Safety, tolerability, and activity of ALV003: Results from two phase 1 single, escalating-dose clinical trials

Digestive Diseases and Sciences

Volumn 57, Issue 2, 2012, Pages 440-450

  Siegel, Matthew ^a   Garber, Mitchell E ^a   Spencer, Andrew G ^a   Botwick, Wendy ^a   Kumar, Pawan ^a   Williams, Robert N ^a   Kozuka, Kenji ^a   Shreeniwas, Revati ^a   Pratha, Vijaya ^b   Adelman, Daniel C ^a  

^a Alvine Pharmaceuticals   (United States)

^b Clinical Applications Laboratories   (United States)

Author keywords

ALV003; Celiac disease; Clinical trial; Gluten; Phase I; Protease

Indexed keywords

ALV 003; DRUG ANTIBODY; GLUTEN; PROTEINASE; UNCLASSIFIED DRUG;

ADULT; ANTIBODY TITER; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DIET RESTRICTION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DOSE ESCALATION; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; ENZYME ACTIVITY; FEMALE; FEVER; FLATULENCE; GASTRIC SUCTION; HEADACHE; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; MALE; NASOGASTRIC TUBE; NAUSEA; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; TACHYCARDIA; WHEAT;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; BLOTTING, WESTERN; CELIAC DISEASE; CROSS-OVER STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUTENS; HUMANS; MALE; PEPTIDE HYDROLASES; SINGLE-BLIND METHOD; STOMACH; YOUNG ADULT;

EID: 84856744117     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1906-5     Document Type: Article

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