Cannabinoids, endocannabinoids and stress

Cannabinoids

Volumn , Issue , 2014, Pages 139-174

  Hillard, Cecilia J ^a   Liu, Qing song ^a   Liu, XiaoQian ^a   Pan, Bin ^a   Roberts, Christopher J ^a   Shi, Leyu ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Central nervous system (CNS); ECB signalling (ECS); Endocannabinoid (eCB); Hypothalamic pituitary adrenocortical(HPA) axis; Stress; Sympathetic nervous system (SNS)

Indexed keywords

EID: 84947595350     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118451281.ch5     Document Type: Chapter

References (179)

1. Agrawal, A., Nelson, E.C., Littlefield, A.K., et al. (2012) Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression. Arch Gen Psychiatry., 69, 732-740.
2. Ahluwalia, J., Urban, L., Capogna, M., et al. (2000) Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience, 100, 685-688.
3. Atkinson, H.C., Leggett, J.D., Wood, S.A., et al. (2010) Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic. Endocrinology, 151, 3720-3727.
4. Bab, I. and Zimmer, A. (2008) Cannabinoid receptors and the regulation of bone mass. Br J Pharmacol., 153, 182-188.
5. 1 receptor knockout mice. Life Sci., 75, 2959-2970.
6. Baschant, U., Lane, N.E. and Tuckermann, J. (2012) The multiple facets of glucocorticoid action in rheumatoid arthritis. Nat Rev Rheumatol., 8, 645-655.
7. 1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol., 63, 908-914.
8. Bisogno, T., Howell, F.,Williams, G., et al. (2003) Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol., 163, 463-468.
9. Blankman, J.L., Simon, G.M. and Cravatt, B.F. (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol., 14, 1347-1356.
10. Bortolato, M., Mangieri, R.A., Fu, J., et al. (2007) Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry, 62, 1103-1110.
11. Bouaboula, M., Rinaldi, M., Carayon, P., et al. (1993) Cannabinoid-receptor expression in human leukocytes. Eur J Biochem., 214, 173-180.
12. Bowles, N.P., Hill, M.N., Bhagat, S.M., et al. (2012) Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice. Neurosci., 204, 83-89.
13. 2 receptor messenger RNAs during embryonic development in the rat. Neurosci., 82, 1131-1149.
14. Bujarski, S.J., Norberg, M.M. and Copeland, J. (2012) The association between distress tolerance and cannabis use-related problems: the mediating and moderating roles of coping motives and gender. Addict Behav., 37, 1181-1184.
15. 1 receptors expression in brain areas associated with PTSD symptoms. Neurosci Lett., 533, 34-38.
16. Carrier, E.J., Patel, S. and Hillard, C.J. (2005) Endocannabinoids in neuroimmunology and stress. Curr Drug Targets CNS Neurol Disord., 4, 657-665.
17. Chabrol, H., Duconge, E., Casas, C. et al. (2005) Relations between cannabis use and dependence, motives for cannabis use and anxious, depressive and borderline symptomatology. Addict Behav., 30, 829-840.
18. Charney, D.S. (2004) Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry, 161, 195-216.
19. Colodzin, M., Bachur, N.R.,Weissbach, H. and Udenfriend, S. (1963) Enzymatic formation of fatty acid amides of ethanolamine by rat liver microsomes. Biochem Biophys Res Commun., 10, 165-170.
20. Cota, D., Steiner,M.A., Marsicano, G., et al. (2007) Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function. Endocrinology, 148, 1574-1581.
21. Coutts, A.A., Irving, A.J., Mackie, K. et al. (2002) Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus. J Comp Neurol., 448, 410-422.
22. Crippa, J.A., Zuardi, A.W., Martin-Santos, R. et al. (2009) Cannabis and anxiety: a critical review of the evidence. Hum Psychopharmacol., 24, 515-523.
23. Dantzer, R., O'Connor, J.C., Freund, G.G. et al. (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci., 9, 46-56.
24. De Bitencourt, R.M., Pamplona, F.A. and Takahashi, R.N. (2013) A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: Potential extinction enhancers. Neuropharmacol., 64, 389-395.
