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Volumn 114, Issue 19, 2009, Pages 3983-3993

Modeling the functional heterogeneity of leukemia stem cells: Role of STAT5 in leukemia stem cell self-renewal

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; STAT5 PROTEIN;

EID: 75649149337     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-06-227603     Document Type: Article
Times cited : (70)

References (62)
  • 1
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352(3):254-266.
    • (2005) N Engl J Med. , vol.352 , Issue.3 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 2
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
    • Fröhling S, Schlenk RF, Breitruck J, et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood. 2002;100(13):4372-4380.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4372-4380
    • Fröhling, S.1    Schlenk, R.F.2    Breitruck, J.3
  • 3
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99(12):4326- 4335.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 4
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
    • Preudhomme C, Sagot C, Boissel N, et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood. 2002;100(8):2717-2723.
    • (2002) Blood , vol.100 , Issue.8 , pp. 2717-2723
    • Preudhomme, C.1    Sagot, C.2    Boissel, N.3
  • 5
    • 0036682174 scopus 로고    scopus 로고
    • Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: A study of the Acute Myeloid Leukemia Study Group Ulm
    • Döhner K, Tobis K, Ulrich R, et al. Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm. J Clin Oncol. 2002;20(15):3254-3261.
    • (2002) J Clin Oncol. , vol.20 , Issue.15 , pp. 3254-3261
    • Döhner, K.1    Tobis, K.2    Ulrich, R.3
  • 6
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367(6464):645-648.
    • (1994) Nature , vol.367 , Issue.6464 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 7
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • Somervaille TC, Cleary ML. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 2006;10(4):257-268.
    • (2006) Cancer Cell , vol.10 , Issue.4 , pp. 257-268
    • Somervaille, T.C.1    Cleary, M.L.2
  • 8
    • 33750626083 scopus 로고    scopus 로고
    • Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia
    • Deshpande AJ, Cusan M, Rawat VP, et al. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell. 2006;10(5):363-374.
    • (2006) Cancer Cell , vol.10 , Issue.5 , pp. 363-374
    • Deshpande, A.J.1    Cusan, M.2    Rawat, V.P.3
  • 9
    • 41249103144 scopus 로고    scopus 로고
    • Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
    • Kirstetter P, Schuster MB, Bereshchenko O, et al. Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell. 2008;13(4):299-310.
    • (2008) Cancer Cell , vol.13 , Issue.4 , pp. 299-310
    • Kirstetter, P.1    Schuster, M.B.2    Bereshchenko, O.3
  • 10
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick JE. Stem cell concepts renew cancer research. Blood. 2008;112(13):4793-4807.
    • (2008) Blood , vol.112 , Issue.13 , pp. 4793-4807
    • Dick, J.E.1
  • 11
    • 39649125467 scopus 로고    scopus 로고
    • An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
    • Guzman ML, Rossi RM, Neelakantan S, et al. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood. 2007;110(13):4427-4435.
    • (2007) Blood , vol.110 , Issue.13 , pp. 4427-4435
    • Guzman, M.L.1    Rossi, R.M.2    Neelakantan, S.3
  • 12
    • 33749337234 scopus 로고    scopus 로고
    • Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
    • Kornblau SM, Womble M, Qiu YH, et al. Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood. 2006;108(7):2358-2365.
    • (2006) Blood , vol.108 , Issue.7 , pp. 2358-2365
    • Kornblau, S.M.1    Womble, M.2    Qiu, Y.H.3
  • 13
    • 28444446313 scopus 로고    scopus 로고
    • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): Association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    • Verhaak RG, Goudswaard CS, van Putten W, et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood. 2005;106(12):3747-3754.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3747-3754
    • Verhaak, R.G.1    Goudswaard, C.S.2    Van Putten, W.3
  • 14
    • 23044459136 scopus 로고    scopus 로고
    • Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
    • Alcalay M, Tiacci E, Bergomas R, et al. Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood. 2005;106(3):899-902.
