메뉴 건너뛰기




Volumn 29, Issue 3, 2015, Pages 503-521

Therapeutic approaches for celiac disease

Author keywords

Celiac disease; Genome wide association study; Gluten free diet; Investigational therapies; Pathogenesis

Indexed keywords

BTB AND CNC HOMOLOG 2; ENZYME INHIBITOR; FUCOSYLTRANSFERASE; GLUCOCORTICOID; GLUTEN; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; INTERLEUKIN 15; LARAZOTIDE; LEUKOCYTE ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; PROTEIN INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE KAPPA; PROTEINASE; REGULATOR OF G PROTEIN SIGNALLING 1; UNCLASSIFIED DRUG;

EID: 84947026904     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2015.04.005     Document Type: Review
Times cited : (41)

References (145)
  • 2
    • 84879788657 scopus 로고    scopus 로고
    • Systematic review: Worldwide variation in the frequency of coeliac disease and changes over time
    • J.Y. Kang, A.H.Y. Kang, A. Green, K.A. Gwee, and K.Y. Ho Systematic review: worldwide variation in the frequency of coeliac disease and changes over time Aliment Pharmacol Ther 38 3 2013 226 245
    • (2013) Aliment Pharmacol Ther , vol.38 , Issue.3 , pp. 226-245
    • Kang, J.Y.1    Kang, A.H.Y.2    Green, A.3    Gwee, K.A.4    Ho, K.Y.5
  • 3
    • 77951900616 scopus 로고    scopus 로고
    • Diagnostic testing for celiac disease among patients with abdominal symptoms: A systematic review
    • D.A.W.M. van der Windt, P. Jellema, C.J. Mulder, C.M.F. Kneepkens, and H.E. van der Horst Diagnostic testing for celiac disease among patients with abdominal symptoms: a systematic review JAMA 303 17 2010 1738 1746
    • (2010) JAMA , vol.303 , Issue.17 , pp. 1738-1746
    • Van Der Windt, D.A.W.M.1    Jellema, P.2    Mulder, C.J.3    Kneepkens, C.M.F.4    Van Der Horst, H.E.5
  • 4
    • 34347324029 scopus 로고    scopus 로고
    • A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    • D.A. van Heel, L. Franke, K.A. Hunt, R. Gwilliam, A. Zhernakova, M. Inouye, and et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 Nat Genet 39 7 2007 827 829
    • (2007) Nat Genet , vol.39 , Issue.7 , pp. 827-829
    • Van Heel, D.A.1    Franke, L.2    Hunt, K.A.3    Gwilliam, R.4    Zhernakova, A.5    Inouye, M.6
  • 5
    • 33748492561 scopus 로고    scopus 로고
    • Malignancies and mortality in patients with coeliac disease and dermatitis herpetiformis: 30-year population-based study
    • M. Viljamaa, K. Kaukinen, E. Pukkala, K. Hervonen, T. Reunala, and P. Collin Malignancies and mortality in patients with coeliac disease and dermatitis herpetiformis: 30-year population-based study Dig Liver Dis 38 6 2006 374 380
    • (2006) Dig Liver Dis , vol.38 , Issue.6 , pp. 374-380
    • Viljamaa, M.1    Kaukinen, K.2    Pukkala, E.3    Hervonen, K.4    Reunala, T.5    Collin, P.6
  • 6
    • 10844236439 scopus 로고    scopus 로고
    • Malignant lymphomas in coeliac disease: Evidence of increased risks for lymphoma types other than enteropathy-type T cell lymphoma
    • K.E. Smedby, M. Akerman, H. Hildebrand, B. Glimelius, A. Ekbom, and J. Askling Malignant lymphomas in coeliac disease: evidence of increased risks for lymphoma types other than enteropathy-type T cell lymphoma Gut 54 1 2005 54 59
    • (2005) Gut , vol.54 , Issue.1 , pp. 54-59
    • Smedby, K.E.1    Akerman, M.2    Hildebrand, H.3    Glimelius, B.4    Ekbom, A.5    Askling, J.6
  • 7
    • 59849112637 scopus 로고    scopus 로고
    • Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association
    • Y. Gao, S.Y. Kristinsson, L.R. Goldin, M. Björkholm, N.E. Caporaso, and O. Landgren Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association Gastroenterology 136 1 2009 91 98
    • (2009) Gastroenterology , vol.136 , Issue.1 , pp. 91-98
    • Gao, Y.1    Kristinsson, S.Y.2    Goldin, L.R.3    Björkholm, M.4    Caporaso, N.E.5    Landgren, O.6
  • 8
    • 79956290534 scopus 로고    scopus 로고
    • Novel therapies for coeliac disease
    • L.M. Sollid, and C. Khosla Novel therapies for coeliac disease J Intern Med 269 2011 604 613
    • (2011) J Intern Med , vol.269 , pp. 604-613
    • Sollid, L.M.1    Khosla, C.2
  • 9
    • 84891741591 scopus 로고    scopus 로고
    • Advances in the treatment of coeliac disease: An immunopathogenic perspective
    • K. Kaukinen, K. Lindfors, and M. Mäki Advances in the treatment of coeliac disease: an immunopathogenic perspective Nat Publ Group 11 1 2013 36 44
    • (2013) Nat Publ Group , vol.11 , Issue.1 , pp. 36-44
    • Kaukinen, K.1    Lindfors, K.2    Mäki, M.3
  • 10
    • 84930519328 scopus 로고    scopus 로고
    • The present and the future in the diagnosis and management of celiac disease
    • N.E. Castillo, T.G. Theethira, and D.A. Leffler The present and the future in the diagnosis and management of celiac disease Gastroenterol Rep 2014 1 9
    • (2014) Gastroenterol Rep , pp. 1-9
    • Castillo, N.E.1    Theethira, T.G.2    Leffler, D.A.3
  • 11
    • 24044515912 scopus 로고    scopus 로고
    • Celiac disease genetics: Current concepts and practical applications
    • L.M. Sollid, and B.A. Lie Celiac disease genetics: current concepts and practical applications Clin Gastroenterol Hepatol 3 9 2005 843 851
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.9 , pp. 843-851
    • Sollid, L.M.1    Lie, B.A.2
  • 12
    • 0028828948 scopus 로고
    • Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma
    • E.M. Nilsen, K.E. Lundin, P. Krajci, H. Scott, L.M. Sollid, and P. Brandtzaeg Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma Gut 37 6 1995 766 776
    • (1995) Gut , vol.37 , Issue.6 , pp. 766-776
    • Nilsen, E.M.1    Lundin, K.E.2    Krajci, P.3    Scott, H.4    Sollid, L.M.5    Brandtzaeg, P.6
  • 14
    • 82255192188 scopus 로고    scopus 로고
    • Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
    • G. Trynka, K.A. Hunt, N.A. Bockett, J. Romanos, V. Mistry, A. Szperl, and et al. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease Nat Genet 43 12 2011 1193 1201
    • (2011) Nat Genet , vol.43 , Issue.12 , pp. 1193-1201
    • Trynka, G.1    Hunt, K.A.2    Bockett, N.A.3    Romanos, J.4    Mistry, V.5    Szperl, A.6
  • 15
    • 0037183929 scopus 로고    scopus 로고
    • Structural basis for gluten intolerance in celiac sprue
    • L. Shan, I. Parrot, ø. Molberg, F. Hausch, F. Filiz, G.M. Gray, and et al. Structural basis for gluten intolerance in celiac sprue Science 297 5590 2002 2275 2279
    • (2002) Science , vol.297 , Issue.5590 , pp. 2275-2279
    • Shan, L.1    Parrot, I.2    Molberg, ø.3    Hausch, F.4    Filiz, F.5    Gray, G.M.6
  • 16
    • 0030838044 scopus 로고    scopus 로고
    • Identification of tissue transglutaminase as the autoantigen of celiac disease
    • W. Dieterich, T. Ehnis, M. Bauer, P. Donner, U. Volta, E.O. Riecken, and et al. Identification of tissue transglutaminase as the autoantigen of celiac disease Nat Med 3 7 1997 797 801
    • (1997) Nat Med , vol.3 , Issue.7 , pp. 797-801
    • Dieterich, W.1    Ehnis, T.2    Bauer, M.3    Donner, P.4    Volta, U.5    Riecken, E.O.6
  • 17
    • 1642447710 scopus 로고    scopus 로고
    • Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
