메뉴 건너뛰기




Volumn 6, Issue SEP, 2015, Pages

Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity

Author keywords

Autoimmune diseases; Hyporesponsiveness; Immunotherapy; Regulatory T cells; T cell anergy; Tolerogenic dendritic cells

Indexed keywords

ADENOSINE A2A RECEPTOR; AUTOANTIGEN; B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DEXAMETHASONE; EARLY GROWTH RESPONSE FACTOR 2; GLUTAMATE DECARBOXYLASE 65; INTERLEUKIN 10; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 84946570532     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00488     Document Type: Short Survey
Times cited : (9)

References (79)
  • 1
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol (2010) 11(1):7-13. doi: 10.1038/ni.1818.
    • (2010) Nat Immunol , vol.11 , Issue.1 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 2
    • 74049160009 scopus 로고    scopus 로고
    • Mechanisms maintaining peripheral tolerance
    • Mueller D. Mechanisms maintaining peripheral tolerance. Nat Immunol (2010) 11(1):21-7. doi:10.1038/ni.1817.
    • (2010) Nat Immunol , vol.11 , Issue.1 , pp. 21-27
    • Mueller, D.1
  • 3
    • 0042971652 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells
    • Steinman R, Hawiger D, Nussenzweig M. Tolerogenic dendritic cells. Annu Rev Immunol (2003) 21:685-711. doi:10.1146/annurev.immunol.21.120601.141040.
    • (2003) Annu Rev Immunol , vol.21 , pp. 685-711
    • Steinman, R.1    Hawiger, D.2    Nussenzweig, M.3
  • 4
    • 14744278597 scopus 로고    scopus 로고
    • Molecular mechanisms that set the stage for DC-T cell engagement
    • van Gisbergen K, Paessens L, Geijtenbeek T, van Kooyk Y. Molecular mechanisms that set the stage for DC-T cell engagement. Immunol Lett (2005) 97(2):199-208. doi:10.1016/j.imlet.2004.11.008.
    • (2005) Immunol Lett , vol.97 , Issue.2 , pp. 199-208
    • van Gisbergen, K.1    Paessens, L.2    Geijtenbeek, T.3    van Kooyk, Y.4
  • 5
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: is there a common molecular mechanism?
    • Schwartz R. Models of T cell anergy: is there a common molecular mechanism? J Exp Med (1996) 184(1):1-8. doi:10.1084/jem.184.1.1.
    • (1996) J Exp Med , vol.184 , Issue.1 , pp. 1-8
    • Schwartz, R.1
  • 6
    • 84859508662 scopus 로고    scopus 로고
    • Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients
    • Raïch-Regué D, Grau-López L, Naranjo-Gómez M, Ramo-Tello C, Pujol-Borrell R, Martínez-Cáceres E, et al. Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients. Eur J Immunol (2012) 42(3):771-82. doi:10.1002/eji.201141835.
    • (2012) Eur J Immunol , vol.42 , Issue.3 , pp. 771-782
    • Raïch-Regué, D.1    Grau-López, L.2    Naranjo-Gómez, M.3    Ramo-Tello, C.4    Pujol-Borrell, R.5    Martínez-Cáceres, E.6
  • 7
    • 84904254796 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells induce antigen-specific hyporesponsiveness in insulin-and glutamic acid decarboxylase 65-autoreactive T lymphocytes from type 1 diabetic patients
    • Segovia-Gamboa N, Rodríguez-Arellano M, Rangel-Cruz R, Sánchez-Díaz M, Ramírez-Reyes J, Faradji R, et al. Tolerogenic dendritic cells induce antigen-specific hyporesponsiveness in insulin-and glutamic acid decarboxylase 65-autoreactive T lymphocytes from type 1 diabetic patients. Clin Immunol (2014) 154(1):72-83. doi:10.1016/j.clim.2014.06.009.
    • (2014) Clin Immunol , vol.154 , Issue.1 , pp. 72-83
    • Segovia-Gamboa, N.1    Rodríguez-Arellano, M.2    Rangel-Cruz, R.3    Sánchez-Díaz, M.4    Ramírez-Reyes, J.5    Faradji, R.6
  • 8
    • 78149487035 scopus 로고    scopus 로고
    • Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis
    • Harry R, Anderson A, Isaacs J, Hilkens C. Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis. Ann Rheum Dis (2010) 69(11):2042-50. doi:10.1136/ard.2009.126383.
    • (2010) Ann Rheum Dis , vol.69 , Issue.11 , pp. 2042-2050
    • Harry, R.1    Anderson, A.2    Isaacs, J.3    Hilkens, C.4
  • 9
    • 84923846328 scopus 로고    scopus 로고
    • Beneficial effect of tolerogenic dendritic cells pulsed with MOG autoantigen in experimental autoimmune encephalomyelitis
    • Mansilla M, Sellès-Moreno C, Fàbregas-Puig S, Amoedo J, Navarro-Barriuso J, Teniente-Serra A, et al. Beneficial effect of tolerogenic dendritic cells pulsed with MOG autoantigen in experimental autoimmune encephalomyelitis. CNS Neurosci Ther (2015) 21(3):222-30. doi:10.1111/cns.12342.
