메뉴 건너뛰기




Volumn 34, Issue 26, 2015, Pages 3452-3462

WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FIBROBLAST GROWTH FACTOR 1; NICLOSAMIDE; WNT7A PROTEIN; WNT PROTEIN; WNT7A PROTEIN, HUMAN;

EID: 84933037846     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.277     Document Type: Article
Times cited : (77)

References (54)
  • 2
    • 2642571071 scopus 로고    scopus 로고
    • Frequency of symptoms of ovarian cancer in women presenting to primary care clinics
    • Goff BA, Mandel LS, Melancon CH, Muntz HG. Frequency of symptoms of ovarian cancer in women presenting to primary care clinics. JAMA 2004; 291: 2705-2712.
    • (2004) JAMA , vol.291 , pp. 2705-2712
    • Goff, B.A.1    Mandel, L.S.2    Melancon, C.H.3    Muntz, H.G.4
  • 3
    • 29144490181 scopus 로고    scopus 로고
    • An evolutionary conserved role of Wnt signaling in stem cell fate decision
    • Teo R, Mohrlen F, Plickert G, Muller WA, Frank U. An evolutionary conserved role of Wnt signaling in stem cell fate decision. Dev Biol 2006; 289: 91-99.
    • (2006) Dev Biol , vol.289 , pp. 91-99
    • Teo, R.1    Mohrlen, F.2    Plickert, G.3    Muller, W.A.4    Frank, U.5
  • 4
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P. Wnt signaling and cancer. Genes Dev 2000; 14: 1837-1851.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 5
    • 84863012773 scopus 로고    scopus 로고
    • N-myc downstream regulated gene 1 modulates Wnt-beta-catenin signalling and pleiotropically suppresses metastasis
    • Liu W, Xing F, Iiizumi-Gairani M, Okuda H, Watabe M, Pai SK et al. N-myc downstream regulated gene 1 modulates Wnt-beta-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol Med 2012; 4: 93-108.
    • (2012) EMBO Mol Med , vol.4 , pp. 93-108
    • Liu, W.1    Xing, F.2    Iiizumi-Gairani, M.3    Okuda, H.4    Watabe, M.5    Pai, S.K.6
  • 6
    • 33846193290 scopus 로고    scopus 로고
    • The many ways of Wnt in cancer
    • Polakis P. The many ways of Wnt in cancer. Curr Opin Genet Dev 2007; 17: 45-51.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 45-51
    • Polakis, P.1
  • 9
    • 84858605181 scopus 로고    scopus 로고
    • WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/ beta-catenin pathway
    • Yoshioka S, King ML, Ran S, Okuda H, MacLean JA 2nd, McAsey ME et al. WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/ beta-catenin pathway. Mol Cancer Res 2012; 10: 469-482.
    • (2012) Mol Cancer Res , vol.10 , pp. 469-482
    • Yoshioka, S.1    King, M.L.2    Ran, S.3    Okuda, H.4    Maclean, J.A.5    McAsey, M.E.6
  • 10
    • 0029143960 scopus 로고
    • Molecular mechanisms of angiogenesis: Fibroblast growth factor signal transduction
    • Friesel RE, Maciag T. Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J 1995; 9: 919-925.
    • (1995) FASEB J , vol.9 , pp. 919-925
    • Friesel, R.E.1    Maciag, T.2
  • 11
  • 12
    • 34250200790 scopus 로고    scopus 로고
    • Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas
    • Birrer MJ, Johnson ME, Hao K, Wong KK, Park DC, Bell A et al. Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas. J Clin Oncol 2007; 25: 2281-2287.
    • (2007) J Clin Oncol , vol.25 , pp. 2281-2287
    • Birrer, M.J.1    Johnson, M.E.2    Hao, K.3    Wong, K.K.4    Park, D.C.5    Bell, A.6
  • 13
    • 84891819848 scopus 로고    scopus 로고
    • Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome
    • Meng QH, Xu E, Hildebrandt MA, Liang D, Lu K, Ye Y et al. Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome. Clin Chem 2014; 60: 222-232.
    • (2014) Clin Chem , vol.60 , pp. 222-232
    • Meng, Q.H.1    Xu, E.2    Hildebrandt, M.A.3    Liang, D.4    Lu, K.5    Ye, Y.6
  • 14
    • 84867395354 scopus 로고    scopus 로고
    • Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer
    • Smith G, Ng MT, Shepherd L, Herrington CS, Gourley C, Ferguson MJ et al. Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer. Br J Cancer 2012; 107: 1327-1336.
