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Volumn 137, Issue 4, 2011, Pages 621-627

Expression of the Wnt antagonist DKK3 is frequently suppressed in sporadic epithelial ovarian cancer

Author keywords

DKK3; Gene expression; Ovarian cancer; Wnt signaling

Indexed keywords

DICKKOPF 3 PROTEIN; MESSENGER RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 79954431274     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-010-0916-6     Document Type: Article
Times cited : (26)

References (38)
  • 1
    • 0032919173 scopus 로고    scopus 로고
    • Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation
    • HX An MW Beckmann G Reifenberger HG Bender D Niederacher 1999 Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation Am J Pathol 154 113 118 9916925 10.1016/S0002-9440(10)65257-1 1:CAS:528:DyaK1MXnsFGjsw%3D%3D (Pubitemid 29031618)
    • (1999) American Journal of Pathology , vol.154 , Issue.1 , pp. 113-118
    • An, H.-X.1    Beckmann, M.W.2    Reifenberger, G.3    Bender, H.G.4    Niederacher, D.5
  • 3
    • 67649440886 scopus 로고    scopus 로고
    • The biology of ovarian cancer: New opportunities for translation
    • 19461667 10.1038/nrc2644 1:CAS:528:DC%2BD1MXmt1Skt7g%3D
    • RC Bast Jr B Hennessy GB Mills 2009 The biology of ovarian cancer: new opportunities for translation Nat Rev Cancer 9 415 428 19461667 10.1038/nrc2644 1:CAS:528:DC%2BD1MXmt1Skt7g%3D
    • (2009) Nat Rev Cancer , vol.9 , pp. 415-428
    • Bast Jr., R.C.1    Hennessy, B.2    Mills, G.B.3
  • 4
    • 19744368302 scopus 로고    scopus 로고
    • Cancer of the ovary
    • DOI 10.1056/NEJMra041842
    • SA Cannistra 2004 Cancer of the ovary N Engl J Med 351 2519 2529 15590954 10.1056/NEJMra041842 1:CAS:528:DC%2BD2cXhtVGksbbM (Pubitemid 39603165)
    • (2004) New England Journal of Medicine , vol.351 , Issue.24
    • Cannistra, S.A.1
  • 8
    • 67650666507 scopus 로고    scopus 로고
    • Dkk-3 expression in the tumor endothelium: A novel prognostic marker of pancreatic adenocarcinomas
    • 19493271 10.1111/j.1349-7006.2009.01208.x 1:CAS:528:DC%2BD1MXhtVWnsLrE
    • D Fong M Hermann G Untergasser D Pirkebner A Draxl M Heitz P Moser R Margreiter P Hengster A Amberger 2009 Dkk-3 expression in the tumor endothelium: a novel prognostic marker of pancreatic adenocarcinomas Cancer Sci 100 1414 1420 19493271 10.1111/j.1349-7006.2009.01208.x 1:CAS:528:DC%2BD1MXhtVWnsLrE
    • (2009) Cancer Sci , vol.100 , pp. 1414-1420
    • Fong, D.1    Hermann, M.2    Untergasser, G.3    Pirkebner, D.4    Draxl, A.5    Heitz, M.6    Moser, P.7    Margreiter, R.8    Hengster, P.9    Amberger, A.10
  • 9
    • 51749098230 scopus 로고    scopus 로고
    • Wnt signaling in ovarian tumorigenesis
    • 17986238 10.1111/j.1525-1438.2007.01127.x 1:STN:280: DC%2BD1cnjsVWmsQ%3D%3D
    • TA Gatcliffe BJ Monk K Planutis RF Holcombe 2008 Wnt signaling in ovarian tumorigenesis Int J Gynecol Cancer 18 954 962 17986238 10.1111/j.1525-1438. 2007.01127.x 1:STN:280:DC%2BD1cnjsVWmsQ%3D%3D
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 954-962
    • Gatcliffe, T.A.1    Monk, B.J.2    Planutis, K.3    Holcombe, R.F.4
  • 10
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way
    • DOI 10.1242/dev.01117
    • X He M Semenov K Tamai X Zeng 2004 LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way Development 131 1663 1677 15084453 10.1242/dev.01117 1:CAS:528:DC%2BD2cXjvVaqtbc%3D (Pubitemid 38559836)
    • (2004) Development , vol.131 , Issue.8 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 11