    • (2015) CNS Neurosci Ther , vol.21 , Issue.3 , pp. 222-230
    • Mansilla, M.1    Sellès-Moreno, C.2    Fàbregas-Puig, S.3    Amoedo, J.4    Navarro-Barriuso, J.5    Teniente-Serra, A.6
  • 10
    • 34547907690 scopus 로고    scopus 로고
    • Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine
    • Popov I, Li M, Zheng X, San H, Zhang X, Ichim T, et al. Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine. Arthritis Res Ther (2006) 8(5):R141. doi:10.1186/ar2031.
    • (2006) Arthritis Res Ther , vol.8 , Issue.5 , pp. R141
    • Popov, I.1    Li, M.2    Zheng, X.3    San, H.4    Zhang, X.5    Ichim, T.6
  • 11
    • 0033970592 scopus 로고    scopus 로고
    • Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival
    • Min W, Gorczynski R, Huang X, Kushida M, Kim P, Obataki M, et al. Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival. J Immunol (2000) 164(1):161-7. doi:10.4049/jimmunol.164.1.161.
    • (2000) J Immunol , vol.164 , Issue.1 , pp. 161-167
    • Min, W.1    Gorczynski, R.2    Huang, X.3    Kushida, M.4    Kim, P.5    Obataki, M.6
  • 12
    • 33744963191 scopus 로고    scopus 로고
    • Dendritic cells activated by lipopolysaccharide after dexamethasone treatment induce donor-specific allograft hyporesponsiveness
    • Emmer P, van der Vlag J, Adema G, Hilbrands L. Dendritic cells activated by lipopolysaccharide after dexamethasone treatment induce donor-specific allograft hyporesponsiveness. Transplantation (2006) 81(10):1451-9. doi:10.1097/01.tp.0000208801.51222.bd.
    • (2006) Transplantation , vol.81 , Issue.10 , pp. 1451-1459
    • Emmer, P.1    van der Vlag, J.2    Adema, G.3    Hilbrands, L.4
  • 13
    • 0035838981 scopus 로고    scopus 로고
    • Regulation of T cell immunity by dendritic cells
    • Lanzavecchia A, Sallusto F. Regulation of T cell immunity by dendritic cells. Cell (2001) 106(3):263-6. doi:10.1016/S0092-8674(01)00455-X.
    • (2001) Cell , vol.106 , Issue.3 , pp. 263-266
    • Lanzavecchia, A.1    Sallusto, F.2
  • 14
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman R. Dendritic cells and the control of immunity. Nature (1998) 392(6673):245-52. doi:10.1038/32588.
    • (1998) Nature , vol.392 , Issue.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.2
  • 16
    • 84874038489 scopus 로고    scopus 로고
    • Therapeutic potential of semi-mature dendritic cells for tolerance induction
    • Lutz M. Therapeutic potential of semi-mature dendritic cells for tolerance induction. Front Immunol (2012) 3:123. doi:10.3389/fimmu.2012.00123.
    • (2012) Front Immunol , vol.3 , pp. 123
    • Lutz, M.1
  • 17
    • 84925548986 scopus 로고    scopus 로고
    • The instructive role of dendritic cells on T-cell responses
    • Sallusto F, Lanzavecchia A. The instructive role of dendritic cells on T-cell responses. Arthritis Res (2002) 4(Suppl 3):32. doi:10.1186/ar567.
    • (2002) Arthritis Res , vol.4 , pp. 32
    • Sallusto, F.1    Lanzavecchia, A.2
  • 18
    • 78649516162 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor drives the in vitro differentiation of human dendritic cells that induce anergy in naïve T cells
    • Rossetti M, Gregori S, Roncarolo M. Granulocyte-colony stimulating factor drives the in vitro differentiation of human dendritic cells that induce anergy in naïve T cells. Eur J Immunol (2010) 40(11):3097-106. doi:10.1002/eji.201040659.
    • (2010) Eur J Immunol , vol.40 , Issue.11 , pp. 3097-3106
    • Rossetti, M.1    Gregori, S.2    Roncarolo, M.3
  • 19
    • 77949893984 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells
    • Torres-Aguilar H, Aguilar-Ruiz S, González-Pérez G, Munguía R, Bajaña S, Meraz-Ríos M, et al. Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells. J Immunol (2010) 184(4):1765-75. doi:10.4049/jimmunol.0902133.
    • (2010) J Immunol , vol.184 , Issue.4 , pp. 1765-1775
    • Torres-Aguilar, H.1    Aguilar-Ruiz, S.2    González-Pérez, G.3    Munguía, R.4    Bajaña, S.5    Meraz-Ríos, M.6
  • 20
    • 46949102513 scopus 로고    scopus 로고
    • Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells
    • Anderson A, Sayers B, Haniffa M, Swan D, Diboll J, Wang X-N, et al. Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells. J Leukoc Biol (2008) 84(1):124-33. doi:10.1189/jlb.1107744.