25. De Kloet, E.R., Vreugdenhil, E., Oitzl, M.S. and Joels, M. (1998) Brain corticosteroid receptor balance in health and disease. Endocr Rev., 19, 269-301.
26. Dean, C. (2011a) Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat. Am J Physiol Regul Integr Comp Physiol., 301, R1765-1772.
27. Dean, C. (2011b) Endocannabinoid modulation of sympathetic and cardiovascular responses to acute stress in the periaqueductal gray of the rat. Am J Physiol Regul Integr Comp Physiol., 300, R771-779.
28. Devane,W.A., Dysarz, F.A.3rd, Johnson, M.R., et al. (1988) Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol., 34, 605-613.
29. Devane, W.A., Hanus, L., Breuer, A., et al. (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science, 258, 1946-1949.
30. Di, S., Malcher-Lopes, R., Halmos, K.C. and Tasker, J.G. (2003) Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J Neurosci., 23, 4850-4857.
31. Di, S., Malcher-Lopes, R., Marcheselli, V.L., et al. (2005) Rapid glucocorticoidmediated endocannabinoid release and opposing regulation of glutamate and GABA inputs to hypothalamic magnocellular neurons. Endocrinology, 146, 4292-4301.
32. Edwards, D.A., Kim, J. and Alger, B.E. (2006) Multiple mechanisms of endocannabinoid response initiation in hippocampus. J Neurophysiol., 95, 67-75.
33. Evanson, N.K., Tasker, J.G., Hill, M.N., et al. (2010) Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. Endocrinology, 151, 4811-4819.
34. Fegley, D., Gaetani, S., Duranti, A., et al. (2005) Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3′-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther., 313, 352-358.
35. Finn, D.P. (2010) Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance. Immunobiology, 215, 629-646.
36. Fox, C.L., Towe, S.L., Stephens, R.S., et al. (2011) Motives for cannabis use in high-risk adolescent users. Psychol Addict Behav., 25, 492-500.
37. Freund, T.F., Katona, I. and Piomelli, D. (2003) Role of endogenous cannabinoids in synaptic signaling. Physiol Rev., 83, 1017-1066.
38. Ganon-Elazar, E. and Akirav, I. (2009) Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance. J Neurosci., 29, 11078-11088.
39. Gaoni,Y. and Mechoulam, R. (1964) Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc., 86, 1646-1647.
40. 1-receptors and beta-adrenoceptors in the regional hemodynamic responses to lipopolysaccharide infusion in conscious rats. Am J Physiol Heart Circ Physiol., 288, H2280-2288.
41. 1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. Am J Physiol., 276, H2085-H2093.
42. Goldstein, D.S. (2011) Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases. Endocrine Regulations, 45, 91-8.
43. Golech, S.A., McCarron, R.M., Chen, Y., et al. (2004) Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. Brain Res Mol Brain Res., 132, 87-92.
44. Gray, M., Veccharelli, H., Kim, A., et al. (2013) International Cannabinoid Research Society Annual Meeting Vancouver, BC.
45. Gulyas, A.I., Cravatt, B.F., Bracey, M.H., et al. (2004) Segregation of two endocannabinoid-hydrolyzing enzymes into pre-and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Eur J Neurosci., 20, 441-458.
46. Herkenham,M., Lynn, A.B., Little,M.D., et al. (1990) Cannabinoid receptor localization in brain. Proc Natl Acad Sci., 87, 1932-1936.
47. Herman, J.P., Figueiredo, H., Mueller, N.K., et al. (2003) Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol., 24, 151-180.
48. Hermann, H.,Marsicano, G. and Lutz, B. (2002) Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain. Neuroscience, 109, 451-460.
49. Hill, M.N. and McEwen, B.S. (2009) Endocannabinoids: The silent partner of glucocorticoids in the synapse. Proc Natl Acad Sci USA, 106, 4579-4580.
50. Hill, M.N., Ho, W.S., Meier, S.E., et al. (2005a) Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala. Eur J Pharmacol., 528, 99-102.
