메뉴 건너뛰기




Volumn 8, Issue 2, 2012, Pages

Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL SELECTION; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; EX VIVO STUDY; EXOSOME; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNE SYSTEM; IN VITRO STUDY; MAGNETIC ACTIVATED CELL SORTING; MEMBRANE VESICLE; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRION; PRION DISEASE; QUANTITATIVE ANALYSIS; SCRAPIE; STATISTICAL MODEL; T LYMPHOCYTE; VIRUS EXAMINATION; VIRUS RELEASE; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CELL SEPARATION; ELECTRON MICROSCOPY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; SPLEEN; ULTRASTRUCTURE;

EID: 84860914406     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002538     Document Type: Article
Times cited : (40)

References (133)
  • 1
    • 0034916581 scopus 로고    scopus 로고
    • Prion diseases of humans and animals: their causes and molecular basis
    • Collinge J, (2001) Prion diseases of humans and animals: their causes and molecular basis. Annu Rev Neurosci 24: 519-550.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 519-550
    • Collinge, J.1
  • 2
    • 0014190760 scopus 로고
    • Self Replication and scrapie
    • Griffith JS, (1967) Self Replication and scrapie. Nature 215: 1043-1044.
    • (1967) Nature , vol.215 , pp. 1043-1044
    • Griffith, J.S.1
  • 3
    • 0020321767 scopus 로고
    • Novel proteinaceous infectious particles cause scrapie
    • Prusiner SB, (1982) Novel proteinaceous infectious particles cause scrapie. Science 216: 136-144.
    • (1982) Science , vol.216 , pp. 136-144
    • Prusiner, S.B.1
  • 4
    • 0031720905 scopus 로고    scopus 로고
    • Eight prion strains PrPSc molecules with different conformations
    • Safar J, Wille H, Itri V, Groth D, Serban H, et al. (1998) Eight prion strains PrPSc molecules with different conformations. Nat Med 4: 1157-1165.
    • (1998) Nat Med , vol.4 , pp. 1157-1165
    • Safar, J.1    Wille, H.2    Itri, V.3    Groth, D.4    Serban, H.5
  • 5
    • 33846490771 scopus 로고    scopus 로고
    • Proteinase K-sensitive disease-associated ovine prion protein revealed by conformation-dependent immunoassay
    • Thackray AM, Hopkins L, Bujdoso R, (2007) Proteinase K-sensitive disease-associated ovine prion protein revealed by conformation-dependent immunoassay. Biochem J 401: 475-483.
    • (2007) Biochem J , vol.401 , pp. 475-483
    • Thackray, A.M.1    Hopkins, L.2    Bujdoso, R.3
  • 6
    • 0037159185 scopus 로고    scopus 로고
    • Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes
    • Tzaban S, Friedlander G, Schonberger O, Horonchik L, Yedidia Y, et al. (2002) Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes. Biochemistry 41: 12868-12875.
    • (2002) Biochemistry , vol.41 , pp. 12868-12875
    • Tzaban, S.1    Friedlander, G.2    Schonberger, O.3    Horonchik, L.4    Yedidia, Y.5
  • 7
    • 58149280203 scopus 로고    scopus 로고
    • Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin
    • Cronier S, Gros N, Tattum MH, Jackson GS, Clarke AR, et al. (2008) Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin. Biochem J 416: 297-305.
    • (2008) Biochem J , vol.416 , pp. 297-305
    • Cronier, S.1    Gros, N.2    Tattum, M.H.3    Jackson, G.S.4    Clarke, A.R.5
  • 8
    • 78650928306 scopus 로고    scopus 로고
    • Isolation of proteinase k-sensitive prions using pronase e and phosphotungstic Acid
    • D'Castro L, Wenborn A, Gros N, Joiner S, Cronier S, et al. (2010) Isolation of proteinase k-sensitive prions using pronase e and phosphotungstic Acid. PLoS ONE 5: e15679.
    • (2010) PLoS ONE , vol.5
    • D'Castro, L.1    Wenborn, A.2    Gros, N.3    Joiner, S.4    Cronier, S.5
  • 9
    • 0034794703 scopus 로고    scopus 로고
    • Peripheral prion pursuit
    • Aguzzi A, (2001) Peripheral prion pursuit. J Clin Invest 108: 661-662.
    • (2001) J Clin Invest , vol.108 , pp. 661-662
    • Aguzzi, A.1
  • 10
    • 0034891027 scopus 로고    scopus 로고
    • Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion
    • Glatzel M, Heppner FL, Albers KM, Aguzzi A, (2001) Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron 31: 25-34.
    • (2001) Neuron , vol.31 , pp. 25-34
    • Glatzel, M.1    Heppner, F.L.2    Albers, K.M.3    Aguzzi, A.4
  • 11
    • 0031444295 scopus 로고    scopus 로고
    • A crucial role for B cells in neuroinvasive scrapie [see comments]
    • Klein MA, Frigg R, Flechsig E, Raeber AJ, Kalinke U, et al. (1997) A crucial role for B cells in neuroinvasive scrapie [see comments]. Nature 390: 687-690.
    • (1997) Nature , vol.390 , pp. 687-690
    • Klein, M.A.1    Frigg, R.2    Flechsig, E.3    Raeber, A.J.4    Kalinke, U.5
  • 12
    • 0031759918 scopus 로고    scopus 로고
    • PrP expression in B-lymphocytes is not required for prion neuroinvasion
    • Klein M, Frigg R, Raeber A, Flechsig E, Hegyi I, et al. (1998) PrP expression in B-lymphocytes is not required for prion neuroinvasion. Nat Med 4: 1429-1433.
    • (1998) Nat Med , vol.4 , pp. 1429-1433
    • Klein, M.1    Frigg, R.2    Raeber, A.3    Flechsig, E.4    Hegyi, I.5
  • 13
    • 0034686002 scopus 로고    scopus 로고
    • Impaired prion replication in spleens of mice lacking functional follicular dendritic cells
    • Montrasio F, Frigg R, Glatzel M, Klein MA, Mackay F, et al. (2000) Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science 288: 1257-1259.
