-
1
-
-
70450233600
-
The A-Z of bacterial translation inhibitors
-
Wilson DN (2009) The A-Z of bacterial translation inhibitors. Crit Rev Biochem Mol Biol 44:393-433.
-
(2009)
Crit Rev Biochem Mol Biol
, vol.44
, pp. 393-433
-
-
Wilson, D.N.1
-
2
-
-
77952567891
-
Molecular characterization of macrolide- and multidrug-resistant Streptococcus pyogenes isolated from adult patients in Barcelona, Spain (1993-2008)
-
Ardanuy C, et al. (2010) Molecular characterization of macrolide- and multidrug-resistant Streptococcus pyogenes isolated from adult patients in Barcelona, Spain (1993-2008). J Antimicrob Chemother 65:634-643.
-
(2010)
J Antimicrob Chemother
, vol.65
, pp. 634-643
-
-
Ardanuy, C.1
-
3
-
-
68049093117
-
Increase in pneumococcus macrolide resistance, United States
-
Jenkins SG, Farrell DJ (2009) Increase in pneumococcus macrolide resistance, United States. Emerg Infect Dis 15:1260-1264.
-
(2009)
Emerg Infect Dis
, vol.15
, pp. 1260-1264
-
-
Jenkins, S.G.1
Farrell, D.J.2
-
4
-
-
77951962734
-
Mutational analysis of reduced telithromycin susceptibility of Streptococcus pneumoniaeisolated clinically in Japan
-
Takaya A, et al. (2010) Mutational analysis of reduced telithromycin susceptibility of Streptococcus pneumoniaeisolated clinically in Japan. FEMS Microbiol Lett 307:87-93.
-
(2010)
FEMS Microbiol Lett
, vol.307
, pp. 87-93
-
-
Takaya, A.1
-
5
-
-
77952243582
-
Macrolide-resistant Mycoplasma pneumoniae: Characteristics of isolates and clinical aspects of community-acquired pneumonia
-
Morozumi M, et al. (2010) Macrolide-resistant Mycoplasma pneumoniae: Characteristics of isolates and clinical aspects of community-acquired pneumonia. J Infect Chemother 16:78-86.
-
(2010)
J Infect Chemother
, vol.16
, pp. 78-86
-
-
Morozumi, M.1
-
6
-
-
33644610182
-
Structure-based drug design meets the ribosome
-
Franceschi F, Duffy EM (2006) Structure-based drug design meets the ribosome. Biochem Pharmacol 71:1016-1025.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1016-1025
-
-
Franceschi, F.1
Duffy, E.M.2
-
7
-
-
55549114299
-
Design at the atomic level: Generation of novel hybrid biaryloxazolidinones as promising new antibiotics
-
Zhou J, et al. (2008) Design at the atomic level: Generation of novel hybrid biaryloxazolidinones as promising new antibiotics. Bioorg Med Chem Lett 18:6179-6183.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 6179-6183
-
-
Zhou, J.1
-
8
-
-
4544238103
-
Macrolide resistance from the ribosome perspective
-
Franceschi F, et al. (2004) Macrolide resistance from the ribosome perspective. Curr Drug Targets Infect Disord 4:177-191.
-
(2004)
Curr Drug Targets Infect Disord
, vol.4
, pp. 177-191
-
-
Franceschi, F.1
-
9
-
-
0038492422
-
Structural insight into the antibiotic action of telithromycin against resistant mutants
-
Berisio R, et al. (2003) Structural insight into the antibiotic action of telithromycin against resistant mutants. J Bacteriol 185:4276-4279.
-
(2003)
J Bacteriol
, vol.185
, pp. 4276-4279
-
-
Berisio, R.1
-
10
-
-
17444421169
-
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance
-
Tu D, et al. (2005) Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell 121:257-270.
-
(2005)
Cell
, vol.121
, pp. 257-270
-
-
Tu, D.1
-
11
-
-
0035950132
-
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
-
Schlunzen F, et al. (2001) Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413:814-821.
-
(2001)
Nature
, vol.413
, pp. 814-821
-
-
Schlunzen, F.1
-
12
-
-
0037334850
-
Structural basis for the antibiotic activity of ketolides and azalides
-
Schlunzen F, et al. (2003) Structural basis for the antibiotic activity of ketolides and azalides. Structure 11:329-338.