    • C.-Y. Kim, H. Quarsten, E. Bergseng, C. Khosla, and L.M. Sollid Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease Proc Natl Acad Sci U S A 101 12 2004 4175 4179
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.12 , pp. 4175-4179
    • Kim, C.-Y.1    Quarsten, H.2    Bergseng, E.3    Khosla, C.4    Sollid, L.M.5
  • 18
    • 34447618589 scopus 로고    scopus 로고
    • A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease
    • K.N. Henderson, J.A. Tye-Din, H.H. Reid, Z. Chen, N.A. Borg, T. Beissbarth, and et al. A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease Immunity 27 1 2007 23 34
    • (2007) Immunity , vol.27 , Issue.1 , pp. 23-34
    • Henderson, K.N.1    Tye-Din, J.A.2    Reid, H.H.3    Chen, Z.4    Borg, N.A.5    Beissbarth, T.6
  • 19
    • 0034728821 scopus 로고    scopus 로고
    • Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease
    • A. Fasano, T. Not, W. Wang, S. Uzzau, I. Berti, A. Tommasini, and et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease Lancet 355 9214 2000 1518 1519
    • (2000) Lancet , vol.355 , Issue.9214 , pp. 1518-1519
    • Fasano, A.1    Not, T.2    Wang, W.3    Uzzau, S.4    Berti, I.5    Tommasini, A.6
  • 20
    • 28444452580 scopus 로고    scopus 로고
    • Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect
    • A.J. Monsuur, P.I.W. de Bakker, B.Z. Alizadeh, A. Zhernakova, M.R. Bevova, E. Strengman, and et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect Nat Genet 37 12 2005 1341 1344
    • (2005) Nat Genet , vol.37 , Issue.12 , pp. 1341-1344
    • Monsuur, A.J.1    De Bakker, P.I.W.2    Alizadeh, B.Z.3    Zhernakova, A.4    Bevova, M.R.5    Strengman, E.6
  • 21
    • 41149135384 scopus 로고    scopus 로고
    • Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis
    • M.C. Wapenaar, A.J. Monsuur, A.A. van Bodegraven, R.K. Weersma, M.R. Bevova, R.K. Linskens, and et al. Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis Gut 57 4 2008 463 467
    • (2008) Gut , vol.57 , Issue.4 , pp. 463-467
    • Wapenaar, M.C.1    Monsuur, A.J.2    Van Bodegraven, A.A.3    Weersma, R.K.4    Bevova, M.R.5    Linskens, R.K.6
  • 22
    • 4444251461 scopus 로고    scopus 로고
    • A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease
    • S. Hüe, J.-J. Mention, R.C. Monteiro, S. Zhang, C. Cellier, J. Schmitz, and et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease Immunity 21 3 2004 367 377
    • (2004) Immunity , vol.21 , Issue.3 , pp. 367-377
    • Hüe, S.1    Mention, J.-J.2    Monteiro, R.C.3    Zhang, S.4    Cellier, C.5    Schmitz, J.6
  • 23
    • 4444240035 scopus 로고    scopus 로고
    • Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    • B. Meresse, Z. Chen, C. Ciszewski, M. Tretiakova, G. Bhagat, T.N. Krausz, and et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease Immunity 21 3 2004 357 366
    • (2004) Immunity , vol.21 , Issue.3 , pp. 357-366
    • Meresse, B.1    Chen, Z.2    Ciszewski, C.3    Tretiakova, M.4    Bhagat, G.5    Krausz, T.N.6
  • 24
    • 33646675580 scopus 로고    scopus 로고
    • Reprogramming of CTLs into natural killer-like cells in celiac disease
    • B. Meresse, S.A. Curran, C. Ciszewski, G. Orbelyan, M. Setty, G. Bhagat, and et al. Reprogramming of CTLs into natural killer-like cells in celiac disease J Exp Med 203 5 2006 1343 1355
    • (2006) J Exp Med , vol.203 , Issue.5 , pp. 1343-1355
    • Meresse, B.1    Curran, S.A.2    Ciszewski, C.3    Orbelyan, G.4    Setty, M.5    Bhagat, G.6
  • 27
    • 72149097662 scopus 로고    scopus 로고
    • Efficacy of budesonide therapy in the early phase of treatment of adult coeliac disease patients with malabsorption: An in vivo/ in vitropilot study
    • C. Ciacci, L. Maiuri, I. Russo, R. Tortora, C. Bucci, C. Cappello, and et al. Efficacy of budesonide therapy in the early phase of treatment of adult coeliac disease patients with malabsorption: an in vivo/ in vitropilot study Clin Exp Pharmacol P 36 12 2009 1170 1176
    • (2009) Clin Exp Pharmacol P , vol.36 , Issue.12 , pp. 1170-1176
    • Ciacci, C.1    Maiuri, L.2    Russo, I.3    Tortora, R.4    Bucci, C.5    Cappello, C.6
  • 28
    • 84871629803 scopus 로고    scopus 로고
    • Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: A pilot randomized controlled trial
    • Das P. Shalimar, V. Sreenivas, S. Datta Gupta, S.K. Panda, and G.K. Makharia Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial Dig Dis Sci 57 12 2012 3116 3125
    • (2012) Dig Dis Sci , vol.57 , Issue.12 , pp. 3116-3125
    • Shalimar, D.P.1    Sreenivas, V.2    Datta Gupta, S.3    Panda, S.K.4    Makharia, G.K.5
  • 31
    • 7444226234 scopus 로고    scopus 로고
    • Comparative biochemical analysis of three bacterial prolyl endopeptidases: Implications for coeliac sprue
    • L. Shan, T. Marti, L.M. Sollid, G.M. Gray, and C. Khosla Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue Biochem J 383 Pt 2 2004 311 318
    • (2004) Biochem J , vol.383 , pp. 311-318
    • Shan, L.1    Marti, T.2    Sollid, L.M.3    Gray, G.M.4    Khosla, C.5
  • 32
    • 38349083815 scopus 로고    scopus 로고
    • Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: Implications for coeliac disease
    • C. Mitea, R. Havenaar, J.W. Drijfhout, L. Edens, L. Dekking, and F. Koning Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease Gut 57 1 2008 25 32
    • (2008) Gut , vol.57 , Issue.1 , pp. 25-32
    • Mitea, C.1    Havenaar, R.2    Drijfhout, J.W.3    Edens, L.4    Dekking, L.5    Koning, F.6
  • 33
    • 33846955435 scopus 로고    scopus 로고
    • Prolyl endopeptidases
    • J. Gass, and C. Khosla Prolyl endopeptidases Cell Mol Life Sci 64 2007 345 355
    • (2007) Cell Mol Life Sci , vol.64 , pp. 345-355
    • Gass, J.1    Khosla, C.2
  • 35
    • 22144497680 scopus 로고    scopus 로고
    • Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue
    • G.G. Pyle, B. Paaso, B.E. Anderson, D.D. Allen, T. Marti, Q. Li, and et al. Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue Clin Gastroenterol Hepatol 3 7 2005 687 694
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.7 , pp. 687-694
    • Pyle, G.G.1    Paaso, B.2    Anderson, B.E.3    Allen, D.D.4    Marti, T.5    Li, Q.6
  • 36
    • 33745455375 scopus 로고    scopus 로고
    • Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease
    • M.T. Bethune, P. Strop, Y. Tang, L.M. Sollid, and C. Khosla Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease Chem Biol 13 6 2006 637 647
    • (2006) Chem Biol , vol.13 , Issue.6 , pp. 637-647
    • Bethune, M.T.1    Strop, P.2    Tang, Y.3    Sollid, L.M.4    Khosla, C.5
  • 37
    • 33747608177 scopus 로고    scopus 로고
    • Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat
    • J. Gass Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat J Pharmacol Exp Ther 318 3 2006 1178 1186
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.3 , pp. 1178-1186
    • Gass, J.1
  • 39
    • 76049115164 scopus 로고    scopus 로고
    • The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo
    • J.A. Tye-Din, R.P. Anderson, R.A. Ffrench, G.J. Brown, P. Hodsman, M. Siegel, and et al. The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo Clin Immunol 134 3 2010 289 295