    • (2000) Science , vol.288 , pp. 1257-1259
    • Montrasio, F.1    Frigg, R.2    Glatzel, M.3    Klein, M.A.4    Mackay, F.5
  • 14
    • 0033930508 scopus 로고    scopus 로고
    • Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie
    • Mabbott NA, Mackay F, Minns F, Bruce ME, (2000) Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nat Med 6: 719-720.
    • (2000) Nat Med , vol.6 , pp. 719-720
    • Mabbott, N.A.1    Mackay, F.2    Minns, F.3    Bruce, M.E.4
  • 15
    • 0021212843 scopus 로고
    • Pathogenesis of mouse scrapie: distribution of agent in the pulp and stroma of infected spleens
    • Clarke MC, Kimberlin RH, (1984) Pathogenesis of mouse scrapie: distribution of agent in the pulp and stroma of infected spleens. Vet Microbiol 9: 215-225.
    • (1984) Vet Microbiol , vol.9 , pp. 215-225
    • Clarke, M.C.1    Kimberlin, R.H.2
  • 16
    • 0024519176 scopus 로고
    • The role of the spleen in the neuroinvasion of scrapie in mice
    • Kimberlin RH, Walker CA, (1989) The role of the spleen in the neuroinvasion of scrapie in mice. Virus Res 12: 201-211.
    • (1989) Virus Res , vol.12 , pp. 201-211
    • Kimberlin, R.H.1    Walker, C.A.2
  • 17
    • 4544224048 scopus 로고    scopus 로고
    • Antiprion immunotherapy: to suppress or to stimulate?
    • Aguzzi A, Sigurdson CJ, (2004) Antiprion immunotherapy: to suppress or to stimulate? Nat Rev Immunol 4: 725-736.
    • (2004) Nat Rev Immunol , vol.4 , pp. 725-736
    • Aguzzi, A.1    Sigurdson, C.J.2
  • 18
    • 0038186806 scopus 로고    scopus 로고
    • PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain
    • Blättler T, Brandner S, Raeber AJ, Klein MA, Voigtländer T, et al. (1997) PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 389: 69-73.
    • (1997) Nature , vol.389 , pp. 69-73
    • Blättler, T.1    Brandner, S.2    Raeber, A.J.3    Klein, M.A.4    Voigtländer, T.5
  • 19
    • 0034953560 scopus 로고    scopus 로고
    • Efficient lymphoreticular prion propagation requires PrPc in stromal and hematopoietic cells
    • Kaeser PS, Klein MA, Schwarz P, Aguzzi A, (2001) Efficient lymphoreticular prion propagation requires PrPc in stromal and hematopoietic cells. J Virol 75: 7097-7106.
    • (2001) J Virol , vol.75 , pp. 7097-7106
    • Kaeser, P.S.1    Klein, M.A.2    Schwarz, P.3    Aguzzi, A.4
  • 20
    • 0019199611 scopus 로고
    • Pathogenesis of mouse scrapie: evidence for neural spread of infection to the CNS
    • Kimberlin RH, Walker CA, (1980) Pathogenesis of mouse scrapie: evidence for neural spread of infection to the CNS. J Gen Virol 51: 183-187.
    • (1980) J Gen Virol , vol.51 , pp. 183-187
    • Kimberlin, R.H.1    Walker, C.A.2
  • 21
    • 0035957340 scopus 로고    scopus 로고
    • B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice
    • Montrasio F, Cozzio A, Flechsig E, Rossi D, Klein MA, et al. (2001) B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice. Proc Natl Acad Sci U S A 98: 4034-4037.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4034-4037
    • Montrasio, F.1    Cozzio, A.2    Flechsig, E.3    Rossi, D.4    Klein, M.A.5
  • 22
    • 0037154263 scopus 로고    scopus 로고
    • Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells
    • Prinz M, Montrasio F, Klein MA, Schwarz P, Priller J, et al. (2002) Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Proc Natl Acad Sci USA 99: 919-924.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 919-924
    • Prinz, M.1    Montrasio, F.2    Klein, M.A.3    Schwarz, P.4    Priller, J.5
  • 23
    • 57449112742 scopus 로고    scopus 로고
    • Lymphotoxin-Dependent Prion Replication in Inflammatory Stromal Cells of Granulomas
    • Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, et al. (2008) Lymphotoxin-Dependent Prion Replication in Inflammatory Stromal Cells of Granulomas. Immunity 29: 998-1008.
    • (2008) Immunity , vol.29 , pp. 998-1008
    • Heikenwalder, M.1    Kurrer, M.O.2    Margalith, I.3    Kranich, J.4    Zeller, N.5
  • 25
    • 0034798246 scopus 로고    scopus 로고
    • Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie
    • Aucouturier P, Geissmann F, Damotte D, Saborio GP, Meeker HC, et al. (2001) Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie. J Clin Invest 108: 703-708.
    • (2001) J Clin Invest , vol.108 , pp. 703-708
    • Aucouturier, P.1    Geissmann, F.2    Damotte, D.3    Saborio, G.P.4    Meeker, H.C.5
  • 26
    • 0015301828 scopus 로고
    • Isolation from mouse spleen of cell populations with high specific infectivity for scrapie virus
    • Lavelle GC, Sturman L, Hadlow WJ, (1972) Isolation from mouse spleen of cell populations with high specific infectivity for scrapie virus. Infect Immun 5: 319-323.
    • (1972) Infect Immun , vol.5 , pp. 319-323
    • Lavelle, G.C.1    Sturman, L.2    Hadlow, W.J.3
  • 27
    • 0033947543 scopus 로고    scopus 로고
    • Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy
    • Jeffrey M, McGovern G, Goodsir CM, Brown KL, Bruce ME, (2000) Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy. J Pathol 191: 323-332.
    • (2000) J Pathol , vol.191 , pp. 323-332
    • Jeffrey, M.1    McGovern, G.2    Goodsir, C.M.3    Brown, K.L.4    Bruce, M.E.5
  • 28
    • 0034068675 scopus 로고    scopus 로고
    • Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis
    • Beringue V, Demoy M, Lasmézas CI, Gouritin B, Weingarten C, et al. (2000) Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis. J Pathol 190: 495-502.
