L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium

Molecular Vision

Volumn 20, Issue , 2014, Pages 73-88

  Promsote, Wanwisa ^a   Veeranan Karmegam, Rajalakshmi ^a   Ananth, Sudha ^a   Shen, Defen ^b   Chan, Chi Chao ^b   Lambert, Nevin A ^a   Ganapathy, Vadivel ^a   Martin, Pamela M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; G PROTEIN COUPLED RECEPTOR; INTERLEUKIN 6; MONOCARBOXYLATE TRANSPORTER; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN GPR109A; PROTEIN SLC5A8; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; ATP-BINDING CASSETTE TRANSPORTERS; CATION TRANSPORT PROTEINS; CELL LINE; CHEMOKINE CCL2; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; PYRROLIDONECARBOXYLIC ACID; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER; THIAZOLIDINES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84891852102     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Ding X, Patel M, Chan CC. Molecular pathology of age-related macular degeneration. Prog Retin Eye Res 2009; 28:1-18. [PMID: 19026761]
2. Ambati J, Fowler BJ. Mechanisms of age-related macular degeneration. Neuron 2012; 75:26-39. [PMID: 22794258]
3. Cai X, McGinnis JF. Oxidative stress: the achilles' heel of neurodegenerative diseases of the retina. Front Biosci 2012; 17:1976-95. [PMID: 22201850]
4. Chu XK, Wang Y, Ardeljan D, Tuo J, Chan CC. Controversial view of a genetically altered mouse model of focal retinal degeneration. Bioengineered 2013; 4:130-5. [PMID: 23196746]
5. Porta P, Aebi S, Summer K, Lauterburg BH. L-2-Oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human. J Pharmacol Exp Ther 1991; 257:331-4. [PMID: 2019996]
6. Anderson ME, Meister A. Marked increase of cysteine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboyxlate. FASEB J 1989; 3:1632-6. [PMID: 2920877]
7. Williamson JM, Boettcher B, Meister A. Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis. Proc Natl Acad Sci USA 1982; 79:6246-9. [PMID: 6959113]
8. Williamson JM, Meister A. Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-prolinase substrate. Proc Natl Acad Sci USA 1981; 78:936-9. [PMID: 6940159]
9. Moslen MT, Whitehead RF, Ferguson AE, Kanz MF. Protection by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug, against 1, 1-dichloroethylene hepatotoxicity in rats is associated with decreases in toxin metabolism and cytochrome P-450. J Pharmacol Exp Ther 1989; 248:157-63. [PMID: 2913268]
10. Brodeur J, Goyal R. Effect of a cysteine produg, L-2-oxothiazolidine-4-carboyxlate acid, on the metabolism and toxicity of bromobenzene: an acute study. Can J Physiol Pharmacol 1987; 65:816-22. [PMID: 3621045]
11. Vita JA, Frei B, Holbrook M, Gokce N, Leaf C, Keaney FJ Jr. L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. J Clin Invest 1998; 101:1408-14. [PMID: 9502783]
12. Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Park KH, Kim UH, Kim CY, Lee YC. A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma. Mol Pharmacol 2005; 68:1281-90. [PMID: 16103046]
13. Mesina JE, Page RH, Hetzel FW, Choop M. Administration of L-2-oxothiazolidine-4-carboxylic acid increases glutathione levels in rat brain. Brain Res 1989; 478:181-3. [PMID: 2924114]
14. Babu E, Ananth S, Veeranan-Karmegam R, Coothankandaswamy V, Smith SB, Boettger T, Ganapathy V, Martin PM. Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboyxlate to enhance glutathione production in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2011; 52:5749-57. [PMID: 21508099]
15. Čolak E., Majkić-Singh N., Žoric L., Radosavljević A., Kosanović-Jaković N., The impact of inflammation to the antioxidant defense parameters in AMD patients. Aging Clin Exp Res 2012; 24:588-94. [PMID: 22982945]
16. Kauppinen A, Niskaneu H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K. Oxidative stress activates NLRP3 inflammosomes in ARPE-19 cells - implications for age-related macular degeneration (AMD). Immunol Lett 2012; 147:29-33. [PMID: 22698681]
17. Bian Q, Gao S, Zhou J, Qin J, Taylor A, Johnson EJ, Tang G, Sparrow JR, Gierhart D, Shang F. Lutein and zeaxanthin supplementation reduces photo-oxodiative damage and modulates the expression of inflammation-related genes in RPE. Free Radic Biol Med 2012; 53:1298-1307. [PMID: 22732187]
