Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

Molecular Cell

Volumn 58, Issue 5, 2015, Pages 832-844

  Polikanov, Yury S ^a,b   Starosta, Agata L ^c   Juette, Manuel F ^d   Altman, Roger B ^d   Terry, Daniel S ^d   Lu, Wanli ^e   Burnett, Benjamin J ^d   Dinos, George ^f   Reynolds, Kevin A ^e   Blanchard, Scott C ^d,g   Steitz, Thomas A ^a,b   Wilson, Daniel N ^c  

^a YALE UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e PORTLAND STATE UNIVERSITY   (United States)

^f UNIVERSITY OF PATRAS   (Greece)

^g Tri Institutional Training Program in Computational Biology and Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC A201A; HYGROMYCIN; PEPTIDYLTRANSFERASE; TRANSFER RNA; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; CINNAMIC ACID DERIVATIVE; HYGROMYCIN B;

ARTICLE; CHEMICAL BOND; COMPLEX FORMATION; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; FLUORESCENCE RESONANCE ENERGY TRANSFER; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN SYNTHESIS; RIBOSOME; STEREOSPECIFICITY; THERMUS THERMOPHILUS; ANALOGS AND DERIVATIVES; ANTIBIOTIC RESISTANCE; CHEMICAL STRUCTURE; CHEMISTRY; DISK DIFFUSION; DRUG EFFECTS; ESCHERICHIA COLI; HYDROGEN BOND; LARGE RIBOSOMAL SUBUNIT; PROTEIN CONFORMATION; SMALL RIBOSOMAL SUBUNIT; X RAY CRYSTALLOGRAPHY;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CINNAMATES; CRYSTALLOGRAPHY, X-RAY; DISK DIFFUSION ANTIMICROBIAL TESTS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; HYDROGEN BONDING; HYGROMYCIN B; MODELS, MOLECULAR; PROTEIN CONFORMATION; RIBOSOME SUBUNITS, LARGE, BACTERIAL; RIBOSOME SUBUNITS, SMALL, BACTERIAL; RNA, TRANSFER; THERMUS THERMOPHILUS;

EID: 84946490396     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.04.014     Document Type: Article

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