A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease

PLoS Genetics

Volumn 8, Issue 1, 2012, Pages

  Chabod, Marianne ^a,b,c   Pedros, Christophe ^a,b,c   Lamouroux, Lucille ^a,b,c   Colacios, Céline ^a,b,c   Bernard, Isabelle ^a,b,c   Lagrange, Dominique ^a,b,c   Balz Hara, Daniela ^a,b,c   Mosnier, Jean Francois ^d   Laboisse, Christian ^d   Vergnolle, Nathalie ^a,b,c   Andreoletti, Olivier ^e   Roth, Marie Paule ^a,b,c   Liblau, Roland ^a,b,c   Fournié, Gilbert J ^a,b,c   Saoudi, Abdelhadi ^a,b,c   Dejean, Anne S ^a,b,c  

^a University of Toulouse III   (France)

^b CNRS   (France)

^c UNIVERSITÉ PAUL SABATIER   (France)

^d UNIVERSITÉ DE NANTES   (France)

^e UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHROMOSOME 1; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; ENTERITIS; GENE DISRUPTION; GENE EXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC COMPLEMENTATION; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTOPENIA; MALE; MUTATOR GENE; NONHUMAN; PHENOTYPE; RAT; REGULATORY T LYMPHOCYTE; SPONTANEOUS MUTATION; TH17 CELL; TH2 CELL; THEMIS GENE; ANIMAL; CHROMOSOME MAP; FRAMESHIFT MUTATION; GENETIC LINKAGE; GENETICS; METABOLISM; THYMUS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

INTERLEUKIN 2 RECEPTOR ALPHA; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CHROMOSOME MAPPING; FRAMESHIFT MUTATION; GENETIC LINKAGE; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOPENIA; RATS; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TH2 CELLS; THYMUS GLAND;

EID: 84857488264     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002461     Document Type: Article

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