The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition

Journal of Biological Chemistry

Volumn 290, Issue 5, 2015, Pages 2547-2559

  Singh, Krishna K ^a,b   Lovren, Fina ^a   Pan, Yi ^a   Quan, Adrian ^a   Ramadan, Azza ^a   Matkar, Pratiek N ^a   Ehsan, Mehroz ^a   Sandhu, Paul ^a   Mantella, Laura E ^a   Gupta, Nandini ^a   Teoh, Hwee ^a   Parotto, Matteo ^b   Tabuchi, Arata ^a   Kuebler, Wolfgang M ^a,b,c   Al Omran, Mohammed ^a,b,d   Finkel, Toren ^e   Verma, Subodh ^a,b,d,e  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; COLLAGEN; FIBROBLASTS; GENES;

AUTOPHAGY GENES; BLEOMYCINS; COLLAGEN ACCUMULATION; EXTRACELLULAR MATRIX COMPONENTS; FIBROBLAST PROLIFERATION; PROGRESSIVE DISEASE; PULMONARY FIBROSIS; THERAPEUTIC TARGETS;

ENDOTHELIAL CELLS;

BIOLOGICAL MARKER; BLEOMYCIN; COLLAGEN; TRANSFORMING GROWTH FACTOR BETA; ATG7 PROTEIN, HUMAN; ATG7 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATG7 GENE; AUTOPHAGY; CELL LOSS; CELL STRUCTURE; CELL TRANSFORMATION; DISEASE PREDISPOSITION; ENDOTHELIAL TO MESENCHYMAL TRANSITION; ENDOTHELIUM CELL; ESSENTIAL GENE; GENE LOSS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LUNG FIBROSIS; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL LINE; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MESODERM; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL;

MUS;

ANIMALS; BLEOMYCIN; CELL LINE; ENDOTHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MESODERM; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; PULMONARY FIBROSIS; REAL-TIME POLYMERASE CHAIN REACTION; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84921919189     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.604603     Document Type: Article

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