Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: Implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis

Journal of Biological Chemistry

Volumn 288, Issue 22, 2013, Pages 15699-15711

  Basso, Manuela ^a,b   Pozzi, Silvia ^a   Tortarolo, Massimo ^a   Fiordaliso, Fabio ^a   Bisighini, Cinzia ^a   Pasetto, Laura ^a   Spaltro, Gabriella ^a   Lidonnici, Dario ^a   Gensano, Francesco ^a   Battaglia, Elisa ^a   Bendotti, Caterina ^a   Bonetto, Valentina ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; DISEASE SPREADING; MOTOR NEURON DISEASE; OVER-EXPRESSION; PROTEIN SECRETION; SECRETED PROTEIN; SECRETORY PATHWAYS; SUPEROXIDE DISMUTASES;

BRAIN; NEURODEGENERATIVE DISEASES; OXYGEN; PATHOLOGY; PROTEINS;

NEURONS;

COPPER ZINC SUPEROXIDE DISMUTASE; PROTEIN P97; VALOSIN CONTAINING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; ASTROCYTE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; EXOSOME; MOTONEURON; MOUSE; MUTATION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SECRETORY PATHWAY; SPINAL CORD NERVE CELL;

AMYOTROPHIC LATERAL SCLEROSIS (LOU GEHRIG'S DISEASE); ASTROCYTES; DISEASE SPREADING; EXOSOMES; PROTEOMICS; SUPEROXIDE DISMUTASE (SOD);

ADENOSINE TRIPHOSPHATASES; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ASTROCYTES; CELL CYCLE PROTEINS; CELL DEATH; EXOSOMES; HUMANS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NERVE TISSUE PROTEINS; SUPEROXIDE DISMUTASE;

EID: 84878389217     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.425066     Document Type: Article

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