51. Hill, M.N., Patel, S., Carrier, E.J., et al. (2005b) Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. Neuropsychopharmacology, 30, 508-515.
52. 1 receptor density in the hippocampus. Hippocampus, 18, 221-226.
53. Hill, M.N., Carrier, E.J., McLaughlin, R.J., et al. (2008b) Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. J Neurochem., 106, 2322-2336.
54. Hill, M.N., Hunter, R.G. and McEwen, B.S. (2009a) Chronic stress differentially regulates cannabinoid CB(1) receptor binding in distinct hippocampal subfields. Eur J Pharmacol., 614, 66-69.
55. Hill, M.N., McLaughlin, R.J., Morrish, A.C., et al. (2009b) Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. Neuropsychopharmacology, 34, 2733-2745.
56. Hill, M.N., Karatsoreos, I.N., Hillard, C.J. and McEwen, B.S. (2010a) Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo. Psychoneuroendocrinology, 35, 1333-1338.
57. Hill, M.N.,McLaughlin, R.J., Bingham, B., et al. (2010b) Endogenous cannabinoid signaling is essential for stress adaptation. Proc Natl Acad Sci USA, 107, 9406-9411.
58. Hill, M.N., McLaughlin, R.J., Pan, B., et al. (2011) Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. J Neurosci., 31, 10506-10515.
59. 1). J Pharmacol Exp Ther., 289, 1427-1433.
60. Hillard, C.J., Weinlander, K.M. and Stuhr, K.L. (2012) Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. Neuroscience, 204, 207-229.
61. Hohmann, A.G., Suplita, R.L., Bolton, N.M., et al. (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature, 435, 1108-1112.
62. Hollister, L.E., Moore, F., Kanter, S. and Noble, E. (1970) 1-tetrahydrocannabinol, synhexyl and marijuana extract administered orally in man: catecholamine excretion, plasma cortisol levels and platelet serotonin content. Psychopharmacologia, 17, 354-360.
63. Hong, S., Zheng, G., Wu, X., et al. (2011) Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat. Gastroenterology, 140, 627-637.
64. Howlett, A.C. (1985) Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes. Mol Pharmacol., 27, 429-436.
65. Hu,W., Zhang, M., Czeh, B., et al. (2011) Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats. Brain Res Bull., 85, 374-379.
66. 1-selective cannabinoid receptor antagonist SR141716. Arch Gen Psychiatry, 58, 322-328.
67. Hyman, S.M. and Sinha, R. (2009) Stress-related factors in cannabis use and misuse: implications for prevention and treatment. J Subst Abuse Treat., 36, 400-413.
68. 1 receptors on peripheral sympathetic nerves. Br J Pharmacol., 118, 2023-2028.
69. Izzo, A.A. and Sharkey, K.A. (2010) Cannabinoids and the gut: new developments and emerging concepts. Pharmacol Ther., 126, 21-38.
70. 1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab., 7, 227-235.
71. Joels, M., Sarabdjitsingh, R.A. and Karst, H. (2012) Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes. Pharmacol Rev., 64, 901-938.
72. 1 receptor mediates fear extinction via habituation-like processes. J Neurosci., 26, 6677-6686.
73. Kamprath, K., Plendl,W., Marsicano, G., et al. (2009) Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling. Genes Brain Behav., 8, 203-211.
74. Kamprath, K., Romo-Parra, H., Haring, M., et al. (2011) Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala. Neuropsychopharmacology, 36, 652-663.
75. Kaplan, H.B., Martin, S.S., Johnson, R.J. and Robbins, C.A. (1986) Escalation of marijuana use: application of a general theory of deviant behavior. J Health Soc Behav., 27, 44-61.
76. Karst, H., Berger, S., Turiault, M., et al. (2005) Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci USA, 102, 19204-19207.
77. Karst, H., Berger, S., Erdmann, G., et al. (2010) Metaplasticity of amygdalar responses to the stress hormone corticosterone. Proc Natl Acad Sci USA, 107, 14449-14454.
78. 1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J Neurosci., 19, 4544-4558.
79. Katona, I., Urban, G.M., Wallace, M., et al. (2006) Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci., 26, 5628-5637.
