Identification of urinary biomarkers for age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 7, 2011, Pages 4639-4644

  Guymer, Robyn H ^a   Tao, Lingwei W ^a   Goh, Jonathan K ^a   Liew, Danny ^a   Ischenko, Olga ^b   Robman, Liubov D ^a   Aung, KhinZaw ^a   Cipriani, Tania ^a   Cain, Melinda ^a   Richardson, Andrea J ^a   Baird, Paul N ^a   Langham, Robyn ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENT COMPONENT C3A; COMPLEMENT FACTOR H; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1; ANAPHYLATOXIN; COMPLEMENT C3A, DES ARG (77); COMPLEMENT C3A, DES-ARG-(77);

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE PHOTOGRAPHY; FEMALE; GEOGRAPHIC ATROPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA ANGIOGRAPHY; RETINA MACULA AGE RELATED DEGENERATION; SINGLE NUCLEOTIDE POLYMORPHISM; SUBRETINAL NEOVASCULARIZATION; AUSTRALIA; COMPARATIVE STUDY; DISEASE COURSE; IMMUNOASSAY; MIDDLE AGED; PATHOLOGY; PREVALENCE; RETINA MACULA DEGENERATION; RETROSPECTIVE STUDY; URINE;

ADULT; AGED; AGED, 80 AND OVER; ANAPHYLATOXINS; BIOLOGICAL MARKERS; CHEMOKINE CCL2; COMPLEMENT C3A; CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOASSAY; MACULAR DEGENERATION; MALE; MIDDLE AGED; PREVALENCE; RETROSPECTIVE STUDIES; TOMOGRAPHY, OPTICAL COHERENCE; TRANSFORMING GROWTH FACTOR BETA1; VICTORIA;

EID: 80052349179     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-7120     Document Type: Article

References (28)

1. Anderson DH, Mullins RF, Hageman GS, et al. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol. 2002;134:411-431.
2. Hageman GS, Anderson DH, Johnson LV, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A. 2005;102:7227-7232.
3. Nussenblatt RB, Ferris F 3rd. Age-related macular degeneration and the immune response: implications for therapy. Am J Ophthalmol. 2007;144:618-626.
4. Penfold PL, Killingsworth MC, Sarks SH. Senile macular degeneration: the involvement of immunocompetent cells. Graefes Arch Clin Exp Ophthalmol. 1985;223:69-76.
5. Xu H, Chen M, Forrester JV. Para-inflammation in the aging retina. Prog Retin Eye Res. 2009;28:348-368.
6. Boekhoorn SS, Vingerling JR, Witteman JC, et al. C-reactive protein level and risk of aging macula disorder: The Rotterdam Study. Arch Ophthalmol. 2007;125:1396-1401.
7. Klein R, Klein BE, Knudtson MD, et al. Systemic markers of inflammation, endothelial dysfunction, and age-related maculopathy. Am J Ophthalmol. 2005;140:35-44.
8. Robman L, Baird PN, Dimitrov PN, et al. C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression. Ophthalmology. 117: 1982-1988.
9. Seddon JM, Gensler G, Milton RC, et al. Association between C-reactive protein and age-related macular degeneration. JAMA. 2004;291:704-710.
10. Seddon JM, George S, Rosner B, et al. Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. Arch Ophthalmol. 2005;123:774-782.
11. Wu KH, Tan AG, Rochtchina E, et al. Circulating inflammatory markers and hemostatic factors in age-related maculopathy: a population-based case-control study. Invest Ophthalmol Vis Sci. 2007;48:1983-1988.
12. Adachi J, Kumar C, Zhang Y, et al. The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol. 2006;7:R80.
13. Pang JX, Ginanni N, Dongre AR, et al. Biomarker discovery in urine by proteomics. J Proteome Res. 2002;1:161-169.
14. Yamamoto T, Langham RG, Ronco P, et al. Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA. Proteomics. 2008;8:2156-2159.
15. Decramer S, Gonzalez de Peredo A, Breuil B, et al. Urine in clinical proteomics. Mol Cell Proteomics. 2008;7:1850-1862.
16. Huang SJ, Costa DL, Gross NE, et al. Peripheral drusen in membranoproliferative glomerulonephritis type II. Retina. 2003;23: 429-431.
17. Shaw EA, Colville D, Wang YY, et al. Characterization of the peripheral retinopathy in X-linked and autosomal recessive Alport syndrome. Nephrol Dial Transplant. 2007;22:104-108.
18. Grassi MA, Folk JC, Scheetz TE, et al. Complement factor H polymorphism p. Tyr402His and cuticular drusen. Arch Ophthalmol. 2007;125:93-97.
19. Xing C, Sivakumaran TA, Wang JJ, et al. Complement factor H polymorphisms, renal phenotypes and age-related macular degeneration: the Blue Mountains Eye Study. Genes Immun. 2008;9:231-239.
20. Basile DP. The transforming growth factor beta system in kidney disease and repair: recent progress and future directions. Curr Opin Nephrol Hypertens. 1999;8:21-30.
21. Wada T, Furuichi K, Sakai N, et al. Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy. Kidney Int. 2000;58:1492-1499.
22. Sivaprasad S, Adewoyin T, Bailey TA, et al. Estimation of systemic complement C3 activity in age-related macular degeneration. Arch Ophthalmol. 2007;125:515-519.
23. Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-related maculopathy and agerelated macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol. 1995;39:367-374.
24. Baird PN, Islam FM, Richardson AJ, et al. Analysis of the Y402H variant of the complement factor H gene in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006;47:4194-4198.
25. Ambati J, Anand A, Fernandez S, et al. An animal model of agerelated macular degeneration in senescent Ccl-2-or Ccr-2-deficient mice. Nat Med. 2003;9:1390-1397.
26. Jonas JB, Tao Y, Neumaier M, Findeisen P. Monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in exudative agerelated macular degeneration. Arch Ophthalmol. 2010;128:1281-1286.
27. Tam FW, Riser BL, Meeran K, et al. Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Cytokine. 2009;47:37-42.
28. Ohlsson S, Bakoush O, Tencer J, et al. Monocyte chemoattractant protein 1 is a prognostic marker in ANCA-associated small vessel vasculitis. Mediators Inflamm. 2009;2009:584916.