    • (2010) Clin Immunol , vol.134 , Issue.3 , pp. 289-295
    • Tye-Din, J.A.1    Anderson, R.P.2    Ffrench, R.A.3    Brown, G.J.4    Hodsman, P.5    Siegel, M.6
  • 40
    • 84856744117 scopus 로고    scopus 로고
    • Safety, tolerability, and activity of ALV003: Results from two phase 1 single, escalating-dose clinical trials
    • M. Siegel, M. Garber, A. Spencer, and W. Botwick Safety, tolerability, and activity of ALV003: results from two phase 1 single, escalating-dose clinical trials Dig Dis Sci 57 2012 440 450
    • (2012) Dig Dis Sci , vol.57 , pp. 440-450
    • Siegel, M.1    Garber, M.2    Spencer, A.3    Botwick, W.4
  • 43
    • 67651248240 scopus 로고    scopus 로고
    • A food-grade enzyme preparation with modest gluten detoxification properties
    • J. Ehren, B. Morón, E. Martin, M.T. Bethune, G.M. Gray, and C. Khosla A food-grade enzyme preparation with modest gluten detoxification properties PLoS One 4 7 2009 e6313
    • (2009) PLoS One , vol.4 , Issue.7 , pp. e6313
    • Ehren, J.1    Morón, B.2    Martin, E.3    Bethune, M.T.4    Gray, G.M.5    Khosla, C.6
  • 44
    • 59849086162 scopus 로고    scopus 로고
    • Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium
    • M. Pinier, E.F. Verdu, M.N. Eddine, C.S. David, A. Vézina, N. Rivard, and et al. Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium YGAST 136 1 2009 288 298
    • (2009) YGAST , vol.136 , Issue.1 , pp. 288-298
    • Pinier, M.1    Verdu, E.F.2    Eddine, M.N.3    David, C.S.4    Vézina, A.5    Rivard, N.6
  • 45
    • 84856207904 scopus 로고    scopus 로고
    • The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues
    • e12
    • M. Pinier, G. Fuhrmann, H.J. Galipeau, N. Rivard, J.A. Murray, C.S. David, and et al. The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues Gastroenterology 142 2 2012 316 325 e12
    • (2012) Gastroenterology , vol.142 , Issue.2 , pp. 316-325
    • Pinier, M.1    Fuhrmann, G.2    Galipeau, H.J.3    Rivard, N.4    Murray, J.A.5    David, C.S.6
  • 46
    • 70349736175 scopus 로고    scopus 로고
    • Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
    • A. Tripathi, K.M. Lammers, S. Goldblum, T. Shea-Donohue, S. Netzel-Arnett, M.S. Buzza, and et al. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2 Proc Natl Acad Sci 106 39 2009 16799 16804
    • (2009) Proc Natl Acad Sci , vol.106 , Issue.39 , pp. 16799-16804
    • Tripathi, A.1    Lammers, K.M.2    Goldblum, S.3    Shea-Donohue, T.4    Netzel-Arnett, S.5    Buzza, M.S.6
  • 47
    • 46049100586 scopus 로고    scopus 로고
    • Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3
    • e3
    • K.M. Lammers, R. Lu, J. Brownley, B. Lu, C. Gerard, K. Thomas, and et al. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3 Gastroenterology 135 1 2008 194 204 e3
    • (2008) Gastroenterology , vol.135 , Issue.1 , pp. 194-204
    • Lammers, K.M.1    Lu, R.2    Brownley, J.3    Lu, B.4    Gerard, C.5    Thomas, K.6
  • 48
    • 33646426645 scopus 로고    scopus 로고
    • Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
    • S. Drago, R. Asmar El, M. Di Pierro, M. Grazia Clemente, A.T.A. Sapone, M. Thakar, and et al. Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines Scand J Gastroenterol 41 4 2006 408 419
    • (2006) Scand J Gastroenterol , vol.41 , Issue.4 , pp. 408-419
    • Drago, S.1    Asmar El, R.2    Di Pierro, M.3    Grazia Clemente, M.4    Sapone, A.T.A.5    Thakar, M.6
  • 49
    • 0035374570 scopus 로고    scopus 로고
    • Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    • M. Di Pierro, R. Lu, S. Uzzau, W. Wang, K. Margaretten, C. Pazzani, and et al. Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain J Biol Chem 276 22 2001 19160 19165
    • (2001) J Biol Chem , vol.276 , Issue.22 , pp. 19160-19165
    • Di Pierro, M.1    Lu, R.2    Uzzau, S.3    Wang, W.4    Margaretten, K.5    Pazzani, C.6
  • 50
    • 0037302604 scopus 로고    scopus 로고
    • Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function
    • M.G. Clemente, S. De Virgiliis, J.S. Kang, R. Macatagney, M.P. Musu, M.R. Di Pierro, and et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function Gut 52 2 2003 218 223
    • (2003) Gut , vol.52 , Issue.2 , pp. 218-223
    • Clemente, M.G.1    De Virgiliis, S.2    Kang, J.S.3    Macatagney, R.4    Musu, M.P.5    Di Pierro, M.R.6
  • 51
    • 34547852241 scopus 로고    scopus 로고
    • The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: A proof of concept study
    • B. Paterson, K. Lammers, and M. Arrieta The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study Aliment Pharmacol Ther 26 2007 757 766
    • (2007) Aliment Pharmacol Ther , vol.26 , pp. 757-766
    • Paterson, B.1    Lammers, K.2    Arrieta, M.3
  • 52
    • 84867101199 scopus 로고    scopus 로고
    • A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge
    • D.A. Leffler, C.P. Kelly, H.Z. Abdallah, A.M. Colatrella, L.A. Harris, F. Leon, and et al. A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge Am J Gastroenterol 107 10 2012 1554 1562
    • (2012) Am J Gastroenterol , vol.107 , Issue.10 , pp. 1554-1562
    • Leffler, D.A.1    Kelly, C.P.2    Abdallah, H.Z.3    Colatrella, A.M.4    Harris, L.A.5    Leon, F.6
  • 53
    • 84872717725 scopus 로고    scopus 로고
    • Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: A randomised placebo-controlled study
    • C. Kelly, P. Green, and J. Murray Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study Aliment Pharmacol Ther 37 2013 252 262
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 252-262
    • Kelly, C.1    Green, P.2    Murray, J.3
  • 54
    • 84930017488 scopus 로고    scopus 로고
    • Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: A randomized controlled trial
    • D.A. Leffler, C.P. Kelly, P.H.R. Green, R.N. Fedorak, A. DiMarino, W. Perrow, and et al. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial Gastroenterology 2015 1 58
    • (2015) Gastroenterology , pp. 1-58
    • Leffler, D.A.1    Kelly, C.P.2    Green, P.H.R.3    Fedorak, R.N.4    DiMarino, A.5    Perrow, W.6
  • 55
    • 0037031090 scopus 로고    scopus 로고
    • Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomised controlled trial
    • W.L.G. Oldfield, M. Larché, and A.B. Kay Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial Lancet 360 9326 2002 47 53
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 47-53
    • Oldfield, W.L.G.1    Larché, M.2    Kay, A.B.3
  • 56
    • 18244391173 scopus 로고    scopus 로고
    • T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity
    • A. Verhoef, C. Alexander, A.B. Kay, and M. Larché T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity PLoS Med 2 3 2005 e78
    • (2005) PLoS Med , vol.2 , Issue.3 , pp. e78
    • Verhoef, A.1    Alexander, C.2    Kay, A.B.3    Larché, M.4
  • 57
    • 84947047164 scopus 로고    scopus 로고
    • A phase i study to determine safety, tolerability and bioactivity of Nexvax2 in HLA DQ2+ volunteers with celiac disease following a long-term
    • S-437-S-438
    • G.J. Brown, J. Daveson, J.K. Marjason, R.A. Ffrench, D. Smith, M. Sullivan, and et al. A phase I study to determine safety, tolerability and bioactivity of Nexvax2 in HLA DQ2+ volunteers with celiac disease following a long-term Strict Gluten Free Diet YGAST 140 5 2011 S-437-S-438
