Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma

Carcinogenesis

Volumn 33, Issue 12, 2012, Pages 2334-2343

  Zhu, Jing ^a   Zhang, Shu ^a,b   Gu, Liying ^a   Di, Wen ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Municipal Science and Technology Commission   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; DICKKOPF 2 PROTEIN; FOCAL ADHESION KINASE; GELATINASE A; GLYCOPROTEIN; MYC PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INVASION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; MAJOR CLINICAL STUDY; METHYLATION; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

ANIMALS; AZACITIDINE; CELL LINE, TUMOR; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEOPLASM INVASIVENESS; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; WNT SIGNALING PATHWAY;

EID: 84870327013     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs278     Document Type: Article

References (53)

1. Wodarz, A. et al. (1998) Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol., 14, 59-88.
2. Kharaishvili, G. et al. (2011) Wnt signaling in prostate development and carcinogenesis. Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub., 155, 11-18.
3. Clevers, H. (2006) Wnt/beta-catenin signaling in development and disease. Cell, 127, 469-480.
4. Jeays-Ward, K. et al. (2003) Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development, 130, 3663-3670.
5. Ricken, A. et al. (2002) Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. Endocrinology, 143, 2741-2749.
6. King, T.D. et al. (2012) The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer. J. Cell. Biochem., 113, 13-18.
7. Sato, H. et al. (2007) Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. Carcinogenesis, 28, 2459-2466.
8. Matsui, A. et al. (2009) DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer. Cancer Sci., 100, 1923-1930.
9. Yue, W. et al. (2008) Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis, 29, 84-92.
10. Oliva, E. et al. (2006) High frequency of beta-catenin mutations in borderline endometrioid tumours of the ovary. J. Pathol., 208, 708-713.
11. Komiya, Y. et al. (2008) Wnt signal transduction pathways. Organogenesis, 4, 68-75.
12. Zorn, A.M. (2001) Wnt signalling: antagonistic Dickkopfs. Curr. Biol., 11, R592-R595.
13. Jones, S.E. et al. (2002) Secreted Frizzled-related proteins: searching for relationships and patterns. Bioessays, 24, 811-820.
14. Kawano, Y. et al. (2003) Secreted antagonists of the Wnt signalling pathway. J. Cell. Sci., 116(Pt 13), 2627-2634.
15. Krupnik, V.E. et al. (1999) Functional and structural diversity of the human Dickkopf gene family. Gene, 238, 301-313.
16. Mao, B. et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature, 411, 321-325.
17. Li, L. et al. (2002) Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J. Biol. Chem., 277, 5977-5981.
18. Mao, B. et al. (2003) Kremen2 modulates Dickkopf2 activity during Wnt/ LRP6 signaling. Gene, 302, 179-183.
19. Abarzua, F. et al. (2005) Adenovirus-mediated overexpression of REIC/ Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-kinase. Cancer Res., 65, 9617-9622.
20. Lee, E.J. et al. (2009) Dkk3, downregulated in cervical cancer, functions as a negative regulator of beta-catenin. Int. J. Cancer, 124, 287-297.
21. Hirata, H. et al. (2009) Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. Clin. Cancer Res., 15, 5678-5687.
22. Kuphal, S. et al. (2006) Expression of Dickkopf genes is strongly reduced in malignant melanoma. Oncogene, 25, 5027-5036.
23. Asadollahi, R. et al. (2010) Epigenetics of ovarian cancer: from the lab to the clinic. Gynecol. Oncol., 118, 81-87.
24. Rius, M. et al. (2011) Epigenetic cancer therapy: rationales, targets and drugs. Oncogene. [Epub ahead of print]
25. Christensen, B.C. et al. (2011) Epigenomics in environmental health. Front. Genet., 2, 84.
26. Dey, P. (2011) Epigenetic changes in tumor microenvironment. Indian J. Cancer, 48, 507-512.
27. Bender, C.M. et al. (1998) Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res., 58, 95-101.
28. Christoph, F. et al. (2006) Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer. Br. J. Cancer, 95, 1701-1707.
29. Strathdee, G. et al. (1999) A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene, 18, 2335-2341.
30. Plumb, J.A. et al. (2000) Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res., 60, 6039-6044.
31. Li, Y. et al. (2009) Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis. Am. J. Obstet. Gynecol., 200, 177.e1-177.e9.
32. Steele, N. et al. (2009) Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo. Br. J. Cancer, 100, 758-763.
33. Licchesi, J.D. et al. (2008) Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis, 29, 895-904.
34. Chim, C.S. et al. (2007) Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. Leukemia, 21, 2527-2536.
35. Nojima, M. et al. (2007) Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene, 26, 4699-4713.
36. Urakami, S. et al. (2006) Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA. Clin. Cancer Res., 12, 6989-6997.
37. Aguilera, O. et al. (2006) Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene, 25, 4116-4121.
38. Suzuki, H. et al. (2008) Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br. J. Cancer, 98, 1147-1156.
39. Veeck, J. et al. (2008) Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours. Breast Cancer Res., 10, R82.
40. Roman-Gomez, J. et al. (2004) Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia. Br. J. Cancer, 91, 707-713.
41. Mao, B. et al. (2002) Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature, 417, 664-667.
42. Wu, G.Q. et al. (2009) Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. Int. J. Cancer, 125, 2631-2642.
43. Sillanpää, S. et al. (2007) Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer. Gynecol. Oncol., 104, 296-303.
44. Dudal, J. et al. (2005) Transmigration of human ovarian adenocarcinoma cells through endothelial extracellular matrix involves alpha integrins and the participation of MMP2. Int. J. Cancer, 114, 531-543.
45. Cao, L. et al. (2011) Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer. Oncogene, in press.
46. Lee, A.Y. et al. (2004) Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma. Biochem. Biophys. Res. Commun., 323, 1246-1250.
47. Mikheev, A.M. et al. (2004) A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation. Carcinogenesis, 25, 47-59.
48. Kashiwakura, Y. et al. (2008) Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and Smad regulates REIC/Dickkopf-3-induced apoptosis. Cancer Res., 68, 8333-8341.
49. Fidler, I.J. et al. (1990) Genetic control of cancer metastasis. J. Natl. Cancer Inst., 82, 166-168.
50. Tester, A.M. et al. (2000) MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits. Clin. Exp. Metastasis, 18, 553-560.
51. Luo, M. et al. (2010) Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett., 289, 127-139.
52. Vogelstein, B. et al. (1988) Genetic alterations during colorectal-tumor development. N. Engl. J. Med., 319, 525-532.
53. Gatcliffe, T.A. et al. (2008) Wnt signaling in ovarian tumorigenesis. Int. J. Gynecol. Cancer, 18, 954-962.