PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

Neurobiology of Aging

Volumn 34, Issue 3, 2013, Pages 770-790

  Magnaudeix, Amandine ^a   Wilson, Cornelia M ^a,b   Page, Guylène ^c   Bauvy, Chantal ^d   Codogno, Patrice ^d   Lévêque, Philippe ^a   Labrousse, François ^e   Corre Delage, Manuela ^e   Yardin, Catherine ^a,b   Terro, Faraj ^a,b  

^a UNIVERSITY OF LIMOGES   (France)

^b HÔpital de la Mère et de l'Enfant   (France)

^c EA 3808 Cibles moléculaires et Thérapeutique de la maladie d'Alzheimer   (France)

^d INSERM   (France)

^e DUPUYTREN UNIVERSITY HOSPITAL   (France)

Author keywords

Alzheimer's disease; Autophagy; Neuron; PP2A; Protein aggregation

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHOPROTEIN PHOSPHATASE 2A; SHORT HAIRPIN RNA;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BRAIN CELL; CELL STRESS; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; MACROAUTOPHAGY; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; AUTOPHAGY; CELLS, CULTURED; GENE SILENCING; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; PROTEIN PHOSPHATASE 2; RATS; RATS, WISTAR; RNA, SMALL INTERFERING; UBIQUITINATED PROTEINS;

EID: 84870512554     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.06.026     Document Type: Article

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