Identification of a novel HtrA1-susceptible cleavage site in human aggrecan. Evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo

Journal of Biological Chemistry

Volumn 284, Issue 40, 2009, Pages 27352-27359

  Chamberland, Angela ^a   Wang, Eunice ^a   Jones, Aled R ^a   Collins Racie, Lisa A ^a   LaVallie, Edward R ^a   Huang, Ying ^a   Liu, Lin ^a   Morris, Elizabeth A ^a   Flannery, Carl R ^a   Yang, Zhiyong ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALGINATE CULTURE; C-PROPEPTIDE; CARTILAGE TISSUES; CHONDROCYTES; CLEAVAGE SITES; DEGENERATIVE JOINT DISEASE; ELEVATED LEVEL; HUMAN ARTICULAR CARTILAGE; IN-VIVO; OSTEOARTHRITIC CARTILAGE; OVER-EXPRESSION; PROCOLLAGEN; PROTEIN COMPONENTS; PROTEOGLYCANS; PROTEOMIC ANALYSIS; SERINE PROTEASE; WESTERN-BLOT ANALYSIS; WILD TYPES;

AMINO ACIDS; CARTILAGE; DEGRADATION; LIGAMENTS; MASS SPECTROMETRY; PROTEOLYSIS;

JOINTS (ANATOMY);

AGGRECAN; ALGINIC ACID; PROTEOGLYCAN; SERINE PROTEINASE; SERINE PROTEINASE HTRA1; UNCLASSIFIED DRUG; EPITOPE; GLUCURONIC ACID; HEXURONIC ACID; HTRA1 PROTEIN, HUMAN;

ARTICLE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN METABOLISM; WESTERN BLOTTING; AGE; AGED; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CARTILAGE; CASE CONTROL STUDY; CHEMISTRY; DISEASE COURSE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MUTATION; PATHOLOGY;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGGRECANS; ALGINATES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARTILAGE; CASE-CONTROL STUDIES; CELLS, CULTURED; CHONDROCYTES; DISEASE PROGRESSION; EPITOPES; FEMALE; GENE EXPRESSION REGULATION; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; OSTEOARTHRITIS; SERINE ENDOPEPTIDASES;

EID: 70350448424     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.037051     Document Type: Article

References (26)

1. Clausen, T., Southan, C., and Ehrmann, M. (2002) Mol. Cell 10, 443-455
2. Dewan, A., Liu, M., Hartman, S., Zhang, S. S., Liu, D. T., Zhao, C., Tam, P. O., Chan, W. M., Lam, D. S., Snyder, M., Barnstable, C., Pang, C. P., and Hoh, J. (2006) Science 314, 989-992
3. Grau, S., Baldi, A., Bussani, R., Tian, X., Stefanescu, R., Przybylski, M., Richards, P., Jones, S. A., Shridhar, V., Clausen, T., and Ehrmann, M. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 6021-6026
4. Grau, S., Richards, P. J., Kerr, B., Hughes, C., Caterson, B., Williams, A. S., Junker, U., Jones, S. A., Clausen, T., and Ehrmann, M. (2006) J. Biol. Chem. 281, 6124-6129
5. Hu, S. I., Carozza, M., Klein, M., Nantermet, P., Luk, D., and Crowl, R. M. (1998) J. Biol. Chem. 273, 34406-34412
6. Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M., and Oka, C. (2005) Bone 37, 323-336
7. Yang, Z., Camp, N. J., Sun, H., Tong, Z., Gibbs, D., Cameron, D. J., Chen, H., Zhao, Y., Pearson, E., Li, X., Chien, J., Dewan, A., Harmon, J., Bernstein, P. S., Shridhar, V., Zabriskie, N. A., Hoh, J., Howes, K., and Zhang, K. (2006) Science 314, 992-993
8. Bowden, M. A., Di Nezza-Cossens, L. A., Jobling, T., Salamonsen, L. A., and Nie, G. (2006) Gynecol. Oncol. 103, 253-260
9. Chien, J., Staub, J., Hu, S. I., Erickson-Johnson, M. R., Couch, F. J., Smith, D. I., Crowl, R. M., Kaufmann, S. H., and Shridhar, V. (2004) Oncogene 23, 1636-1644
10. Baldi, A., De Luca, A., Morini, M., Battista, T., Felsani, A., Baldi, F., Catricalà, C., Amantea, A., Noonan, D. M., Albini, A., Natali, P. G., Lombardi, D., and Paggi, M. G. (2002) Oncogene 21, 6684-6688
11. Hadfield, K. D., Rock, C. F., Inkson, C. A., Dallas, S. L., Sudre, L., Wallis, G. A., Boot-Handford, R. P., and Canfield, A. E. (2008) J. Biol. Chem. 283, 5928-5938
12. Ganu, V., Melton, R., Hu, S., Koehn, J., Klein, M., and Liebman, J. (2001) Orthopaedic Research Society 47th Annual Meeting, February 25-28, 2001, San Francisco, CA, Vol. 26, p. 266
13. Goldberg, R., Crowl, R., and Hu, S. (2000) Orthopaedic Research Society 46th Annual Meeting, March 12-15, 2000, Orlando, FL, Vol. 25, p. 164
14. Oka, C., Tsujimoto, R., Kajikawa, M., Koshiba-Takeuchi, K., Ina, J., Yano, M., Tsuchiya, A., Ueta, Y., Soma, A., Kanda, H., Matsumoto, M., and Kawaichi, M. (2004) Development 131, 1041-1053
15. Tocharus, J., Tsuchiya, A., Kajikawa, M., Ueta, Y., Oka, C., and Kawaichi, M. (2004) Dev. Growth Differ. 46, 257-274
16. Hou, J., Clemmons, D. R., and Smeekens, S. (2005) J. Cell Biochem. 94, 470-484
17. Enobakhare, B. O., Bader, D. L., and Lee, D. A. (1996) Anal. Biochem. 243, 189-191
18. Wu, J., Liu, W., Bemis, A., Wang, E., Qiu, Y., Morris, E. A., Flannery, C. R., and Yang, Z. (2007) Arthritis Rheum. 56, 3675-3684
19. Murwantoko, Yano, M., Ueta, Y., Murasaki, A., Kanda, H., Oka, C., and Kawaichi, M. (2004) Biochem. J. 381, 895-904
20. Song, R. H., Tortorella, M. D., Malfait, A. M., Alston, J. T., Yang, Z., Arner, E. C., and Griggs, D. W. (2007) Arthritis Rheum. 56, 575-585
21. Chockalingam, P. S., Zeng, W., Morris, E. A., and Flannery, C. R. (2004) Arthritis Rheum. 50, 2839-2848
22. Chubinskaya, S., Mikhail, R., Deutsch, A., and Tindal, M. H. (2001) J. Histochem. Cytochem. 49, 1165-1176
23. Chelius, D., Zhang, T., Wang, G., and Shen, R. F. (2003) Anal. Chem. 75, 6658-6665
24. Nelson, F., Dahlberg, L., Laverty, S., Reiner, A., Pidoux, I., Ionescu, M., Fraser, G. L., Brooks, E., Tanzer, M., Rosenberg, L. C., Dieppe, P., and Robin Poole, A. (1998) J. Clin. Invest. 102, 2115-2125
25. Lohmander, L. S., Neame, P. J., and Sandy, J. D. (1993) Arthritis Rheum. 36, 1214-1222
26. Sandy, J. D., Flannery, C. R., Neame, P. J., and Lohmander, L. S. (1992) J. Clin. Invest. 89, 1512-1516