    • (2011) Strict Gluten Free Diet YGAST , vol.140 , Issue.5
    • Brown, G.J.1    Daveson, J.2    Marjason, J.K.3    Ffrench, R.A.4    Smith, D.5    Sullivan, M.6
  • 58
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • J.L. Round, and S.K. Mazmanian The gut microbiota shapes intestinal immune responses during health and disease Nat Rev Immunol 9 5 2009 313 323
    • (2009) Nat Rev Immunol , vol.9 , Issue.5 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 59
    • 0037022008 scopus 로고    scopus 로고
    • Crohn's disease
    • F. Shanahan Crohn's disease Lancet 359 9300 2002 62 69
    • (2002) Lancet , vol.359 , Issue.9300 , pp. 62-69
    • Shanahan, F.1
  • 60
    • 0036886298 scopus 로고    scopus 로고
    • The current future understanding of inflammatory bowel disease
    • D.K. Podolsky The current future understanding of inflammatory bowel disease Best Pract Res Cl Ha 16 6 2002 933 943
    • (2002) Best Pract Res Cl Ha , vol.16 , Issue.6 , pp. 933-943
    • Podolsky, D.K.1
  • 61
    • 84925223549 scopus 로고    scopus 로고
    • Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet
    • P. Wacklin, P. Laurikka, K. Lindfors, P. Collin, T. Salmi, M.-L.L.A. hdeaho, and et al. Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet Am J Gastroenterol 109 12 2014 1933 1941
    • (2014) Am J Gastroenterol , vol.109 , Issue.12 , pp. 1933-1941
    • Wacklin, P.1    Laurikka, P.2    Lindfors, K.3    Collin, P.4    Salmi, T.5    Hdeaho, M.-L.L.A.6
  • 62
    • 29644441042 scopus 로고    scopus 로고
    • VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for celiac sprue probiotics and gluten intolerance
    • M.D. Angelis, C.G. Rizzello, A. Fasano, M.G. Clemente, C.D. Simone, M. Silano, and et al. VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for celiac sprue probiotics and gluten intolerance Biochim Biophys Acta 1762 1 2006 80 93
    • (2006) Biochim Biophys Acta , vol.1762 , Issue.1 , pp. 80-93
    • Angelis, M.D.1    Rizzello, C.G.2    Fasano, A.3    Clemente, M.G.4    Simone, C.D.5    Silano, M.6
  • 63
    • 84872953741 scopus 로고    scopus 로고
    • Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease
    • E. Smecuol, H.J. Hwang, E. Sugai, L. Corso, A.C. Cherñavsky, F.P. Bellavite, and et al. Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease J Clin Gastroenterol 47 2 2013 139 147
    • (2013) J Clin Gastroenterol , vol.47 , Issue.2 , pp. 139-147
    • Smecuol, E.1    Hwang, H.J.2    Sugai, E.3    Corso, L.4    Cherñavsky, A.C.5    Bellavite, F.P.6
  • 64
    • 73349085552 scopus 로고    scopus 로고
    • Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial
    • P. Bager, J. Arnved, S. Ronborg, J. Wohlfahrt, L.K. Poulsen, T. Westergaard, and et al. Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial J Allergy Clin Immunol 125 1 2010 123 130
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.1 , pp. 123-130
    • Bager, P.1    Arnved, J.2    Ronborg, S.3    Wohlfahrt, J.4    Poulsen, L.K.5    Westergaard, T.6
  • 65
    • 29244453651 scopus 로고    scopus 로고
    • A proof of concept study establishing Necator americanus in Crohn's patients and reservoir donors
    • J. Croese, J. O'neil, J. Masson, S. Cooke, W. Melrose, D. Pritchard, and et al. A proof of concept study establishing Necator americanus in Crohn's patients and reservoir donors Gut 55 1 2006 136 137
    • (2006) Gut , vol.55 , Issue.1 , pp. 136-137
    • Croese, J.1    O'Neil, J.2    Masson, J.3    Cooke, S.4    Melrose, W.5    Pritchard, D.6
  • 66
    • 79952427391 scopus 로고    scopus 로고
    • Effect of hookworm infection on wheat Challenge in celiac disease - A randomised double-blinded placebo controlled trial
    • A. Daveson, D. Jones, S. Gaze, and H. McSorley Effect of hookworm infection on wheat Challenge in celiac disease - a randomised double-blinded placebo controlled trial PLoS One 6 3 2011 e17366
    • (2011) PLoS One , vol.6 , Issue.3 , pp. e17366
    • Daveson, A.1    Jones, D.2    Gaze, S.3    McSorley, H.4
  • 67
    • 84922341089 scopus 로고    scopus 로고
    • Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease
    • e5
    • J. Croese, P. Giacomin, S. Navarro, A. Clouston, L. McCann, A. Dougall, and et al. Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease J Allergy Clin Immunol 135 2 2015 508 516 e5
    • (2015) J Allergy Clin Immunol , vol.135 , Issue.2 , pp. 508-516
    • Croese, J.1    Giacomin, P.2    Navarro, S.3    Clouston, A.4    McCann, L.5    Dougall, A.6
  • 68
    • 38749093329 scopus 로고    scopus 로고
    • Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease
    • T. Matysiak-Budnik, I.C. Moura, M. Arcos-Fajardo, C. Lebreton, S. Ménard, C. Candalh, and et al. Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease J Exp Med 205 1 2008 143 154
    • (2008) J Exp Med , vol.205 , Issue.1 , pp. 143-154
    • Matysiak-Budnik, T.1    Moura, I.C.2    Arcos-Fajardo, M.3    Lebreton, C.4    Ménard, S.5    Candalh, C.6
  • 69
    • 79952525777 scopus 로고    scopus 로고
    • Epithelial transport and deamidation of gliadin peptides: A role for coeliac disease patient immunoglobulin A
    • T. Rauhavirta, S.W. Qiao, Z. Jiang, E. Myrsky, J. Loponen, I.R. Korponay-Szabó, and et al. Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A Clin Exp Immunol 164 1 2011 127 136
    • (2011) Clin Exp Immunol , vol.164 , Issue.1 , pp. 127-136
    • Rauhavirta, T.1    Qiao, S.W.2    Jiang, Z.3    Myrsky, E.4    Loponen, J.5    Korponay-Szabó, I.R.6
  • 70
    • 70349463158 scopus 로고    scopus 로고
    • Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes
    • S. Yokoyama, N. Watanabe, N. Sato, P.-Y. Perera, L. Filkoski, T. Tanaka, and et al. Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes Proc Natl Acad Sci 106 37 2009 15849 15854
    • (2009) Proc Natl Acad Sci , vol.106 , Issue.37 , pp. 15849-15854
    • Yokoyama, S.1    Watanabe, N.2    Sato, N.3    Perera, P.-Y.4    Filkoski, L.5    Tanaka, T.6
  • 71
    • 77953192176 scopus 로고    scopus 로고
    • IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis
    • G. Malamut, R.E. Machhour, N. Montcuquet, S. Martin-Lanneree, I. Dusanter-Fourt, V. Verkarre, and et al. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis J Clin Invest 120 6 2010 2131
    • (2010) J Clin Invest , vol.120 , Issue.6 , pp. 2131
    • Malamut, G.1    Machhour, R.E.2    Montcuquet, N.3    Martin-Lanneree, S.4    Dusanter-Fourt, I.5    Verkarre, V.6
  • 74
    • 0035656107 scopus 로고    scopus 로고
    • Synthesis and evaluation of novel dipeptide-bound 1, 2, 4-thiadiazoles as irreversible inhibitors of Guinea pig liver transglutaminase
    • C. Marrano, P. de Macédo, P. Gagnon, D. Lapierre, C. Gravel, and J.W. Keillor Synthesis and evaluation of novel dipeptide-bound 1, 2, 4-thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase Bioorg Med Chem 9 12 2001 3231 3241
    • (2001) Bioorg Med Chem , vol.9 , Issue.12 , pp. 3231-3241
    • Marrano, C.1    De Macédo, P.2    Gagnon, P.3    Lapierre, D.4    Gravel, C.5    Keillor, J.W.6
  • 75
    • 0036132253 scopus 로고    scopus 로고