    • (2000) J Pathol , vol.190 , pp. 495-502
    • Beringue, V.1    Demoy, M.2    Lasmézas, C.I.3    Gouritin, B.4    Weingarten, C.5
  • 29
    • 21344472810 scopus 로고    scopus 로고
    • Role of gut macrophages in mice orally contaminated with scrapie or BSE
    • Maignien T, Shakweh M, Calvo P, Marce D, Sales N, et al. (2005) Role of gut macrophages in mice orally contaminated with scrapie or BSE. Int J Pharm 298: 293-304.
    • (2005) Int J Pharm , vol.298 , pp. 293-304
    • Maignien, T.1    Shakweh, M.2    Calvo, P.3    Marce, D.4    Sales, N.5
  • 30
    • 0024580902 scopus 로고
    • Pathogenesis of scrapie in mice after intragastric infection
    • Kimberlin RH, Walker CA, (1989) Pathogenesis of scrapie in mice after intragastric infection. Virus Res 12: 213-220.
    • (1989) Virus Res , vol.12 , pp. 213-220
    • Kimberlin, R.H.1    Walker, C.A.2
  • 31
    • 0032883356 scopus 로고    scopus 로고
    • Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus)
    • Sigurdson CJ, Williams ES, Miller MW, Spraker TR, O'Rourke KI, et al. (1999) Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus). J Gen Virol 80: 2757-2764.
    • (1999) J Gen Virol , vol.80 , pp. 2757-2764
    • Sigurdson, C.J.1    Williams, E.S.2    Miller, M.W.3    Spraker, T.R.4    O'Rourke, K.I.5
  • 32
    • 0034536342 scopus 로고    scopus 로고
    • Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie
    • Andreoletti O, Berthon P, Marc D, Sarradin P, Grosclaude J, et al. (2000) Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie. J Gen Virol 81: 3115-3126.
    • (2000) J Gen Virol , vol.81 , pp. 3115-3126
    • Andreoletti, O.1    Berthon, P.2    Marc, D.3    Sarradin, P.4    Grosclaude, J.5
  • 33
    • 0037377727 scopus 로고    scopus 로고
    • Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes
    • Prinz M, Huber G, Macpherson AJS, Heppner FL, Glatzel M, et al. (2003) Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes. Am J Pathol 162: 1103-1111.
    • (2003) Am J Pathol , vol.162 , pp. 1103-1111
    • Prinz, M.1    Huber, G.2    Macpherson, A.J.S.3    Heppner, F.L.4    Glatzel, M.5
  • 34
    • 0030576516 scopus 로고    scopus 로고
    • Epithelial M cells: Gateways for mucosal infection and immunization
    • Neutra MR, Frey A, Kraehenbuhl JP, (1996) Epithelial M cells: Gateways for mucosal infection and immunization. Cell 86: 345-348.
    • (1996) Cell , vol.86 , pp. 345-348
    • Neutra, M.R.1    Frey, A.2    Kraehenbuhl, J.P.3
  • 35
    • 33646000633 scopus 로고    scopus 로고
    • Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep
    • Jeffrey M, Gonzalez L, Espenes A, Press CM, Martin S, et al. (2006) Transportation of prion protein across the intestinal mucosa of scrapie-susceptible and scrapie-resistant sheep. J Pathol 209: 4-14.
    • (2006) J Pathol , vol.209 , pp. 4-14
    • Jeffrey, M.1    Gonzalez, L.2    Espenes, A.3    Press, C.M.4    Martin, S.5
  • 36
    • 0141593548 scopus 로고    scopus 로고
    • A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions
    • Klohn PC, Stoltze L, Flechsig E, Enari M, Weissmann C, (2003) A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. Proc Natl Acad Sci U S A 100: 11666-11671.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11666-11671
    • Klohn, P.C.1    Stoltze, L.2    Flechsig, E.3    Enari, M.4    Weissmann, C.5
  • 38
    • 79952167224 scopus 로고    scopus 로고
    • Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
    • Sandberg MK, Al Doujaily H, Sharps B, Clarke AR, Collinge J, (2011) Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature 470: 540-542.
    • (2011) Nature , vol.470 , pp. 540-542
    • Sandberg, M.K.1    Al Doujaily, H.2    Sharps, B.3    Clarke, A.R.4    Collinge, J.5
  • 41
    • 77957923715 scopus 로고    scopus 로고
    • Characterization of the role of dendritic cells in prion transfer to primary neurons
    • Langevin C, Gousset K, Costanzo M, Goff ORL, Zurzolo C, (2010) Characterization of the role of dendritic cells in prion transfer to primary neurons. Biochem J 431: 189-198.
    • (2010) Biochem J , vol.431 , pp. 189-198
    • Langevin, C.1    Gousset, K.2    Costanzo, M.3    Goff, O.R.L.4    Zurzolo, C.5
  • 44
    • 0034254524 scopus 로고    scopus 로고
    • Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface
    • Denzer K, van Eijk M, Kleijmeer MJ, Jakobson E, de Groot C, et al. (2000) Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. J Immunol 165: 1259-1265.
    • (2000) J Immunol , vol.165 , pp. 1259-1265
    • Denzer, K.1    van Eijk, M.2    Kleijmeer, M.J.3    Jakobson, E.4    de Groot, C.5
  • 46
    • 0141962590 scopus 로고    scopus 로고
    • Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid
    • Admyre C, Grunewald J, Thyberg J, Gripenback S, Tornling G, et al. (2003) Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J 22: 578-583.
    • (2003) Eur Respir J , vol.22 , pp. 578-583
    • Admyre, C.1    Grunewald, J.2    Thyberg, J.3    Gripenback, S.4    Tornling, G.5
  • 48
    • 35348938217 scopus 로고    scopus 로고
    • Exosomes in urine: Who would have thought.?
    • Knepper MA, Pisitkun T, (2007) Exosomes in urine: Who would have thought.? Kidney Int 72: 1043-1045.
    • (2007) Kidney Int , vol.72 , pp. 1043-1045
    • Knepper, M.A.1    Pisitkun, T.2
  • 49
    • 49249089853 scopus 로고    scopus 로고
    • Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma
    • Almqvist N, Loennqvist A, Hultkrantz S, Rask C, Telemo E, (2008) Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma. Immunology 125: 21-27.