    • (2008) J Leukoc Biol , vol.84 , Issue.1 , pp. 124-133
    • Anderson, A.1    Sayers, B.2    Haniffa, M.3    Swan, D.4    Diboll, J.5    Wang, X.-N.6
  • 21
    • 77953379447 scopus 로고    scopus 로고
    • Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells
    • Zheng X, Suzuki M, Ichim T, Zhang X, Sun H, Zhu F, et al. Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells. J Immunol (2010) 184(11):6457-64. doi:10.4049/jimmunol.0901717.
    • (2010) J Immunol , vol.184 , Issue.11 , pp. 6457-6464
    • Zheng, X.1    Suzuki, M.2    Ichim, T.3    Zhang, X.4    Sun, H.5    Zhu, F.6
  • 22
    • 84878005244 scopus 로고    scopus 로고
    • A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines
    • García-González P, Morales R, Hoyos L, Maggi J, Campos J, Pesce B, et al. A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines. J Transl Med (2013) 11:128. doi:10.1186/1479-5876-11-128.
    • (2013) J Transl Med , vol.11 , pp. 128
    • García-González, P.1    Morales, R.2    Hoyos, L.3    Maggi, J.4    Campos, J.5    Pesce, B.6
  • 23
    • 2142752959 scopus 로고    scopus 로고
    • Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells
    • Roncarolo M, Gregori S, Levings M. Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells. Novartis Found Symp (2003) 252:115. doi:10.1002/0470871628.ch9.
    • (2003) Novartis Found Symp , vol.252 , pp. 115
    • Roncarolo, M.1    Gregori, S.2    Levings, M.3
  • 24
    • 84863116620 scopus 로고    scopus 로고
    • Targeting self-and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells
    • Li D, Romain G, Flamar A-L, Duluc D, Dullaers M, Li X-H, et al. Targeting self-and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med (2012) 209(1):109-21. doi:10.1084/jem.20110399.
    • (2012) J Exp Med , vol.209 , Issue.1 , pp. 109-121
    • Li, D.1    Romain, G.2    Flamar, A.-L.3    Duluc, D.4    Dullaers, M.5    Li, X.-H.6
  • 25
    • 70449368149 scopus 로고    scopus 로고
    • Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1
    • Unger W, Laban S, Kleijwegt F, van der Slik A, Roep B. Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1. Eur J Immunol (2009) 39(11):3147-59. doi:10.1002/eji.200839103.
    • (2009) Eur J Immunol , vol.39 , Issue.11 , pp. 3147-3159
    • Unger, W.1    Laban, S.2    Kleijwegt, F.3    van der Slik, A.4    Roep, B.5
  • 26
    • 0032901501 scopus 로고    scopus 로고
    • Immunophenotypical and functional heterogeneity of dendritic cells generated from murine bone marrow cultured with different cytokine combinations: implications for anti-tumoral cell therapy
    • Masurier C, Pioche-Durieu C, Colombo B, Lacave R, Lemoine F, Klatzmann D, et al. Immunophenotypical and functional heterogeneity of dendritic cells generated from murine bone marrow cultured with different cytokine combinations: implications for anti-tumoral cell therapy. Immunology (1999) 96(4):569-77. doi:10.1046/j.1365-2567.1999.00728.x.
    • (1999) Immunology , vol.96 , Issue.4 , pp. 569-577
    • Masurier, C.1    Pioche-Durieu, C.2    Colombo, B.3    Lacave, R.4    Lemoine, F.5    Klatzmann, D.6
  • 27
    • 0033560725 scopus 로고    scopus 로고
    • Generation and function of bone marrow-derived dendritic cells from CD4/CD8(-/-) double-knockout mice
    • Corsi M, Sandberg J, Wasserman K, Maes H, Kiessling R. Generation and function of bone marrow-derived dendritic cells from CD4/CD8(-/-) double-knockout mice. Immunol Lett (1999) 67(3):243-9. doi:10.1016/S0165-2478(99)00018-8.
    • (1999) Immunol Lett , vol.67 , Issue.3 , pp. 243-249
    • Corsi, M.1    Sandberg, J.2    Wasserman, K.3    Maes, H.4    Kiessling, R.5
  • 28
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz M, Kukutsch N, Ogilvie A, Rössner S, Koch F, Romani N, et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods (1999) 223(1):77-92. doi:10.1016/s0022-1759(98)00204-x.
    • (1999) J Immunol Methods , vol.223 , Issue.1 , pp. 77-92
    • Lutz, M.1    Kukutsch, N.2    Ogilvie, A.3    Rössner, S.4    Koch, F.5    Romani, N.6
  • 29
    • 84937542228 scopus 로고    scopus 로고
    • GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c(+)MHCII(+) macrophages and dendritic cells
    • Helft J, Böttcher J, Chakravarty P, Zelenay S, Huotari J, Schraml B, et al. GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c(+)MHCII(+) macrophages and dendritic cells. Immunity (2015) 42(6):1197-211. doi:10.1016/j.immuni.2015.05.018.