    • (2005) Blood , vol.106 , Issue.3 , pp. 899-902
    • Alcalay, M.1    Tiacci, E.2    Bergomas, R.3
  • 15
    • 34548125335 scopus 로고    scopus 로고
    • Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias
    • Mullighan CG, Kennedy A, Zhou X, et al. Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias. Leukemia. 2007;21(9):2000-2009.
    • (2007) Leukemia , vol.21 , Issue.9 , pp. 2000-2009
    • Mullighan, C.G.1    Kennedy, A.2    Zhou, X.3
  • 16
    • 27844501600 scopus 로고    scopus 로고
    • Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemia
    • Heuser M, Wingen LU, Steinemann D, et al. Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemia. Haematologica. 2005;90(11):1484-1492.
    • (2005) Haematologica. , vol.90 , Issue.11 , pp. 1484-1492
    • Heuser, M.1    Wingen, L.U.2    Steinemann, D.3
  • 17
    • 0029061177 scopus 로고
    • Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11
    • Buijs A, Sherr S, van Baal S, et al. Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene. 1995;10(8):1511-1519.
    • (1995) Oncogene. , vol.10 , Issue.8 , pp. 1511-1519
    • Buijs, A.1    Sherr, S.2    Van Baal, S.3
  • 18
    • 34548841921 scopus 로고    scopus 로고
    • MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML
    • Heuser M, Argiropoulos B, Kuchenbauer F, et al. MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood. 2007;110(5):1639-1647.
    • (2007) Blood , vol.110 , Issue.5 , pp. 1639-1647
    • Heuser, M.1    Argiropoulos, B.2    Kuchenbauer, F.3
  • 19
    • 34447642168 scopus 로고    scopus 로고
    • MN1 overexpression is an important step in the development of inv(16) AML
    • Carella C, Bonten J, Sirma S, et al. MN1 overexpression is an important step in the development of inv(16) AML. Leukemia. 2007;21(8):1679-1690.
    • (2007) Leukemia , vol.21 , Issue.8 , pp. 1679-1690
    • Carella, C.1    Bonten, J.2    Sirma, S.3
  • 20
    • 0037421957 scopus 로고    scopus 로고
    • The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription
    • van Wely KH, Molijn AC, Buijs A, et al. The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. Oncogene. 2003;22(5):699-709.
    • (2003) Oncogene. , vol.22 , Issue.5 , pp. 699-709
    • Van Wely, K.H.1    Molijn, A.C.2    Buijs, A.3
  • 21
    • 53349091416 scopus 로고    scopus 로고
    • MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR induced gene expression
    • Meester-Smoor MA, Janssen MJ, Grosveld GC, et al. MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR induced gene expression. Carcinogenesis. 2008;29(10):2025-2034.
    • (2008) Carcinogenesis , vol.29 , Issue.10 , pp. 2025-2034
    • Meester-Smoor, M.A.1    Janssen, M.J.2    Grosveld, G.C.3
  • 22
    • 9044249724 scopus 로고    scopus 로고
    • The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
    • Borrow J, Shearman AM, Stanton VP Jr, et al. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet. 1996;12(2):159-167.
    • (1996) Nat Genet. , vol.12 , Issue.2 , pp. 159-167
    • Borrow, J.1    Shearman, A.M.2    Stanton Jr., V.P.3
  • 23
    • 9044241254 scopus 로고    scopus 로고
    • Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15; p15) in human myeloid leukaemia
    • Nakamura T, Largaespada DA, Lee MP, et al. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15; p15) in human myeloid leukaemia. Nat Genet. 1996;12(2):154-158.
    • (1996) Nat Genet. , vol.12 , Issue.2 , pp. 154-158
    • Nakamura, T.1    Largaespada, D.A.2    Lee, M.P.3
  • 24
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999;286(5439):531-537.
    • (1999) Science , vol.286 , Issue.5439 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3
  • 25
    • 0032126633 scopus 로고    scopus 로고
    • Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
    • Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 1998;17(13):3714-3725.
    • (1998) EMBO J. , vol.17 , Issue.13 , pp. 3714-3725
    • Kroon, E.1    Krosl, J.2    Thorsteinsdottir, U.3    Baban, S.4    Buchberg, A.M.5    Sauvageau, G.6
  • 27
    • 0037804796 scopus 로고    scopus 로고
    • Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1
    • Pineault N, Buske C, Feuring-Buske M, et al. Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1. Blood. 2003;101(11):4529-4538.
