorylation in human cancers. Int J Biol Markers 23: 1-9.
    • (2008) Int J Biol Markers , vol.23 , pp. 1-9
    • Cicenas, J.1
  • 45
    • 77954617702 scopus 로고    scopus 로고
    • AKT phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positivebreast cancer
    • Yang SX, Costantino JP, Kim C, Mamounas EP, Nguyen D, et al. (2010) AKT phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positivebreast cancer. J Clin Oncol 28: 2974-2981.
    • (2010) J Clin Oncol , vol.28 , pp. 2974-2981
    • Yang, S.X.1    Costantino, J.P.2    Kim, C.3    Mamounas, E.P.4    Nguyen, D.5
  • 46
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM, (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146: 905-916.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 47
    • 79961189334 scopus 로고    scopus 로고
    • MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer
    • Tang JT, Wang JL, Du W, Hong J, Zhao SL, et al. (2011) MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer. Carcinogenesis 32: 1207-1215.
    • (2011) Carcinogenesis , vol.32 , pp. 1207-1215
    • Tang, J.T.1    Wang, J.L.2    Du, W.3    Hong, J.4    Zhao, S.L.5
  • 48
    • 79551553893 scopus 로고    scopus 로고
    • MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance
    • Ye G, Fu G, Cui S, Zhao S, Bernaudo S, et al. (2011) MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance. J Cell Sci 124: 359-368.
    • (2011) J Cell Sci , vol.124 , pp. 359-368
    • Ye, G.1    Fu, G.2    Cui, S.3    Zhao, S.4    Bernaudo, S.5
  • 49
    • 79958201190 scopus 로고    scopus 로고
    • Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation, apoptosis, migration and invasion
    • Lopez JA, Alvarez-Salas LM, (2011) Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation, apoptosis, migration and invasion. Biochem Biophys Res Commun 409: 513-519.
    • (2011) Biochem Biophys Res Commun , vol.409 , pp. 513-519
    • Lopez, J.A.1    Alvarez-Salas, L.M.2
  • 50
    • 78249234164 scopus 로고    scopus 로고
    • miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions
    • Hagman Z, Larne O, Edsjo A, Bjartell A, Ehrnstrom RA, et al. (2010) miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions. Int J Cancer 127: 2768-2776.
    • (2010) Int J Cancer , vol.127 , pp. 2768-2776
    • Hagman, Z.1    Larne, O.2    Edsjo, A.3    Bjartell, A.4    Ehrnstrom, R.A.5
  • 51
    • 79959216175 scopus 로고    scopus 로고
    • TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer
    • Stinson S, Lackner MR, Adai AT, Yu N, Kim H-J, et al. (2011) TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Science Signaling 4: 1-11.
    • (2011) Science Signaling , vol.4 , pp. 1-11
    • Stinson, S.1    Lackner, M.R.2    Adai, A.T.3    Yu, N.4    Kim, H.-J.5
  • 53
    • 33748308883 scopus 로고    scopus 로고
    • Targeting proteases: successes, failures and future prospects
    • Turk B, (2006) Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov 5: 785-799.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 785-799
    • Turk, B.1
  • 54
    • 30644467608 scopus 로고    scopus 로고
    • Matrix metalloproteinase-induced genomic instability
    • Radisky D, Bissell M, (2006) Matrix metalloproteinase-induced genomic instability. Curr Opin Genet Dev 16: 45-50.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 45-50
    • Radisky, D.1    Bissell, M.2
  • 55
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM, (2002) Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295: 2387-2392.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 56
    • 0036716282 scopus 로고    scopus 로고
    • Strategies for MMP inhibition in cancer: innovations for the post-trial era
    • Overall CM, Lopez-Otin C, (2002) Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2: 657-672.
    • (2002) Nat Rev Cancer , vol.2 , pp. 657-672
    • Overall, C.M.1    Lopez-Otin, C.2
  • 57
    • 34648815810 scopus 로고    scopus 로고
    • Emerging roles of proteases in tumour suppression
    • Lopez-Otin C, Matrisian LM, (2007) Emerging roles of proteases in tumour suppression. Nat Rev Cancer 7: 800-808.