18. Sparrow JR, Hicks D, Hamel CP. The retinal pigment epithelium in health and disease. Curr Mol Med 2010; 10:802-23. [PMID: 21091424]
19. Cai J, Nelson KC, Wu M, Sternberg P Jr, Dones DP. Oxidative damage and protection of the RPE. Prog Retin Eye Res 2000; 19:205-21. [PMID: 10674708]
20. Detrick B, Hooks JJ. Immune regulation in the retina. Immunol Res 2010; 47:153-61. [PMID: 20082152]
21. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Prog Retin Eye Res 2000; 45:115-34. [PMID: 11033038]
22. Park SJ, Lee KS, Lee SJ, Kim SR, Park SY, Jeon MS, Lee HB, Lee YC. L-2-Oxothiazolidine-4-carboxylic acid or α-Lipoic acid attenuates airway remodeling: involvement of nuclear factor-kB (NF-kB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF). Int J Mol Sci 2012; 13:7915-37. [PMID: 22942681]
23. Lee KS, Kim SR, Park SJ, Min KH, Jin SM, Li L, Lee YC. Antioxidant down-regulates interleukin-18 expression in asthma. Mol Pharmacol 2006; 70:1184-93. [PMID: 16822930]
24. Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC. An antioxidant modulates expression of receptor activator of NF-kappaB in asthma. Exp Mol Med 2006; 38:217-29. [PMID: 16819280]
25. Martin PM, Ananth S, Cresci G, Roon P, Smith S, Ganapathy V. Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium. Mol Vis 2009; 15:362-72. [PMID: 19223991]
26. Gambhir D, Ananth S, Veeranan-Karmegam R, Elangovan S, Hester S, Jennings E, Offermanns S, Nussbaum JJ, Smith SB, Thangaraju M, Ganapathy V, Martin PM. GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy. Invest Ophthalmol Vis Sci 2012; 53:2208-17. [PMID: 22427566]
27. Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S. PUMA-G and HM74 are receptors fornicotinic acid and mediate its anti-lipolytic effect. Nat Med 2003; 9:352-5. [PMID: 12563315]
28. Frank H, Groger N, Diener M, Becker C, Braun T, Boettger T. Lacturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J Biol Chem 2008; 283:24729-37. [PMID: 18562324]
29. Bridges CC, El-Sherbeny A, Ola MS, Ganapathy V, Smith SB. Transcellular transfer of folate across the retinal pigment epithelium. Curr Eye Res 2002; 24:129-38. [PMID: 12187485]
30. Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S, Ganapathy V. Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J Biol Chem 2010; 285:27601-8. [PMID: 20601425]
31. Gnana-Prakasam JP, Ananth S, Prasad PD, Zhang M, Atherton SS, Martin PM, Smith SB, Ganapathy V. Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium. Invest Ophthalmol Vis Sci 2011; 52:3751-8. [PMID: 21357408]
32. Hollins B, Kuravi S, Digby GJ, Lambert NA. The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers. Cell Signal 2009; 21:1015-21. [PMID: 19258039]
33. Yokota H, Narayanan SP, Zhang W, Liu H, Rojas M, Xu Z, Lemtalsi T, Nagaoka T, Yoshida A, Brooks SE, Caldwell RW, Caldwell RB. Invest Ophthalmol Vis Sci 2011; 52:8123-31. [PMID: 21917939]
34. Jonas JB, Tao Y, Neumaier M, Findeisen P. Monocyte chemoattractant protein 1, intercellar adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration. Arch Ophthalmol 2010; 128:1218-26.
35. Jonas JB, Tao Y, Neumaier M, Findeisen P. Cytokine concentration in aqueous humour of eyes with exudative age-related macular degeneration. Acta Ophthalmol (Copenh) 2012; 90:e381-8. [PMID: 22490043]
36. Miao H, Tao Y, Li X. Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization. Mol Vis 2012; 18:574-80. [PMID: 22419849]
37. Mattapallil MJ, Wawrousek EF, Chan CC, Zhao H, Roychoudhury J, Ferguson TA, Caspi RR. The Rrd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 2012; 53:2921-7. [PMID: 22447858]
38. Penfold PL, Madigan MC, Gillies MC, Provis JM. Immunological and aetiological aspects of macular degeneration. Prog Retin Eye Res 2001; 20:385-414. [PMID: 11286898]
39. Lakkaraju A, Finnemann SC, Rodriguez-Boulan E. The lipofuscin fluorophore A2E perturbs cholesterol metabolism in Retinal Pigment Epithelial Cells. Proc Natl Acad Sci USA 2007; 104:11026-31. [PMID: 17578916]
40. Tserentsoodol N, Sztein J, Campos M, Gordiyenko NV, Fariss RN, Lee JW, Fliesler SJ, Rodriguez IR. Uptake of cholesterol by the retina occurs primarily via a low density lipo-protein receptor-mediated process. Mol Vis 2006; 12:1306-18. [PMID: 17110914]