    • (2012) Br J Cancer , vol.107 , pp. 1327-1336
    • Smith, G.1    Ng, M.T.2    Shepherd, L.3    Herrington, C.S.4    Gourley, C.5    Ferguson, M.J.6
  • 15
    • 83455182133 scopus 로고    scopus 로고
    • Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/beta-catenin pathway
    • Lu W, Lin C, Roberts MJ, Waud WR, Piazza GA, Li Y. Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/beta-catenin pathway. PLoS ONE 2011; 6: e29290.
    • (2011) PLoS ONE , vol.6 , pp. e29290
    • Lu, W.1    Lin, C.2    Roberts, M.J.3    Waud, W.R.4    Piazza, G.A.5    Li, Y.6
  • 17
    • 79958812414 scopus 로고    scopus 로고
    • Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations
    • Osada T, Chen M, Yang XY, Spasojevic I, Vandeusen JB, Hsu D et al. Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res 2011; 71: 4172-4182.
    • (2011) Cancer Res , vol.71 , pp. 4172-4182
    • Osada, T.1    Chen, M.2    Yang, X.Y.3    Spasojevic, I.4    Vandeusen, J.B.5    Hsu, D.6
  • 18
    • 79960263940 scopus 로고    scopus 로고
    • Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer
    • Sack U, Walther W, Scudiero D, Selby M, Kobelt D, Lemm M et al. Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer. J Natl Cancer Inst 2011; 103: 1018-1036.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1018-1036
    • Sack, U.1    Walther, W.2    Scudiero, D.3    Selby, M.4    Kobelt, D.5    Lemm, M.6
  • 20
    • 70350489312 scopus 로고    scopus 로고
    • The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling
    • Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK et al. The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry 2009; 48: 10267-10274.
    • (2009) Biochemistry , vol.48 , pp. 10267-10274
    • Chen, M.1    Wang, J.2    Lu, J.3    Bond, M.C.4    Ren, X.R.5    Lyerly, H.K.6
  • 21
    • 32944462571 scopus 로고    scopus 로고
    • Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas
    • Hendrix ND, Wu R, Kuick R, Schwartz DR, Fearon ER, Cho KR. Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas. Cancer Res 2006; 66: 1354-1362.
    • (2006) Cancer Res , vol.66 , pp. 1354-1362
    • Hendrix, N.D.1    Wu, R.2    Kuick, R.3    Schwartz, D.R.4    Fearon, E.R.5    Cho, K.R.6
  • 24
    • 0030985446 scopus 로고    scopus 로고
    • Differential regulation of human fibroblast growth factor 1 transcripts provides a distinct mechanism of cell-specific growth factor expression
    • Chotani MA, Chiu IM. Differential regulation of human fibroblast growth factor 1 transcripts provides a distinct mechanism of cell-specific growth factor expression. Cell Growth Differ 1997; 8: 999-1013.
    • (1997) Cell Growth Differ , vol.8 , pp. 999-1013
    • Chotani, M.A.1    Chiu, I.M.2
  • 26
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev 2006; 5: 997-1014.
    • (2006) Nat Rev , vol.5 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 27
    • 77955635157 scopus 로고    scopus 로고
    • Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: A high-throughput screening approach
    • Chen W, Chen M, Barak LS. Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach. Am J Physiol Gastrointest Liver Physiol 2010; 299: G293-G300.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , pp. G293-G300
    • Chen, W.1    Chen, M.2    Barak, L.S.3
  • 28
    • 79951981206 scopus 로고    scopus 로고
    • Drugging the cancer stem cell compartment: Lessons learned from the hedgehog and Wnt signal transduction pathways
    • Dodge ME, Lum L. Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annu Rev Pharmacol Toxicol 2011; 51: 289-310.
    • (2011) Annu Rev Pharmacol Toxicol , vol.51 , pp. 289-310
    • Dodge, M.E.1    Lum, L.2
  • 29
    • 4344619713 scopus 로고    scopus 로고
    • Pharmacological inhibitors of glycogen synthase kinase 3
    • Meijer L, Flajolet M, Greengard P. Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci 2004; 25: 471-480.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 471-480
    • Meijer, L.1    Flajolet, M.2    Greengard, P.3
  • 30
    • 0035855624 scopus 로고    scopus 로고
    • Induction of FGF receptor 2-IIIb expression and response to its ligands in epithelial ovarian cancer
    • Steele IA, Edmondson RJ, Bulmer JN, Bolger BS, Leung HY, Davies BR. Induction of FGF receptor 2-IIIb expression and response to its ligands in epithelial ovarian cancer. Oncogene 2001; 20: 5878-5887.
