Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

Nature Immunology

Volumn 16, Issue 7, 2015, Pages 766-774

  Swaminathan, Srividya ^a   Klemm, Lars ^a,b   Park, Eugene ^a,c   Papaemmanuil, Elli ^d   Ford, Anthony ^e   Kweon, Soo Mi ^f   Trageser, Daniel ^f   Hasselfeld, Brian ^f   Henke, Nadine ^g   Mooster, Jana ^g   Geng, Huimin ^a   Schwarz, Klaus ^h   Kogan, Scott C ^a   Casellas, Rafael ⁱ   Schatz, David G ^j   Lieber, Michael R ^f   Greaves, Mel F ^e   Müschen, Markus ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g HEINRICH HEINE UNIVERSITY   (Germany)

^h UNIVERSITY OF ULM   (Germany)

ⁱ NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^j YALE UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CD19 ANTIGEN; CYTOSINE; GENOMIC DNA; INTERLEUKIN 7; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAG1 PROTEIN; RAG2 PROTEIN; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; RAG-1 PROTEIN; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; BONE MARROW CELL; CHILDHOOD LEUKEMIA; CHROMOSOME TRANSLOCATION; CLONAL EVOLUTION; CONTROLLED STUDY; DNA BINDING; FEMALE; FETUS LIVER; GENETIC RISK; GENOTYPE; GERMLINE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; LEUKEMOGENESIS; LYMPHOPOIESIS; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; OVERALL SURVIVAL; POSTNATAL DEVELOPMENT; PRE B LYMPHOCYTE; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; SOMATIC HYPERMUTATION; SOMATIC MUTATION; UPREGULATION; ADOLESCENT; ANIMAL; ANTIBODY SPECIFICITY; CHILD; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOBLOTTING; IMMUNOLOGY; INFANT; KNOCKOUT MOUSE; MALE; METABOLISM; NONOBESE DIABETIC MOUSE; PRESCHOOL CHILD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; TRANSGENIC MOUSE; TUMOR CELL CULTURE;

ADOLESCENT; ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; CLONAL EVOLUTION; CYTIDINE DEAMINASE; DNA-BINDING PROTEINS; FEMALE; FLOW CYTOMETRY; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOBLOTTING; INFANT; MALE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR CELLS, B-LYMPHOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 84931562132     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3160     Document Type: Article

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