Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: A pilot randomized controlled trial

Digestive Diseases and Sciences

Volumn 57, Issue 12, 2012, Pages 3116-3125

  Shalimar, ^a   Das, Prasenjit ^a   Sreenivas, Vishnubhatla ^a   Datta Gupta, Siddhartha ^a   Panda, Subrat K ^a   Makharia, Govind K ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Apoptosis; Apoptotic index; Cell regeneration; Gluten free diet; Immunohistochemistry; Prednisolone

Indexed keywords

COMPLEMENT COMPONENT C3; HISTONE H2AX; KI 67 ANTIGEN; PREDNISOLONE; PROTEIN BCL 2; PROTEIN P53; X LINKED INHIBITOR OF APOPTOSIS;

ADULT; APOPTOSIS; ARTICLE; CELIAC DISEASE; CELL INFILTRATION; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG WITHDRAWAL; FOLLOW UP; GLUTEN FREE DIET; HEMOGLOBIN BLOOD LEVEL; HUMAN; INTESTINE VILLUS ATROPHY; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION;

ADOLESCENT; ADULT; APOPTOSIS; BIOLOGICAL MARKERS; CELIAC DISEASE; CELL PROLIFERATION; CHILD; DIET, GLUTEN-FREE; DUODENUM; EPITHELIAL CELLS; HUMANS; INTESTINAL MUCOSA; PILOT PROJECTS; PREDNISOLONE; YOUNG ADULT;

EID: 84871629803     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2294-1     Document Type: Article

References (31)

1. Lee SK, Lo W, Memeo L, et al. Duodenal histology in patients with celiac disease after treatment with a gluten-free diet. Gastrointest Endosc. 2003;57:187-191.
2. Cellier C, Delabesse E, Helmer C, et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet. 2000;356:203-208.
3. Laurin P, Wolving M, Falth-Magnusson K. Even small amounts of gluten cause relapse in children with celiac disease. J Pediatr Gastroenterol Nutr. 2002;34:26-30.
4. Mustalahti K, Lohiniemi S, Collin P, et al. Gluten-free diet and quality of life in patients with screen-detected celiac disease. Eff Clin Pract. 2002;5:105-113.
5. Mitchison HC, Mardini H, Gillespie S, et al. A pilot study of fluticasone propionate in untreated coeliac disease. Gut. 1991;32:260-265.
6. Nowell PC. Inhibition of human leucocyte mitosis by prednisolone in vitro. Cancer Res. 1961;21:1518-1521.
7. Balow JE, Rosenthal AS. Glucocorticoid suppression of macrophage migratory inhibitory factor. J Exp Med. 1973;137:1031-1041.
8. Heilman DH, Gambrill MR, Leichner JP. The effect of hydrocortisone on the incorporation of titrated thymidine by human blood lymphocytes cultured with phytohaemagglutinin and pokeweed mitogens. Clin Exp Immunol. 1973;15:203-212.
9. Wahl SM, Altman LC, Rosenstreich DL. Inhibition of in vitro lymphokine synthesis of glucocorticosteroids. J Immunol. 1975;115:476-481.
10. Mulder CJ, Wahab PJ, Meijer JW, et al. A pilot study of recombinant human interleukin-10 in adults with refractory celiac disease. Eur J Gastroenterol Hepatol. 2001;13:1183-1188.
11. Branski D. New insights in celiac disease. RMMJ. 2012;3:e0006.
12. Greco L, Gobbetti M, Auricchio R, et al. Safety for patients with celiac disease of baked goods made of wheat four hydrolyzed during food processing. Clin Gastroenerol Hepatol. 2011;9:24-29.
13. Paterson BM, Lammers KM, Arrieta MC, Fasano A, Meddings JB. The safety, tolerance, pharmacokinetic and pharmaco-dynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment Pharmacol Ther. 2007;26:757-766.
14. Wall AJ, Douglas AP, Booth CC, et al. Response of the jejunal mucosa in adult coeliac disease to oral prednisolone. Gut. 1970;11:7-14.
15. Bergrem H, Opedal I. Bioavailability of prednisolone in patients with intestinal malabsorption: the importance of measuring serum protein-binding. Scan J Gastroenterol. 1983;18:545-549.
16. Pickup ME, Farah F, Lowe JR, et al. Prednisolone absorption in coeliac disease. Eur J Drug Metab Pharmacokinet. 1979;4:87-89.
17. Ciacci C, Maiuri L, Russo L, et al. Efficacy of budesonide therapy in the early phase of treatment of adult coeliac disease patients with malabsorption: an in vivo/in vitro pilot study. Clin Exp Pharmacol Physiol. 2009;36:1170-1176.
18. Moss SF, Attia L, Scholes JV, et al. Increased small intestinal apoptosis in coeliac disease. Gut. 1996;39:811-817.
19. Shiner M, Eran M, Freier S, et al. Are intraepithelial lymphocytes in celiac mucosa responsible for inducing programmed cell death (apoptosis) in enterocytes? Histochemical demonstration of perforins in cytoplasmic granules of intraepithelial lymphocytes. J Pediatr Gastroenterol Nutr. 1998;27:393-396.
20. Groisman GM, Sabo E, Meir A, et al. Enterocyte apoptosis and proliferation are increased in microvillous inclusion disease (familial microvillous atrophy). Hum Pathol. 2000;31:1404-1410.
21. Croft DN, Cotton PB. Gastrointestinal cell loss in man. Its measurement and significance. Digestion. 1973;8:144-160.
22. Iwanaga T, Han H, Adachi K, et al. A novel mechanism for the disposing of effete epithelial cells in the small intestine of guinea pigs. Gastroenterology. 1993;105:1089-1097.
23. Hall PA, Coates PJ, Ansari B, et al. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J Cell Sci. 1994;107:3569-3577.
24. Strater J, Koretz K, Gunthert AR, et al. In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis. Gut. 1995;37:819-825.
25. Marsh MN. Mucosal pathology in gluten sensitivity. In: Marsh MN, ed. Coeliac Disease. Blackwell: Oxford; 1992:136-191.
26. Riecken EO, Stewart JS, Booth CC, Pearse AGE. A histochemical study on the role of lysosomal enzymes in idiopathic steatorrhoea before and during a gluten-free diet. Gut. 1966;7:317-332.
27. Spiro HM, Filipe MI, Stewart JS, Booth CG, Pearse AGE. Functional histochemistry of the small bowel mucosa in malabsorption syndromes. Gut. 1964;5:145-154.
28. Weissman G. Localization and stabilization of lysosomes. Fed Proc. 1964;23:1038-1044.
29. Radlovic NP, Mladenovic MM, Stojsic ZM, Brdar RS. Short-term corticosteroids for celiac crisis in infants. Indian Pediatr. 2011;48:641-642.
30. Das P, Shalimar, Sreenivas V, Dattagupta S, Panda SK, Makharia GK. Mechanism of villous atrophy in celiac disease: role of apoptosis and epithelial regeneration. J Gastroenterol Hepatol. 2010;25:A36 (abstract).
31. Van der Woude CJ, Jansen PLM, Tiebosch ATMG, et al. Active celiac disease induces an anti-apoptotic phenotype which limits apoptosis. 2004; http://dissertations.ub.rug.nl/FILES/faculties/medicine/2004/c.j.van.der.woude/ c6.pdf. Accessed April 28, 2011.