    • (2008) Immunology , vol.125 , pp. 21-27
    • Almqvist, N.1    Loennqvist, A.2    Hultkrantz, S.3    Rask, C.4    Telemo, E.5
  • 52
    • 84934440773 scopus 로고    scopus 로고
    • Assaying Prions in Cell Culture: The Standard Scrapie Cell Assay (SSCA) and the Scrapie Cell Assay in End Point Format (SCEPA)
    • Mahal SP, Demczyk CA, Smith EW Jr, Klohn PC, Weissmann C, (2008) Assaying Prions in Cell Culture: The Standard Scrapie Cell Assay (SSCA) and the Scrapie Cell Assay in End Point Format (SCEPA). Methods Mol Biol 459: 49-68.
    • (2008) Methods Mol Biol , vol.459 , pp. 49-68
    • Mahal, S.P.1    Demczyk, C.A.2    Smith Jr., E.W.3    Klohn, P.C.4    Weissmann, C.5
  • 53
    • 3142683548 scopus 로고    scopus 로고
    • TL-139-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    • Krug A, French AR, Barchet W, Fischer JAA, Dzionek A, et al. (2004) TL-139-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21: 107-119.
    • (2004) Immunity , vol.21 , pp. 107-119
    • Krug, A.1    French, A.R.2    Barchet, W.3    Fischer, J.A.A.4    Dzionek, A.5
  • 55
    • 0001147282 scopus 로고
    • Animal virus titration techniques
    • Dougherty RM, (1964) Animal virus titration techniques. Tech Exp Virol pp. 183-186.
    • (1964) Tech Exp Virol , pp. 183-186
    • Dougherty, R.M.1
  • 56
    • 1142285202 scopus 로고    scopus 로고
    • Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents
    • Vorberg I, Raines A, Story B, Priola SA, (2004) Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. J Infect Dis 189: 431-439.
    • (2004) J Infect Dis , vol.189 , pp. 431-439
    • Vorberg, I.1    Raines, A.2    Story, B.3    Priola, S.A.4
  • 57
    • 0033577717 scopus 로고    scopus 로고
    • PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice
    • Raeber AJ, Klein MA, Frigg R, Flechsig E, Aguzzi A, et al. (1999) PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. EMBO J 18: 2702-2706.
    • (1999) EMBO J , vol.18 , pp. 2702-2706
    • Raeber, A.J.1    Klein, M.A.2    Frigg, R.3    Flechsig, E.4    Aguzzi, A.5
  • 59
    • 0024519176 scopus 로고
    • The Role of the Spleen in the Neuroinvasion of Scrapie in Mice
    • Kimberlin RH, Walker CA, (1989) The Role of the Spleen in the Neuroinvasion of Scrapie in Mice. Virus Res 12: 201-211.
    • (1989) Virus Res , vol.12 , pp. 201-211
    • Kimberlin, R.H.1    Walker, C.A.2
  • 60
    • 0033577717 scopus 로고    scopus 로고
    • PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice
    • Raeber AJ, Klein MA, Frigg R, Flechsig E, Aguzzi A, et al. (1999) PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. EMBO J 18: 2702-2706.
    • (1999) EMBO J , vol.18 , pp. 2702-2706
    • Raeber, A.J.1    Klein, M.A.2    Frigg, R.3    Flechsig, E.4    Aguzzi, A.5
  • 61
    • 33750372639 scopus 로고    scopus 로고
    • Prion protein expression by mouse dendritic cells is restricted to the nonplasmacytoid subsets and correlates with the maturation state
    • del Hoyo GM, Lopez-Bravo M, Metharom P, Ardavin C, Aucouturier P, (2006) Prion protein expression by mouse dendritic cells is restricted to the nonplasmacytoid subsets and correlates with the maturation state. J Immunol 177: 6137-6142.
    • (2006) J Immunol , vol.177 , pp. 6137-6142
    • del Hoyo, G.M.1    Lopez-Bravo, M.2    Metharom, P.3    Ardavin, C.4    Aucouturier, P.5
  • 62
    • 33646447972 scopus 로고    scopus 로고
    • Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells
    • Rybner-Barnier C, Jacquemot C, Cuche C, Dore G, Majlessi L, et al. (2006) Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells. J Virol 80: 4656-4663.
    • (2006) J Virol , vol.80 , pp. 4656-4663
    • Rybner-Barnier, C.1    Jacquemot, C.2    Cuche, C.3    Dore, G.4    Majlessi, L.5
  • 63
    • 3543092761 scopus 로고    scopus 로고
    • The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy
    • Brown P, Rohwer RG, Dunstan BC, MacAuley C, Gajdusek DC, et al. (1998) The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy. Transfusion 38: 810-816.
    • (1998) Transfusion , vol.38 , pp. 810-816
    • Brown, P.1    Rohwer, R.G.2    Dunstan, B.C.3    MacAuley, C.4    Gajdusek, D.C.5
  • 64
    • 0036561118 scopus 로고    scopus 로고
    • Brain and buffy coat transmission of bovine spongiform encephalopathy to the primate Microcebus murinus
    • Bons N, Lehmann S, Mestre-Frances N, Dormont D, Brown P, (2002) Brain and buffy coat transmission of bovine spongiform encephalopathy to the primate Microcebus murinus. Transfusion 42: 513-516.
    • (2002) Transfusion , vol.42 , pp. 513-516
    • Bons, N.1    Lehmann, S.2    Mestre-Frances, N.3    Dormont, D.4    Brown, P.5
  • 65
    • 0345165981 scopus 로고    scopus 로고
    • Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy
    • Cervenakova L, Yakovleva O, McKenzie C, Kolchinsky S, McShane L, et al. (2003) Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy. Transfusion 43: 1687-1694.
    • (2003) Transfusion , vol.43 , pp. 1687-1694
    • Cervenakova, L.1    Yakovleva, O.2    McKenzie, C.3    Kolchinsky, S.4    McShane, L.5
  • 66
    • 24744446203 scopus 로고    scopus 로고
    • Detection of prions in blood
    • Castilla J, Saa P, Soto C, (2005) Detection of prions in blood. Nat Med 11: 982-985.
    • (2005) Nat Med , vol.11 , pp. 982-985
    • Castilla, J.1    Saa, P.2    Soto, C.3
  • 67
    • 33745879463 scopus 로고    scopus 로고
    • Presymptomatic detection of prions in blood
    • Saa P, Castilla J, Soto C, (2006) Presymptomatic detection of prions in blood. Science 313: 92-94.
