-
1
-
-
0034940160
-
Neurodegenerative tauopathies
-
Lee, V. M., Goedert, M., and Trojanowski, J. Q. (2001) Neurodegenerative tauopathies Annu. Rev. Neurosci. 24, 1121-1159
-
(2001)
Annu. Rev. Neurosci.
, vol.24
, pp. 1121-1159
-
-
Lee, V.M.1
Goedert, M.2
Trojanowski, J.Q.3
-
2
-
-
84877906835
-
Tau pathology and neurodegeneration
-
Spillantini, M. G. and Goedert, M. (2013) Tau pathology and neurodegeneration Lancet Neurol. 12, 609-622
-
(2013)
Lancet Neurol.
, vol.12
, pp. 609-622
-
-
Spillantini, M.G.1
Goedert, M.2
-
3
-
-
84861758226
-
Trans-cellular Propagation of Tau Aggregation by Fibrillar Species
-
Kfoury, N., Holmes, B. B., Jiang, H., Holtzman, D. M., and Diamond, M. I. (2012) Trans-cellular Propagation of Tau Aggregation by Fibrillar Species J. Biol. Chem. 287, 19440-19451
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 19440-19451
-
-
Kfoury, N.1
Holmes, B.B.2
Jiang, H.3
Holtzman, D.M.4
Diamond, M.I.5
-
4
-
-
84857275902
-
Propagation of tau pathology in a model of early Alzheimer's disease
-
de Calignon, A., Polydoro, M., Suarez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., Spires-Jones, T. L., and Hyman, B. T. (2012) Propagation of tau pathology in a model of early Alzheimer's disease Neuron 73, 685-697
-
(2012)
Neuron
, vol.73
, pp. 685-697
-
-
De Calignon, A.1
Polydoro, M.2
Suarez-Calvet, M.3
William, C.4
Adamowicz, D.H.5
Kopeikina, K.J.6
Pitstick, R.7
Sahara, N.8
Ashe, K.H.9
Carlson, G.A.10
Spires-Jones, T.L.11
Hyman, B.T.12
-
5
-
-
84856454190
-
Trans-synaptic spread of tau pathology in vivo
-
Liu, L., Drouet, V., Wu, J. W., Witter, M. P., Small, S. A., Clelland, C., and Duff, K. (2012) Trans-synaptic spread of tau pathology in vivo PLoS One 7, e31302
-
(2012)
PLoS One
, vol.7
-
-
Liu, L.1
Drouet, V.2
Wu, J.W.3
Witter, M.P.4
Small, S.A.5
Clelland, C.6
Duff, K.7
-
6
-
-
84878723720
-
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
-
Clavaguera, F., Akatsu, H., Fraser, G., Crowther, R. A., Frank, S., Hench, J., Probst, A., Winkler, D. T., Reichwald, J., Staufenbiel, M., Ghetti, B., Goedert, M., and Tolnay, M. (2013) Brain homogenates from human tauopathies induce tau inclusions in mouse brain Proc. Natl. Acad. Sci. U.S.A. 110, 9535-9540
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 9535-9540
-
-
Clavaguera, F.1
Akatsu, H.2
Fraser, G.3
Crowther, R.A.4
Frank, S.5
Hench, J.6
Probst, A.7
Winkler, D.T.8
Reichwald, J.9
Staufenbiel, M.10
Ghetti, B.11
Goedert, M.12
Tolnay, M.13
-
7
-
-
84872346089
-
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy
-
Iba, M., Guo, J. L., McBride, J. D., Zhang, B., Trojanowski, J. Q., and Lee, V. M. (2013) Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy J. Neurosci. 33, 1024-1037
-
(2013)