    • (2007) Nat Rev Cancer , vol.7 , pp. 800-808
    • Lopez-Otin, C.1    Matrisian, L.M.2
  • 58
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery JP, (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15: 740-746.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 59
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF, (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315: 1650-1659.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 60
    • 79959421475 scopus 로고    scopus 로고
    • HIF-1(alpha) mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression
    • Yoo YG, Christensen J, Gu J, Huang LE, (2011) HIF-1(alpha) mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression. Sci Signal 21: pt4.
    • (2011) Sci Signal , vol.21
    • Yoo, Y.G.1    Christensen, J.2    Gu, J.3    Huang, L.E.4
  • 61
    • 79951820679 scopus 로고    scopus 로고
    • HIF-1a confers aggressive malignant traits on human tumor cells independent of its canonical transcription function
    • Yoo YG, Christensen J, Huang LE, (2011) HIF-1a confers aggressive malignant traits on human tumor cells independent of its canonical transcription function. Cancer Res 71: 1244-1252.
    • (2011) Cancer Res , vol.71 , pp. 1244-1252
    • Yoo, Y.G.1    Christensen, J.2    Huang, L.E.3
  • 62
    • 33751074452 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 in human breast and prostate cancer
    • Kimbro KS, Simons JW, (2006) Hypoxia-inducible factor-1 in human breast and prostate cancer. Endoc Relat Cancer 13: 739-749.
    • (2006) Endoc Relat Cancer , vol.13 , pp. 739-749
    • Kimbro, K.S.1    Simons, J.W.2
  • 63
    • 24344440832 scopus 로고    scopus 로고
    • Hypoxia-induced dedifferentiation of tumor cells - a mechanisms behind heterogeneity and aggressiveness of solid tumors
    • Axelson H, Fredlund E, Overberger M, Landberg G, Pahlman S, (2005) Hypoxia-induced dedifferentiation of tumor cells - a mechanisms behind heterogeneity and aggressiveness of solid tumors. Semin Cell Dev Biol 16: 554-563.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 554-563
    • Axelson, H.1    Fredlund, E.2    Overberger, M.3    Landberg, G.4    Pahlman, S.5
  • 64
    • 34147193960 scopus 로고    scopus 로고
    • Differential expression of hypoxia and (lymph)angiogenesis-related genes at different metastatic sites in breast cancer
    • Van den Eynden GG, Van Laere SJ, Van der Auwera I, Gilles L, Burn JL, et al. (2007) Differential expression of hypoxia and (lymph)angiogenesis-related genes at different metastatic sites in breast cancer. Clin Exp Metastasis 24: 13-23.
    • (2007) Clin Exp Metastasis , vol.24 , pp. 13-23
    • van den Eynden, G.G.1    van Laere, S.J.2    van der Auwera, I.3    Gilles, L.4    Burn, J.L.5
  • 65
    • 77957280345 scopus 로고    scopus 로고
    • Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer
    • Ceppi P, Mudduluru G, Kumarswamy R, Rapa I, Scagliotti GV, et al. (2010) Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res 8: 1207-1216.
    • (2010) Mol Cancer Res , vol.8 , pp. 1207-1216
    • Ceppi, P.1    Mudduluru, G.2    Kumarswamy, R.3    Rapa, I.4    Scagliotti, G.V.5
  • 66
    • 77649251655 scopus 로고    scopus 로고
    • Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells
    • Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, et al. (2010) Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells. PLoS One 13: e8697.
    • (2010) PLoS One , vol.13
    • Vrba, L.1    Jensen, T.J.2    Garbe, J.C.3    Heimark, R.L.4    Cress, A.E.5
  • 67
    • 84859911725 scopus 로고    scopus 로고
    • Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
    • Doi:10.1038/Onc.2011.383 Epub Ahead of Print
    • Davalos V, Moutinho C, Villanueva A, Boque R, Silva P, et al. (2011) Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene doi:10.1038/onc.2011.383 Epub ahead of print.