    • 32244448828 scopus 로고    scopus 로고
    • Vang-like 2 and noncanonical Wnt signaling in outflow tract development
    • DOI 10.1016/j.tcm.2005.11.005, PII S1050173805002197
    • DJ Henderson HM Phillips B Chaudhry 2006 Vang-like 2 and noncanonical Wnt signaling in outflow tract development Trends Cardiovasc 16 38 45 10.1016/j.tcm.2005.11.005 1:CAS:528:DC%2BD28Xhtlaltbw%3D (Pubitemid 43214524)
    • (2006) Trends in Cardiovascular Medicine , vol.16 , Issue.2 , pp. 38-45
    • Henderson, D.J.1    Phillips, H.M.2    Chaudhry, B.3
  • 12
    • 9244240664 scopus 로고    scopus 로고
    • Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-β-Catenin Pathway
    • DOI 10.1158/0008-5472.CAN-03-1952
    • BH Hoang T Kubo JH Healey R Yang SS Nathan EA Kolb B Mazza PA Meyers R Gorlick 2004 Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway Cancer Res 64 2734 2739 15087387 10.1158/0008-5472.CAN-03-1952 1:CAS:528:DC%2BD2cXjtV2ltL8%3D (Pubitemid 38500609)
    • (2004) Cancer Research , vol.64 , Issue.8 , pp. 2734-2739
    • Hoang, B.H.1    Kubo, T.2    Healey, J.H.3    Yang, R.4    Nathan, S.S.5    Kolb, E.A.6    Mazza, B.7    Meyers, P.A.8    Gorlick, R.9
  • 13
    • 11244323971 scopus 로고    scopus 로고
    • Dickkopf-3/REIC functions as a suppressor gene of tumor growth
    • 15516983 1:CAS:528:DC%2BD2cXhtVGmtbjO
    • SY Hsieh PS Hsieh CT Chiu WY Chen 2004 Dickkopf-3/REIC functions as a suppressor gene of tumor growth Oncogene 23 9183 9189 15516983 1:CAS:528:DC%2BD2cXhtVGmtbjO
    • (2004) Oncogene , vol.23 , pp. 9183-9189
    • Hsieh, S.Y.1    Hsieh, P.S.2    Chiu, C.T.3    Chen, W.Y.4
  • 15
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • DOI 10.1242/jcs.00623
    • Y Kawano R Kypta 2003 Secreted antagonists of the Wnt signalling pathway J Cell Sci 116 2627 2634 12775774 10.1242/jcs.00623 1:CAS:528: DC%2BD3sXlsFamtLs%3D (Pubitemid 36857216)
    • (2003) Journal of Cell Science , vol.116 , Issue.13 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 16
    • 33750202545 scopus 로고    scopus 로고
    • Regulation of prostate cell growth and morphogenesis by Dickkopf-3
    • DOI 10.1038/sj.onc.1209661, PII 1209661
    • Y Kawano M Kitaoka Y Hamada MM Walker J Waxman RM Kypta 2006 Regulation of prostate cell growth and morphogenesis by Dickkopf-3 Oncogene 25 6528 6537 16751809 10.1038/sj.onc.1209661 1:CAS:528:DC%2BD28XhtV2gsrvE (Pubitemid 44607085)
    • (2006) Oncogene , vol.25 , Issue.49 , pp. 6528-6537
    • Kawano, Y.1    Kitaoka, M.2    Hamada, Y.3    Walker, M.M.4    Waxman, J.5    Kypta, R.M.6
  • 17
    • 57649122080 scopus 로고    scopus 로고
    • REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer
    • 18654608 10.1038/cgt.2008.58 1:CAS:528:DC%2BD1cXhsV2hsrnJ
    • K Kawasaki M Watanabe M Sakaguchi Y Ogasawara K Ochiai Y Nasu H Doihara Y Kashiwakura NH Huh H Kumon H Date 2009 REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer Cancer Gene Ther 16 65 72 18654608 10.1038/cgt.2008.58 1:CAS:528:DC%2BD1cXhsV2hsrnJ
    • (2009) Cancer Gene Ther , vol.16 , pp. 65-72
    • Kawasaki, K.1    Watanabe, M.2    Sakaguchi, M.3    Ogasawara, Y.4    Ochiai, K.5    Nasu, Y.6    Doihara, H.7    Kashiwakura, Y.8    Huh, N.H.9    Kumon, H.10    Date, H.11
  • 18
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • DOI 10.1038/nrc2389, PII NRC2389
    • A Klaus W Birchmeier 2008 Wnt signalling and its impact on development and cancer Nat Rev Cancer 8 387 398 18432252 10.1038/nrc2389 1:CAS:528:DC%2BD1cXltVGlu7c%3D (Pubitemid 351589714)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.5 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 19