    • (2001) Oncogene , vol.20 , pp. 5878-5887
    • Steele, I.A.1    Edmondson, R.J.2    Bulmer, J.N.3    Bolger, B.S.4    Leung, H.Y.5    Davies, B.R.6
  • 31
    • 84874030601 scopus 로고    scopus 로고
    • Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer
    • Zaid TM, Yeung TL, Thompson MS, Leung CS, Harding T, Co NN et al. Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer. Clin Cancer Res 2013; 19: 809-820.
    • (2013) Clin Cancer Res , vol.19 , pp. 809-820
    • Zaid, T.M.1    Yeung, T.L.2    Thompson, M.S.3    Leung, C.S.4    Harding, T.5    Co, N.N.6
  • 32
    • 13244299109 scopus 로고    scopus 로고
    • FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development
    • Chamorro MN, Schwartz DR, Vonica A, Brivanlou AH, Cho KR, Varmus HE. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J 2005; 24: 73-84.
    • (2005) EMBO J , vol.24 , pp. 73-84
    • Chamorro, M.N.1    Schwartz, D.R.2    Vonica, A.3    Brivanlou, A.H.4    Cho, K.R.5    Varmus, H.E.6
  • 33
    • 79957989939 scopus 로고    scopus 로고
    • Drug discovery approaches to target Wnt signaling in cancer stem cells
    • Curtin JC, Lorenzi MV. Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget 2010; 1: 563-577.
    • (2010) Oncotarget , vol.1 , pp. 563-577
    • Curtin, J.C.1    Lorenzi, M.V.2
  • 36
    • 84883182795 scopus 로고    scopus 로고
    • Uterine glands: Development, function and experimental model systems
    • Cooke PS, Spencer TE, Bartol FF, Hayashi K. Uterine glands: development, function and experimental model systems. Mol Hum Reprod 2013; 19: 547-558.
    • (2013) Mol Hum Reprod , vol.19 , pp. 547-558
    • Cooke, P.S.1    Spencer, T.E.2    Bartol, F.F.3    Hayashi, K.4
  • 37
    • 0032722717 scopus 로고    scopus 로고
    • Wnt genes and endocrine disruption of the female reproductive tract: A genetic approach
    • Sassoon D. Wnt genes and endocrine disruption of the female reproductive tract: a genetic approach. Mol Cell Endocrinol 1999; 158: 1-5.
    • (1999) Mol Cell Endocrinol , vol.158 , pp. 1-5
    • Sassoon, D.1
  • 38
    • 70349616273 scopus 로고    scopus 로고
    • Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
    • Balgi AD, Fonseca BD, Donohue E, Tsang TC, Lajoie P, Proud CG et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS ONE 2009; 4: e7124.
    • (2009) PLoS ONE , vol.4 , pp. e7124
    • Balgi, A.D.1    Fonseca, B.D.2    Donohue, E.3    Tsang, T.C.4    Lajoie, P.5    Proud, C.G.6
  • 39
    • 84861212263 scopus 로고    scopus 로고
    • Structureactivity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling
    • Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD et al. Structureactivity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem 2012; 287: 17530-17545.
    • (2012) J Biol Chem , vol.287 , pp. 17530-17545
    • Fonseca, B.D.1    Diering, G.H.2    Bidinosti, M.A.3    Dalal, K.4    Alain, T.5    Balgi, A.D.6
  • 40
    • 77950212486 scopus 로고    scopus 로고
    • Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: Inactivation of the NFkappaB pathway and generation of reactive oxygen species
    • Jin Y, Lu Z, Ding K, Li J, Du X, Chen C et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NFkappaB pathway and generation of reactive oxygen species. Cancer Res 2010; 70: 2516-2527.
    • (2010) Cancer Res , vol.70 , pp. 2516-2527
    • Jin, Y.1    Lu, Z.2    Ding, K.3    Li, J.4    Du, X.5    Chen, C.6
  • 41
    • 84885228492 scopus 로고    scopus 로고
    • Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer
    • Li R, Hu Z, Sun SY, Chen ZG, Owonikoko TK, Sica GL et al. Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther 2013; 12: 2200-2212.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2200-2212
    • Li, R.1    Hu, Z.2    Sun, S.Y.3    Chen, Z.G.4    Owonikoko, T.K.5    Sica, G.L.6
  • 42
    • 84896278080 scopus 로고    scopus 로고
    • Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer
    • You S, Li R, Park D, Xie M, Sica GL, Cao Y et al. Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. Mol Cancer Ther 2014; 13: 606-616.