    • (2011) Oncogene
    • Davalos, V.1    Moutinho, C.2    Villanueva, A.3    Boque, R.4    Silva, P.5
  • 68
    • 56749095797 scopus 로고    scopus 로고
    • Transcriptional regulation of cell polarity in EMT and cancer
    • Moreno-Bueno G, Portillo F, Cano A, (2008) Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 27: 6958-6969.
    • (2008) Oncogene , vol.27 , pp. 6958-6969
    • Moreno-Bueno, G.1    Portillo, F.2    Cano, A.3
  • 69
    • 33751311939 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta signaling in human cancer: targeting a tumor suppressor network as a therapeutic strategy
    • Biswas S, Criswell TL, Wang SE, Arteaga CL, (2006) Inhibition of transforming growth factor-beta signaling in human cancer: targeting a tumor suppressor network as a therapeutic strategy. Clin Cancer Res 12: 4142-4146.
    • (2006) Clin Cancer Res , vol.12 , pp. 4142-4146
    • Biswas, S.1    Criswell, T.L.2    Wang, S.E.3    Arteaga, C.L.4
  • 70
    • 0034480072 scopus 로고    scopus 로고
    • An elevated serum level of transforming growth factor-beta 1 (TGF-beta 1) significantly correlated with lymph node metastasis and poor prognosis in patients with gastric carcinoma
    • Saito H, Tsujitani S, Oka S, Kondo A, Ikeguchi M, et al. (2000) An elevated serum level of transforming growth factor-beta 1 (TGF-beta 1) significantly correlated with lymph node metastasis and poor prognosis in patients with gastric carcinoma. Anticancer Res 20: 4489-4493.
    • (2000) Anticancer Res , vol.20 , pp. 4489-4493
    • Saito, H.1    Tsujitani, S.2    Oka, S.3    Kondo, A.4    Ikeguchi, M.5
  • 71
    • 0035892767 scopus 로고    scopus 로고
    • Preoperative plasma levels of transforming growth factor beta(1) strongly predict clinical outcome in patients with bladder carcinoma
    • Shariat SF, Kim JH, Andrews B, Kattan MW, Wheeler TM, et al. (2001) Preoperative plasma levels of transforming growth factor beta(1) strongly predict clinical outcome in patients with bladder carcinoma. Cancer 92: 2985-2992.
    • (2001) Cancer , vol.92 , pp. 2985-2992
    • Shariat, S.F.1    Kim, J.H.2    Andrews, B.3    Kattan, M.W.4    Wheeler, T.M.5
  • 72
    • 33746701947 scopus 로고    scopus 로고
    • Elevated plasma TGF-beta1 levels correlate with decreased survival of metastatic breast cancer patients
    • Ivanovic V, Demajo M, Krtolica K, Krajnovic M, Konstantinovic M, et al. (2006) Elevated plasma TGF-beta1 levels correlate with decreased survival of metastatic breast cancer patients. Clin Chim Acta 371: 191-193.
    • (2006) Clin Chim Acta , vol.371 , pp. 191-193
    • Ivanovic, V.1    Demajo, M.2    Krtolica, K.3    Krajnovic, M.4    Konstantinovic, M.5
  • 73
    • 12144291128 scopus 로고    scopus 로고
    • HtrA1 serine protease inhibits signaling mediated by tgf-beta family proteins
    • Oka C, Tsujimoto R, Kajikawa M, Koshiba-Takeuchi K, Ina J, et al. (2004) HtrA1 serine protease inhibits signaling mediated by tgf-beta family proteins. Development 131: 1041-1053.
    • (2004) Development , vol.131 , pp. 1041-1053
    • Oka, C.1    Tsujimoto, R.2    Kajikawa, M.3    Koshiba-Takeuchi, K.4    Ina, J.5
  • 74
    • 32444433202 scopus 로고    scopus 로고
    • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M, (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160: 1-40.