J. Neurosci.
, vol.33
, pp. 1024-1037
-
-
Iba, M.1
Guo, J.L.2
McBride, J.D.3
Zhang, B.4
Trojanowski, J.Q.5
Lee, V.M.6
-
8
-
-
67650077008
-
Transmission and spreading of tauopathy in transgenic mouse brain
-
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., Jucker, M., Goedert, M., and Tolnay, M. (2009) Transmission and spreading of tauopathy in transgenic mouse brain Nat. Cell Biol. 11, 909-913
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 909-913
-
-
Clavaguera, F.1
Bolmont, T.2
Crowther, R.A.3
Abramowski, D.4
Frank, S.5
Probst, A.6
Fraser, G.7
Stalder, A.K.8
Beibel, M.9
Staufenbiel, M.10
Jucker, M.11
Goedert, M.12
Tolnay, M.13
-
10
-
-
0003986552
-
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease
-
Wischik, C. M., Novak, M., Thogersen, H. C., Edwards, P. C., Runswick, M. J., Jakes, R., Walker, J. E., Milstein, C., Roth, M., and Klug, A. (1988) Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease Proc. Natl. Acad. Sci. U.S.A. 85, 4506-4510
-
(1988)
Proc. Natl. Acad. Sci. U.S.A.
, vol.85
, pp. 4506-4510
-
-
Wischik, C.M.1
Novak, M.2
Thogersen, H.C.3
Edwards, P.C.4
Runswick, M.J.5
Jakes, R.6
Walker, J.E.7
Milstein, C.8
Roth, M.9
Klug, A.10
-
11
-
-
0027398169
-
Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament
-
Novak, M., Kabat, J., and Wischik, C. M. (1993) Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament EMBO J. 12, 365-370
-
(1993)
EMBO J.
, vol.12
, pp. 365-370
-
-
Novak, M.1
Kabat, J.2
Wischik, C.M.3
-
12
-
-
0024044195
-
Structural characterization of the core of the paired helical filament of Alzheimer disease
-
Wischik, C. M., Novak, M., Edwards, P. C., Klug, A., Tichelaar, W., and Crowther, R. A. (1988) Structural characterization of the core of the paired helical filament of Alzheimer disease Proc. Natl. Acad. Sci. U.S.A. 85, 4884-4888
-
(1988)
Proc. Natl. Acad. Sci. U.S.A.
, vol.85
, pp. 4884-4888
-
-
Wischik, C.M.1
Novak, M.2
Edwards, P.C.3
Klug, A.4
Tichelaar, W.5
Crowther, R.A.6
-
13
-
-
84875279731
-
The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush
-
Wegmann, S., Medalsy, I. D., Mandelkow, E., and Muller, D. J. (2013) The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush Proc. Natl. Acad. Sci. U.S.A. 110, E313-E321
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. E313-E321
-
-
Wegmann, S.1
Medalsy, I.D.2
Mandelkow, E.3
Muller, D.J.4
-
14
-
-
63649160214
-
Conformational diversity of wild-type Tau fibrils specified by templated conformation change
-
Frost, B., Ollesch, J., Wille, H., and Diamond, M. I. (2009) Conformational diversity of wild-type Tau fibrils specified by templated conformation change J. Biol. Chem. 284, 3546-3551
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3546-3551
-
-
Frost, B.1
Ollesch, J.2
Wille, H.3
Diamond, M.I.4
-
15
-
-
84862551790
-
Conformational basis for asymmetric seeding barrier in filaments of three- and four-repeat tau
-
Siddiqua, A., Luo, Y., Meyer, V., Swanson, M. A., Yu, X., Wei, G., Zheng, J., Eaton, G. R., Ma, B., Nussinov, R., Eaton, S. S., and Margittai, M. (2012) Conformational basis for asymmetric seeding barrier in filaments of three- and four-repeat tau J. Am. Chem. Soc. 134, 10271-10278
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 10271-10278
-
-
Siddiqua, A.1
Luo, Y.2
Meyer, V.3