    • (2015) Immunity , vol.42 , Issue.6 , pp. 1197-1211
    • Helft, J.1    Böttcher, J.2    Chakravarty, P.3    Zelenay, S.4    Huotari, J.5    Schraml, B.6
  • 30
    • 84878997106 scopus 로고    scopus 로고
    • Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
    • Shalek A, Satija R, Adiconis X, Gertner R, Gaublomme J, Raychowdhury R, et al. Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature (2013) 498(7453):236-40. doi:10.1038/nature12172.
    • (2013) Nature , vol.498 , Issue.7453 , pp. 236-240
    • Shalek, A.1    Satija, R.2    Adiconis, X.3    Gertner, R.4    Gaublomme, J.5    Raychowdhury, R.6
  • 31
    • 84903185013 scopus 로고    scopus 로고
    • Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
    • Shalek A, Satija R, Shuga J, Trombetta J, Gennert D, Lu D, et al. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature (2014) 510(7505):363-9. doi:10.1038/nature13437.
    • (2014) Nature , vol.510 , Issue.7505 , pp. 363-369
    • Shalek, A.1    Satija, R.2    Shuga, J.3    Trombetta, J.4    Gennert, D.5    Lu, D.6
  • 32
    • 0033939942 scopus 로고    scopus 로고
    • Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo
    • Lutz M, Suri R, Niimi M, Ogilvie A, Kukutsch N, Rössner S, et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol (2000) 30(7):1813-22. doi:10.1002/1521-4141(200007)30:7<1813::AID-IMMU1813>3.0.CO;2-8.
    • (2000) Eur J Immunol , vol.30 , Issue.7 , pp. 1813-1822
    • Lutz, M.1    Suri, R.2    Niimi, M.3    Ogilvie, A.4    Kukutsch, N.5    Rössner, S.6
  • 33
    • 84984763849 scopus 로고    scopus 로고
    • Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides
    • Giannoukakis N, Bonham C, Qian S, Chen Z, Peng L, Harnaha J, et al. Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides. Mol Ther (2000) 1(5 Pt 1):430-7. doi:10.1006/mthe.2000.0060.
    • (2000) Mol Ther , vol.1 , Issue.5 , pp. 430-437
    • Giannoukakis, N.1    Bonham, C.2    Qian, S.3    Chen, Z.4    Peng, L.5    Harnaha, J.6
  • 34
    • 85056051996 scopus 로고    scopus 로고
    • Systemic administration of tolerogenic dendritic cells ameliorates murine inflammatory arthritis
    • Healy L, Collins H, Thompson S. Systemic administration of tolerogenic dendritic cells ameliorates murine inflammatory arthritis. Open Rheumatol J (2008) 2:71-80. doi:10.2174/1874312900802010071.
    • (2008) Open Rheumatol J , vol.2 , pp. 71-80
    • Healy, L.1    Collins, H.2    Thompson, S.3
  • 35
    • 34548642078 scopus 로고    scopus 로고
    • Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms
    • van Duivenvoorde L, Han W, Bakker A, Louis-Plence P, Charbonnier L-M, Apparailly F, et al. Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms. J Immunol (2007) 179(3):1506-15. doi:10.4049/jimmunol.179.3.1506.
    • (2007) J Immunol , vol.179 , Issue.3 , pp. 1506-1515
    • van Duivenvoorde, L.1    Han, W.2    Bakker, A.3    Louis-Plence, P.4    Charbonnier, L.-M.5    Apparailly, F.6
  • 36
    • 0037302966 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases
    • Adorini L, Penna G, Giarratana N, Uskokovic M. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases. J Cell Biochem (2003) 88(2):227-33. doi:10.1002/jcb.10340.
    • (2003) J Cell Biochem , vol.88 , Issue.2 , pp. 227-233
    • Adorini, L.1    Penna, G.2    Giarratana, N.3    Uskokovic, M.4
  • 37
    • 26444591571 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders
    • Chorny A, Gonzalez-Rey E, Fernandez-Martin A, Pozo D, Ganea D, Delgado M. Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders. Proc Natl Acad Sci U S A (2005) 102(38):13562-7. doi:10.1073/pnas.0504484102.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.38 , pp. 13562-13567
    • Chorny, A.1    Gonzalez-Rey, E.2    Fernandez-Martin, A.3    Pozo, D.4    Ganea, D.5    Delgado, M.6
  • 38
    • 0042389785 scopus 로고    scopus 로고
    • T cell anergy
    • Epub 2002/12/10. PubMed
    • Schwartz RH. T cell anergy. Annu Rev Immunol (2003) 21:305-34. Epub 2002/12/10. PubMed. doi:10.1146/annurev.immunol.21.120601.141110.