    • (2003) Blood , vol.101 , Issue.11 , pp. 4529-4538
    • Pineault, N.1    Buske, C.2    Feuring-Buske, M.3
  • 28
    • 17144372606 scopus 로고    scopus 로고
    • Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA
    • Pineault N, Abramovich C, Humphries RK. Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA. Leukemia. 2005;19(4):636-643.
    • (2005) Leukemia , vol.19 , Issue.4 , pp. 636-643
    • Pineault, N.1    Abramovich, C.2    Humphries, R.K.3
  • 29
    • 34347213447 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation
    • Slape C, Hartung H, Lin YW, Bies J, Wolff L, Aplan PD. Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. Cancer Res. 2007;67(11):5148-5155.
    • (2007) Cancer Res. , vol.67 , Issue.11 , pp. 5148-5155
    • Slape, C.1    Hartung, H.2    Lin, Y.W.3    Bies, J.4    Wolff, L.5    Aplan, P.D.6
  • 30
    • 0034322479 scopus 로고    scopus 로고
    • Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors
    • Schambach A, Wodrich H, Hildinger M, Bohne J, Krausslich HG, Baum C. Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors. Mol Ther. 2000;2(5):435-445.
    • (2000) Mol Ther. , vol.2 , Issue.5 , pp. 435-445
    • Schambach, A.1    Wodrich, H.2    Hildinger, M.3    Bohne, J.4    Krausslich, H.G.5    Baum, C.6
  • 31
    • 3843096003 scopus 로고    scopus 로고
    • NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation
    • Gurevich RM, Aplan PD, Humphries RK. NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation. Blood. 2004;104(4):1127-1136.
    • (2004) Blood , vol.104 , Issue.4 , pp. 1127-1136
    • Gurevich, R.M.1    Aplan, P.D.2    Humphries, R.K.3
  • 32
    • 0030833570 scopus 로고    scopus 로고
    • Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
    • Udy GB, Towers RP, Snell RG, et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci U S A. 1997;94(14):7239-7244.
    • (1997) Proc Natl Acad Sci U S A. , vol.94 , Issue.14 , pp. 7239-7244
    • Udy, G.B.1    Towers, R.P.2    Snell, R.G.3
  • 33
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAKSTAT signaling pathway
    • Meraz MA, White JM, Sheehan KC, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAKSTAT signaling pathway. Cell. 1996;84(3):431-442.
    • (1996) Cell , vol.84 , Issue.3 , pp. 431-442
    • Meraz, M.A.1    White, J.M.2    Sheehan, K.C.3
  • 34
    • 61849093097 scopus 로고    scopus 로고
    • Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation
    • Heuser M, Yap DB, Leung M, et al. Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation. Blood. 2009;113(7):1432-1443.
    • (2009) Blood , vol.113 , Issue.7 , pp. 1432-1443
    • Heuser, M.1    Yap, D.B.2    Leung, M.3
  • 35
    • 33845263501 scopus 로고    scopus 로고
    • High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics
    • Heuser M, Beutel G, Krauter J, et al. High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. Blood. 2006;108(12):3898-3905.
    • (2006) Blood , vol.108 , Issue.12 , pp. 3898-3905
    • Heuser, M.1    Beutel, G.2    Krauter, J.3
  • 36
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 37
    • 18944403577 scopus 로고    scopus 로고
    • Cytotoxicity determination without photochemical artifacts
    • Heuser M, Kopun M, Rittgen W, Granzow C. Cytotoxicity determination without photochemical artifacts. Cancer Lett. 2005;223(1):57-66.
    • (2005) Cancer Lett. , vol.223 , Issue.1 , pp. 57-66
    • Heuser, M.1    Kopun, M.2    Rittgen, W.3    Granzow, C.4
  • 38
    • 11144358111 scopus 로고    scopus 로고
    • Prognostically useful gene-expression profiles in acute myeloid leukemia
    • Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004;350(16):1617-1628.