    • Synthesis of dipeptide-bound epoxides and alpha,beta-unsaturated amides as potential irreversible transglutaminase inhibitors
    • P. de Macédo, C. Marrano, and J.W. Keillor Synthesis of dipeptide-bound epoxides and alpha,beta-unsaturated amides as potential irreversible transglutaminase inhibitors Bioorg Med Chem 10 2 2002 355 360
    • (2002) Bioorg Med Chem , vol.10 , Issue.2 , pp. 355-360
    • De Macédo, P.1    Marrano, C.2    Keillor, J.W.3
  • 76
    • 17844391272 scopus 로고    scopus 로고
    • Chemistry and biology of dihydroisoxazole derivatives: Selective inhibitors of human transglutaminase 2
    • K. Choi, M. Siegel, J. Piper, L. Yuan, E. Cho, P. Strnad, and et al. Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2 Chem Biol 12 4 2005 469 475
    • (2005) Chem Biol , vol.12 , Issue.4 , pp. 469-475
    • Choi, K.1    Siegel, M.2    Piper, J.3    Yuan, L.4    Cho, E.5    Strnad, P.6
  • 77
    • 33845501601 scopus 로고    scopus 로고
    • Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles
    • R.E. Watts, M. Siegel, and C. Khosla Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles J Med Chem 49 25 2006 7493 7501
    • (2006) J Med Chem , vol.49 , Issue.25 , pp. 7493-7501
    • Watts, R.E.1    Siegel, M.2    Khosla, C.3
  • 78
    • 15044349470 scopus 로고    scopus 로고
    • Structure-activity relationship study of novel tissue transglutaminase inhibitors
    • E. Duval, A. Case, R.L. Stein, and G.D. Cuny Structure-activity relationship study of novel tissue transglutaminase inhibitors Bioorg Med Chem Lett 15 7 2005 1885 1889
    • (2005) Bioorg Med Chem Lett , vol.15 , Issue.7 , pp. 1885-1889
    • Duval, E.1    Case, A.2    Stein, R.L.3    Cuny, G.D.4
  • 79
    • 48249124215 scopus 로고    scopus 로고
    • Cinnamoyl inhibitors of tissue transglutaminase
    • C. Pardin, J.N. Pelletier, W.D. Lubell, and J.W. Keillor Cinnamoyl inhibitors of tissue transglutaminase J Org Chem 73 15 2008 5766 5775
    • (2008) J Org Chem , vol.73 , Issue.15 , pp. 5766-5775
    • Pardin, C.1    Pelletier, J.N.2    Lubell, W.D.3    Keillor, J.W.4
  • 81
    • 79955469942 scopus 로고    scopus 로고
    • Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2
    • C. Klöck, X. Jin, K. Choi, C. Khosla, P.B. Madrid, A. Spencer, and et al. Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2 Bioorg Med Chem Lett 21 9 2011 2692 2696
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.9 , pp. 2692-2696
    • Klöck, C.1    Jin, X.2    Choi, K.3    Khosla, C.4    Madrid, P.B.5    Spencer, A.6
  • 82
    • 84900459349 scopus 로고    scopus 로고
    • Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice
    • T.R. Diraimondo, C. Klöck, R. Warburton, Z. Herrera, K. Penumatsa, D. Toksoz, and et al. Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice ACS Chem Biol 9 1 2014 266 275
    • (2014) ACS Chem Biol , vol.9 , Issue.1 , pp. 266-275
    • Diraimondo, T.R.1    Klöck, C.2    Warburton, R.3    Herrera, Z.4    Penumatsa, K.5    Toksoz, D.6
  • 83
    • 0035827627 scopus 로고    scopus 로고
    • Targeted inactivation of Gh/Tissue transglutaminase II
    • N. Nanda Targeted inactivation of Gh/Tissue transglutaminase II J Biol Chem 276 23 2001 20673 20678
    • (2001) J Biol Chem , vol.276 , Issue.23 , pp. 20673-20678
    • Nanda, N.1
  • 84
    • 0034747685 scopus 로고    scopus 로고
    • Gene disruption of tissue transglutaminase
    • V. De Laurenzi, and G. Melino Gene disruption of tissue transglutaminase Mol Cell Biol 21 1 2001 148 155
    • (2001) Mol Cell Biol , vol.21 , Issue.1 , pp. 148-155
    • De Laurenzi, V.1    Melino, G.2
  • 85
    • 63749132353 scopus 로고    scopus 로고
    • Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: Summary of mutations (including 23 novel) and modeling of TGase-1
    • M.L. Herman, S. Farasat, P.J. Steinbach, M.-H. Wei, O. Toure, P. Fleckman, and et al. Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1 Hum Mutat 30 4 2009 537 547
    • (2009) Hum Mutat , vol.30 , Issue.4 , pp. 537-547
    • Herman, M.L.1    Farasat, S.2    Steinbach, P.J.3    Wei, M.-H.4    Toure, O.5    Fleckman, P.6
  • 86
    • 79960076132 scopus 로고    scopus 로고
    • Factor XIII: A coagulation factor with multiple plasmatic and cellular functions
    • L. Muszbek, Z. Bereczky, Z. Bagoly, I. Komáromi, and É. Katona Factor XIII: a coagulation factor with multiple plasmatic and cellular functions Physiol Rev 91 3 2011 931 972
    • (2011) Physiol Rev , vol.91 , Issue.3 , pp. 931-972
    • Muszbek, L.1    Bereczky, Z.2    Bagoly, Z.3    Komáromi, I.4    Katona, É.5
  • 88
    • 84923808396 scopus 로고    scopus 로고
    • Discovery of potent and specific dihydroisoxazole inhibitors of human transglutaminase 2
    • C. Klöck, Z. Herrera, M. Albertelli, and C. Khosla Discovery of potent and specific dihydroisoxazole inhibitors of human transglutaminase 2 J Med Chem 57 21 2014 9042 9064
    • (2014) J Med Chem , vol.57 , Issue.21 , pp. 9042-9064
    • Klöck, C.1    Herrera, Z.2    Albertelli, M.3    Khosla, C.4
  • 89
    • 34548120540 scopus 로고    scopus 로고
    • Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
    • J. Xia, E. Bergseng, B. Fleckenstein, M. Siegel, C.-Y. Kim, C. Khosla, and et al. Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease Bioorg Med Chem 15 20 2007 6565 6573
    • (2007) Bioorg Med Chem , vol.15 , Issue.20 , pp. 6565-6573
    • Xia, J.1    Bergseng, E.2    Fleckenstein, B.3    Siegel, M.4    Kim, C.-Y.5    Khosla, C.6
  • 90
    • 38949146048 scopus 로고    scopus 로고
    • Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with celiac disease
    • V.V. Kapoerchan, M. Wiesner, M. Overhand, G.A. van der Marel, F. Koning, and H.S. Overkleeft Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with celiac disease Bioorg Med Chem 16 4 2008 2053 2062
    • (2008) Bioorg Med Chem , vol.16 , Issue.4 , pp. 2053-2062
    • Kapoerchan, V.V.1    Wiesner, M.2    Overhand, M.3    Van Der Marel, G.A.4    Koning, F.5    Overkleeft, H.S.6
  • 91
    • 77951939305 scopus 로고    scopus 로고
    • Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library
    • U. Jüse, Y. van de Wal, F. Koning, L.M. Sollid, and B. Fleckenstein Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library HIM 71 5 2010 475 481
    • (2010) HIM , vol.71 , Issue.5 , pp. 475-481
    • Jüse, U.1    Van De Wal, Y.2    Koning, F.3    Sollid, L.M.4    Fleckenstein, B.5
  • 92
    • 78650846041 scopus 로고    scopus 로고
    • Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: A potential therapy for celiac disease
    • J. Huan, R. Meza-Romero, J.L. Mooney, A.A. Vandenbark, H. Offner, and G.G. Burrows Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease Mucosal Immunol 4 1 2010 112 120
    • (2010) Mucosal Immunol , vol.4 , Issue.1 , pp. 112-120
    • Huan, J.1    Meza-Romero, R.2    Mooney, J.L.3    Vandenbark, A.A.4    Offner, H.5    Burrows, G.G.6
  • 93
    • 0036183420 scopus 로고    scopus 로고
    • Successful infliximab treatment for steroid-refractory celiac disease: A case report
    • H.R. Gillett, I.D.R. Arnott, M. McIntyre, S. Campbell, A. Dahele, M. Priest, and et al. Successful infliximab treatment for steroid-refractory celiac disease: a case report Gastroenterology 122 3 2002 800 805