    • 41349100528 scopus 로고    scopus 로고
    • Pathogenesis of ovarian cancer: Lessons from morphology and molecular biology and their clinical implications
    • DOI 10.1097/PGP.0b013e318161e4f5
    • RJ Kurman IEM Shih 2008 Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications Int J Gynecol Pathol 27 151 160 18317228 (Pubitemid 351450677)
    • (2008) International Journal of Gynecological Pathology , vol.27 , Issue.2 , pp. 151-160
    • Kurman, R.J.1    Shih, I.-M.2
  • 21
    • 20144383392 scopus 로고    scopus 로고
    • Functional epigenomics identifies genes frequently silenced in prostate cancer
    • DOI 10.1158/0008-5472.CAN-04-4407
    • D Lodygin A Epanchintsev A Menssen J Diebold H Hermeking 2005 Functional epigenomics identifies genes frequently silenced in prostate cancer Cancer Res 65 4218 4227 15899813 10.1158/0008-5472.CAN-04-4407 1:CAS:528: DC%2BD2MXktlSmtrk%3D (Pubitemid 40775660)
    • (2005) Cancer Research , vol.65 , Issue.10 , pp. 4218-4227
    • Lodygin, D.1    Epanchintsev, A.2    Menssen, A.3    Diebold, J.4    Hermeking, H.5
  • 22
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • DOI 10.1038/35077108
    • B Mao W Wu Y Li D Hoppe P Stannek A Glinka C Niehrs 2001 LDL-receptor-related protein 6 is a receptor for Dickkopf proteins Nature 411 321 325 11357136 10.1038/35077108 1:CAS:528:DC%2BD3MXjvF2qtbo%3D (Pubitemid 32467039)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 23
    • 33845359084 scopus 로고    scopus 로고
    • Function and biological roles of the Dickkopf family of Wnt modulators
    • DOI 10.1038/sj.onc.1210054, PII 1210054
    • C Nierhs 2006 Function and biological roles of the Dickkopf family of Wnt modulators Oncogene 25 7469 7481 10.1038/sj.onc.1210054 (Pubitemid 44885746)
    • (2006) Oncogene , vol.25 , Issue.57 , pp. 7469-7481
    • Niehrs, C.1
  • 24
    • 0035407792 scopus 로고    scopus 로고
    • Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer
    • 11408931 1:CAS:528:DC%2BD3MXltFeisr4%3D
    • I Nozaki T Tsuji O Iijima Y Ohmura A Andou M Miyazaki N Shimizu M Namba 2001 Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer Int J Oncol 19 117 121 11408931 1:CAS:528:DC%2BD3MXltFeisr4%3D
    • (2001) Int J Oncol , vol.19 , pp. 117-121
    • Nozaki, I.1    Tsuji, T.2    Iijima, O.3    Ohmura, Y.4    Andou, A.5    Miyazaki, M.6    Shimizu, N.7    Namba, M.8
  • 25
    • 0032054206 scopus 로고    scopus 로고
    • Mutations in the β-catenin gene (CTNNB1) in endometrioid ovarian carcinomas
    • J Palacios C Gamallo 1998 Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas Cancer Res 58 1344 1347 9537226 1:CAS:528:DyaK1cXit1elu7w%3D (Pubitemid 28193586)
    • (1998) Cancer Research , vol.58 , Issue.7 , pp. 1344-1347
    • Palacios, J.1    Gamallo, C.2
  • 30
    • 0036422194 scopus 로고    scopus 로고
    • Non-canonical Wnt signalling and regulation of gastrulation movements
    • DOI 10.1016/S1084-9521(02)00052-6
    • M Tada ML Concha CP Heisenberg 2002 Non-canonical Wnt signalling and regulation of gastrulation movements Semin Cell Dev Biol 13 251 260 12137734 10.1016/S1084-9521(02)00052-6 1:CAS:528:DC%2BD38Xms1Wktr8%3D (Pubitemid 35304530)
    • (2002) Seminars in Cell and Developmental Biology , vol.13 , Issue.3 , pp. 251-260
    • Tada, M.1    Concha, M.L.2    Heisenberg, C.-P.3
  • 31
    • 33947520510 scopus 로고    scopus 로고
    • REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer
    • 17273781 1:CAS:528:DC%2BD2sXivVOns7Y%3D
    • R Tanimoto F Abarzua M Sakaguchi M Takaishi Y Nasu H Kumon NH Huh 2007 REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer Int J Mol Med 19 363 368 17273781 1:CAS:528:DC%2BD2sXivVOns7Y%3D
    • (2007) Int J Mol Med , vol.19 , pp. 363-368
    • Tanimoto, R.1    Abarzua, F.2    Sakaguchi, M.3    Takaishi, M.4    Nasu, Y.5    Kumon, H.6    Huh, N.H.7
  • 33
    • 33646247418 scopus 로고    scopus 로고
    • Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection
    • 16609023 10.1158/1078-0432.CCR-05-2468 1:CAS:528:DC%2BD28XjtlChsrs%3D
    • S Urakami H Shiina H Enokida T Kawakami K Kawamoto H Hirata Y Tanaka N Kikuno M Nakagawa M Igawa R Dahiya 2006 Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection Clin Cancer Res 12 2109 2116 16609023 10.1158/1078-0432.CCR-05- 2468 1:CAS:528:DC%2BD28XjtlChsrs%3D
    • (2006) Clin Cancer Res , vol.12 , pp. 2109-2116
    • Urakami, S.1    Shiina, H.2    Enokida, H.3    Kawakami, T.4    Kawamoto, K.5    Hirata, H.6    Tanaka, Y.7    Kikuno, N.8    Nakagawa, M.9    Igawa, M.10    Dahiya, R.11
  • 34
    • 59449089531 scopus 로고    scopus 로고
    • Wnt signalling in human breast cancer: Expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours
    • 18826564 10.1186/bcr2151
    • J Veeck N Bektas A Hartmann G Kristiansen U Heindrichs R Knüchel E Dahl 2008 Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours Breast Cancer Res 10 R82 18826564 10.1186/bcr2151
    • (2008) Breast Cancer Res , vol.10 , pp. 82
    • Veeck, J.1    Bektas, N.2    Hartmann, A.3    Kristiansen, G.4    Heindrichs, U.5    Knüchel, R.6    Dahl, E.7
  • 35
    • 0033609680 scopus 로고    scopus 로고
    • β-Catenin mutation and expression analysis in ovarian cancer: Exon 3 mutations and nuclear translocation in 16% of endometrioid tumours
    • K Wright P Wilson S Morland I Campbell M Walsh T Hurst B Ward M Cummings G Chenevix-Trench 1999 beta-catenin mutation and expression analysis in ovarian cancer: exon 3 mutations and nuclear translocation in 16% of endometrioid tumours Int J Cancer 82 625 629 10417756 10.1002/(SICI)1097-0215(19990827)82: 5<625::AID-IJC1>3.0.CO;2-2 1:CAS:528:DyaK1MXltFOit7w%3D (Pubitemid 29356957)
    • (1999) International Journal of Cancer , vol.84 , Issue.5 , pp. 625-629
    • Wright, K.1    Wilson, P.2    Morland, S.3    Campbell, I.4    Walsh, M.5    Hurst, T.6    Ward, B.7    Cummings, M.8    Chenevix-Trench, G.9
  • 36
    • 0035890615 scopus 로고    scopus 로고
    • Diverse mechanisms of β-catenin deregulation in ovarian endometrioid adenocarcinomas
    • R Wu Y Zhai ER Fearon KR Cho 2001 Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas Cancer Res 61 8247 8255 11719457 1:CAS:528:DC%2BD3MXovVShsb4%3D (Pubitemid 33091619)
    • (2001) Cancer Research , vol.61 , Issue.22 , pp. 8247-8255
    • Wu, R.1    Zhai, Y.2    Fearon, E.R.3    Cho, K.R.4
  • 37
    • 38849145619 scopus 로고    scopus 로고
    • Downregulation of Dkk3 activates β-catenin/TCF-4 signaling in lung cancer
    • DOI 10.1093/carcin/bgm267
    • W Yue Q Sun S Dacic RJ Landreneau JM Siegfried J Yu L Zhang 2008 Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer Carcinogenesis 29 84 92 18048388 10.1093/carcin/bgm267 1:CAS:528: DC%2BD1cXhs1aitLg%3D (Pubitemid 351201745)
    • (2008) Carcinogenesis , vol.29 , Issue.1 , pp. 84-92
    • Yue, W.1    Sun, Q.2    Dacic, S.3    Landreneau, R.J.4    Siegfried, J.M.5    Yu, J.6    Zhang, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.