Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry

Neuroscience Letters

Volumn 254, Issue 3, 1998, Pages 137-140

  Tsou, Kang ^a   Nogueron, M Isabel ^c   Muthian, Shanmugam ^c   Sañudo Peña, M Clara ^a   Hillard, Cecilia J ^c   Deutsch, Dale G ^d   Walker, J Michael ^a,b  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

2 Arachidonylglycerol; Amidohydrolase; Cannabinoids; Fatty acid amide hydrolase; N arachidonylethanolamine

Indexed keywords

HYDROLASE;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; CENTRAL NERVOUS SYSTEM; ENZYME LOCALIZATION; IMMUNOHISTOCHEMISTRY; MALE; MITRAL CELL; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; PYRAMIDAL NERVE CELL; RAT; TISSUE DISTRIBUTION;

AMIDOHYDROLASES; ANIMALS; BRAIN; CEREBELLAR CORTEX; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NEOCORTEX; NEURONS; OLFACTORY BULB; ORGAN SPECIFICITY; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0032476070     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00700-9     Document Type: Article

References (15)

1. Arreaza G., Devane W.A., Omeir R.L., Sajnani G., Kunz J., Cravatt B.F., Deutsch D.G. The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine. Neurosci. Letts. 234:1997;59-62.
2. Cravatt B.F., Giang D.K., Mayfield S.P., Bolger D.L., Lerner R.A., Guila N.B. Molecular characterization of an enzyme that degrades neuromodulatory fatty acid amides. Nature. 384:1996;84-87.
3. Cravatt B.F., Prospero-Garcia O., Siuzdak G., Gilul N., Henriksen S., Bolger D.L., Lerner R.A. Chemical characterization of a family of brain lipids that induce sleep. Science. 268:1995;1506-1509.
4. Desarnaud F., Cadas H., Piomelli D. Anandamide amidohydrolase activity in rat brain microsomes. J. Biol. Chem. 270:1995;6030-6035.
5. Deutsch D.G., Chin S.A. Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem. Pharmacol. 46:1993;791-796.
6. Devane W.A., Axelrod J. Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. Proc. Natl. Acad. Sci. USA. 91:1994;6698-6701.
7. Goparaju S.K., Ueda N., Yamaguchi H., Yamamoto S. Anandamide amidohydrolase reacting with 2-arachidonylglycerol, another cannabinoid receptor ligand. FEBS Letts. 422:1998;69-73.
8. Herkenham M., Lynn A.B., Little M.D., Johnson M.R., Melvin L.S., DeCosta B.R., Rice K.C. Cannabinoid receptor localization in brain. Proc. Natl. Acad. Sci. USA. 87:1990;1932-1936.
9. Hillard C., Wilkison D.M., Edgemond W.S., Campbell W.B. Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. Biochim. Biophys. Acta. 1257:1995;249-256.
10. Kitahama K., Arai R., Maeda T., Jouvet M. Demonstration of monoamine oxidase type B in serotonergic and type A in noradrenergic neurons in the cat dorsal pontine tegmentum by an improved histochemical technique. Neurosci. Lett. 71:1986;19-24.
11. Kruszka K.K., Gross R.W. The ATP- and CoA-independent synthesis of anandamide, a cannabinoid receptor agonist. J. Biol. Chem. 269:1994;14345-14348.
12. Natarajan V., Schmid P.C., Reddy P.V., Schmid H.H. Catabolism of N-acylethanolamine phospholipids by dog brain preparations. J. Neurochem. 42:1984;1613-1619.
13. Schmid P.C., Zuzarte-Augustin M.L., Schmid H.H. Properties of rat liver N-acylethanolamine amidohydrolase. J. Biol. Chem. 260:1985;14145-14149.
14. Thomas E.A., Cravatt B.F., Danielson P.F., Gilula N.B., Sutcliffe J.G. Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. J. Neurosci. Res. 50:1997;1047-1052.
15. Tsou K., Brown S., Sanudo-Pena M.C., Mackie K., Walker J.M. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience. 83:1998;393-411.