41. Nagineni CN, Samuel W, Nagineni S, Pardhasaradhi K, Wiggert B, Detrick B, Hooks JJ. Transforming growth factor-β induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: Involvement of mitogen-activated protein kinases. J Cell Physiol 2003; 197:453-62. [PMID: 14566975]
42. Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: Implications for age-related macular degeneration. Invest Ophthalmol Vis Sci 2013; 54:110-20. [PMID: 23221073]
43. Korybalska K, Wieczorowska-Tobis K, Polubinska A, Wisniewska J, Moberly J, Martis L, Breborowicz A, Oreopoulos DG. L-2-oxothiazolidine-4-carboxylate: an agent that modulates lipopolysaccharide-induced peritonitis in rats. Perit Dial Int 2002; 22:293-300. [PMID: 12227385]
44. Fawcett JP, Schiller B, Jiang R, Moran J, Walker RJ. Supplementation with L-2-oxothiazolidine-4-carboxylic acid, a cysteine precursor, does not protect against lipid peroxidation in puromycin aminonucleoside-induced nephropathy. Exp Nephrol 1996; 4:248-52. [PMID: 8864728]
45. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodrigues SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA. The G protein-coupled repertoires of human and mouse. Proc Natl Acad Sci USA 2003; 100:4903-8. [PMID: 12679517]
46. Audet M, Bouvier M. Restructuring G-protein coupled receptor activation. Cell 2012; 151:14-23. [PMID: 23021212]
47. Benyó Z, Gille A, Bennett CL, Clausen BE, Offermanns S. Nicotinic acid-induced flushing is mediated by activation of epidermal Langerhans cells. Mol Pharmacol 2006; 70:1844-9. [PMID: 17008386]
48. Li X, Millar JS, Brownell N, Briand F, Rader DJ. Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes. Biochem Pharmacol 2010; 80:1450-7. [PMID: 20655299]
49. Wernerman J, Hammarqvist F. Modulation of endogenous glutathione availability. Curr Opin Clin Nutr Metab Care 1999; 2:487-492. [PMID: 10678678]
50. Vita JA, Frei B, Holbrook M, Gokce N, Leaf C, Keaney JF Jr. L-2-oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. J Clin Invest 1998; 101:1408-14. [PMID: 9502783]
51. Barditch-Crovo P, Noe D, Skowron G, Lederman M, Kalayjian RC, Borum P, Buier R, Rowe WB, Goldberg D, Lietman P. A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus. J Clin Pharmacol 1998; 38:357-63. [PMID: 9590463]
52. Holmes RP, Assismos DG, Leaf CD, Whalen JJ. The effects of (L)-2-oxothiazolidine-carboxylate on urinary oxalate excretion. J Urol 1997; 158:34-7. [PMID: 9186317]
53. Moberly JB, Logan J, Borum PR, Story KO, Webb LE, Jassal SV, Mupas L, Rodela H, Alghamdi GA, Moran JE, Wolfson M, Martis L, Oreopoulous DG. Elevation of whole-blood glutathione in peritoneal dialysis patients by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug (Procysteine). J Am Soc Nephrol 1998; 9:1093-9. [PMID: 9621294]
54. Gaudana R, Ananthula HK, Parenky A, Mitra AK. Ocular drug delivery. AAPS J 2010; 12:348-60. [PMID: 20437123]
55. Lee JH, Pidaparti RM, Atkinson GM, Moorth RS. Design of an implantable device for ocular drug delivery. J Drug Deliv 2012; xxx:527516-.
56. Evans JR, Lawrenson JG. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev 2012; 11:CD000254[PMID: 23152201]
57. Gamcsik MP, Clark MD, Ludeman SM, Springer JB, D'Alessandro MA, Simpson NE, Pourdeyhimi R, Johnson CB, Teeter SD, Blackband SJ, Thelwall PE. Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy. Neurochem Res 2011; 36:443-51. [PMID: 21161591]
58. Schuller-Levis GB, Park E. Taurine: new implications for an old amino acid. FEMS Microbiol Lett 2003; 226:195-202. [PMID: 14553911]
59. Redmond HP, Stapleton PP, Neary P, Bouchier-Hayes D. Immunonutrition: the role of taurine. Nutrition 1998; 14:599-604. [PMID: 9684263]
60. Martin PM, Dun Y, Mysona B, Ananth S, Roon P, Smith SB, Ganapathy V. Expression of the sodium-coupled monocarboxylates transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina. Invest Ophthalmol Vis Sci 2007; 48:3356-63. [PMID: 17591909]
61. Hein TW, Xu W, Kuo L. Dilation of retinal arterioles in response to lactate: role of nitric oxide, guanyly cyclase, and ATP-sensitive potassium channels. Invest Ophthalmol Vis Sci 2006; 47:693-9. [PMID: 16431969]
62. Adijanto J, Philp NJ. The SLC16A family of mono-carboxylate transporters (MCTs) -physiology and function in cellular metabolism, pH homeostasis, and fluid transport. Curr Top Membr. 2012; 70:275-311.[PMID: 177990]