Swanson, M.A.4
Yu, X.5
Wei, G.6
Zheng, J.7
Eaton, G.R.8
Ma, B.9
Nussinov, R.10
Eaton, S.S.11
Margittai, M.12
-
16
-
-
79956223051
-
Variations in filament conformation dictate seeding barrier between three- and four-repeat Tau
-
Dinkel, P. D., Siddiqua, A., Huynh, H., Shah, M., and Margittai, M. (2011) Variations in filament conformation dictate seeding barrier between three- and four-repeat Tau Biochemistry 50, 4330-4336
-
(2011)
Biochemistry
, vol.50
, pp. 4330-4336
-
-
Dinkel, P.D.1
Siddiqua, A.2
Huynh, H.3
Shah, M.4
Margittai, M.5
-
17
-
-
84902486430
-
Distinct tau prion strains propagate in cells and mice and define different tauopathies
-
Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., Miller, T. M., Grinberg, L. T., Seeley, W. W., and Diamond, M. I. (2014) Distinct tau prion strains propagate in cells and mice and define different tauopathies Neuron 82, 1271-1288
-
(2014)
Neuron
, vol.82
, pp. 1271-1288
-
-
Sanders, D.W.1
Kaufman, S.K.2
Devos, S.L.3
Sharma, A.M.4
Mirbaha, H.5
Li, A.6
Barker, S.J.7
Foley, A.C.8
Thorpe, J.R.9
Serpell, L.C.10
Miller, T.M.11
Grinberg, L.T.12
Seeley, W.W.13
Diamond, M.I.14
-
18
-
-
0032428153
-
A nucleated assembly mechanism of Alzheimer paired helical filaments
-
Friedhoff, P., von Bergen, M., Mandelkow, E. M., Davies, P., and Mandelkow, E. (1998) A nucleated assembly mechanism of Alzheimer paired helical filaments Proc. Natl. Acad. Sci. U.S.A. 95, 15712-15717
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 15712-15717
-
-
Friedhoff, P.1
Von Bergen, M.2
Mandelkow, E.M.3
Davies, P.4
Mandelkow, E.5
-
19
-
-
0035859102
-
Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
-
Saborio, G. P., Permanne, B., and Soto, C. (2001) Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding Nature 411, 810-813
-
(2001)
Nature
, vol.411
, pp. 810-813
-
-
Saborio, G.P.1
Permanne, B.2
Soto, C.3
-
20
-
-
34547491652
-
Formation of native prions from minimal components in vitro
-
Deleault, N. R., Harris, B. T., Rees, J. R., and Supattapone, S. (2007) Formation of native prions from minimal components in vitro Proc. Natl. Acad. Sci. U.S.A. 104, 9741-9746
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 9741-9746
-
-
Deleault, N.R.1
Harris, B.T.2
Rees, J.R.3
Supattapone, S.4
-
21
-
-
0029937271
-
NMR structure of the mouse prion protein domain PrP(121-231)
-
Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R., and Wuthrich, K. (1996) NMR structure of the mouse prion protein domain PrP(121-231) Nature 382, 180-182
-
(1996)
Nature
, vol.382
, pp. 180-182
-
-
Riek, R.1
Hornemann, S.2
Wider, G.3
Billeter, M.4
Glockshuber, R.5
Wuthrich, K.6
-
22
-
-
0017758306
-
Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly
-
Cleveland, D. W., Hwo, S. Y., and Kirschner, M. W. (1977) Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly J. Mol. Biol. 116, 227-247
-
(1977)
J. Mol. Biol.
, vol.116
, pp. 227-247
-
-
Cleveland, D.W.1
Hwo, S.Y.2
Kirschner, M.W.3
-
23
-
-
61349120815
-
Structural polymorphism of 441-residue tau at single residue resolution
-
Mukrasch, M. D., Bibow, S., Korukottu, J., Jeganathan, S., Biernat, J., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2009) Structural polymorphism of 441-residue tau at single residue resolution PLoS Biol. 7, e34
-
(2009)
PLoS Biol.
