Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 40, 2010, Pages 17152-17157

  Dunkle, Jack A ^a   Xiong, Liqun ^b   Mankin, Alexander S ^b   Cate, Jamie H D ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Chloramphenicol; Clindamycin; Erythromycin; Ribosome structure; Telithromycin

Indexed keywords

ANTIBIOTIC AGENT; CHLORAMPHENICOL; CLINDAMYCIN; ERYTHROMYCIN; KETOLIDE; LINCOSAMIDE; MACROLIDE; NUCLEOTIDE; PEPTIDYLTRANSFERASE; RNA 23S; TELITHROMYCIN;

ANTIMICROBIAL ACTIVITY; ARCHAEBACTERIUM; ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEINOCOCCUS RADIODURANS; DRUG MECHANISM; ESCHERICHIA COLI; HALOARCULA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN STRUCTURE; RIBOSOME; SPECIES DIFFERENCE; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CHLORAMPHENICOL; CLINDAMYCIN; DEINOCOCCUS; ERYTHROMYCIN; ESCHERICHIA COLI; HALOARCULA MARISMORTUI; KETOLIDES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PEPTIDYL TRANSFERASES; RIBOSOMES; RNA, RIBOSOMAL, 23S; X-RAY DIFFRACTION;

ARCHAEA; BACTERIA (MICROORGANISMS); DEINOCOCCUS RADIODURANS; ESCHERICHIA COLI; EUKARYOTA; HALOARCULA MARISMORTUI;

EID: 78049302075     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007988107     Document Type: Article

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