    • (2003) Annu Rev Immunol , vol.21 , pp. 305-334
    • Schwartz, R.H.1
  • 39
    • 79954459308 scopus 로고    scopus 로고
    • Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family
    • Bour-Jordan H, Esensten J, Martinez-Llordella M, Penaranda C, Stumpf M, Bluestone J. Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family. Immunol Rev (2011) 241(1):180-205. doi:10.1111/j.1600-065X.2011.01011.x.
    • (2011) Immunol Rev , vol.241 , Issue.1 , pp. 180-205
    • Bour-Jordan, H.1    Esensten, J.2    Martinez-Llordella, M.3    Penaranda, C.4    Stumpf, M.5    Bluestone, J.6
  • 40
    • 0028114542 scopus 로고
    • Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor
    • Boussiotis V, Barber D, Nakarai T, Freeman G, Gribben J, Bernstein G, et al. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science (1994) 266(5187):1039-42. doi:10.1126/science.7973657.
    • (1994) Science , vol.266 , Issue.5187 , pp. 1039-1042
    • Boussiotis, V.1    Barber, D.2    Nakarai, T.3    Freeman, G.4    Gribben, J.5    Bernstein, G.6
  • 41
    • 32044440789 scopus 로고    scopus 로고
    • Adaptive tolerance and clonal anergy are distinct biochemical states
    • Chiodetti L, Choi S, Barber D, Schwartz R. Adaptive tolerance and clonal anergy are distinct biochemical states. J Immunol (2006) 176(4):2279-91. doi:10.4049/jimmunol.176.4.2279.
    • (2006) J Immunol , vol.176 , Issue.4 , pp. 2279-2291
    • Chiodetti, L.1    Choi, S.2    Barber, D.3    Schwartz, R.4
  • 42
    • 49249089425 scopus 로고    scopus 로고
    • Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
    • Fife B, Bluestone J. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev (2008) 224:166-82. doi:10.1111/j.1600-065X.2008.00662.x.
    • (2008) Immunol Rev , vol.224 , pp. 166-182
    • Fife, B.1    Bluestone, J.2
  • 43
    • 0035102196 scopus 로고    scopus 로고
    • CTLA-4 regulates induction of anergy in vivo
    • Greenwald R, Boussiotis V, Lorsbach R, Abbas A, Sharpe A. CTLA-4 regulates induction of anergy in vivo. Immunity (2001) 14(2):145-55. doi:10.1016/S1074-7613(01)00097-8.
    • (2001) Immunity , vol.14 , Issue.2 , pp. 145-155
    • Greenwald, R.1    Boussiotis, V.2    Lorsbach, R.3    Abbas, A.4    Sharpe, A.5
  • 44
    • 61849123188 scopus 로고    scopus 로고
    • Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism
    • Bishop K, Harris J, Mordes J, Greiner D, Rossini A, Czech M, et al. Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism. Cell Immunol (2009) 256(1-2):86-91. doi:10.1016/j.cellimm.2009.01.008.
    • (2009) Cell Immunol , vol.256 , Issue.1-2 , pp. 86-91
    • Bishop, K.1    Harris, J.2    Mordes, J.3    Greiner, D.4    Rossini, A.5    Czech, M.6
  • 45
    • 38049141544 scopus 로고    scopus 로고
    • A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
    • Zarek P, Huang C-T, Lutz E, Kowalski J, Horton M, Linden J, et al. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood (2008) 111(1):251-9. doi:10.1182/blood-2007-03-081646.
    • (2008) Blood , vol.111 , Issue.1 , pp. 251-259
    • Zarek, P.1    Huang, C.-T.2    Lutz, E.3    Kowalski, J.4    Horton, M.5    Linden, J.6
  • 46
    • 18244375249 scopus 로고    scopus 로고
    • Egr-2 and Egr-3 are negative regulators of T cell activation
    • Safford M, Collins S, Lutz M, Allen A, Huang C-T, Kowalski J, et al. Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol (2005) 6(5):472-80. doi:10.1038/ni1193.
    • (2005) Nat Immunol , vol.6 , Issue.5 , pp. 472-480
    • Safford, M.1    Collins, S.2    Lutz, M.3    Allen, A.4    Huang, C.-T.5    Kowalski, J.6
  • 47
    • 12144290293 scopus 로고    scopus 로고
    • Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
    • Heissmeyer V, Macián F, Im S-H, Varma R, Feske S, Venuprasad K, et al. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 5(3):255-65. doi:10.1038/ni1047.
    • (2004) Nat Immunol , vol.5 , Issue.3 , pp. 255-265
    • Heissmeyer, V.1    Macián, F.2    Im, S.-H.3    Varma, R.4    Feske, S.5    Venuprasad, K.6
  • 48
    • 0037077135 scopus 로고    scopus 로고
    • Transcriptional mechanisms underlying lymphocyte tolerance
    • Macián F, García-Cózar F, Im S-H, Horton H, Byrne M, Rao A. Transcriptional mechanisms underlying lymphocyte tolerance. Cell (2002) 109(6):719-31. doi:10.1016/S0092-8674(02)00767-5.