    • (2014) Mol Cancer Ther , vol.13 , pp. 606-616
    • You, S.1    Li, R.2    Park, D.3    Xie, M.4    Sica, G.L.5    Cao, Y.6
  • 43
    • 79961087833 scopus 로고    scopus 로고
    • E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
    • Kim NG, Koh E, Chen X, Gumbiner BM. E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci USA 2011; 108: 11930-11935.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11930-11935
    • Kim, N.G.1    Koh, E.2    Chen, X.3    Gumbiner, B.M.4
  • 44
    • 79958789619 scopus 로고    scopus 로고
    • E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via beta-catenin-Egr1-mediated PTEN expression
    • Lau MT, Klausen C, Leung PC. E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via beta-catenin-Egr1-mediated PTEN expression. Oncogene 2011; 30: 2753-2766.
    • (2011) Oncogene , vol.30 , pp. 2753-2766
    • Lau, M.T.1    Klausen, C.2    Leung, P.C.3
  • 45
    • 0032510494 scopus 로고    scopus 로고
    • A causal role for E-cadherin in the transition from adenoma to carcinoma
    • Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998; 392: 190-193.
    • (1998) Nature , vol.392 , pp. 190-193
    • Perl, A.K.1    Wilgenbus, P.2    Dahl, U.3    Semb, H.4    Christofori, G.5
  • 46
    • 0027685701 scopus 로고
    • Cadherins in cancer: Implications for invasion and metastasis
    • Takeichi M. Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol 1993; 5: 806-811.
    • (1993) Curr Opin Cell Biol , vol.5 , pp. 806-811
    • Takeichi, M.1
  • 48
    • 34347272732 scopus 로고    scopus 로고
    • WNTs in the ovine uterus: Potential regulation of periimplantation ovine conceptus development
    • Hayashi K, Burghardt RC, Bazer FW, Spencer TE. WNTs in the ovine uterus: potential regulation of periimplantation ovine conceptus development. Endocrinology 2007; 148: 3496-3506.
    • (2007) Endocrinology , vol.148 , pp. 3496-3506
    • Hayashi, K.1    Burghardt, R.C.2    Bazer, F.W.3    Spencer, T.E.4
  • 50
    • 1642475141 scopus 로고    scopus 로고
    • Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis
    • Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res 2004; 64: 622-630.
    • (2004) Cancer Res , vol.64 , pp. 622-630
    • Singh, A.P.1    Moniaux, N.2    Chauhan, S.C.3    Meza, J.L.4    Batra, S.K.5
  • 51
    • 84889065385 scopus 로고    scopus 로고
    • The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis
    • Maclean JA 2nd, Hu Z, Welborn JP, Song HW, Rao MK, Wayne CM et al. The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis. J Biol Chem 2013; 288: 34809-34825.
    • (2013) J Biol Chem , vol.288 , pp. 34809-34825
    • Maclean, J.A.1    Hu, Z.2    Welborn, J.P.3    Song, H.W.4    Rao, M.K.5    Wayne, C.M.6
  • 52
    • 52649085237 scopus 로고    scopus 로고
    • Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    • Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res 2008; 14: 5198-5208.
    • (2008) Clin Cancer Res , vol.14 , pp. 5198-5208
    • Tothill, R.W.1    Tinker, A.V.2    George, J.3    Brown, R.4    Fox, S.B.5    Lade, S.6
  • 53
    • 66849097914 scopus 로고    scopus 로고
    • A prognostic gene expression index in ovarian cancer-validation across different independent data sets
    • Denkert C, Budczies J, Darb-Esfahani S, Gyorffy B, Sehouli J, Konsgen D et al. A prognostic gene expression index in ovarian cancer-validation across different independent data sets. J Pathol 2009; 218: 273-280.
    • (2009) J Pathol , vol.218 , pp. 273-280
    • Denkert, C.1    Budczies, J.2    Darb-Esfahani, S.3    Gyorffy, B.4    Sehouli, J.5    Konsgen, D.6
  • 54
    • 48549092983 scopus 로고    scopus 로고
    • A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer
    • Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, Bogomolniy F et al. A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Cancer Res 2008; 68: 5478-5486.
    • (2008) Cancer Res , vol.68 , pp. 5478-5486
    • Bonome, T.1    Levine, D.A.2    Shih, J.3    Randonovich, M.4    Pise-Masison, C.A.5    Bogomolniy, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.