-
(2003)
Structure
, vol.11
, pp. 329-338
-
-
Schlunzen, F.1
-
13
-
-
22244433549
-
Antibiotics targeting ribosomes: Resistance, selectivity, synergism and cellular regulation
-
Yonath A (2005) Antibiotics targeting ribosomes: Resistance, selectivity, synergism and cellular regulation. Annu Rev Biochem 74:649-679.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 649-679
-
-
Yonath, A.1
-
14
-
-
6344291118
-
Molecular basis of bacterial resistance to chloramphenicol and florfenicol
-
Schwarz S, et al. (2004) Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev 28:519-542.
-
(2004)
FEMS Microbiol Rev
, vol.28
, pp. 519-542
-
-
Schwarz, S.1
-
15
-
-
0015223375
-
Correlation between the peptidyl transferase activity of the 50 s ribosomal subunit and the ability of the subunit to interact with antibiotics
-
Vogel Z, et al. (1971) Correlation between the peptidyl transferase activity of the 50 s ribosomal subunit and the ability of the subunit to interact with antibiotics. J Mol Biol 60:339-346.
-
(1971)
J Mol Biol
, vol.60
, pp. 339-346
-
-
Vogel, Z.1
-
16
-
-
0019448863
-
Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance
-
Kearsey SE, Craig IW (1981) Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance. Nature 290:607-608.
-
(1981)
Nature
, vol.290
, pp. 607-608
-
-
Kearsey, S.E.1
Craig, I.W.2
-
17
-
-
0023238983
-
Interaction of antibiotics with functional sites in 16S ribosomal RNA
-
Moazed D, Noller HF (1987) Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature 327:389-394.
-
(1987)
Nature
, vol.327
, pp. 389-394
-
-
Moazed, D.1
Noller, H.F.2
-
18
-
-
0001350056
-
Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA-Leu to 50 S subunits
-
Celma ML, et al. (1971) Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA-Leu to 50 S subunits. FEBS Lett 13:247-251.
-
(1971)
FEBS Lett
, vol.13
, pp. 247-251
-
-
Celma, M.L.1
-
19
-
-
0018186765
-
Cooperative binding of 3′-fragments of transfer ribonucleic acid to the peptidyltransferase center of Escherichia coli ribosomes
-
Ulbrich B, et al. (1978) Cooperative binding of 3′-fragments of transfer ribonucleic acid to the peptidyltransferase center of Escherichia coli ribosomes. Arch Biochem Biophys 190:149-154.
-
(1978)
Arch Biochem Biophys
, vol.190
, pp. 149-154
-
-
Ulbrich, B.1
-
20
-
-
0000255988
-
Identification of a site on 23S ribosomal RNA located at the peptidyl transferase center
-
Barta A, et al. (1984) Identification of a site on 23S ribosomal RNA located at the peptidyl transferase center. Proc Natl Acad Sci USA 81:3607-3611.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 3607-3611
-
-
Barta, A.1
-
21
-
-
0021158357
-
Structure of ribosomal RNA
-
Noller HF (1984) Structure of ribosomal RNA. Annu Rev Biochem 53:119-162.
-
(1984)
Annu Rev Biochem
, vol.53
, pp. 119-162
-
-
Noller, H.F.1
-
22
-
-
0035964256
-
A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition
-
Bayfield MA, et al. (2001) A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition. Proc Natl Acad Sci USA 98:10096-10101.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10096-10101
-
-
Bayfield, M.A.1
-
23
-
-
43449093704
-
Mutations outside the anisomycin-binding site can make ribosomes drug-resistant
-
Blaha G, et al. (2008) Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol 379:505-519.
-
(2008)
J Mol Biol
, vol.379
, pp. 505-519
-
-
Blaha, G.1
-
24
-
-
4344569647
-
The contribution of metal ions to the structural stability of the large ribosomal subunit
-
Klein DJ, et al. (2004) The contribution of metal ions to the structural stability of the large ribosomal subunit. RNA 10:1366-1379.
-
(2004)
RNA
, vol.10
, pp. 1366-1379
-
-
Klein, D.J.1
-
25
-
-
0001482984
-
Low-temperature crystal and molecular-structure of nitrobenzene
-
Boese R, et al. (1992) Low-temperature crystal and molecular-structure of nitrobenzene. Struct Chem 3:363-368.
-
(1992)
Struct Chem
, vol.3
, pp. 363-368
-
-
Boese, R.1
-
26
-
-
0030604166
-
Barrier to internal rotation of the nitro group in ortho-nitrophenols from gas-phase electron diffraction
-
Borisenko KB, Hargittai I (1996) Barrier to internal rotation of the nitro group in ortho-nitrophenols from gas-phase electron diffraction. J Mol Struct 382:171-176.