    • (2002) Cell , vol.109 , Issue.6 , pp. 719-731
    • Macián, F.1    García-Cózar, F.2    Im, S.-H.3    Horton, H.4    Byrne, M.5    Rao, A.6
  • 49
    • 0037396674 scopus 로고    scopus 로고
    • GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells
    • Anandasabapathy N, Ford G, Bloom D, Holness C, Paragas V, Seroogy C, et al. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity (2003) 18(4):535-47. doi:10.1016/s1074-7613(03)00084-0.
    • (2003) Immunity , vol.18 , Issue.4 , pp. 535-547
    • Anandasabapathy, N.1    Ford, G.2    Bloom, D.3    Holness, C.4    Paragas, V.5    Seroogy, C.6
  • 50
    • 0034642499 scopus 로고    scopus 로고
    • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
    • Bachmaier K, Krawczyk C, Kozieradzki I, Kong Y, Sasaki T, Oliveira-dos-Santos A, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature (2000) 403(6766):211-6. doi:10.1038/35003228.
    • (2000) Nature , vol.403 , Issue.6766 , pp. 211-216
    • Bachmaier, K.1    Krawczyk, C.2    Kozieradzki, I.3    Kong, Y.4    Sasaki, T.5    Oliveira-dos-Santos, A.6
  • 51
    • 4143137360 scopus 로고    scopus 로고
    • Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction
    • Jeon M-S, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C, et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 21(2):167-77. doi:10.1016/j.immuni.2004.07.013.
    • (2004) Immunity , vol.21 , Issue.2 , pp. 167-177
    • Jeon, M.-S.1    Atfield, A.2    Venuprasad, K.3    Krawczyk, C.4    Sarao, R.5    Elly, C.6
  • 52
    • 84871885298 scopus 로고    scopus 로고
    • Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo
    • Zheng Y, Zha Y, Driessens G, Locke F, Gajewski T. Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. J Exp Med (2012) 209(12):2157-63. doi:10.1084/jem.20120342.
    • (2012) J Exp Med , vol.209 , Issue.12 , pp. 2157-2163
    • Zheng, Y.1    Zha, Y.2    Driessens, G.3    Locke, F.4    Gajewski, T.5
  • 53
    • 10344239897 scopus 로고    scopus 로고
    • Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells
    • Harris J, Bishop K, Phillips N, Mordes J, Greiner D, Rossini A, et al. Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol (2004) 173(12):7331-8. doi:10.4049/jimmunol.173.12.7331.
    • (2004) J Immunol , vol.173 , Issue.12 , pp. 7331-7338
    • Harris, J.1    Bishop, K.2    Phillips, N.3    Mordes, J.4    Greiner, D.5    Rossini, A.6
  • 54
    • 4644285392 scopus 로고    scopus 로고
    • E3 ubiquitin ligases as T cell anergy factors
    • Mueller D. E3 ubiquitin ligases as T cell anergy factors. Nat Immunol (2004) 5(9):883-90. doi:10.1038/ni1106.
    • (2004) Nat Immunol , vol.5 , Issue.9 , pp. 883-890
    • Mueller, D.1
  • 55
    • 33646881121 scopus 로고    scopus 로고
    • Functional and molecular comparison of anergic and regulatory T lymphocytes
    • Knoechel B, Lohr J, Zhu S, Wong L, Hu D, Ausubel L, et al. Functional and molecular comparison of anergic and regulatory T lymphocytes. J Immunol (2006) 176(11):6473-83. doi:10.4049/jimmunol.176.11.6473.
    • (2006) J Immunol , vol.176 , Issue.11 , pp. 6473-6483
    • Knoechel, B.1    Lohr, J.2    Zhu, S.3    Wong, L.4    Hu, D.5    Ausubel, L.6
  • 56
    • 34248151591 scopus 로고    scopus 로고
    • GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype
    • MacKenzie D, Schartner J, Lin J, Timmel A, Jennens-Clough M, Fathman C, et al. GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. J Biol Chem (2007) 282(13):9696-702. doi:10.1074/jbc. M604192200.
    • (2007) J Biol Chem , vol.282 , Issue.13 , pp. 9696-9702
    • MacKenzie, D.1    Schartner, J.2    Lin, J.3    Timmel, A.4    Jennens-Clough, M.5    Fathman, C.6
  • 57
    • 77951034912 scopus 로고    scopus 로고
    • Cbl-b and itch: key regulators of peripheral T-cell tolerance
    • Venuprasad K. Cbl-b and itch: key regulators of peripheral T-cell tolerance. Cancer Res (2010) 70(8):3009-12. doi:10.1158/0008-5472.can-09-4076.
