A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat

Mammalian Genome

Volumn 18, Issue 11, 2007, Pages 779-786

  Asano, Atsushi ^a,b   Tsubomatsu, Kouta ^a   Jung, Cha Gyun ^c   Sasaki, Nobuya ^a   Agui, Takashi ^a,c  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE TYPE KAPPA; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DELETION MUTANT; GENE DELETION; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENOME ANALYSIS; IMMUNE DEFICIENCY; INTRON; LINKAGE ANALYSIS; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; RAT; TH1 CELL; THYMUS;

ANIMALS; BASE SEQUENCE; BONE MARROW TRANSPLANTATION; DNA; DNA PRIMERS; FEMALE; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTRONS; LINKAGE (GENETICS); MALE; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED LEC; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 2; SEQUENCE DELETION; T-LYMPHOCYTES, HELPER-INDUCER; TRANSDUCTION, GENETIC; TRANSPLANTATION, ISOGENEIC;

RATTUS;

EID: 36348963611     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-007-9062-0     Document Type: Article

References (35)

1. - thymocytes in a mutant strain (LEC) of rat. J Exp Med 172:1615-1624
2. - thymocytes in LEC mutant rats. Eur J Immunol 21:2277-2280
3. - thymocytes. Eur J Immunol 21:2537-2541
4. Alonso A, Sasin J, Bottini N, Friedberg I, Osterman A, et al. (2004) Protein tyrosine phosphatases in the human genome. Cell 117:699-711
5. Bousso P, Bhakta NR, Lewis RS, Robey E (2002) Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296:1876-1880
6. Cooney KA, Wetzel JC, Consolino CM, Wonjo KJ (1996) Identification and characterization of proximal 6q deletion in prostate cancer. Cancer Res 56:4150-4153
7. Gallegos AM, Bevan MJ (2004) Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 200:1039-1049
8. Hayashi M, Okui T, Endoh D, Sato F, Kasai N, et al. (1994) Radiation hypersensitivity of LEC strain rats controlled by a single autosomal recessive gene. Mutat Res 314:135-142
9. He X, Dave VP, Zhang Y, Hua X, Nicolas E, et al. (2005) The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433:826-833
10. Jiang YP, Wang H, D'Eustachio P, Musacchio JM, Schlessinger J, et al. (1993) Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region. Mol Cell Biol 13:2942-2951
11. + T cells and the thid (T-helper immunodeficiency) phenotype in the LEC rat. Exp Anim 50:337-340
12. Koop EA, Lopes SM, Feiken E, Bluyssen HA, van der Valk M, et al. (2003) Receptor protein tyrosine phosphatase mu expression as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Int J Dev Biol 47:345-354
13. Kose H, Sakai T, Tsukumo S, Wei K, Yamada T, et al. (2007) Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase κ gene in LEC rats. Genomics 89:673-677
14. Ladi E, Yin X, Chtanova T, Robey EA (2006) Thymic microenvironments for T cell differentiation and selection. Nat Immunol 7:338-343
15. Laky K, Fleischacker C, Fowlkes B (2006) TCR and Notch signaling in CD4 and CD8 T-cell development. Immunol Rev 209:274-283
16. Lind EF, Prockop SE, Porritt HE, Petrie HT (2001) Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J Exp Med 194:127-134
17. Liu X, Bosselut R (2004) Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nat Immunol 5:280-288
18. Manly KF, Cudmore RH Jr, Meer JM (2001) Map Manager QTX, cross-platform software for genetic mapping. Mamm Genome 12:930-932
19. McArdle L, Rafferty M, Mælandsmo GM, Bergin O, Farr CJ, et al. (2001) Protein tyrosine phosphatase genes downregulated in melanoma. J Invest Dermatol 117:1255-1260
20. Nakamura M, Kishi M, Sakaki T, Hashimoto H, Nakase H, et al. (2003) Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas. Cancer Res 63:737-741
21. Porritt HE, Gordon K, Petrie HT (2003) Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice. J Exp Med 198:957-962
22. + cells of LEC mutant rats. Immunology 79:491-497
23. Sap J, Jiang YP, Friedlander D, Grumet M, Schlessinger J (1994) Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding. Mol Cell Biol 14:1-9
24. Shen P, Canoll P, Sap J, Musacchio JM (1999) Expression of a truncated receptor protein tyrosine phosphatase kappa in the brain of an adult transgenic mouse. Brain Res 826:157-171
25. Siggs OM, Makaroff LE, Liston A (2006) The why and how of thymocyte negative selection. Curr Opin Immunol 18:175-183
26. Singer A, Bosselut R (2004) CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision. Adv Immunol 83:91-131
27. Skarnes WC, Moss JM, Hurtley SM, Beddington RS (1995) Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci USA 92:6592-6596
28. Sun G, Liu X, Mercado P, Jenkinson SR, Kypriotou M, et al. (2005) The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol 6:373-381
29. Theile M, Seitz S, Arnold W, Jandrig B, Frege R, et al. (1996) A defined chromosome 6q fragment (at D6S310) harbors a putative tumor suppressor gene for breast cancer. Oncogene 13:677-685
30. Wang SE, Wu FY, Shin I, Qu S, Arteaga CL (2005) Transforming growth factor β (TGF-β)-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-β function. Mol Cell Biol 25:4703-4715
31. Wei K, Muramatsu Y, Sakai T, Yamada T, Matsumoto K (1997) Chromosomal mapping of the T-helper immunodeficiency (thid) locus in LEC rats. Immunogenetics 47:99-102
32. Witt CM, Raychaudhuri S, Schaefer B, Chakraborty AK, Robey EA (2005) Directed migration of positively selected thymocytes visualized in real time. PLoS Biol 3:e160
33. Yamada T, Natori T, Izumi K, Sakai T, Agui T, et al. (1991) Inheritance of T-helper immunodeficiency (thid) in LEC mutant rats. Immunogenetics 33:216-219
34. Yang Y, Gil MC, Choi EY, Park SH, Pyun KH, et al. (1997) Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase. Gene 186:77-82
35. Zondag GC, Koningstein GM, Jiang YP, Sap J, Moolenaar WH, et al. (1995) Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain. J Biol Chem 270:14247-14250