Exposing synonymous mutations

Trends in Genetics

Volumn 30, Issue 7, 2014, Pages 308-321

  Hunt, Ryan C ^a   Simhadri, Vijaya L ^a   Iandoli, Matthew ^a   Sauna, Zuben E ^a   Kimchi Sarfaty, Chava ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

Codon usage; MRNA structure; Synonymous mutation; Synonymous single nucleotide polymorphism; Translation speed

Indexed keywords

CATECHOL METHYLTRANSFERASE; CHYMOTRYPSIN; MULTIDRUG RESISTANCE PROTEIN 1; CODON; MESSENGER RNA;

AMINO ACID SEQUENCE; CODON; CODON USAGE; CPG ISLAND; DISEASE ASSOCIATION; DNA BASE COMPOSITION; EXON; EXON SKIPPING; GENE CONTROL; GENE MUTATION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MISSENSE MUTATION; NONSENSE MEDIATED MRNA DECAY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN SYNTHESIS; REVIEW; RNA STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; START CODON; SYNONYMOUS MUTATION; TRANSLATION INITIATION; ANIMAL; BIOLOGY; CHEMISTRY; CONFORMATION; GENETICS; METABOLISM; MUTATION; PROCEDURES; PROTEIN UNFOLDING; PROTEINOSIS; RNA SPLICING; RNA STABILITY;

ANIMALS; CODON; COMPUTATIONAL BIOLOGY; HUMANS; MUTATION; NUCLEIC ACID CONFORMATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN UNFOLDING; RNA SPLICING; RNA STABILITY; RNA, MESSENGER;

EID: 84903485906     PISSN: 01689525     EISSN: 13624555     Source Type: Journal    
DOI: 10.1016/j.tig.2014.04.006     Document Type: Review

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