    • (2004) N Engl J Med. , vol.350 , Issue.16 , pp. 1617-1628
    • Valk, P.J.1    Verhaak, R.G.2    Beijen, M.A.3
  • 39
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledgebased approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545-15550.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , Issue.43 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 40
    • 77950416489 scopus 로고    scopus 로고
    • Massachusetts Institute of Technology Accessed July 2008
    • Massachusetts Institute of Technology. Molecular Signatures Database (MSigDB). http://www.broad.mit.edu/gsea/msigdb/index.jsp. Accessed July 2008.
  • 41
    • 0141956433 scopus 로고    scopus 로고
    • Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF
    • Martinez-Moczygemba M, Huston DP. Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF. J Allergy Clin Immunol. 2003;112(4):653-665.
    • (2003) J Allergy Clin Immunol. , vol.112 , Issue.4 , pp. 653-665
    • Martinez-Moczygemba, M.1    Huston, D.P.2
  • 42
    • 44349166602 scopus 로고    scopus 로고
    • PML targeting eradicates quiescent leukaemia-initiating cells
    • Ito K, Bernardi R, Morotti A, et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature. 2008;453(7198):1072-1078.
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1072-1078
    • Ito, K.1    Bernardi, R.2    Morotti, A.3
  • 43
    • 0026063878 scopus 로고
    • Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors
    • Emanuel PD, Bates LJ, Castleberry RP, Gualtieri RJ, Zuckerman KS. Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood. 1991;77(5):925-929.
    • (1991) Blood , vol.77 , Issue.5 , pp. 925-929
    • Emanuel, P.D.1    Bates, L.J.2    Castleberry, R.P.3    Gualtieri, R.J.4    Zuckerman, K.S.5
  • 44
    • 0038278866 scopus 로고    scopus 로고
    • Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
    • Tartaglia M, Niemeyer CM, Fragale A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet. 2003;34(2):148-150.
    • (2003) Nat Genet. , vol.34 , Issue.2 , pp. 148-150
    • Tartaglia, M.1    Niemeyer, C.M.2    Fragale, A.3
  • 45
    • 18244395853 scopus 로고    scopus 로고
    • Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor
    • Chan RJ, Leedy MB, Munugalavadla V, et al. Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. Blood. 2005;105(9):3737-3742.
    • (2005) Blood , vol.105 , Issue.9 , pp. 3737-3742
    • Chan, R.J.1    Leedy, M.B.2    Munugalavadla, V.3
  • 46
    • 0032896457 scopus 로고    scopus 로고
    • RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)
    • Flotho C, Valcamonica S, Mach-Pascual S, et al. RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). Leukemia. 1999;13(1):32-37.
    • (1999) Leukemia , vol.13 , Issue.1 , pp. 32-37
    • Flotho, C.1    Valcamonica, S.2    Mach-Pascual, S.3
  • 47
    • 0032125716 scopus 로고    scopus 로고
    • Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1
    • Side LE, Emanuel PD, Taylor B, et al. Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. Blood. 1998;92(1):267-272.
    • (1998) Blood , vol.92 , Issue.1 , pp. 267-272
    • Side, L.E.1    Emanuel, P.D.2    Taylor, B.3
  • 48
    • 52949129499 scopus 로고    scopus 로고
    • Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
    • Kotecha N, Flores NJ, Irish JM, et al. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008;14(4):335-343.
    • (2008) Cancer Cell , vol.14 , Issue.4 , pp. 335-343
    • Kotecha, N.1    Flores, N.J.2    Irish, J.M.3
  • 49
    • 64849114262 scopus 로고    scopus 로고
    • Aberrant GM-CSF signal transduction pathway in juvenile myelomonocytic leukemia assayed by flow cytometric intracellular STAT5 phosphorylation measurement
    • Gaipa G, Bugarin C, Longoni D, et al. Aberrant GM-CSF signal transduction pathway in juvenile myelomonocytic leukemia assayed by flow cytometric intracellular STAT5 phosphorylation measurement. Leukemia. 2009;23(4):791-793.