    • (2002) Gastroenterology , vol.122 , Issue.3 , pp. 800-805
    • Gillett, H.R.1    Arnott, I.D.R.2    McIntyre, M.3    Campbell, S.4    Dahele, A.5    Priest, M.6
  • 94
    • 37048999189 scopus 로고    scopus 로고
    • Treatment of life-threatening type i refractory coeliac disease with long-term infliximab
    • G. Costantino, A. Torre della, M.A. Presti Lo, R. Caruso, E. Mazzon, and W. Fries Treatment of life-threatening type I refractory coeliac disease with long-term infliximab Dig Liver Dis 40 1 2008 74 77
    • (2008) Dig Liver Dis , vol.40 , Issue.1 , pp. 74-77
    • Costantino, G.1    Torre Della, A.2    Presti Lo, M.A.3    Caruso, R.4    Mazzon, E.5    Fries, W.6
  • 95
    • 73949092345 scopus 로고    scopus 로고
    • Fontolizumab in moderate to severe Crohn's disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study
    • W. Reinisch, W. de Villiers, L. Bene, L. Simon, I. Rácz, S. Katz, and et al. Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study Inflamm Bowel Dis 16 2 2010 233 242
    • (2010) Inflamm Bowel Dis , vol.16 , Issue.2 , pp. 233-242
    • Reinisch, W.1    De Villiers, W.2    Bene, L.3    Simon, L.4    Rácz, I.5    Katz, S.6
  • 96
    • 78649270953 scopus 로고    scopus 로고
    • Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of NI-0401 (a fully human anti-CD3 monoclonal antibody) in patients with moderate to severe active Crohn's disease
    • C.J. van der Woude, P. Stokkers, A.A. van Bodegraven, G. Van Assche, Z. Hebzda, L. Paradowski, and et al. Phase I, double-blind, randomized, placebo-controlled, dose-escalation study of NI-0401 (a fully human anti-CD3 monoclonal antibody) in patients with moderate to severe active Crohn's disease Inflamm Bowel Dis 16 10 2010 1708 1716
    • (2010) Inflamm Bowel Dis , vol.16 , Issue.10 , pp. 1708-1716
    • Van Der Woude, C.J.1    Stokkers, P.2    Van Bodegraven, A.A.3    Van Assche, G.4    Hebzda, Z.5    Paradowski, L.6
  • 97
    • 67649933375 scopus 로고    scopus 로고
    • Treatment of patients with new onset type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years
    • K.C. Herold, S. Gitelman, C. Greenbaum, J. Puck, W. Hagopian, P. Gottlieb, and et al. Treatment of patients with new onset type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years Clin Immunol 132 2 2009 166 173
    • (2009) Clin Immunol , vol.132 , Issue.2 , pp. 166-173
    • Herold, K.C.1    Gitelman, S.2    Greenbaum, C.3    Puck, J.4    Hagopian, W.5    Gottlieb, P.6
  • 98
    • 77951201153 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of a chimeric/humanized anti-CD3 monoclonal antibody, otelixizumab (TRX4), in subjects with psoriasis and with type 1 diabetes mellitus
    • P. Wiczling, M. Rosenzweig, L. Vaickus, and W.J. Jusko Pharmacokinetics and pharmacodynamics of a chimeric/humanized anti-CD3 monoclonal antibody, otelixizumab (TRX4), in subjects with psoriasis and with type 1 diabetes mellitus J Clin Pharmacol 50 5 2010 494 506
    • (2010) J Clin Pharmacol , vol.50 , Issue.5 , pp. 494-506
    • Wiczling, P.1    Rosenzweig, M.2    Vaickus, L.3    Jusko, W.J.4
  • 100
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • S.L. Hauser, E. Waubant, D.L. Arnold, T. Vollmer, J. Antel, R.J. Fox, and et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis N Engl J Med 358 7 2008 676 688
    • (2008) N Engl J Med , vol.358 , Issue.7 , pp. 676-688
    • Hauser, S.L.1    Waubant, E.2    Arnold, D.L.3    Vollmer, T.4    Antel, J.5    Fox, R.J.6
  • 101
    • 70349202876 scopus 로고    scopus 로고
    • A randomized, double-blind, pharmacokinetic study of oral maribavir with tacrolimus in stable renal transplant recipients
    • M.D. Pescovitz, R. Bloom, J. Pirsch, J. Johnson, S. Gelone, and S.A. Villano A randomized, double-blind, pharmacokinetic study of oral maribavir with tacrolimus in stable renal transplant recipients Am J Transplant 9 10 2009 2324 2330
    • (2009) Am J Transplant , vol.9 , Issue.10 , pp. 2324-2330
    • Pescovitz, M.D.1    Bloom, R.2    Pirsch, J.3    Johnson, J.4    Gelone, S.5    Villano, S.A.6
  • 102
    • 0031438699 scopus 로고    scopus 로고
    • Autoantibodies in coeliac disease: Tissue transglutaminase-guilt by association?
    • L.M. Sollid, O. Molberg, S. McAdam, and K.E. Lundin Autoantibodies in coeliac disease: tissue transglutaminase-guilt by association? Gut 41 6 1997 851 852
    • (1997) Gut , vol.41 , Issue.6 , pp. 851-852
    • Sollid, L.M.1    Molberg, O.2    McAdam, S.3    Lundin, K.E.4
  • 103
    • 78650043915 scopus 로고    scopus 로고
    • Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab
    • H. Mei, D. Frölich, C. Giesecke, and C. Loddenkemper Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab Blood 116 24 2010 5181 5190
    • (2010) Blood , vol.116 , Issue.24 , pp. 5181-5190
    • Mei, H.1    Frölich, D.2    Giesecke, C.3    Loddenkemper, C.4
  • 104
    • 48849115839 scopus 로고    scopus 로고
    • Differentiation and homing of IgA-secreting cells
    • J.R. Mora, and U.H. Andrian von Differentiation and homing of IgA-secreting cells Mucosal Immunol 1 2 2008 96 109
    • (2008) Mucosal Immunol , vol.1 , Issue.2 , pp. 96-109
    • Mora, J.R.1    Andrian Von, U.H.2
  • 105
    • 34250011713 scopus 로고    scopus 로고
    • Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation
    • R.W. Olaussen, M.R. Karlsson, K.E.A. Lundin, J. Jahnsen, P. Brandtzaeg, and I.N. Farstad Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation Gastroenterology 132 7 2007 2371 2382
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2371-2382
    • Olaussen, R.W.1    Karlsson, M.R.2    Lundin, K.E.A.3    Jahnsen, J.4    Brandtzaeg, P.5    Farstad, I.N.6
  • 106
    • 64049108887 scopus 로고    scopus 로고
    • Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin α4β7-positive T cells in blood
    • A.D. Di Sabatino, L. Rovedatti, M.M. Rosado, R. Carsetti, G.R. Corazza, T.T. MacDonald, and et al. Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin α4β7-positive T cells in blood Hum Pathol 40 5 2009 699 704
    • (2009) Hum Pathol , vol.40 , Issue.5 , pp. 699-704
    • Di Sabatino, A.D.1    Rovedatti, L.2    Rosado, M.M.3    Carsetti, R.4    Corazza, G.R.5    MacDonald, T.T.6
  • 107
    • 77957244016 scopus 로고    scopus 로고
    • Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease
    • M.J. Walters, Y. Wang, N. Lai, T. Baumgart, B.N. Zhao, D.J. Dairaghi, and et al. Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease J Pharmacol Exp Ther 335 1 2010 61 69
    • (2010) J Pharmacol Exp Ther , vol.335 , Issue.1 , pp. 61-69
    • Walters, M.J.1    Wang, Y.2    Lai, N.3    Baumgart, T.4    Zhao, B.N.5    Dairaghi, D.J.6
  • 110
    • 77950243833 scopus 로고    scopus 로고
    • Multiple common variants for celiac disease influencing immune gene expression
    • P.C.A. Dubois, G. Trynka, L. Franke, K.A. Hunt, J. Romanos, A. Curtotti, and et al. Multiple common variants for celiac disease influencing immune gene expression Nat Genet 42 4 2010 295 302
    • (2010) Nat Genet , vol.42 , Issue.4 , pp. 295-302
    • Dubois, P.C.A.1    Trynka, G.2    Franke, L.3    Hunt, K.A.4    Romanos, J.5    Curtotti, A.6
  • 112
