Cannabinoid receptor expression and phosphorylation are differentially regulated between male and female cerebellum and brain stem after repeated stress: Implication for PTSD and drug abuse

Neuroscience Letters

Volumn 502, Issue 1, 2011, Pages 5-9

  Xing, Guoqiang ^a   Carlton, Janis ^a   Zhang, Lei ^a   Jiang, Xiaolong ^a   Fullerton, Carol ^a   Li, He ^a   Ursano, Robert ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Brain stem; Cannabinoid receptor; Cerebellum; Sex dimorphism; Traumatic stress

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN STEM; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG ABUSE; ELECTRIC SHOCK; FEMALE; GENE EXPRESSION; MALE; NONHUMAN; NOTE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; STRESS; WESTERN BLOTTING;

ANIMALS; BRAIN STEM; CEREBELLUM; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; ELECTRIC STIMULATION; FEMALE; HUMANS; MALE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CANNABINOID; SEX CHARACTERISTICS; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; SUBSTANCE-RELATED DISORDERS;

EID: 80051794153     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.05.013     Document Type: Note

References (49)

1. Asmundson G.J., Coons M.J., Taylor S., Katz J. PTSD and the experience of pain: research and clinical implications of shared vulnerability and mutual maintenance models. Can. J. Psychiatry 2002, 47:930-937.
2. Asmundson G.J., Katz J. Understanding pain and posttraumatic stress disorder comorbidity: do pathological responses to trauma alter the perception of pain?. Pain 2008, 138:247-249.
3. Bonn-Miller M.O., Vujanovic A.A., Feldner M.T., Bernstein A., Zvolensky M.J. Posttraumatic stress symptom severity predicts marijuana use coping motives among traumatic event-exposed marijuana users. J. Trauma. Stress 2007, 20:577-586.
4. Bornovalova M.A., Ouimette P., Crawford A.V., Levy R. Testing gender effects on the mechanisms explaining the association between post-traumatic stress symptoms and substance use frequency. Addict. Behav. 2009, 34:685-692.
5. Bradshaw H.B., Rimmerman N., Krey J.F., Walker J.M. Sex and hormonal cycle differences in rat brain levels of pain-related cannabimimetic lipid mediators. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 291:R349-R358.
6. Braga M.F., Aroniadou-Anderjaska V., Manion S.T., Hough C.J., Li H. Stress impairs alpha(1A) adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala. Neuropsychopharmacology 2004, 29:45-58.
7. Breslau N., Chilcoat H.D., Kessler R.C., Peterson E.L., Lucia V.C. Vulnerability to assaultive violence: further specification of the sex difference in post-traumatic stress disorder. Psychol. Med. 1999, 29:813-821.
8. Butkevich I., Mikhailenko V., Semionov P., Bagaeva T., Otellin V., Aloisi A.M. Effects of maternal corticosterone and stress on behavioral and hormonal indices of formalin pain in male and female offspring of different ages. Horm. Behav. 2009, 55:149-157.
9. Caudell K.A., Gallucci B.B. Neuroendocrine and immunological responses of women to stress. West. J. Nurs. Res. 1995, 17:672-692.
10. Craft R.M. Sex differences in behavioral effects of cannabinoids. Life Sci. 2005, 77:2471-2478.
11. De Bellis M.D., Kuchibhatla M. Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol. Psychiatry 2006, 60:697-703.
12. Dogrul A., Gardell L.R., Ma S., Ossipov M.H., Porreca F., Lai J. 'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice. Pain 2002, 100:203-209.