    • (2010) Cancer Res , vol.70 , Issue.8 , pp. 3009-3012
    • Venuprasad, K.1
  • 58
    • 69549124480 scopus 로고    scopus 로고
    • CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2
    • Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, et al. CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci U S A (2009) 106(33):13974-9. doi:10.1073/pnas.0906872106.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.33 , pp. 13974-13979
    • Okamura, T.1    Fujio, K.2    Shibuya, M.3    Sumitomo, S.4    Shoda, H.5    Sakaguchi, S.6
  • 59
    • 34249323427 scopus 로고    scopus 로고
    • Transcriptional regulation of T cell tolerance
    • Bandyopadhyay S, Soto-Nieves N, Macián F. Transcriptional regulation of T cell tolerance. Semin Immunol (2007) 19(3):180-7. doi:10.1016/j.smim.2007.02.006.
    • (2007) Semin Immunol , vol.19 , Issue.3 , pp. 180-187
    • Bandyopadhyay, S.1    Soto-Nieves, N.2    Macián, F.3
  • 60
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A, Stroud J, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 126(2):375-87. doi:10.1016/j.cell.2006.05.042.
    • (2006) Cell , vol.126 , Issue.2 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3    Feuerer, M.4    Lapan, A.5    Stroud, J.6
  • 61
    • 0031964338 scopus 로고    scopus 로고
    • Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
    • Buer J, Lanoue A, Franzke A, Garcia C, von Boehmer H, Sarukhan A. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J Exp Med (1998) 187(2):177-83. doi:10.1084/jem.187.2.177.
    • (1998) J Exp Med , vol.187 , Issue.2 , pp. 177-183
    • Buer, J.1    Lanoue, A.2    Franzke, A.3    Garcia, C.4    von Boehmer, H.5    Sarukhan, A.6
  • 62
    • 0036530016 scopus 로고    scopus 로고
    • CD4+ and CD8+ anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity
    • Steinbrink K. CD4+ and CD8+ anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood (2002) 99(7):2468-76. doi:10.1182/blood. V99.7.2468.
    • (2002) Blood , vol.99 , Issue.7 , pp. 2468-2476
    • Steinbrink, K.1
  • 63
    • 0042467814 scopus 로고    scopus 로고
    • Suppressor activity of anergic T cells induced by IL-10-treated human dendritic cells: association with IL-2-and CTLA-4-dependent G1 arrest of the cell cycle regulated by p27Kip1
    • Kubsch S, Graulich E, Knop J, Steinbrink K. Suppressor activity of anergic T cells induced by IL-10-treated human dendritic cells: association with IL-2-and CTLA-4-dependent G1 arrest of the cell cycle regulated by p27Kip1. Eur J Immunol (2003) 33(7):1988-97. doi:10.1002/eji.200323600.
    • (2003) Eur J Immunol , vol.33 , Issue.7 , pp. 1988-1997
    • Kubsch, S.1    Graulich, E.2    Knop, J.3    Steinbrink, K.4
  • 64
    • 84923080822 scopus 로고    scopus 로고
    • Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-) IL-10(+) regulatory T cells by engaging CD28 and CTLA-4
    • Pletinckx K, Vaeth M, Schneider T, Beyersdorf N, Hünig T, Berberich-Siebelt F, et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-) IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. Eur J Immunol (2015) 45(2):480-91. doi:10.1002/eji.201444991.
    • (2015) Eur J Immunol , vol.45 , Issue.2 , pp. 480-491
    • Pletinckx, K.1    Vaeth, M.2    Schneider, T.3    Beyersdorf, N.4    Hünig, T.5    Berberich-Siebelt, F.6
  • 65
    • 34547098277 scopus 로고    scopus 로고
    • Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
    • Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood (2007) 110(4):1225-32. doi:10.1182/blood-2006-12-064527.
    • (2007) Blood , vol.110 , Issue.4 , pp. 1225-1232
    • Borsellino, G.1    Kleinewietfeld, M.2    Di Mitri, D.3    Sternjak, A.4    Diamantini, A.5    Giometto, R.6
  • 66
    • 36249024247 scopus 로고    scopus 로고
    • Regulatory T cells-a brief history and perspective
    • Sakaguchi S, Wing K, Miyara M. Regulatory T cells-a brief history and perspective. Eur J Immunol (2007) 37(Suppl 1):23. doi:10.1002/eji.200737593.
    • (2007) Eur J Immunol , vol.37 , pp. 23
    • Sakaguchi, S.1    Wing, K.2    Miyara, M.3
  • 68
    • 0036144888 scopus 로고    scopus 로고
    • Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo
    • Gavin M, Clarke S, Negrou E, Gallegos A, Rudensky A. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol (2002) 3(1):33-41. doi:10.1038/ni743.
    • (2002) Nat Immunol , vol.3 , Issue.1 , pp. 33-41
    • Gavin, M.1    Clarke, S.2    Negrou, E.3    Gallegos, A.4    Rudensky, A.5
  • 69
    • 33645059454 scopus 로고    scopus 로고
    • Imbalance of regulatory T cells in human autoimmune diseases
    • Dejaco C, Duftner C, Grubeck-Loebenstein B, Schirmer M. Imbalance of regulatory T cells in human autoimmune diseases. Immunology (2006) 117(3):289-300. doi:10.1111/j.1365-2567.2005.02317.x.
