4-hydroxytamoxifen leads to prPSc clearance by conveying both prpC and prPSc to lysosomes independently of autophagy

Journal of Cell Science

Volumn 126, Issue 6, 2013, Pages 1345-1354

  Marzo, Ludovica ^a,b   Marijanovic, Zrinka ^a   Browman, Duncan ^a   Chamoun, Zeina ^a   Caputo, Anna ^a   Zurzolo, Chiara ^a,b  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Autophagy; Cholesterol; Lysosomal degradation; Oht; Prpsc; Tam

Indexed keywords

AFIMOXIFENE; CELL PROTEIN; CHOLESTEROL; PRION PROTEIN; TAMOXIFEN;

ALZHEIMER DISEASE; ARTICLE; AUTOPHAGY; CELL MIGRATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG CLEARANCE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; LYSOSOME; NERVE CELL; NERVE CELL DIFFERENTIATION; PARKINSON DISEASE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN TRANSPORT; SURVIVAL TIME;

AUTOPHAGY; CHOLESTEROL; LYSOSOMAL DEGRADATION; OHT; PRPSC; TAM;

ANIMALS; AUTOPHAGY; CELL LINE; HUMANS; LYSOSOMES; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PRION DISEASES; PROTEIN TRANSPORT; PROTEOLYSIS; PRPC PROTEINS; PRPSC PROTEINS; RATS; RNA, SMALL INTERFERING; TAMOXIFEN;

EID: 84877896109     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.114801     Document Type: Article

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