13. Driessen M., Schulte S., Luedecke C., Schaefer I., Sutmann F., Ohlmeier M., Kemper U., Koesters G., Chodzinski C., Schneider U., Broese T., Dette C., Havemann-Reinicke U. Trauma and PTSD in patients with alcohol, drug, or dual dependence: a multi-center study. Alcohol. Clin. Exp. Res. 2008, 32:481-488.
14. Egertova M., Elphick M.R. Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB. J. Comp. Neurol. 2000, 422:159-171.
15. Fan F., Tao Q., Abood M., Martin B.R. Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice. Brain Res. 1996, 706:13-20.
16. Fattore L., Spano M.S., Altea S., Angius F., Fadda P., Fratta W. Cannabinoid self-administration in rats: sex differences and the influence of ovarian function. Br. J. Pharmacol. 2007, 152:795-804.
17. Fattore L., Spano M.S., Deiana S., Melis V., Cossu G., Fadda P., Fratta W. An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives. Brain Res. Rev. 2007, 53:1-16.
18. Garcia D.E., Brown S., Hille B., Mackie K. Protein kinase C disrupts cannabinoid actions by phosphorylation of the CB1 cannabinoid receptor. J. Neurosci. 1998, 18:2834-2841.
19. Haller J., Bakos N., Szirmay M., Ledent C., Freund T.F. The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. Eur. J. Neurosci. 2002, 16:1395-1398.
20. Herkenham M., Lynn A.B., Little M.D., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Cannabinoid receptor localization in brain. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:1932-1936.
21. Hernandez-Avila C.A., Rounsaville B.J., Kranzler H.R. Opioid-, cannabis- and alcohol-dependent women show more rapid progression to substance abuse treatment. Drug Alcohol Depend. 2004, 74:265-272.
22. Hill M.N., Carrier E.J., Ho W.S., Shi L., Patel S., Gorzalka B.B., Hillard C.J. Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. Hippocampus 2008, 18:221-226.
23. Koenen K.C., Lyons M.J., Goldberg J., Simpson J., Williams W.M., Toomey R., Eisen S.A., True W., Tsuang M.T. Co-twin control study of relationships among combat exposure, combat-related PTSD, and other mental disorders. J. Trauma. Stress 2003, 16:433-438.
24. Lopez-Gallardo M., Llorente R., Llorente-Berzal A., Marco E.M., Prada C., Di Marzo V., Viveros M.P. Neuronal and glial alterations in the cerebellar cortex of maternally deprived rats: gender differences and modulatory effects of two inhibitors of endocannabinoid inactivation. Dev. Neurobiol. 2008, 68:1429-1440.
25. Mackie K. Distribution of cannabinoid receptors in the central and peripheral nervous system. Handb. Exp. Pharmacol. 2005, 299-325.
26. Malcher-Lopes R., Franco A., Tasker J.G. Glucocorticoids shift arachidonic acid metabolism toward endocannabinoid synthesis: a non-genomic anti-inflammatory switch. Eur. J. Pharmacol. 2008, 583:322-339.
27. Marsicano G., Wotjak C.T., Azad S.C., Bisogno T., Rammes G., Cascio M.G., Hermann H., Tang J., Hofmann C., Zieglgansberger W., Di Marzo V., Lutz B. The endogenous cannabinoid system controls extinction of aversive memories. Nature 2002, 418:530-534.
28. Martin M., Ledent C., Parmentier M., Maldonado R., Valverde O. Involvement of CB1 cannabinoid receptors in emotional behaviour. Psychopharmacology (Berl) 2002, 159:379-387.
29. Mathew R.J., Wilson W.H., Turkington T.G., Coleman R.E. Cerebellar activity and disturbed time sense after THC. Brain Res. 1998, 797:183-189.
30. Mellman T.A., Kumar A., Kulick-Bell R., Kumar M., Nolan B. Nocturnal/daytime urine noradrenergic measures and sleep in combat-related PTSD. Biol. Psychiatry 1995, 38:174-179.