    • (2006) Chem Biol Interact , vol.160 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Izakovic, M.4    Mazur, M.5
  • 75
    • 77950023207 scopus 로고    scopus 로고
    • Oxidative stress and oxidative damage in carcinogenesis
    • Klaunig JE, Kamendulis LM, Hocevar BA, (2010) Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol 38: 96-109.
    • (2010) Toxicol Pathol , vol.38 , pp. 96-109
    • Klaunig, J.E.1    Kamendulis, L.M.2    Hocevar, B.A.3
  • 77
    • 79952235291 scopus 로고    scopus 로고
    • Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
    • Polo SE, Jackson SP, (2011) Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 25: 409-433.
    • (2011) Genes Dev , vol.25 , pp. 409-433
    • Polo, S.E.1    Jackson, S.P.2
  • 78
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks reponsive to DNA damage
    • Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks reponsive to DNA damage. Science 316: 1160-1166.
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1    Ballif, B.A.2    Smogorzewska, A.3    McDonald, E.R.4    Hurov, K.E.5
  • 79
    • 33745823159 scopus 로고    scopus 로고
    • The ATM-mediated DNA-damage reponse: taking shape
    • Shiloh Y, (2006) The ATM-mediated DNA-damage reponse: taking shape. Trend Biochem Sci 31: 402-410.
    • (2006) Trend Biochem Sci , vol.31 , pp. 402-410
    • Shiloh, Y.1
  • 80
    • 39049163047 scopus 로고    scopus 로고
    • Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance
    • Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, et al. (2008) Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res 68: 605-614.
    • (2008) Cancer Res , vol.68 , pp. 605-614
    • Chan, N.1    Koritzinsky, M.2    Zhao, H.3    Bindra, R.4    Glazer, P.M.5
  • 83
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, et al. (2009) Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci 106: 13820-13825.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3    Dixon, J.M.4    Neumeister, V.M.5
  • 84
    • 33749430095 scopus 로고    scopus 로고
    • Identifying accessible sites in RNA: the first step in designing antisense reagents
    • Pan WH, Clawson GA, (2006) Identifying accessible sites in RNA: the first step in designing antisense reagents. Curr Med Chem 13: 3083-3103.
    • (2006) Curr Med Chem , vol.13 , pp. 3083-3103
    • Pan, W.H.1    Clawson, G.A.2
  • 85
    • 2342449376 scopus 로고    scopus 로고
    • A Self-Processing Ribozyme Cassette: Utility against Human Papillomavirus 11 E6/E7 mRNA and Hepatitis B virus
    • Pan W, Xin P, Morrey J, Clawson G, (2004) A Self-Processing Ribozyme Cassette: Utility against Human Papillomavirus 11 E6/E7 mRNA and Hepatitis B virus. Mol Therapy 9: 596-606.
    • (2004) Mol Therapy , vol.9 , pp. 596-606
    • Pan, W.1    Xin, P.2    Morrey, J.3    Clawson, G.4
  • 86
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochbert Y, (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Royal Statistical Soc, Serie B (Methodological) 57: 289-300.
    • (1995) J Royal Statistical Soc, Serie B (Methodological) , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochbert, Y.2
  • 87
    • 0035733108 scopus 로고    scopus 로고
    • The control of the false discovery rate in multiple testing under dependency
    • Benjamini Y, Yekutieli D, (2001) The control of the false discovery rate in multiple testing under dependency. Annals Statistics 29: 1165-1188.
    • (2001) Annals Statistics , vol.29 , pp. 1165-1188
    • Benjamini, Y.1    Yekutieli, D.2
  • 88
    • 36348992780 scopus 로고    scopus 로고
    • Bonferroni and Sidak corrections for multiple comparisons
    • In: Salkind NJ, editors, editor
    • Abdi H, (2007) Bonferroni and Sidak corrections for multiple comparisons. In: Salkind NJ, editors. editor. Encyclopedia of Measurement and Statistics. Thousand Oaks, CA: Sage.
    • (2007)
    • Abdi, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.