Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer

Hepatology

Volumn 55, Issue 3, 2012, Pages 941-952

  Friedbichler, Katrin ^a   Themanns, Madeleine ^a   Mueller, Kristina M ^a   Schlederer, Michaela ^a   Kornfeld, Jan Wilhelm ^b   Terracciano, Luigi M ^c   Kozlov, Andrey V ^d   Haindl, Susanne ^d   Kenner, Lukas ^a,e   Kolbe, Thomas ^f,g   Mueller, Mathias ^h   Snibson, Kenneth J ⁱ   Heim, Markus H ^c   Moriggl, Richard ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f Institute of Laboratory Animal Science   (Austria)

^g UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^h Vetmeduni Vienna   (Austria)

ⁱ UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH HORMONE; HEPATOCYTE NUCLEAR FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE 2; LEUKEMIA INHIBITORY FACTOR RECEPTOR; PROLACTIN RECEPTOR; PROTEIN C JUN; STAT3 PROTEIN; STAT5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY GROWTH; CANCER GROWTH; CELL CYCLE REGULATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DNA DAMAGE; GENE DELETION; GIGANTISM; GLOMERULAR DYSFUNCTION; GROWTH CURVE; GROWTH HORMONE BLOOD LEVEL; INFLAMMATION; LIFE EXPECTANCY; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; LIVER CANCER; LIVER CELL; LIVER CELL CARCINOMA; MALE; MORTALITY; MOUSE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR VOLUME;

ANIMALS; BODY SIZE; CARCINOMA, HEPATOCELLULAR; DISEASE MODELS, ANIMAL; FATTY LIVER; GIGANTISM; GROWTH HORMONE; HEPATOCYTES; INFLAMMATION; LIPID METABOLISM; LIVER; LIVER NEOPLASMS; MICE; MICE, TRANSGENIC; MORTALITY, PREMATURE; PROTO-ONCOGENE PROTEINS C-JUN; SHEEP; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR;

EID: 84857444311     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24765     Document Type: Article

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