    • (2006) Science , vol.313 , pp. 92-94
    • Saa, P.1    Castilla, J.2    Soto, C.3
  • 68
    • 77951690405 scopus 로고    scopus 로고
    • Discrimination between prion-infected and normal blood samples by protein misfolding cyclic amplification
    • Tattum MH, Jones S, Pal S, Collinge J, Jackson GS, (2010) Discrimination between prion-infected and normal blood samples by protein misfolding cyclic amplification. Transfusion 50: 996-1002.
    • (2010) Transfusion , vol.50 , pp. 996-1002
    • Tattum, M.H.1    Jones, S.2    Pal, S.3    Collinge, J.4    Jackson, G.S.5
  • 70
    • 0018103381 scopus 로고
    • Suppression of Polyclonal B-Cell Activation in Scrapie-Infected C3H-Hej Mice
    • Garfin DE, Stites DP, Zitnik LA, Prusiner SB, (1978) Suppression of Polyclonal B-Cell Activation in Scrapie-Infected C3H-Hej Mice. J Immunol 120: 1986-1990.
    • (1978) J Immunol , vol.120 , pp. 1986-1990
    • Garfin, D.E.1    Stites, D.P.2    Zitnik, L.A.3    Prusiner, S.B.4
  • 71
    • 0019508185 scopus 로고
    • Evidence for Normal Cell-Mediated-Immunity in Scrapie-Infected Mice
    • Kingsbury DT, Smeltzer DA, Gibbs CJ, Gajdusek DC, (1981) Evidence for Normal Cell-Mediated-Immunity in Scrapie-Infected Mice. Infect Immun 32: 1176-1180.
    • (1981) Infect Immun , vol.32 , pp. 1176-1180
    • Kingsbury, D.T.1    Smeltzer, D.A.2    Gibbs, C.J.3    Gajdusek, D.C.4
  • 73
    • 1442302400 scopus 로고    scopus 로고
    • Murine scrapie infection causes an abnormal germinal centre reaction in the spleen
    • McGovern G, Brown KL, Bruce ME, Jeffrey M, (2004) Murine scrapie infection causes an abnormal germinal centre reaction in the spleen. J Comp Pathol 130: 181-194.
    • (2004) J Comp Pathol , vol.130 , pp. 181-194
    • McGovern, G.1    Brown, K.L.2    Bruce, M.E.3    Jeffrey, M.4
  • 74
    • 68749109338 scopus 로고    scopus 로고
    • CD21 B cell populations are altered following subcutaneous scrapie inoculation in sheep
    • Eaton SL, Anderson MJ, Hamilton S, Gonzalez L, Sales J, et al. (2009) CD21 B cell populations are altered following subcutaneous scrapie inoculation in sheep. Vet Immunol Immunopathol 131: 105-109.
    • (2009) Vet Immunol Immunopathol , vol.131 , pp. 105-109
    • Eaton, S.L.1    Anderson, M.J.2    Hamilton, S.3    Gonzalez, L.4    Sales, J.5
  • 75
    • 33947709328 scopus 로고    scopus 로고
    • Packaging of prions into exosomes is associated with a novel pathway of PrP processing
    • Vella L, Sharples R, Lawson V, Masters C, Cappai R, et al. (2007) Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol 211: 582-590.
    • (2007) J Pathol , vol.211 , pp. 582-590
    • Vella, L.1    Sharples, R.2    Lawson, V.3    Masters, C.4    Cappai, R.5
  • 76
    • 53349177064 scopus 로고    scopus 로고
    • Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles
    • Alais S, Simoes S, Baas D, Lehmann S, Raposo G, et al. (2008) Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles. Biol Cell 100: 603-615.
    • (2008) Biol Cell , vol.100 , pp. 603-615
    • Alais, S.1    Simoes, S.2    Baas, D.3    Lehmann, S.4    Raposo, G.5
  • 77
    • 0023645106 scopus 로고
    • Vesicle Formation During Reticulocyte Maturation - Association of Plasma-Membrane Activities with Released Vesicles (Exosomes)
    • Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C, (1987) Vesicle Formation During Reticulocyte Maturation- Association of Plasma-Membrane Activities with Released Vesicles (Exosomes). J Biol Chem 262: 9412-9420.
    • (1987) J Biol Chem , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 79
    • 21744435080 scopus 로고    scopus 로고
    • Cell biology - The ins and outs of exosomes
    • Couzin J, (2005) Cell biology- The ins and outs of exosomes. Science 308: 1862-1863.
    • (2005) Science , vol.308 , pp. 1862-1863
    • Couzin, J.1
  • 81
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: Composition, biogenesis and function
    • Thery C, Zitvogel L, Amigorena S, (2002) Exosomes: Composition, biogenesis and function. Nat Rev Immunol 2: 569-579.
    • (2002) Nat Rev Immunol , vol.2 , pp. 569-579
    • Thery, C.1    Zitvogel, L.2    Amigorena, S.3
  • 82
    • 0040089526 scopus 로고    scopus 로고
    • Molecular characterization of dendritic cell-derived exosomes: Selective accumulation of the heat shock protein hsc73
    • Thery C, Regnault A, Garin J, Wolfers J, Zitvogel L, et al. (1999) Molecular characterization of dendritic cell-derived exosomes: Selective accumulation of the heat shock protein hsc73. J Cell Biol 147: 599-610.
    • (1999) J Cell Biol , vol.147 , pp. 599-610
    • Thery, C.1    Regnault, A.2    Garin, J.3    Wolfers, J.4    Zitvogel, L.5
  • 83
    • 39549098142 scopus 로고    scopus 로고
    • Different types of in vitro generated human monocyte-derived dendritic cells release exosomes with distinct phenotypes
    • Johansson SM, Admyre C, Scheynius A, Gabrielsson S, (2008) Different types of in vitro generated human monocyte-derived dendritic cells release exosomes with distinct phenotypes. Immunology 123: 491-499.
    • (2008) Immunology , vol.123 , pp. 491-499
    • Johansson, S.M.1    Admyre, C.2    Scheynius, A.3    Gabrielsson, S.4
  • 84
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, et al. (2001) Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 7: 297-303.