31. Morgan C.A., Grillon C., Lubin H., Southwick S.M. Startle reflex abnormalities in women with sexual assault-related posttraumatic stress disorder. Am. J. Psychiatry 1997, 154:1076-1080.
32. Morgan C.A., Grillon C., Southwick S.M., Davis M., Charney D.S. Exaggerated acoustic startle reflex in Gulf War veterans with posttraumatic stress disorder. Am. J. Psychiatry 1996, 153:64-68.
33. Narimatsu S., Watanabe K., Yamamoto I., Yoshimura H. Sex difference in the oxidative metabolism of delta 9-tetrahydrocannabinol in the rat. Biochem. Pharmacol. 1991, 41:1187-1194.
34. Nong L., Newton C., Cheng Q., Friedman H., Roth M.D., Klein T.W. Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. J. Neuroimmunol. 2002, 127:169-176.
35. Nunnink S.E., Goldwaser G., Heppner P.S., Pittman J.O., Nievergelt C.M., Baker D.G. Female veterans of the OEF/OIF conflict: concordance of PTSD symptoms and substance misuse. Addict. Behav. 2010, 35:655-659.
36. Okulate G.T., Jones O.B. Post-traumatic stress disorder, survivor guilt and substance use--a study of hospitalised Nigerian army veterans. S. Afr. Med. J. 2006, 96:144-146.
37. Oviedo A., Glowa J., Herkenham M. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain Res. 1993, 616:293-302.
38. Pole N., Neylan T.C., Otte C., Henn-Hasse C., Metzler T.J., Marmar C.R. Prospective prediction of posttraumatic stress disorder symptoms using fear potentiated auditory startle responses. Biol. Psychiatry 2009, 65:235-240.
39. Pratchett L.C., Pelcovitz M.R., Yehuda R. Trauma and violence: are women the weaker sex?. Psychiatr. Clin. N. Am. 2010, 33:465-474.
40. Rodriguez de Fonseca F., Cebeira M., Ramos J.A., Martin M., Fernandez-Ruiz J.J. Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life Sci. 1994, 54:159-170.
41. Romero J., Garcia-Palomero E., Castro J.G., Garcia-Gil L., Ramos J.A., Fernandez-Ruiz J.J. Effects of chronic exposure to delta9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions. Brain Res. Mol. Brain Res. 1997, 46:100-108.
42. Schlicker E., Gothert M. Interactions between the presynaptic alpha2-autoreceptor and presynaptic inhibitory heteroreceptors on noradrenergic neurones. Brain Res. Bull. 1998, 47:129-132.
43. Sullivan T.P., Holt L.J. PTSD symptom clusters are differentially related to substance use among community women exposed to intimate partner violence. J. Trauma. Stress 2008, 21:173-180.
44. Tseng A.H., Craft R.M. CB(1) receptor mediation of cannabinoid behavioral effects in male and female rats. Psychopharmacology (Berl) 2004, 172:25-30.
45. Tseng A.H., Craft R.M. Sex differences in antinociceptive and motoric effects of cannabinoids. Eur. J. Pharmacol. 2001, 430:41-47.
46. Uriguen L., Perez-Rial S., Ledent C., Palomo T., Manzanares J. Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors. Neuropharmacology 2004, 46:966-973.
47. Ursano R.J., Fullerton C.S. Posttraumatic stress disorder: cerebellar regulation of psychological, interpersonal, and biological responses to trauma?. Psychiatry 1999, 62:325-328.
48. Van Sickle M.D., Duncan M., Kingsley P.J., Mouihate A., Urbani P., Mackie K., Stella N., Makriyannis A., Piomelli D., Davison J.S., Marnett L.J., Di Marzo V., Pittman Q.J., Patel K.D., Sharkey K.A. Identification and functional characterization of brain stem cannabinoid CB2 receptors. Science 2005, 310:329-332.
49. Vetter S., Rossegger A., Rossler W., Bisson J.I., Endrass J. Exposure to the tsunami disaster, PTSD symptoms and increased substance use - an Internet based survey of male and female residents of Switzerland. BMC Public Health 2008, 8:92.