80. 1 and the induction of GDP/GTP exchange. J Neurochem., 72, 2379-2387.
81. Keller-Wood, M.E. and Dallman, M.F. (1984) Corticosteroid inhibition of ACTH secretion. Endocr Rev., 5, 1-24.
82. Khansari, D.N., Murgo, A.J. and Faith, R.E. (1990) Effects of stress on the immune system. Immunology Today, 11, 170-175.
83. Kim, J. and Alger, B.E. (2004) Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. Nat Neurosci., 7, 697-698.
84. Ko, J.Y., Wu, R.W., Kuo, S.J., et al. (2012) Cannabinoid receptor 1 mediates glucocorticoid-induced bone loss in rats by perturbing bone mineral acquisition and marrow adipogenesis. Arthritis Rheum., 64, 1204-1214.
85. Konturek, P.C., Brzozowski, T. and Konturek, S.J. (2011) Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol., 62, 591-599.
86. Koob, G.F. (2009) Brain stress systems in the amygdala and addiction. Brain Res., 1293, 61-75.
87. Kozak, K.R., Prusakiewicz, J.J. and Marnett, L.J. (2004) Oxidative metabolism of endocannabinoids by COX-2. Curr Pharm Des., 10, 659-667.
88. 1-cannabinoid receptor immunoreactivity in the porcine enteric nervous system. Cell Tissue Res., 302, 73-80.
89. Kunos, G., Batkai, S., Offertaler, L., et al. (2002) The quest for a vascular endothelial cannabinoid receptor. Chem Phys Lipids, 121, 45-56.
90. Kupferschmidt, D.A., Newman, A.E., Boonstra, R. and Erb, S. (2012) Antagonism of cannabinoid 1 receptors reverses the anxiety-like behavior induced by central injections of corticotropin-releasing factor and cocaine withdrawal. Neuroscience, 204, 125-133.
91. Kurihara, J., Nishigaki, M., Suzuki, S., et al. (2001) 2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves. Jpn J Pharmacol, 87, 93-96.
92. Lafourcade, M., Elezgarai, I., Mato, S., et al. (2007) Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. PLoS ONE, 2, e709.
93. Lai, M.C. and Huang, L.T. (2011) Effects of early life stress on neuroendocrine and neurobehavior: mechanisms and implications. Pediatr Neonatol., 52, 122-129.
94. Lightman, S.L. (2008) The neuroendocrinology of stress: a never ending story. J Neuroendocrinol., 20, 880-884.
95. Llorente-Berzal, A., Fuentes, S., Gagliano, H., et al. (2011) Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour. Addict Biol., 16, 624-637.
96. Lupien, S.J., McEwen, B.S., Gunnar, M.R. and Heim, C. (2009) Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci., 10, 434-445.
97. Ma, Y., Matsuwaki, T., Yamanouchi, K. and Nishihara, M. (2013) Cyclooxygenase-2-related signaling in the hypothalamus plays differential roles in response to various acute stresses. Brain Res., 1508, 23-33.
98. Mackie, K. (2005) Distribution of cannabinoid receptors in the central and peripheral nervous system. Handb Exp Pharmacol., 299-325.
99. Maejima, T., Ohno-Shosaku, T. and Kano, M. (2001) Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals. Neurosci Res., 40, 205-210.
100. Mailleux, P. and Vanderhaeghen, J.J. (1993) Glucocorticoid regulation of cannabinoid receptor messenger RNA levels in the rat caudate-putamen. An in situ hybridization study. Neurosci Lett., 156, 51-53.
101. Maletic, V. and Raison, C.L. (2009) Neurobiology of depression, fibromyalgia and neuropathic pain. Front Biosci., 14, 5291-5338.
102. Manzanares, J., Corchero, J. and Fuentes, J.A. (1999) Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of delta(9)-tetrahydrocannabinol in rats. Brain Res., 839, 173-179.
103. Marin, M.T., Cruz, F.C. and Planeta, C.S. (2007) Chronic restraint or variable stresses differently affect the behavior, corticosterone secretion and body weight in rats. Physiol Behav., 90, 29-35.