    • (2001) Nat Med , vol.7 , pp. 297-303
    • Wolfers, J.1    Lozier, A.2    Raposo, G.3    Regnault, A.4    Thery, C.5
  • 85
    • 0034689004 scopus 로고    scopus 로고
    • The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
    • Inaba K, Turley S, Iyoda T, Yamaide F, Shimoyama S, et al. (2000) The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J Exp Med 191: 927-936.
    • (2000) J Exp Med , vol.191 , pp. 927-936
    • Inaba, K.1    Turley, S.2    Iyoda, T.3    Yamaide, F.4    Shimoyama, S.5
  • 87
    • 34948874323 scopus 로고    scopus 로고
    • T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes
    • Muntasell A, Berger AC, Roche PA, (2007) T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes. EMBO J 26: 4263-4272.
    • (2007) EMBO J , vol.26 , pp. 4263-4272
    • Muntasell, A.1    Berger, A.C.2    Roche, P.A.3
  • 88
    • 70350681050 scopus 로고    scopus 로고
    • Paracrine induction of endothelium by tumor exosomes
    • Hood JL, Pan H, Lanza GM, Wickline SA, (2009) Paracrine induction of endothelium by tumor exosomes. Lab Invest 89: 1317-1328.
    • (2009) Lab Invest , vol.89 , pp. 1317-1328
    • Hood, J.L.1    Pan, H.2    Lanza, G.M.3    Wickline, S.A.4
  • 89
    • 75149125508 scopus 로고    scopus 로고
    • The role of microparticles in the pathogenesis of rheumatic diseases
    • Beyer C, Pisetsky DS, (2010) The role of microparticles in the pathogenesis of rheumatic diseases. Nat Rev Rheumatol 6: 21-29.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 21-29
    • Beyer, C.1    Pisetsky, D.S.2
  • 90
    • 33747869842 scopus 로고    scopus 로고
    • Host cell responses of Salmonella typhimurium infected human dendritic cells
    • Kiama SG, Dreher D, Cochand L, Kok M, Obregon C, et al. (2006) Host cell responses of Salmonella typhimurium infected human dendritic cells. Immunol Cell Biol 84: 475-481.
    • (2006) Immunol Cell Biol , vol.84 , pp. 475-481
    • Kiama, S.G.1    Dreher, D.2    Cochand, L.3    Kok, M.4    Obregon, C.5
  • 91
    • 33748147424 scopus 로고    scopus 로고
    • Circulating microparticles - A potential prognostic marker for atherosclerotic vascular disease
    • Boulanger CM, Amabile N, Tedgui A, (2006) Circulating microparticles- A potential prognostic marker for atherosclerotic vascular disease. Hypertension 48: 180-186.
    • (2006) Hypertension , vol.48 , pp. 180-186
    • Boulanger, C.M.1    Amabile, N.2    Tedgui, A.3
  • 92
    • 37349104035 scopus 로고    scopus 로고
    • Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis
    • Schiller M, Bekeredjian-Ding I, Heyder P, Blank N, Ho AD, et al. (2008) Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis. Cell Death Differ 15: 183-191.
    • (2008) Cell Death Differ , vol.15 , pp. 183-191
    • Schiller, M.1    Bekeredjian-Ding, I.2    Heyder, P.3    Blank, N.4    Ho, A.D.5
  • 93
    • 33751549663 scopus 로고    scopus 로고
    • TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway
    • Calzolari A, Raggi C, Deaglio S, Sposi NM, Stafsnes M, et al. (2006) TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway. J Cell Sci 119: 4486-4498.
    • (2006) J Cell Sci , vol.119 , pp. 4486-4498
    • Calzolari, A.1    Raggi, C.2    Deaglio, S.3    Sposi, N.M.4    Stafsnes, M.5
  • 94
    • 0037111302 scopus 로고    scopus 로고
    • Release and intercellular transfer of cell surface CD81 via microparticles
    • Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, et al. (2002) Release and intercellular transfer of cell surface CD81 via microparticles. J Immunol 169: 5531-5537.
    • (2002) J Immunol , vol.169 , pp. 5531-5537
    • Fritzsching, B.1    Schwer, B.2    Kartenbeck, J.3    Pedal, A.4    Horejsi, V.5
  • 96
    • 65449117971 scopus 로고    scopus 로고
    • High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients
    • Logozzi M, De Milito A, Lugini L, Borghi M, Calabro L, et al. (2009) High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients. PLoS ONE 4: e5219.
    • (2009) PLoS ONE , vol.4
    • Logozzi, M.1    de Milito, A.2    Lugini, L.3    Borghi, M.4    Calabro, L.5
  • 97
    • 0020522298 scopus 로고
    • Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes
    • Kuroda Y, Gibbs CJ Jr, Amyx HL, Gajdusek DC, (1983) Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes. Infect Immun 41: 154-161.
    • (1983) Infect Immun , vol.41 , pp. 154-161
    • Kuroda, Y.1    Gibbs Jr., C.J.2    Amyx, H.L.3    Gajdusek, D.C.4
  • 98
    • 0034068675 scopus 로고    scopus 로고
    • Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis
    • Beringue V, Demoy M, Lasmezas CI, Gouritin B, Weingarten C, et al. (2000) Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis. J Pathol 190: 495-502.
    • (2000) J Pathol , vol.190 , pp. 495-502
    • Beringue, V.1    Demoy, M.2    Lasmezas, C.I.3    Gouritin, B.4    Weingarten, C.5
  • 99
    • 0034798246 scopus 로고    scopus 로고
    • Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie
    • Aucouturier P, Geissmann F, Damotte D, Saborio GP, Meeker HC, et al. (2001) Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie. J Clin Invest 108: 703-708.
