Overexpression of wnt7a is associated with tumor progression and unfavorable prognosis in endometrial cancer

International Journal of Gynecological Cancer

Volumn 23, Issue 2, 2013, Pages 304-311

  Liu, Yunduo ^a   Meng, Fanling ^a   Xu, Ye ^a   Yang, Shanshan ^a   Xiao, Min ^a   Chen, Xiuwei ^a   Lou, Ge ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Endometrial cancer; Immunohistochemistry; Prognosis; Wnt7a

Indexed keywords

WNT7A PROTEIN;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER PROGNOSIS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; ENDOMETRIUM CANCER; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LOG RANK TEST; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION;

ADULT; AGED; CARCINOMA, ENDOMETRIOID; DISEASE PROGRESSION; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; WNT PROTEINS;

EID: 84876244484     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e31827c7708     Document Type: Article

References (20)

1. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
2. Sohaib SA, Houghton SL, Meroni R, et al. Recurrent endometrial cancer: Patterns of recurrent disease and assessment of prognosis. Clin Radiol. 2007;62:28-34.
3. Shiozawa T, Konishi I. Early endometrial carcinoma: Clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment. Int J Clin Oncol. 2006;11:13-21.
4. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005;434:843-850.
5. Yao HH, Matzuk MM, Jorgez CJ, et al. Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn. 2004;230:210-215.
6. Miller C, Degenhardt K, Sassoon DA. Fetal exposure to des results in de-regulation of Wnt7a during uterine morphogenesis. Nat Genet. 1998;20:228-230.
7. Parr BA, McMahon AP. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature. 1998;395:707-710.
8. Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesisVa look outside the nucleus. Science. 2000;287:1606-1609.
9. Boyer A, Goff AK, Boerboom D. Wnt signaling in ovarian follicle biology and tumorigenesis. Trends Endocrinol Metab. 2009;21:25-32.
10. Kirikoshi H, Katoh M. Expression of Wnt7A in human normal tissues and cancer, and regulation of Wnt7A and Wnt7B in human cancer. Int J Oncol. 2002;21:895-900.
11. Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell. 2003;5:367-377.
12. Winn RA, Van Scoyk M, Hammond M, et al. Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. J Biol Chem. 2006;281:26943-26950.
13. Christofori G, Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci. 1999;24:73-76.
14. Tennis MA, Vanscoyk MM, Wilson LA, et al. Methylation of Wnt7a is modulated by DNMT1 and cigarette smoke condensate in non-small cell lung cancer. PLoS One. 2012;7:e32921.
15. Zhang XL, Peng CJ, Peng J, et al. Prognostic role of Wnt7a expression in ovarian carcinoma patients. Neoplasma. 2010;57:545-551.
16. Yoshioka S, King ML, Ran S, et al. Wnt7A regulates tumor growth and progression in ovarian cancer through the Wnt/A-catenin pathway. Mol Cancer Res. 2012;10:469-482.
17. Wagner J, Lehmann L. Estrogens modulate the gene expression of Wnt-7a in cultured endometrial adenocarcinoma cells. Mol Nutr Food Res. 2006;50:368-372.
18. Li S, Chiang TC, Davis GRet alDecreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma. J Clin Endocrinol Metab. 2001;86:454-457.
19. Oehler MK, MacKenzie IZ, Wallwiener D, et al. Wnt-7a is upregulated by norethisterone in human endometrial epithelial cells: A possible mechanism by which progestogens reduce the risk of estrogen-induced endometrial neoplasia. Cancer Lett. 2002;186:75-81.
20. Miller C, Pavlova A, Sassoon DA. Differential expression patterns of Wnt genes in the murine female reproductive tract during development and the estrous cycle. Mech Dev. 1998;76:91-99.