104. Marrs, W.R., Blankman, J.L., Horne, E.A., et al. (2010) The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci., 13, 951-957.
105. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 346, 561-564.
106. McEwen, B.S. (1994) Steroid hormone actions on the brain: when is the genome involved? Horm Behav., 28, 396-405.
107. McLaughlin, R.J., Hill, M.N., Bambico, F.R., et al. (2012) Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. Eur Neuropsychopharmacol., 22, 664-671.
108. Mechoulam, R., Ben-Shabat, S., Hanus, L., et al. (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol., 50, 83-90.
109. 1 -receptor antagonist involves beta2 adrenoceptors. J Pharmacol Exp Ther., 333, 445-453.
110. Moldrich, G. and Wenger, T. (2000) Localization of the CB(1) cannabinoid receptor in the rat brain. An immunohistochemical study*. Peptides, 21, 1735-1742.
111. 1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol., 50, 528-536.
112. Munro, S., Thomas, K.L. and Abu-Shaar, M. (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365, 61-65.
113. Newsom, R.J., Osterlund, C., Masini, C.V., et al. (2012) Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic-pituitary-adrenal axis responses in male Sprague-Dawley rats. Neuroscience, 204, 64-73.
114. Niederhoffer, N., Hansen, H.H., Fernandez-Ruiz, J.J. and Szabo, B. (2001) Effects of cannabinoids on adrenaline release from adrenal medullary cells. Br J Pharmacol., 134, 1319-1327.
115. O'Sullivan, S.E., Kendall, P.J. and Kendall, D.A. (2012) Endocannabinoids and the cardiovascular response to stress. J Psychopharmacol., 26, 71-82.
116. Oropeza, V.C., Mackie, K. and Van Bockstaele, E.J. (2007) Cannabinoid receptors are localized to noradrenergic axon terminals in the rat frontal cortex. Brain Res., 1127, 36-44.
117. Pacher, P. and Gao, B. (2008) Endocannabinoids and liver disease. III. Endocannabinoid effects on immune cells: implications for inflammatory liver diseases. Am J Physiol Gastrointest Liver Physiol., 294, G850-854.
118. Pagotto, U., Marsicano, G., Fezza, F., et al. (2001) Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level. J Clin Endocrinol Metab., 86, 2687-2696.
119. Palanza, P. (2001) Animal models of anxiety and depression: how are females different? Neurosci Biobehav Rev., 25, 219-233.
120. Patel, S. and Hillard, C.J. (2006) Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. J Pharmacol Exp Ther., 318, 304-311.
121. Patel, S. and Hillard, C.J. (2008) Adaptations in endocannabinoid signaling in response to repeated homotypic stress: A novel mechanism for stress habituation. Eur J Neurosci., 27, 2821-2829.
122. Patel, S., Roelke, C.T., Rademacher, D.J., et al. (2004) Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology, 145, 5431-5338.
123. Patel, S., Carrier, E.J., Ho, W.S., et al. (2005a) The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. J Lipid Res., 46, 342-349.
124. Patel, S., Roelke, C.T., Rademacher, D.J. and Hillard, C.J. (2005b) Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling. Eur J Neurosci., 21, 1057-1069.
125. Pfitzer, T., Niederhoffer, N. and Szabo, B. (2005) Search for an endogenous cannabinoid-mediated effect in the sympathetic nervous system. Naunyn Schmiedebergs Arch Pharmacol., 371, 9-17.
126. Quarta, C., Bellocchio, L., Mancini, G., et al. (2010) CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metab., 11, 273-285.
127. Rademacher, D.J. and Hillard, C.J. (2007) Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward. Prog Neuropsychopharmacol Biol Psychiatry, 31, 633-641.
128. Rademacher, D.J., Meier, S.E., Shi, L., et al. (2008) Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. Neuropharmacology, 54, 108-116.
129. Radley, J.J. and Sawchenko, P.E. (2011) A common substrate for prefrontal and hippocampal inhibition of the neuroendocrine stress response. J Neurosci., 31, 9683-9695.