, vol.7
, pp. e34
-
-
Mukrasch, M.D.1
Bibow, S.2
Korukottu, J.3
Jeganathan, S.4
Biernat, J.5
Griesinger, C.6
Mandelkow, E.7
Zweckstetter, M.8
-
24
-
-
0036830506
-
Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis
-
Li, L., von Bergen, M., Mandelkow, E. M., and Mandelkow, E. (2002) Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis J. Biol. Chem. 277, 41390-41400
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 41390-41400
-
-
Li, L.1
Von Bergen, M.2
Mandelkow, E.M.3
Mandelkow, E.4
-
25
-
-
34447639732
-
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes
-
Legname, G., Nguyen, H. O., Peretz, D., Cohen, F. E., DeArmond, S. J., and Prusiner, S. B. (2006) Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes Proc. Natl. Acad. Sci. U.S.A. 103, 19105-19110
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 19105-19110
-
-
Legname, G.1
Nguyen, H.O.2
Peretz, D.3
Cohen, F.E.4
Dearmond, S.J.5
Prusiner, S.B.6
-
26
-
-
24144459823
-
Evaluating triggers and enhancers of tau fibrillization
-
Kuret, J., Congdon, E. E., Li, G., Yin, H., Yu, X., and Zhong, Q. (2005) Evaluating triggers and enhancers of tau fibrillization Microsc. Res. Technol. 67, 141-155
-
(2005)
Microsc. Res. Technol.
, vol.67
, pp. 141-155
-
-
Kuret, J.1
Congdon, E.E.2
Li, G.3
Yin, H.4
Yu, X.5
Zhong, Q.6
-
27
-
-
78549275132
-
Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease
-
Siddiqua, A. and Margittai, M. (2010) Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease J. Biol. Chem. 285, 37920-37926
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37920-37926
-
-
Siddiqua, A.1
Margittai, M.2
-
28
-
-
3142699791
-
Template-assisted filament growth by parallel stacking of tau
-
Margittai, M. and Langen, R. (2004) Template-assisted filament growth by parallel stacking of tau Proc. Natl. Acad. Sci. U.S.A. 101, 10278-10283
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 10278-10283
-
-
Margittai, M.1
Langen, R.2
-
29
-
-
84863983902
-
Evidence for the existence of a secondary pathway for fibril growth during the aggregation of tau
-
Ramachandran, G. and Udgaonkar, J. B. (2012) Evidence for the existence of a secondary pathway for fibril growth during the aggregation of tau J. Mol. Biol. 421, 296-314
-
(2012)
J. Mol. Biol.
, vol.421
, pp. 296-314
-
-
Ramachandran, G.1
Udgaonkar, J.B.2
-
30
-
-
0029114196
-
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments
-
Schweers, O., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (1995) Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments Proc. Natl. Acad. Sci. U.S.A. 92, 8463-8467
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 8463-8467
-
-
Schweers, O.1
Mandelkow, E.M.2
Biernat, J.3
Mandelkow, E.4
-
31
-
-
79960983524
-
Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties
-
Furukawa, Y., Kaneko, K., and Nukina, N. (2011) Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties J. Biol. Chem. 286, 27236-27246
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 27236-27246
-
-
Furukawa, Y.1
Kaneko, K.2
Nukina, N.3
-
32
-
-
33845944898
-
Ultra-efficient replication of infectious prions by automated protein misfolding cyclic amplification
-
Saa, P., Castilla, J., and Soto, C. (2006) Ultra-efficient replication of infectious prions by automated protein misfolding cyclic amplification J. Biol. Chem. 281, 35245-35252
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 35245-35252
-
-
Saa, P.1
Castilla, J.2
Soto, C.3
-
33
-
-
0021527508
-
Kinetics of nucleation-controlled polymerization. A perturbation treatment for use with a secondary pathway
-
Bishop, M. F. and Ferrone, F. A. (1984) Kinetics of nucleation-controlled polymerization. A perturbation treatment for use with a secondary pathway Biophys. J. 46, 631-644
-
(1984)
Biophys. J.
, vol.46
, pp. 631-644
-
-
Bishop, M.F.1
Ferrone, F.A.2
-
34
-
-
0032877134
-
Analysis of protein aggregation kinetics
-
Ferrone, F. (1999) Analysis of protein aggregation kinetics Methods Enzymol. 309, 256-274
-
(1999)
Methods Enzymol.