-
(1996)
J Mol Struct
, vol.382
, pp. 171-176
-
-
Borisenko, K.B.1
Hargittai, I.2
-
27
-
-
0344875468
-
Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: Revisiting the mechanism of chloramphenicol action
-
Xaplanteri MA, et al. (2003) Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: Revisiting the mechanism of chloramphenicol action. Nucleic Acids Res 31:5074-5083.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 5074-5083
-
-
Xaplanteri, M.A.1
-
28
-
-
0040843291
-
Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3′ end of the large ribosomal RNA
-
Blanc H, et al. (1981) Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3′ end of the large ribosomal RNA. Proc Natl Acad Sci USA 78:3789-3793.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 3789-3793
-
-
Blanc, H.1
-
29
-
-
0023604799
-
Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA
-
Moazed D, Noller HF (1987) Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA. Biochimie 69:879-884.
-
(1987)
Biochimie
, vol.69
, pp. 879-884
-
-
Moazed, D.1
Noller, H.F.2
-
30
-
-
0028924641
-
Fine structure of the peptidyl transferase centre on 23 S-like rRNAs deduced from chemical probing of antibiotic-ribosome complexes
-
Rodriguez-Fonseca C, et al. (1995) Fine structure of the peptidyl transferase centre on 23 S-like rRNAs deduced from chemical probing of antibiotic-ribosome complexes. J Mol Biol 247:224-235.
-
(1995)
J Mol Biol
, vol.247
, pp. 224-235
-
-
Rodriguez-Fonseca, C.1
-
31
-
-
0007715651
-
Structure of chloramphenicol acetyltransferase at 1.75-A resolution
-
Leslie AG, et al. (1988) Structure of chloramphenicol acetyltransferase at 1.75-A resolution. Proc Natl Acad Sci USA 85:4133-4137.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 4133-4137
-
-
Leslie, A.G.1
-
32
-
-
0014239874
-
Characterization of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus
-
Shaw WV, Brodsky RF (1968) Characterization of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus. J Bacteriol 95:28-36.
-
(1968)
J Bacteriol
, vol.95
, pp. 28-36
-
-
Shaw, W.V.1
Brodsky, R.F.2
-
33
-
-
29044436081
-
Species-specific antibiotic-ribosome interactions: Implications for drug development
-
Wilson DN, et al. (2005) Species-specific antibiotic-ribosome interactions: Implications for drug development. Biol Chem 386:1239-1252.
-
(2005)
Biol Chem
, vol.386
, pp. 1239-1252
-
-
Wilson, D.N.1
-
34
-
-
43049089746
-
Molecular mechanism of drug-dependent ribosome stalling
-
Vazquez-Laslop N, et al. (2008) Molecular mechanism of drug-dependent ribosome stalling. Mol Cell 30:190-202.
-
(2008)
Mol Cell
, vol.30
, pp. 190-202
-
-
Vazquez-Laslop, N.1
-
35
-
-
69249118597
-
Formation of the first peptide bond: The structure of EF-P bound to the 70S ribosome
-
Blaha G, et al. (2009) Formation of the first peptide bond: The structure of EF-P bound to the 70S ribosome. Science 325:966-970.
-
(2009)
Science
, vol.325
, pp. 966-970
-
-
Blaha, G.1
-
36
-
-
33749354360
-
Structure of the 70S ribosome complexed with mRNA and tRNA
-
Selmer M, et al. (2006) Structure of the 70S ribosome complexed with mRNA and tRNA. Science 313:1935-1942.
-
(2006)
Science
, vol.313
, pp. 1935-1942
-
-
Selmer, M.1
-
37
-
-
66149157000
-
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome
-
Voorhees RM, et al. (2009) Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome. Nat Struct Mol Biol 16:528-533.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 528-533
-
-
Voorhees, R.M.1
-
38
-
-
0036342198
-
The structures of four macrolide antibiotics bound to the large ribosomal subunit
-
Hansen JL, et al. (2002) The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol Cell 10:117-128.
-
(2002)
Mol Cell
, vol.10
, pp. 117-128
-
-
Hansen, J.L.1
-
39
-
-
11244307407
-
Binding site of the bridged macrolides in the Escherichia coli ribosome
-
Xiong L, et al. (2005) Binding site of the bridged macrolides in the Escherichia coli ribosome. Antimicrob Agents Chemother 49:281-288.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 281-288
-
-
Xiong, L.1
-
40
-
-
0035162904
-
Binding site of macrolide antibiotics on the ribosome: New resistance mutation identifies a specific interaction of ketolides with rRNA
-
Garza-Ramos G, et al. (2001) Binding site of macrolide antibiotics on the ribosome: New resistance mutation identifies a specific interaction of ketolides with rRNA. J Bacteriol 183:6898-6907.