130. Reich, C.G., Mohammadi, M.H. and Alger, B.E. (2008) Endocannabinoid modulation of fear responses: learning and statedependent performance effects. J Psychopharmacol., 22, 769-777
131. 1 receptors in male and female rats. Behav Brain Res., 203, 264-269.
132. Rettori, E., De Laurentiis, A., Zorrilla Zubilete, M., et al. (2012) Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat. Neuroimmunomodulation, 19, 293-303.
133. Reul, J.M. and de Kloet, E.R. (1985) Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology, 117, 2505-2511.
134. Riebe, C.J. and Wotjak, C.T. (2011) Endocannabinoids and stress. Stress, 14, 384-397.
135. Robinson, S.A., Loiacono, R.E., Christopoulos, A., et al. (2010) The effect of social isolation on rat brain expression of genes associated with endocannabinoid signalling. Brain Res., 1343, 153-167.
136. 1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. Neuropharmacology, 54, 976-988.
137. Salio, C., Doly, S., Fischer, J., et al. (2002) Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord. Neurosci Lett., 329, 13-16.
138. Schmid, H.H.O., Schmid, P.C. and Natarajan., V. (1990) N-Acylated glycerophospholipids and their derivatives. Prog Lipid Res., 29, 1-43.
139. Sciolino, N.R., Bortolato, M., Eisenstein, S.A., et al. (2010) Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience, 168, 371-386.
140. Seagard, J.L., Dean, C., Patel, S., et al. (2004) Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. Am J Physiol Heart Circ Physiol., 286, H992-H1000.
141. Semenoff-Segundo, A., Porto, A.N., Semenoff, T.A., et al. (2012) Effects of two chronic stress models on ligature-induced periodontitis in Wistar rats. Arch Oral Biol., 57, 66-72.
142. Serrano, A., Rivera, P., Pavon, F.J., et al. (2012) Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala. Alcohol Clin Exp Res., 36, 984-994.
143. Severn, A., Rapson, N.T., Hunter, C.A. and Liew, F.Y. (1992) Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists. J Immunol., 148, 3441-3445.
144. Shen, L., Yang, X.J., Qian,W. and Hou, X.H. (2010) The role of peripheral cannabinoid receptors type 1 in rats with visceral hypersensitivity induced by chronic restraint stress. J Neurogastroenterol Motil., 16, 281-290.
145. Shimizu, T., Lu, L. and Yokotani, K. (2010) Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats. Eur J Pharmacol., 641, 54-60.
146. Simon, G.M. and Cravatt, B.F. (2010) Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo. Mol Biosyst., 6, 1411-1418.
147. Stocco, D.M.,Wang, X., Jo, Y. and Manna, P.R. (2005) Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought. Mol Endocrinol., 19, 2647-2659.
148. Storr, M.A. and Sharkey, K.A. (2007) The endocannabinoid system and gut-brain signalling. Curr Opin Pharmacol., 7, 575-582.
149. Straiker, A., Wager-Miller, J., Hu, S.S., et al. (2011) COX-2 and FAAH can regulate the time course of depolarization induced suppression of excitation. Br J Pharmacol., 164, 1672-1683.
150. Sugiura, T. and Waku, K. (2002) Cannabinoid receptors and their endogenous ligands. J Biochem (Tokyo), 132, 7-12.
151. Sugiura, T., Kondo, S., Sukagawa, A., et al. (1995) 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun., 215, 89-97.
152. Sumislawski, J.J., Ramikie, T.S. and Patel, S. (2011) Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. Neuropsychopharmacology, 36, 2750-2761.
153. 1 receptor regulates bone formation by modulating adrenergic signaling. FASEB J., 22, 285-294.
154. Thoits, P.A. (2010) Stress and health: major findings and policy implications. J Health Soc Behav., 51 Suppl, S41-53.
155. 1 receptors in the rat central nervous system. Neurosci., 83, 393-411.
156. Tsou, K., Nogueron, M.I., Muthian, S., et al. (1998b) Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. Neurosci Lett., 254, 137-140.
157. Ueda, N., Tsuboi, K. and Uyama, T. (2010) N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA). Prog Lipid Res., 49, 299-315.
