Defective autophagy is a key feature of cerebral cavernous malformations

EMBO Molecular Medicine

Volumn 7, Issue 11, 2015, Pages 1403-1417

  Marchi, Saverio ^a   Corricelli, Mariangela ^a   Trapani, Eliana ^b   Bravi, Luca ^c   Pittaro, Alessandra ^b   Delle Monache, Simona ^d   Ferroni, Letizia ^e   Patergnani, Simone ^a   Missiroli, Sonia ^a   Goitre, Luca ^b   Trabalzini, Lorenza ^f   Rimessi, Alessandro ^a   Giorgi, Carlotta ^a   Zavan, Barbara ^e   Cassoni, Paola ^b   Dejana, Elisabetta ^c   Retta, Saverio Francesco ^b   Pinton, Paolo ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

^f UNIVERSITY OF SIENA   (Italy)

Author keywords

Autophagy; CCM; Endothelial to mesenchymal transition (EndMt); mTOR; ROS

Indexed keywords

CCM2 PROTEIN; CELL PROTEIN; KRIT1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN P62; REGULATOR PROTEIN; ULK1 PROTEIN; UNCLASSIFIED DRUG; KRIT1 PROTEIN, HUMAN; KRIT1 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN;

ABLATION THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CAVERNOUS HEMANGIOMA; CCM2 GENE; CELL STRESS; CONTROLLED STUDY; DISEASE COURSE; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE FUNCTION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; KRIT1 GENE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUALITY CONTROL; ANIMAL; BRAIN HEMANGIOMA; CELL CULTURE; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HEMANGIOMA, CAVERNOUS, CENTRAL NERVOUS SYSTEM; HUMANS; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; PROTO-ONCOGENE PROTEINS;

EID: 84945899173     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201505316     Document Type: Article

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