    • 67651166585 scopus 로고    scopus 로고
    • Themis, a T cell-specific protein important for late thymocyte development
    • R. Lesourne, S. Uehara, J. Lee, K.-D. Song, L. Li, J. Pinkhasov, and et al. Themis, a T cell-specific protein important for late thymocyte development Nat Immunol 10 8 2009 840 847
    • (2009) Nat Immunol , vol.10 , Issue.8 , pp. 840-847
    • Lesourne, R.1    Uehara, S.2    Lee, J.3    Song, K.-D.4    Li, L.5    Pinkhasov, J.6
  • 113
    • 84890561320 scopus 로고    scopus 로고
    • Themis sets the signal threshold for positive and negative selection in T-cell development
    • G. Fu, J. Casas, S. Rigaud, V. Rybakin, F. Lambolez, J. Brzostek, and et al. Themis sets the signal threshold for positive and negative selection in T-cell development Nature 504 7480 2013 441 445
    • (2013) Nature , vol.504 , Issue.7480 , pp. 441-445
    • Fu, G.1    Casas, J.2    Rigaud, S.3    Rybakin, V.4    Lambolez, F.5    Brzostek, J.6
  • 114
    • 84857488264 scopus 로고    scopus 로고
    • A spontaneous mutation of the rat themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease
    • M. Chabod, C. Pedros, L. Lamouroux, C. Colacios, I. Bernard, D. Lagrange, and et al. A spontaneous mutation of the rat themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease PLoS Genet 8 1 2012 e1002461
    • (2012) PLoS Genet , vol.8 , Issue.1 , pp. e1002461
    • Chabod, M.1    Pedros, C.2    Lamouroux, L.3    Colacios, C.4    Bernard, I.5    Lagrange, D.6
  • 115
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • L. Jostins, S. Ripke, R.K. Weersma, R.H. Duerr, D.P. McGovern, K.Y. Hui, and et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease Nature 491 7422 2012 119 124
    • (2012) Nature , vol.491 , Issue.7422 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3    Duerr, R.H.4    McGovern, D.P.5    Hui, K.Y.6
  • 116
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • S. Sawcer, G. Hellenthal, M. Pirinen, C.C.A. Spencer, N.A. Patsopoulos, L. Moutsianas, and et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis Nature 476 7359 2011 214 219
    • (2011) Nature , vol.476 , Issue.7359 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3    Spencer, C.C.A.4    Patsopoulos, N.A.5    Moutsianas, L.6
  • 117
    • 84894355582 scopus 로고    scopus 로고
    • THEMIS and PTPRK in celiac intestinal mucosa: Coexpression in disease and after in vitro gliadin challenge
    • C. Bondar, L. Plaza-Izurieta, N. Fernandez-Jimenez, I.N.A. Irastorza, S. Withoff, CEGEC, and et al. THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge Eur J Hum Genet 22 3 2013 358 362
    • (2013) Eur J Hum Genet , vol.22 , Issue.3 , pp. 358-362
    • Bondar, C.1    Plaza-Izurieta, L.2    Fernandez-Jimenez, N.3    Irastorza, I.N.A.4    Withoff, S.5    Cegec6
  • 118
    • 18944382074 scopus 로고    scopus 로고
    • Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} function
    • S.E. Wang, F.Y. Wu, I. Shin, S. Qu, and C.L. Arteaga Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} function Mol Cell Biol 25 11 2005 4703 4715
    • (2005) Mol Cell Biol , vol.25 , Issue.11 , pp. 4703-4715
    • Wang, S.E.1    Wu, F.Y.2    Shin, I.3    Qu, S.4    Arteaga, C.L.5
  • 119
    • 36348963611 scopus 로고    scopus 로고
    • A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat
    • A. Asano, K. Tsubomatsu, C.-G. Jung, N. Sasaki, and T. Agui A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat Mamm Genome 18 11 2007 779 786
    • (2007) Mamm Genome , vol.18 , Issue.11 , pp. 779-786
    • Asano, A.1    Tsubomatsu, K.2    Jung, C.-G.3    Sasaki, N.4    Agui, T.5
  • 120
    • 77749267810 scopus 로고    scopus 로고
    • Contiguous gene deletion of Ptprk and themis causes T-helper immunodeficiency (thid) in the LEC rat
    • R. Iwata, N. Sasaki, and T. Agui Contiguous gene deletion of Ptprk and themis causes T-helper immunodeficiency (thid) in the LEC rat Biomed Res 31 1 2010 83 87
    • (2010) Biomed Res , vol.31 , Issue.1 , pp. 83-87
    • Iwata, R.1    Sasaki, N.2    Agui, T.3
  • 121
  • 122
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium Wellcome Trust Case Control Consortium 2
    • International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, S. Sawcer, G. Hellenthal, M. Pirinen, C.C.A. Spencer, and et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis Nature 476 7359 2011 214 219
    • (2011) Nature , vol.476 , Issue.7359 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3    Spencer, C.C.A.4
  • 123
    • 0028965558 scopus 로고
    • Sequence and expression of a candidate for the human secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype
    • R.J. Kelly, S. Rouquier, D. Giorgi, G.G. Lennon, and J.B. Lowe Sequence and expression of a candidate for the human secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype J Biol Chem 270 9 1995 4640 4649
    • (1995) J Biol Chem , vol.270 , Issue.9 , pp. 4640-4649
    • Kelly, R.J.1    Rouquier, S.2    Giorgi, D.3    Lennon, G.G.4    Lowe, J.B.5
  • 124
    • 79956257405 scopus 로고    scopus 로고
    • Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine
    • P. Wacklin, H. Mäkivuokko, N. Alakulppi, J. Nikkilä, H. Tenkanen, J. Räbinä, and et al. Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine PLoS One 6 5 2011 e20113
    • (2011) PLoS One , vol.6 , Issue.5 , pp. e20113
    • Wacklin, P.1    Mäkivuokko, H.2    Alakulppi, N.3    Nikkilä, J.4    Tenkanen, H.5    Räbinä, J.6
  • 125
    • 84869097522 scopus 로고    scopus 로고
    • Association study of FUT2(rs601338) with celiac disease and inflammatory bowel disease in the Finnish population
    • A.S. Parmar, N. Alakulppi, P. Paavola-Sakki, K. Kurppa, L. Halme, M. Färkkilä, and et al. Association study of FUT2(rs601338) with celiac disease and inflammatory bowel disease in the Finnish population Tissue Antigens 80 6 2012 488 493
    • (2012) Tissue Antigens , vol.80 , Issue.6 , pp. 488-493
    • Parmar, A.S.1    Alakulppi, N.2    Paavola-Sakki, P.3    Kurppa, K.4    Halme, L.5    Färkkilä, M.6
  • 126
    • 77955398591 scopus 로고    scopus 로고
    • Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    • D.P.B. McGovern, M.R. Jones, K.D. Taylor, K. Marciante, X. Yan, M. Dubinsky, and et al. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease Hum Mol Genet 19 17 2010 3468 3476
    • (2010) Hum Mol Genet , vol.19 , Issue.17 , pp. 3468-3476
    • McGovern, D.P.B.1    Jones, M.R.2    Taylor, K.D.3    Marciante, K.4    Yan, X.5    Dubinsky, M.6
  • 127
    • 80053548022 scopus 로고    scopus 로고
    • FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection
    • D.J. Smyth, J.D. Cooper, J.M.M. Howson, P. Clarke, K. Downes, T. Mistry, and et al. FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection Diabetes 60 11 2011 3081 3084
    • (2011) Diabetes , vol.60 , Issue.11 , pp. 3081-3084
    • Smyth, D.J.1    Cooper, J.D.2    Howson, J.M.M.3    Clarke, P.4    Downes, K.5    Mistry, T.6
  • 129
    • 84876377297 scopus 로고    scopus 로고
    • The duodenal microbiota composition of adult celiac disease patients is associated with the clinical manifestation of the disease