-
(2001)
J Bacteriol
, vol.183
, pp. 6898-6907
-
-
Garza-Ramos, G.1
-
41
-
-
0032950956
-
The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA
-
Hansen LH, et al. (1999) The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA. Mol Microbiol 31:623-631.
-
(1999)
Mol Microbiol
, vol.31
, pp. 623-631
-
-
Hansen, L.H.1
-
42
-
-
0019843336
-
Different nucleotide changes in the large rRNA gene of the mitochondrial DNA confer chloramphenicol resistance on two human cell lines
-
Blanc H, et al. (1981) Different nucleotide changes in the large rRNA gene of the mitochondrial DNA confer chloramphenicol resistance on two human cell lines. Nucleic Acids Res 9:5785-5795.
-
(1981)
Nucleic Acids Res
, vol.9
, pp. 5785-5795
-
-
Blanc, H.1
-
43
-
-
15944403640
-
Design, synthesis and ribosome binding of chloramphenicol nucleotide and intercalator conjugates
-
Johansson D, et al. (2005) Design, synthesis and ribosome binding of chloramphenicol nucleotide and intercalator conjugates. Bioorg Med Chem Lett 15:2079-2083.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 2079-2083
-
-
Johansson, D.1
-
44
-
-
0034637161
-
The structural basis of ribosome activity in peptide bond synthesis
-
Nissen P, et al. (2000) The structural basis of ribosome activity in peptide bond synthesis. Science 289:920-930.
-
(2000)
Science
, vol.289
, pp. 920-930
-
-
Nissen, P.1
-
45
-
-
0000184017
-
Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens
-
Or YS, et al. (2000) Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. J Med Chem 43:1045-1049.
-
(2000)
J Med Chem
, vol.43
, pp. 1045-1049
-
-
Or, Y.S.1
-
46
-
-
54049112261
-
R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance
-
Skripkin E, et al. (2008) R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance. Antimicrob Agents Chemother 52:3550-3557.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 3550-3557
-
-
Skripkin, E.1
-
47
-
-
0028963496
-
Erythromycin resistance by ribosome modification
-
Weisblum B (1995) Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother 39:577-585.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 577-585
-
-
Weisblum, B.1
-
48
-
-
0028790412
-
Methylation ofminimalist 23S rRNA sequences in vitro by ErmSF (TlrA) N-methyltransferase
-
Kovalic D, et al. (1995) Methylation ofminimalist 23S rRNA sequences in vitro by ErmSF (TlrA) N-methyltransferase. Biochemistry 34:15838-15844.
-
(1995)
Biochemistry
, vol.34
, pp. 15838-15844
-
-
Kovalic, D.1
-
49
-
-
77949266567
-
The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome
-
Stanley RE, et al. (2010) The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. Nat Struct Mol Biol 17:289-293.
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 289-293
-
-
Stanley, R.E.1
-
51
-
-
34447508216
-
Phaser crystallographic software
-
McCoy AJ, et al. (2007) Phaser crystallographic software. J Appl Crystallogr 40:658-674.
-
(2007)
J Appl Crystallogr
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
-
52
-
-
76449098262
-
PHENIX: A comprehensive Python-based system for macromolecular structure solution
-
Adams PD, et al. (2010) PHENIX: A comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D 66:213-221.
-
(2010)
Acta Crystallogr D
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
-
53
-
-
7544226311
-
PRODRG: A tool for high-throughput crystallography of protein-ligand complexes
-
Schuttelkopf AW, van Aalten DM (2004) PRODRG: A tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallogr D 60:1355-1363.
-
(2004)
Acta Crystallogr D
, vol.60
, pp. 1355-1363
-
-
Schuttelkopf, A.W.1
Van Aalten, D.M.2
-
54
-
-
0027995683
-
Detection, delineation, measurement and display of cavities in macromolecular structures
-
Kleywegt GJ, Jones TA (1994) Detection, delineation, measurement and display of cavities in macromolecular structures. Acta Crystallogr D 50:178-185.
-
(1994)
Acta Crystallogr D
, vol.50
, pp. 178-185
-
-
Kleywegt, G.J.1
Jones, T.A.2
|