, vol.309
, pp. 256-274
-
-
Ferrone, F.1
-
35
-
-
62649173217
-
Branching in amyloid fibril growth
-
Andersen, C. B., Yagi, H., Manno, M., Martorana, V., Ban, T., Christiansen, G., Otzen, D. E., Goto, Y., and Rischel, C. (2009) Branching in amyloid fibril growth Biophys. J. 96, 1529-1536
-
(2009)
Biophys. J.
, vol.96
, pp. 1529-1536
-
-
Andersen, C.B.1
Yagi, H.2
Manno, M.3
Martorana, V.4
Ban, T.5
Christiansen, G.6
Otzen, D.E.7
Goto, Y.8
Rischel, C.9
-
36
-
-
84878994873
-
Proliferation of amyloid-beta42 aggregates occurs through a secondary nucleation mechanism
-
Cohen, S. I., Linse, S., Luheshi, L. M., Hellstrand, E., White, D. A., Rajah, L., Otzen, D. E., Vendruscolo, M., Dobson, C. M., and Knowles, T. P. (2013) Proliferation of amyloid-beta42 aggregates occurs through a secondary nucleation mechanism Proc. Natl. Acad. Sci. U.S.A. 110, 9758-9763
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 9758-9763
-
-
Cohen, S.I.1
Linse, S.2
Luheshi, L.M.3
Hellstrand, E.4
White, D.A.5
Rajah, L.6
Otzen, D.E.7
Vendruscolo, M.8
Dobson, C.M.9
Knowles, T.P.10
-
37
-
-
84901660540
-
Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation
-
Buell, A. K., Galvagnion, C., Gaspar, R., Sparr, E., Vendruscolo, M., Knowles, T. P., Linse, S., and Dobson, C. M. (2014) Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation Proc. Natl. Acad. Sci. U.S.A. 111, 7671-7676
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 7671-7676
-
-
Buell, A.K.1
Galvagnion, C.2
Gaspar, R.3
Sparr, E.4
Vendruscolo, M.5
Knowles, T.P.6
Linse, S.7
Dobson, C.M.8
-
38
-
-
84893441729
-
Single mutations in tau modulate the populations of fibril conformers through seed selection
-
Meyer, V., Dinkel, P. D., Luo, Y., Yu, X., Wei, G., Zheng, J., Eaton, G. R., Ma, B., Nussinov, R., Eaton, S. S., and Margittai, M. (2014) Single mutations in tau modulate the populations of fibril conformers through seed selection Angew. Chem., Int. Ed. 53, 1590-1593
-
(2014)
Angew. Chem., Int. Ed.
, vol.53
, pp. 1590-1593
-
-
Meyer, V.1
Dinkel, P.D.2
Luo, Y.3
Yu, X.4
Wei, G.5
Zheng, J.6
Eaton, G.R.7
Ma, B.8
Nussinov, R.9
Eaton, S.S.10
Margittai, M.11
-
39
-
-
84872714502
-
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
-
Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G., and Duff, K. E. (2013) Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons J. Biol. Chem. 288, 1856-1870
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 1856-1870
-
-
Wu, J.W.1
Herman, M.2
Liu, L.3
Simoes, S.4
Acker, C.M.5
Figueroa, H.6
Steinberg, J.I.7
Margittai, M.8
Kayed, R.9
Zurzolo, C.10
Di Paolo, G.11
Duff, K.E.12
-
40
-
-
33746698975
-
The physical basis of how prion conformations determine strain phenotypes
-
Tanaka, M., Collins, S. R., Toyama, B. H., and Weissman, J. S. (2006) The physical basis of how prion conformations determine strain phenotypes Nature 442, 585-589
-
(2006)
Nature
, vol.442
, pp. 585-589
-
-
Tanaka, M.1
Collins, S.R.2
Toyama, B.H.3
Weissman, J.S.4
-
41
-
-
84886446627
-
Protein rescue from aggregates by powerful molecular chaperone machines
-
Doyle, S. M., Genest, O., and Wickner, S. (2013) Protein rescue from aggregates by powerful molecular chaperone machines Nat. Rev. Mol. Cell Biol. 14, 617-629
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 617-629
-
-
Doyle, S.M.1
Genest, O.2
Wickner, S.3
|