    • P. Wacklin, K. Kaukinen, E. Tuovinen, P. Collin, K. Lindfors, J. Partanen, and et al. The duodenal microbiota composition of adult celiac disease patients is associated with the clinical manifestation of the disease Inflamm Bowel Dis 19 5 2013 934 941
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.5 , pp. 934-941
    • Wacklin, P.1    Kaukinen, K.2    Tuovinen, E.3    Collin, P.4    Lindfors, K.5    Partanen, J.6
  • 130
    • 84868314491 scopus 로고    scopus 로고
    • Modulation of phenotypic and functional maturation of dendritic cells by intestinal bacteria and gliadin: Relevance for celiac disease
    • G. De Palma, J. Kamanova, J. Cinova, M. Olivares, H. Drasarova, L. Tuckova, and et al. Modulation of phenotypic and functional maturation of dendritic cells by intestinal bacteria and gliadin: relevance for celiac disease J Leukoc Biol 92 5 2012 1043 1054
    • (2012) J Leukoc Biol , vol.92 , Issue.5 , pp. 1043-1054
    • De Palma, G.1    Kamanova, J.2    Cinova, J.3    Olivares, M.4    Drasarova, H.5    Tuckova, L.6
  • 131
    • 80052721297 scopus 로고    scopus 로고
    • Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
    • M.A. Ferreira, M.C. Matheson, D.L. Duffy, G.B. Marks, J. Hui, P. Le Souëf, and et al. Identification of IL6R and chromosome 11q13.5 as risk loci for asthma Lancet 378 9795 2011 1006 1014
    • (2011) Lancet , vol.378 , Issue.9795 , pp. 1006-1014
    • Ferreira, M.A.1    Matheson, M.C.2    Duffy, D.L.3    Marks, G.B.4    Hui, J.5    Le Souëf, P.6
  • 132
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • A. Franke, D.P.B. McGovern, J.C. Barrett, K. Wang, G.L. Radford-Smith, T. Ahmad, and et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Nat Genet 42 12 2010 1118 1125
    • (2010) Nat Genet , vol.42 , Issue.12 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.B.2    Barrett, J.C.3    Wang, K.4    Radford-Smith, G.L.5    Ahmad, T.6
  • 133
    • 84861583442 scopus 로고    scopus 로고
    • Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
    • Y. Jin, S.A. Birlea, P.R. Fain, T.M. Ferrara, S. Ben, S.L. Riccardi, and et al. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo Nat Genet 44 6 2012 676 680
    • (2012) Nat Genet , vol.44 , Issue.6 , pp. 676-680
    • Jin, Y.1    Birlea, S.A.2    Fain, P.R.3    Ferrara, T.M.4    Ben, S.5    Riccardi, S.L.6
  • 134
    • 56749183605 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    • J.D. Cooper, D.J. Smyth, A.M. Smiles, V. Plagnol, N.M. Walker, J.E. Allen, and et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci Nat Genet 40 12 2008 1399 12401
    • (2008) Nat Genet , vol.40 , Issue.12 , pp. 1399-12401
    • Cooper, J.D.1    Smyth, D.J.2    Smiles, A.M.3    Plagnol, V.4    Walker, N.M.5    Allen, J.E.6
  • 135
    • 84905981155 scopus 로고    scopus 로고
    • Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network
    • K. Igarashi, K. Ochiai, A. Itoh-Nakadai, and A. Muto Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network Immunol Rev 261 1 2014 116 125
    • (2014) Immunol Rev , vol.261 , Issue.1 , pp. 116-125
    • Igarashi, K.1    Ochiai, K.2    Itoh-Nakadai, A.3    Muto, A.4
  • 136
    • 84879685794 scopus 로고    scopus 로고
    • BACH2 represses effector programs to stabilize treg-mediated immune homeostasis
    • R. Roychoudhuri, K. Hirahara, K. Mousavi, D. Clever, C.A. Klebanoff, M. Bonelli, and et al. BACH2 represses effector programs to stabilize treg-mediated immune homeostasis Nature 498 7455 2013 506 510
    • (2013) Nature , vol.498 , Issue.7455 , pp. 506-510
    • Roychoudhuri, R.1    Hirahara, K.2    Mousavi, K.3    Clever, D.4    Klebanoff, C.A.5    Bonelli, M.6
  • 137
    • 84922419326 scopus 로고    scopus 로고
    • Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels
    • V. Kumar, J. Gutierrez-Achury, K. Kanduri, R. Almeida, B. Hrdlickova, D.V. Zhernakova, and et al. Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels Hum Mol Genet 24 2 2014 397 409
    • (2014) Hum Mol Genet , vol.24 , Issue.2 , pp. 397-409
    • Kumar, V.1    Gutierrez-Achury, J.2    Kanduri, K.3    Almeida, R.4    Hrdlickova, B.5    Zhernakova, D.V.6
  • 138
    • 58149091678 scopus 로고    scopus 로고
    • Shared and distinct genetic variants in type 1 diabetes and celiac disease
    • D.J. Smyth, V. Plagnol, N.M. Walker, J.D. Cooper, K. Downes, J.H.M. Yang, and et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease N Engl J Med 359 26 2008 2767 2777
    • (2008) N Engl J Med , vol.359 , Issue.26 , pp. 2767-2777
    • Smyth, D.J.1    Plagnol, V.2    Walker, N.M.3    Cooper, J.D.4    Downes, K.5    Yang, J.H.M.6
  • 139
    • 77950329947 scopus 로고    scopus 로고
    • Evidence for polygenic susceptibility to multiple sclerosis-The shape of things to come
    • International Multiple Sclerosis Genetics Consortium (imsgc)
    • International Multiple Sclerosis Genetics Consortium (IMSGC), W.S. Bush, S.J. Sawcer, P.L. De Jager, J.R. Oksenberg, J.L. McCauley, and et al. Evidence for polygenic susceptibility to multiple sclerosis-the shape of things to come Am J Hum Genet 86 4 2010 621 625
    • (2010) Am J Hum Genet , vol.86 , Issue.4 , pp. 621-625
    • Bush, W.S.1    Sawcer, S.J.2    De Jager, P.L.3    Oksenberg, J.R.4    McCauley, J.L.5
  • 140
    • 41349103493 scopus 로고    scopus 로고
    • Newly identified genetic risk variants for celiac disease related to the immune response
    • K.A. Hunt, A. Zhernakova, G. Turner, G.A.R. Heap, L. Franke, M. Bruinenberg, and et al. Newly identified genetic risk variants for celiac disease related to the immune response Nat Genet 40 4 2008 395 402
    • (2008) Nat Genet , vol.40 , Issue.4 , pp. 395-402
    • Hunt, K.A.1    Zhernakova, A.2    Turner, G.3    Heap, G.A.R.4    Franke, L.5    Bruinenberg, M.6
  • 141
    • 0034651728 scopus 로고    scopus 로고
    • Regulator of G protein signaling 1 (RGS1) markedly impairs Gi alpha signaling responses of B lymphocytes
    • C. Moratz, V.H. Kang, K.M. Druey, C.S. Shi, A. Scheschonka, P.M. Murphy, and et al. Regulator of G protein signaling 1 (RGS1) markedly impairs Gi alpha signaling responses of B lymphocytes J Immunol 164 4 2000 1829 1838
    • (2000) J Immunol , vol.164 , Issue.4 , pp. 1829-1838
    • Moratz, C.1    Kang, V.H.2    Druey, K.M.3    Shi, C.S.4    Scheschonka, A.5    Murphy, P.M.6
  • 142
    • 2942753952 scopus 로고    scopus 로고
    • Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice
    • C. Moratz, J.R. Hayman, H. Gu, and J.H. Kehrl Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice Mol Cell Biol 24 13 2004 5767 5775
    • (2004) Mol Cell Biol , vol.24 , Issue.13 , pp. 5767-5775
    • Moratz, C.1    Hayman, J.R.2    Gu, H.3    Kehrl, J.H.4
  • 143
    • 80052670810 scopus 로고    scopus 로고
    • Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential
    • D.L. Gibbons, L. Abeler-Dörner, T. Raine, I.-Y. Hwang, A. Jandke, M. Wencker, and et al. Cutting Edge: regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential J Immunol 187 5 2011 2067 2071
    • (2011) J Immunol , vol.187 , Issue.5 , pp. 2067-2071
    • Gibbons, D.L.1    Abeler-Dörner, L.2    Raine, T.3    Hwang, I.-Y.4    Jandke, A.5    Wencker, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.