SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Oncogene

Volumn 34, Issue 46, 2015, Pages 5699-5708

  Kanu, N ^a   Gronroos E ^b   Martinez, P ^b   Burrell, R A ^b   Yi Goh, X ^b   Bartkova, J ^c   Maya Mendoza, A ^c   Mistrik M ^d   Rowan, A J ^b   Patel, H ^b   Rabinowitz, A ^b   East, P ^b   Wilson, G ^b   Santos, C R ^b   McGranahan, N ^b   Gulati, S ^b   Gerlinger, M ^b   Birkbak, N J ^a,b,e   Joshi, T ^e   Alexandrov, L B ^f   Stratton, M R ^f   Powles, T ^g   Matthews, N ^b   Bates, P A ^b   Stewart, A ^b   Szallasi, Z ^e,h   Larkin, J ⁱ   Bartek, J ^c,d   Swanton, C ^a,b   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^d PALACKÝ UNIVERSITY   (Czech Republic)

^e TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^h BOSTON CHILDREN S HOSPITAL   (United States)

ⁱ ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE DELTA; HISTONE H3; LENS EPITHELIUM DERIVED GROWTH FACTOR; LYSINE; MINICHROMOSOME MAINTENANCE PROTEIN 7; PROTEIN; RAD51 PROTEIN; SU(VAR) ENHANCER OF ZESTE TRITHORAX DOMAIN CONTAINING 2; UNCLASSIFIED DRUG; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; NUCLEOSOME; SET2 PROTEIN, HUMAN;

ARTICLE; BIOINFORMATICS; CANCER GROWTH; CHROMATIN; CHROMOSOMAL INSTABILITY; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA REPAIR; DNA STRAND BREAKAGE; FUNCTIONAL GENOMICS; GENOME; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; KIDNEY CANCER; LOSS OF FUNCTION MUTATION; MICROSATELLITE INSTABILITY; MISSENSE MUTATION; NUCLEOSOME; PRIORITY JOURNAL; RECOMBINATION REPAIR; SOMATIC MUTATION; DNA REPLICATION; GENETIC HETEROGENEITY; GENETICS; KIDNEY CARCINOMA; KIDNEY TUMOR; METABOLISM; MUTATION; PATHOLOGY; TUMOR CELL LINE;

CARCINOMA, RENAL CELL; CELL LINE, TUMOR; DNA REPAIR; DNA REPLICATION; GENETIC HETEROGENEITY; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; KIDNEY NEOPLASMS; MICROSATELLITE INSTABILITY; MUTATION; NUCLEOSOMES;

EID: 84947034149     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.24     Document Type: Article

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