Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

Cell

Volumn 121, Issue 2, 2005, Pages 257-270

  Tu, Daqi ^a,c   Blaha, Gregor ^a   Moore, Peter B ^a   Steitz, Thomas A ^a,b  

^a YALE UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; CLINDAMYCIN; DALFOPRISTIN; ERYTHROMYCIN; KETOLIDE; LINCOSAMIDE; MACROLIDE; MIKAMYCIN B; QUINUPRISTIN; TELITHROMYCIN; VIRGINIAMYCIN M; VIRGINIAMYCIN S; ANTIINFECTIVE AGENT; RNA 23S; VIRGINIAMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEINOCOCCUS RADIODURANS; DRUG BINDING; ESCHERICHIA COLI; HALOARCULA MARISMORTUI; MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RIBOSOME; RIBOSOME SUBUNIT; STATISTICAL SIGNIFICANCE; STRUCTURE ANALYSIS; WILD TYPE; BINDING SITE; CHEMISTRY; CRYSTALLOGRAPHY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BINDING SITES; CLINDAMYCIN; CRYSTALLOGRAPHY; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; ESCHERICHIA COLI; HALOARCULA MARISMORTUI; KETOLIDES; MUTATION; PROTEIN BINDING; RIBOSOMES; RNA, RIBOSOMAL, 23S; VIRGINIAMYCIN;

EID: 17444421169     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.02.005     Document Type: Article

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