Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis

Oncotarget

Volumn 6, Issue 30, 2015, Pages 28961-28972

  Wang, Zhengqi ^a   Medrzycki, Magdalena ^a   Bunting, Silvia T ^a   Bunting, Kevin D ^a  

^a CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

Author keywords

B cell transformation; Hematopoiesis; Leukemogenesis; Lymphoid primed multipotent progenitor; Transcription factor

Indexed keywords

PROTEIN BCL 2; STAT5 PROTEIN; BCL2 PROTEIN, MOUSE; MYC PROTEIN; MYC PROTEIN, MOUSE; STAT5A PROTEIN, MOUSE; STAT5B PROTEIN, MOUSE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LEUKEMIA; BINDING SITE; BIOACCUMULATION; BTLA GENE; CANCER GROWTH; CITED2 GENE; CONTROLLED STUDY; DNTT GENE; FETUS; FLK2 GENE; GENE; GENE EXPRESSION; GENE REPRESSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKEMOGENESIS; MOUSE; MPL GENE; NONHUMAN; ONCOGENE MYC; PHENOTYPE; PROTEIN EXPRESSION; SATB1 GENE; SLAMF1 GENE; SPI1 GENE; TIE2 GENE; ANIMAL; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CELL TRANSFORMATION; DEFICIENCY; DISEASE COURSE; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, LEUKEMIC; GENETIC PREDISPOSITION TO DISEASE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; LEUKEMIA, B-CELL; LIVER; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TIME FACTORS;

EID: 84945143810     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5009     Document Type: Article

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