Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway

Cellular and Molecular Life Sciences

Volumn 72, Issue 22, 2015, Pages 4409-4427

  Vilette, Didier ^a   Laulagnier, Karine ^b,c   Huor, Alvina ^a   Alais, Sandrine ^d   Simoes, Sabrina ^e   Maryse, Romao ^e   Provansal, Monique ^f   Lehmann, Sylvain ^f   Andreoletti, Olivier ^a   Schaeffer, Laurent ^b   Raposo, Graça ^e   Leblanc, Pascal ^b  

^a IHAP   (France)

^b UNIVERSITÉ DE LYON   (France)

^c GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

^d CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

^e INSTITUT CURIE   (France)

^f INSERM   (France)

Author keywords

Ceramide; Cholesterol; ESCRT; Exosomes; Prions; PrPres; PrPSc

Indexed keywords

CERAMIDE; CHOLESTEROL; ESCRT PROTEIN; PRION PROTEIN; PROTEIN ESCRT 0; PROTEIN ESCRT I; PROTEIN HRS; REGULATOR PROTEIN; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; UNCLASSIFIED DRUG; 3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; ANILINE DERIVATIVE; BENZYLIDENE DERIVATIVE; DNA BINDING PROTEIN; PRION; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BIOGENESIS; CELL TRANSPORT; CHOLESTEROL TRANSPORT; EXOSOME; LIPOGENESIS; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SUBUNIT; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CONFOCAL MICROSCOPY; DRUG EFFECTS; ELECTRON MICROSCOPY; GENETICS; HUMAN; IMMUNOBLOTTING; METABOLISM; PRION; PROTEIN TRANSPORT; RABBIT; RNA INTERFERENCE; SECRETION (PROCESS); SHEEP; TRANSGENIC MOUSE; TUMOR CELL LINE; ULTRASTRUCTURE;

ANILINE COMPOUNDS; ANIMALS; BENZYLIDENE COMPOUNDS; CELL LINE; CELL LINE, TUMOR; CERAMIDES; DNA-BINDING PROTEINS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EXOSOMES; HUMANS; IMMUNOBLOTTING; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; PRIONS; PROTEIN TRANSPORT; RABBITS; RNA INTERFERENCE; SHEEP; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84945496202     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1945-8     Document Type: Article

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