Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 301, Issue 6, 2011, Pages

  Dean, C ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acute stress; Defense response; Endocannabinoids; Rat; Sympathetic nervous system

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANANDAMIDE; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; EXCITATORY AMINO ACID; HOMOCYSTEIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; GABAERGIC TRANSMISSION; KIDNEY NERVE; MEDICAL RECORD; MICROINJECTION; MICROPIPETTE; NERVE CONDUCTION; NERVE EXCITABILITY; NERVE POTENTIAL; NEUROMODULATION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE;

ANIMALS; ARACHIDONIC ACIDS; BLOOD PRESSURE; ENDOCANNABINOIDS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HOMOCYSTEINE; KIDNEY; PERIAQUEDUCTAL GRAY; POLYUNSATURATED ALKAMIDES; PYRIDAZINES; RATS; RATS, SPRAGUE-DAWLEY; SYMPATHETIC NERVOUS SYSTEM;

EID: 82755164887     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00398.2011     Document Type: Article

References (33)

1. Bandler R, De Paulis A, Vergnes M. Identification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids. Behav Brain Res 15: 107-109, 1985.
2. Barbaresi P. GABA-immunoreactive neurons and terminals in the cat periaqueductal gray matter: A light and electron microscope study. J Neurocytol 34: 471-487, 2006.
3. Brandão ML, Borelli KG, Nobre MJ, Santos JM, Albrechet-Souza L, Oliveira AR, Martinez RC. Gabaergic regulation of the neural organization of fear in the midbrain tectum. Neurosci Biobehav Rev 29: 1299-1311, 2005.
4. Brandao ML, Troncoso AC, de Souza Silva MA, Huston JP. The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations. Eur J Pharmacol 463: 225-233, 2003.
5. Brozoski DT, Dean C, Hopp FA, Hillard CJ, Seagard JL. Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats. Auton Neurosci 150: 82-93, 2009.
6. Chen CY, Bonham A, Dean C, Hopp FA, Hillard CJ, Seagard JL. Retrograde release of endocannabinoids inhibits presynaptic GABA release in baroreceptor second-order neurons in NTS. Auton Neurosci 158: 44-50, 2010.
7. Chevaleyre V, Takahashi KA, Castillo PE. Endocannabinoid-mediated synaptic plasticity in the CNS. Annu Rev Neurosci 29: 37-76, 2006.
8. Dean C. Endocannabinoid modulation of sympathetic and cardiovascular responses to acute stress in the periaqueductal gray of the rat. Am J Physiol Regul Integr Comp Physiol 300: R771-R779, 2011.
9. Dean C, Coote JH. Discharge patterns in postganglionic neurones to skeletal muscle and kidney during activation of the hypothalamic and midbrain defence areas in the cat. Brain Res 377: 271-278, 1986.
10. Depaulis A, Vergnes M. Elicitation of intraspecific defensive behaviors in the rat by microinjection of picrotoxin, a gamma-aminobutyric acid antagonist, into the midbrain periaqueductal gray matter. Brain Res 367: 87-95, 1986.
11. Di Scala G, Schmitt P, Karli P. Flight induced by infusion of bicuculline methiodide into periventricular structures. Brain Res 309: 199-208, 1984.
12. Freund TF, Katona I, Piomelli D. Role of endogenous cannabinoids in synaptic signalling. Physiol Rev 83: 1017-1066, 2003.
13. Fu LW, Longhurst JC. Electroacupuncture modulates vlPAG release of GABA through presynaptic cannbinoid CB1 receptors. J Appl Physiol 106: 1800-1809, 2009.
14. Graeff FG. Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals. Braz J Med Biol Res 27: 811-829, 1994.
15. Hayward LF, Swartz CL, Davenport PW. Respiratory response to activation or disinhibition of the dorsal periaqueductal gray in rats. J Appl Physiol 94: 913-922, 2003.
16. Hilton SM, Redfern WS. A search for brainstem cell groups integrating the defence reaction in the rat. J Physiol 378: 213-228, 1986.
17. Hoffman AF, Lupica CR. Mechanisms of cannabinoid inhibition of GABAA synaptic transmission in the hippocampus. J Neurosci 532: 731-748, 2000.
18. Keay K, Bandler R. Parallel circuits mediating distinct emotional coping reactions to different types of stress. Neurosci Behav Rev 25: 669-678, 2001.
19. Lovick TA. Ventrolateral medullay lesions block the antinociceptive and cardiovascular responses elicited by stimulating the dorsal periaqueductal grey matter in rats. Pain 21: 241-252, 1985.
20. McEwen B. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87: 873-904, 2007.
21. Reichling DB, Basbaum AI. Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphe magnus. J Comp Neurol 302: 370-377, 1990.
22. Schenberg LC, de Auiar JC, Graeff FG. GABA modulation of the defense reaction induced by brain electrical stimulation. Physiol Behav 31: 429-437, 1983.
23. Schenberg LC, Bittencourt AS, Sudre ECM, Vargas LC. Modeling panic attacks. Neurosci Behav Rev 25: 647-659, 2001.
24. Schmitt P, Di Scala G, Brandao M, Karli P. Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray. Eur J Pharmacol 117: 149-158, 1985.
25. Seagard JL, Dean C, Patel S, Rademacher DJ, Hopp FA, Schmeling WT, Hillard CJ. Anandamide conent, and interaction of endocannabinoid/ GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. Am J Physiol Heart Circ Physiol 286: H992-H1000, 2004.
26. Seagard JL, Hopp FA, Hillard CJ, Dean C. Effects of endocannabinoids on discharge of baroreceptive NTS neurons. Neurosci Lett 381: 334-339, 2005.
27. Shaikh MB, Siegel A. GABA-mediated regulation of feline aggression elicited from midbrain periaqueductal gray. Brain Res 507: 51-56, 1990.
28. Szabo B, Dorner L, Pfreundtner C, Norenerg W, Starke K. Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum. Neuroscience 85: 395-403, 1998.
29. Takahashi KA, Linden DJ. Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells. J Neurophysiol 83: 1167-1180, 2000.
30. Tjen-ALooi SC, Li P, Longhurst JC. Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA. J Appl Physiol 106: 1793-1799, 2009.
31. Tredici G, Bianchi R, Gioia M. Short intrinsic circuit in the periaqueductal gray matter of the cat. Neurosci Lett 39: 131-136, 1983.
32. Vaughan CW, Connor M, Bagley EE, Christie MJ. Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro. Mol Pharmacol 57: 288-295, 2000.
33. Vaughan CW, McGregor IS, Christie MJ. Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral medial medulla neurons in vitro. Br J Pharmacol 127: 935-940, 1999.