    • (2001) J Clin Invest , vol.108 , pp. 703-708
    • Aucouturier, P.1    Geissmann, F.2    Damotte, D.3    Saborio, G.P.4    Meeker, H.C.5
  • 100
    • 0037154263 scopus 로고    scopus 로고
    • Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells
    • Prinz M, Montrasio F, Klein MA, Schwarz P, Priller J, et al. (2002) Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Proc Natl Acad Sci U S A 99: 919-924.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 919-924
    • Prinz, M.1    Montrasio, F.2    Klein, M.A.3    Schwarz, P.4    Priller, J.5
  • 101
    • 0035979274 scopus 로고    scopus 로고
    • Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody
    • Enari M, Flechsig E, Weissmann C, (2001) Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci U S A 98: 9295-9299.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9295-9299
    • Enari, M.1    Flechsig, E.2    Weissmann, C.3
  • 102
    • 1142285202 scopus 로고    scopus 로고
    • Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents
    • Vorberg I, Raines A, Story B, Priola SA, (2004) Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. J Infect Dis 189: 431-439.
    • (2004) J Infect Dis , vol.189 , pp. 431-439
    • Vorberg, I.1    Raines, A.2    Story, B.3    Priola, S.A.4
  • 103
    • 0346366990 scopus 로고    scopus 로고
    • Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody
    • Asselin-Paturel C, Brizard G, Pin JJ, Briere F, Trinchieri G, (2003) Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol 171: 6466-6477.
    • (2003) J Immunol , vol.171 , pp. 6466-6477
    • Asselin-Paturel, C.1    Brizard, G.2    Pin, J.J.3    Briere, F.4    Trinchieri, G.5
  • 104
    • 33645078915 scopus 로고    scopus 로고
    • Natural killer cell behavior in lymph nodes revealed by static and real-time imaging
    • Bajenoff M, Breart B, Huang AYC, Qi H, Cazareth J, et al. (2006) Natural killer cell behavior in lymph nodes revealed by static and real-time imaging. J Exp Med 203: 619-631.
    • (2006) J Exp Med , vol.203 , pp. 619-631
    • Bajenoff, M.1    Breart, B.2    Huang, A.Y.C.3    Qi, H.4    Cazareth, J.5
  • 105
    • 11844268647 scopus 로고    scopus 로고
    • The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions
    • Gerosa F, Gobbi A, Zorzi P, Burg S, Briere F, et al. (2005) The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions. J Immunol 174: 727-734.
    • (2005) J Immunol , vol.174 , pp. 727-734
    • Gerosa, F.1    Gobbi, A.2    Zorzi, P.3    Burg, S.4    Briere, F.5
  • 106
    • 34247100277 scopus 로고    scopus 로고
    • Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    • Lucas M, Schachterle W, Oberle K, Aichele P, Diefenbach A, (2007) Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26: 503-517.
    • (2007) Immunity , vol.26 , pp. 503-517
    • Lucas, M.1    Schachterle, W.2    Oberle, K.3    Aichele, P.4    Diefenbach, A.5
  • 107
    • 0031849974 scopus 로고    scopus 로고
    • Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
    • Dieu MC, Vanbervliet B, Vicari A, Bridon JM, Oldham E, et al. (1998) Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 188: 373-386.
    • (1998) J Exp Med , vol.188 , pp. 373-386
    • Dieu, M.C.1    Vanbervliet, B.2    Vicari, A.3    Bridon, J.M.4    Oldham, E.5
  • 108
    • 0025085995 scopus 로고
    • Antigen Processing by Epidermal Langerhans Cells Correlates with the Level of Biosynthesis of Major Histocompatibility Complex Class-Ii Molecules and Expression of Invariant Chain
    • Pure E, Inaba K, Crowley MT, Tardelli L, Witmerpack MD, et al. (1990) Antigen Processing by Epidermal Langerhans Cells Correlates with the Level of Biosynthesis of Major Histocompatibility Complex Class-Ii Molecules and Expression of Invariant Chain. J Exp Med 172: 1459-1469.
    • (1990) J Exp Med , vol.172 , pp. 1459-1469
    • Pure, E.1    Inaba, K.2    Crowley, M.T.3    Tardelli, L.4    Witmerpack, M.D.5
  • 109
    • 20244377997 scopus 로고    scopus 로고
    • CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells
    • Marsland BJ, Battig P, Bauer M, Ruedl C, Lassing U, et al. (2005) CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity 22: 493-505.
    • (2005) Immunity , vol.22 , pp. 493-505
    • Marsland, B.J.1    Battig, P.2    Bauer, M.3    Ruedl, C.4    Lassing, U.5
  • 110
    • 0035862332 scopus 로고    scopus 로고
    • Mice lacking expression of the chemokines CCL21-Ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses
    • Mori S, Nakano H, Aritomi K, Wang CR, Gunn MD, et al. (2001) Mice lacking expression of the chemokines CCL21-Ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J Exp Med 193: 207-217.
    • (2001) J Exp Med , vol.193 , pp. 207-217
    • Mori, S.1    Nakano, H.2    Aritomi, K.3    Wang, C.R.4    Gunn, M.D.5
  • 111
    • 34547581678 scopus 로고    scopus 로고
    • Experimental scrapie in 'plt' mice: an assessment of the role of dendritic-cell migration in the pathogenesis of prion diseases
    • Levavasseur E, Metharom P, Dorban G, Nakano H, Kakiuchi T, et al. (2007) Experimental scrapie in 'plt' mice: an assessment of the role of dendritic-cell migration in the pathogenesis of prion diseases. J Gen Virol 88: 2353-2360.
    • (2007) J Gen Virol , vol.88 , pp. 2353-2360
    • Levavasseur, E.1    Metharom, P.2    Dorban, G.3    Nakano, H.4    Kakiuchi, T.5
  • 112
    • 13844259181 scopus 로고    scopus 로고
    • Chronic lymphocytic inflammation specifies the organ tropism of prions
    • Heikenwalder M, Zeller N, Seeger H, Prinz M, Klohn PC, et al. (2005) Chronic lymphocytic inflammation specifies the organ tropism of prions. Science 307: 1107-1110.
    • (2005) Science , vol.307 , pp. 1107-1110
    • Heikenwalder, M.1    Zeller, N.2    Seeger, H.3    Prinz, M.4    Klohn, P.C.5
  • 113
    • 45549095991 scopus 로고    scopus 로고
    • Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis
    • Bailey-Bucktrout SL, Caulkins SC, Goings G, Fischer JAA, Dzionek A, et al. (2008) Central nervous system plasmacytoid dendritic cells regulate the severity of relapsing experimental autoimmune encephalomyelitis. J Immunol 180: 6457-6461.