158. Ulrich-Lai, Y.M., Arnhold, M.M. and Engeland,W.C. (2006) Adrenal splanchnic innervation contributes to the diurnal rhythm of plasma corticosterone in rats by modulating adrenal sensitivity to ACTH. Am J Physiol Regul Integr Comp Physiol, 290, R1128-1135.
159. Ulrich-Lai, Y.M. and Herman, J.P. (2009) Neural regulation of endocrine and autonomic stress responses. Nature reviews. Neuroscience, 10, 397-409.
160. van Dijk, G. and Buwalda, B. (2008) Neurobiology of the metabolic syndrome: an allostatic perspective. Eur J Pharmacol., 585, 137-146.
161. Varga, K., Lake, K.D., Huangfu, D., et al. (1996) Mechanism of the hypotensive action of anandamide in anesthetized rats. Hypertension, 28, 682-686.
162. Verkuyl, J.M., Karst, H. and Joels, M. (2005) GABAergic transmission in the rat paraventricular nucleus of the hypothalamus is suppressed by corticosterone and stress. Eur J Neurosci., 21, 113-121.
163. 1 receptor antagonism modulates plasma corticosterone in rodents. Eur J Pharmacol., 551, 162-167.
164. Wagner, J.A., Hu, K., Bauersachs, J., et al. (2001) Endogenous cannabinoids mediate hypotension after experimental myocardial infarction. J Am Coll Cardiol., 38, 2048-2054.
165. Waleh, N.S., Cravatt, B.F., Apte-Deshpande, A., et al. (2002) Transcriptional regulation of the mouse fatty acid amide hydrolase gene. Gene, 291, 203-210.
166. Wang, J., Shen, R.Y. and Haj-Dahmane, S. (2012) Endocannabinoids mediate the glucocorticoid-induced inhibition of excitatory synaptic transmission to dorsal raphe serotonin neurons. J Physiol., 590, 5795-5808.
167. Wang, M., Hill, M.N., Zhang, L., et al. (2012) Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. J Psychopharmacol, 26, 56-70.
168. Wang, S., Lim, G., Mao, J., et al. (2007) Central glucocorticoid receptors regulate the upregulation of spinal cannabinoid-1 receptors after peripheral nerve injury in rats. Pain, 131, 96-105.
169. Wang, W., Sun, D., Pan, B., et al. (2010) Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress. Neuropsychopharmacology, 35, 2249-2261.
170. Willner, P. (2005) Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology, 52, 90-110.
171. Woof, J.M. and Mestecky, J. (2005) Mucosal immunoglobulins. Immunol Rev., 206, 64-82.
172. Xing, G., Carlton, J., Zhang, L., et al. (2011) Cannabinoid receptor expression and phosphorylation are differentially regulated between male and female cerebellum and brain stem after repeated stress: Implication for PTSD and drug abuse. Neurosci Lett., 502, 5-9.
173. Yamakawa, K., Matsunaga, M., Isowa, T., et al. (2009) Transient responses of inflammatory cytokines in acute stress. Biol Psychol., 82, 25-32.
174. Young, E. and Korszun, A. (2010) Sex, trauma, stress hormones and depression. Mol Psychiatry, 15, 23-28.
175. Zias, J., Stark, H., Sellgman, J., et al. (1993) Early medical use of cannabis. Nature, 363, 215.
176. Ziegler, C.G., Mohn, C., Lamounier-Zepter, V., et al. (2010a) Expression and function of endocannabinoid receptors in the human adrenal cortex. Horm Metab Res., 42, 88-92.
177. Ziegler, C.G., Mohn, C., Lamounier-Zepter, V. et al. (2010b) Expression and function of endocannabinoid receptors in the human adrenal cortex. Horm Metab Res., 42, 88-92.
178. Zoppi, S., Perez Nievas, B.G., Madrigal, J.L., et al. (2011) Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation. Neuropsychopharmacology, 36, 805-818.
179. Zoppi, S., Madrigal, J.L., Perez-Nievas, B.G., et al. (2012) Endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation. Am J Physiol Gastrointest Liver Physiol., 302, G565-571.