    • (2006) Immunology , vol.117 , Issue.3 , pp. 289-300
    • Dejaco, C.1    Duftner, C.2    Grubeck-Loebenstein, B.3    Schirmer, M.4
  • 70
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang X, Nurieva R, Martinez G, Kang H, Chung Y, Pappu B, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 29(1):44-56. doi:10.1016/j.immuni.2008.05.007.
    • (2008) Immunity , vol.29 , Issue.1 , pp. 44-56
    • Yang, X.1    Nurieva, R.2    Martinez, G.3    Kang, H.4    Chung, Y.5    Pappu, B.6
  • 72
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    • Zappia E, Casazza S, Pedemonte E, Benvenuto F, Bonanni I, Gerdoni E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood (2005) 106(5):1755-61. doi:10.1182/blood-2005-04-1496.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3    Benvenuto, F.4    Bonanni, I.5    Gerdoni, E.6
  • 73
    • 84899562215 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice
    • Ferreira GB, Gysemans CA, Demengeot J, da Cunha JP, Vanherwegen AS, Overbergh L, et al. 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice. J Immunol (2014) 192(9):4210-20. doi:10.4049/jimmunol.1302350.
    • (2014) J Immunol , vol.192 , Issue.9 , pp. 4210-4220
    • Ferreira, G.B.1    Gysemans, C.A.2    Demengeot, J.3    da Cunha, J.P.4    Vanherwegen, A.S.5    Overbergh, L.6
  • 74
    • 78650637508 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells prevent type 1 diabetes in murine models
    • Yin B, Ma G, Yen C-Y, Zhou Z, Wang GX, Divino CM, et al. Myeloid-derived suppressor cells prevent type 1 diabetes in murine models. J Immunol (2010) 185(10):5828-34. doi:10.4049/jimmunol.0903636.
    • (2010) J Immunol , vol.185 , Issue.10 , pp. 5828-5834
    • Yin, B.1    Ma, G.2    Yen, C.-Y.3    Zhou, Z.4    Wang, G.X.5    Divino, C.M.6
  • 75
    • 78649852489 scopus 로고    scopus 로고
    • Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses
    • Stoop JN, Harry RA, von Delwig A, Isaacs JD, Robinson JH, Hilkens CM. Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses. Arthritis Rheum (2010) 62(12):3656-65. doi:10.1002/art.27756.
    • (2010) Arthritis Rheum , vol.62 , Issue.12 , pp. 3656-3665
    • Stoop, J.N.1    Harry, R.A.2    von Delwig, A.3    Isaacs, J.D.4    Robinson, J.H.5    Hilkens, C.M.6
  • 76
    • 84856094049 scopus 로고    scopus 로고
    • Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients
    • Giannoukakis N, Phillips B, Finegold D, Harnaha J, Trucco M. Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care (2011) 34(9):2026-32. doi:10.2337/dc11-0472.
    • (2011) Diabetes Care , vol.34 , Issue.9 , pp. 2026-2032
    • Giannoukakis, N.1    Phillips, B.2    Finegold, D.3    Harnaha, J.4    Trucco, M.5
  • 77
    • 84930453993 scopus 로고    scopus 로고
    • Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients
    • Benham H, Nel H, Law S, Mehdi A, Street S, Ramnoruth N, et al. Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients. Sci Transl Med (2015) 7(290):290ra87. doi:10.1126/scitranslmed.aaa9301.
    • (2015) Sci Transl Med , vol.7 , Issue.290
    • Benham, H.1    Nel, H.2    Law, S.3    Mehdi, A.4    Street, S.5    Ramnoruth, N.6
  • 78
    • 84899115551 scopus 로고    scopus 로고
    • Treatment of recent-onset type 1 diabetic patients with DiaPep277: results of a double-blind, placebo-controlled, randomized phase 3 trial
    • Raz I, Ziegler A, Linn T, Schernthaner G, Bonnici F, Distiller L, et al. Treatment of recent-onset type 1 diabetic patients with DiaPep277: results of a double-blind, placebo-controlled, randomized phase 3 trial. Diabetes Care (2014) 37(5):1392-400. doi:10.2337/dc13-1391.
    • (2014) Diabetes Care , vol.37 , Issue.5 , pp. 1392-1400
    • Raz, I.1    Ziegler, A.2    Linn, T.3    Schernthaner, G.4    Bonnici, F.5    Distiller, L.6
  • 79
    • 70350521825 scopus 로고    scopus 로고
    • Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial
    • Koffeman E, Genovese M, Amox D, Keogh E, Santana E, Matteson E, et al. Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial. Arthritis Rheum (2009) 60(11):3207-16. doi:10.1002/art.24916.
    • (2009) Arthritis Rheum , vol.60 , Issue.11 , pp. 3207-3216
    • Koffeman, E.1    Genovese, M.2    Amox, D.3    Keogh, E.4    Santana, E.5    Matteson, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.