    • (2008) J Immunol , vol.180 , pp. 6457-6461
    • Bailey-Bucktrout, S.L.1    Caulkins, S.C.2    Goings, G.3    Fischer, J.A.A.4    Dzionek, A.5
  • 114
    • 35348849521 scopus 로고    scopus 로고
    • Fatal neurological disease in scrapie-infected mice induced for experimental autoimmune encephalomyelitis
    • Friedman-Levi Y, Ovadia H, Hoftberger R, Einstein O, Abramsky O, et al. (2007) Fatal neurological disease in scrapie-infected mice induced for experimental autoimmune encephalomyelitis. J Virol 81: 9942-9949.
    • (2007) J Virol , vol.81 , pp. 9942-9949
    • Friedman-Levi, Y.1    Ovadia, H.2    Hoftberger, R.3    Einstein, O.4    Abramsky, O.5
  • 116
    • 30044447736 scopus 로고    scopus 로고
    • Immune cell migration in inflammation: present and future therapeutic targets
    • Luster AD, Alon R, von Andrian UH, (2005) Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 6: 1182-1190.
    • (2005) Nat Immunol , vol.6 , pp. 1182-1190
    • Luster, A.D.1    Alon, R.2    von Andrian, U.H.3
  • 118
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes
    • Zitvogel L, Regnault A, Lozier A, Wolfers J, Flament C, et al. (1998) Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med 4: 594-600.
    • (1998) Nat Med , vol.4 , pp. 594-600
    • Zitvogel, L.1    Regnault, A.2    Lozier, A.3    Wolfers, J.4    Flament, C.5
  • 119
    • 70350593773 scopus 로고    scopus 로고
    • Exosomes in tumour immunity
    • Clayton A, Mason MD, (2009) Exosomes in tumour immunity. Curr Oncol 16: 187-190.
    • (2009) Curr Oncol , vol.16 , pp. 187-190
    • Clayton, A.1    Mason, M.D.2
  • 123
    • 33644927263 scopus 로고    scopus 로고
    • Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
    • Booth AM, Fang Y, Fallon JK, Yang JM, Hildreth JEK, et al. (2006) Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J Cell Biol 172: 923-935.
    • (2006) J Cell Biol , vol.172 , pp. 923-935
    • Booth, A.M.1    Fang, Y.2    Fallon, J.K.3    Yang, J.M.4    Hildreth, J.E.K.5
  • 124
    • 33745565356 scopus 로고    scopus 로고
    • Retrovirus infection strongly enhances scrapie infectivity release in cell culture
    • Leblanc P, Alais S, Porto-Carreiro I, Lehmann S, Grassi J, et al. (2006) Retrovirus infection strongly enhances scrapie infectivity release in cell culture. EMBO J 25: 2674-2685.
    • (2006) EMBO J , vol.25 , pp. 2674-2685
    • Leblanc, P.1    Alais, S.2    Porto-Carreiro, I.3    Lehmann, S.4    Grassi, J.5
  • 125
    • 77952648551 scopus 로고    scopus 로고
    • Cell-Produced alpha-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
    • Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, et al. (2010) Cell-Produced alpha-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival. J Neurosci 30: 6838-6851.
    • (2010) J Neurosci , vol.30 , pp. 6838-6851
    • Emmanouilidou, E.1    Melachroinou, K.2    Roumeliotis, T.3    Garbis, S.D.4    Ntzouni, M.5
  • 126
    • 33746593662 scopus 로고    scopus 로고
    • Alzheimer's disease beta-amyloid peptides are released in association with exosomes
    • Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, et al. (2006) Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A 103: 11172-11177.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11172-11177
    • Rajendran, L.1    Honsho, M.2    Zahn, T.R.3    Keller, P.4    Geiger, K.D.5
  • 128
    • 53549121429 scopus 로고    scopus 로고
    • The cellular prion protein is preferentially expressed by CD4(+) CD25(+) Foxp3(+) regulatory T cells
    • Isaacs JD, Garden OA, Kaur G, Collinge J, Jackson GS, et al. (2008) The cellular prion protein is preferentially expressed by CD4(+) CD25(+) Foxp3(+) regulatory T cells. Immunology 125: 313-319.
    • (2008) Immunology , vol.125 , pp. 313-319
    • Isaacs, J.D.1    Garden, O.A.2    Kaur, G.3    Collinge, J.4    Jackson, G.S.5
  • 129
    • 0026528275 scopus 로고
    • Follicular Dendritic Cell-Dependent Adhesion and Proliferation of B-Cells Invitro
    • Kosco MH, Pflugfelder E, Gray D, (1992) Follicular Dendritic Cell-Dependent Adhesion and Proliferation of B-Cells Invitro. J Immunol 148: 2331-2339.
    • (1992) J Immunol , vol.148 , pp. 2331-2339
    • Kosco, M.H.1    Pflugfelder, E.2    Gray, D.3
  • 130
    • 3142683548 scopus 로고    scopus 로고
    • TL-139-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    • Krug A, French AR, Barchet W, Fischer JAA, Dzionek A, et al. (2004) TL-139-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21: 107-119.
    • (2004) Immunity , vol.21 , pp. 107-119
    • Krug, A.1    French, A.R.2    Barchet, W.3    Fischer, J.A.A.4    Dzionek, A.5
  • 132
    • 0029863648 scopus 로고    scopus 로고
    • Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie
    • Fischer M, Rulicke T, Raeber A, Sailer A, Moser M, et al. (1996) Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J 15: 1255-1264.
    • (1996) EMBO J , vol.15 , pp. 1255-1264
    • Fischer, M.1    Rulicke, T.2    Raeber, A.3    Sailer, A.4    Moser, M.5
  • 133
    • 0035928432 scopus 로고    scopus 로고
    • Tissue distribution of protease resistant prion protein in variant CJD using a highly sensitive immuno-blotting assay
    • Wadsworth JD, Joiner S, Hill AF, Campbell TA, Desbruslais M, et al. (2001) Tissue distribution of protease resistant prion protein in variant CJD using a highly sensitive immuno-blotting assay. Lancet 358: 171-180.
    • (2001) Lancet , vol.358 , pp. 171-180
    • Wadsworth, J.D.1    Joiner, S.2    Hill, A.F.3    Campbell, T.A.4    Desbruslais, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.