    • (2009) Leukemia , vol.23 , Issue.4 , pp. 791-793
    • Gaipa, G.1    Bugarin, C.2    Longoni, D.3
  • 50
    • 0035395873 scopus 로고    scopus 로고
    • SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice
    • Lindeman GJ, Wittlin S, Lada H, et al. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev. 2001;15(13):1631-1636.
    • (2001) Genes Dev. , vol.15 , Issue.13 , pp. 1631-1636
    • Lindeman, G.J.1    Wittlin, S.2    Lada, H.3
  • 51
    • 33746498953 scopus 로고    scopus 로고
    • Socs2 and elf5 mediate prolactin-induced mammary gland development
    • Harris J, Stanford PM, Sutherland K, et al. Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol. 2006;20(5):1177-1187.
    • (2006) Mol Endocrinol. , vol.20 , Issue.5 , pp. 1177-1187
    • Harris, J.1    Stanford, P.M.2    Sutherland, K.3
  • 52
    • 41149149301 scopus 로고    scopus 로고
    • Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
    • Hennighausen L, Robinson GW. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev. 2008;22(6):711-721.
    • (2008) Genes Dev. , vol.22 , Issue.6 , pp. 711-721
    • Hennighausen, L.1    Robinson, G.W.2
  • 53
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt RM, Egen C, Wehinger J, et al. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood. 1996;88(3):809-816.
    • (1996) Blood , vol.88 , Issue.3 , pp. 809-816
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3
  • 54
    • 13344279401 scopus 로고    scopus 로고
    • STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
    • Gouilleux-Gruart V, Gouilleux F, Desaint C, et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood. 1996;87(5):1692-1697.
    • (1996) Blood , vol.87 , Issue.5 , pp. 1692-1697
    • Gouilleux-Gruart, V.1    Gouilleux, F.2    Desaint, C.3
  • 55
    • 0031803213 scopus 로고    scopus 로고
    • Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia
    • Hayakawa F, Towatari M, Iida H, et al. Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia. Br J Haematol. 1998;101(3):521-528.
    • (1998) Br J Haematol. , vol.101 , Issue.3 , pp. 521-528
    • Hayakawa, F.1    Towatari, M.2    Iida, H.3
  • 56
    • 33745111882 scopus 로고    scopus 로고
    • Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation
    • Hoelbl A, Kovacic B, Kerenyi MA, et al. Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood. 2006;107(12):4898-4906.
    • (2006) Blood , vol.107 , Issue.12 , pp. 4898-4906
    • Hoelbl, A.1    Kovacic, B.2    Kerenyi, M.A.3
  • 57
    • 34247354963 scopus 로고    scopus 로고
    • Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage
    • Cain JA, Xiang Z, O'Neal J, et al. Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage. Blood. 2007;109(9):3906-3914.
    • (2007) Blood , vol.109 , Issue.9 , pp. 3906-3914
    • Cain, J.A.1    Xiang, Z.2    O'Neal, J.3
  • 58
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial: the Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial: The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92(7):2322-2333.
    • (1998) Blood , vol.92 , Issue.7 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 59
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrozek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002;100(13):4325-4336.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4325-4336
    • Byrd, J.C.1    Mrozek, K.2    Dodge, R.K.3
  • 60
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood. 2000;96(12):3907-3914.
    • (2000) Blood , vol.96 , Issue.12 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3
  • 61
    • 0034598830 scopus 로고    scopus 로고
    • Tandemduplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, et al. Tandemduplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19(5):624-631.
    • (2000) Oncogene. , vol.19 , Issue.5 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3
  • 62
    • 35548954735 scopus 로고    scopus 로고
    • STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells
    • Schepers H, van Gosliga D, Wierenga AT, Eggen BJ, Schuringa JJ, Vellenga E. STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells. Blood. 2007;110(8):2880-2888.
    • (2007) Blood , vol.110 , Issue.8 , pp. 2880-2888
    • Schepers, H.1    Van Gosliga, D.2    Wierenga, A.T.3    Eggen, B.J.4    Schuringa, J.J.5    Vellenga, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.