Tumor necrosis factor-α (TNFα)-induced ceramide generation via ceramide synthases regulates loss of focal adhesion kinase (FAK) and programmed cell death

Journal of Biological Chemistry

Volumn 290, Issue 42, 2015, Pages 25356-25373

  Hernández Corbacho, María José ^a,b   Canals, Daniel ^a,b   Adada, Mohamad M ^a,b   Liu, Mengling ^a,b   Senkal, Can E ^a,b   Yi, Jae Kyo ^a,b   Mao, Cungui ^a,b   Luberto, Chiara ^a,c   Hannun, Yusuf A ^a,b   Obeid, Lina M ^a,b,c,d  

^a Stony Brook Medicine   (United States)

^b Department of Medicine ^*  (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; BIOCHEMISTRY; CELL DEATH; CELL MEMBRANES; CELLS; CYTOLOGY; ENZYMES;

CERAMIDE SYNTHASE; FOCAL ADHESION KINASE; FOCAL ADHESIONS; MEMBRANE PERMEABILIZATION; PROGRAMMED CELL DEATHS; RECYCLING PATHWAYS; SALVAGE PATHWAY; TUMOR NECROSIS FACTORS;

CERAMIDES;

CASPASE 7; CERAMIDE; CERAMIDE SYNTHASE; DIHYDROCERAMIDE; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INHIBITOR; FUMONISIN B1; SPHINGOLIPID; SYNTHETASE; THERMOZYMOCIDIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; Y 15; CASPASE; DIHYDROCERAMIDE DESATURASE; FUMONISIN; OXIDOREDUCTASE; TUMOR NECROSIS FACTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; BREAST CANCER; BREAST CANCER CELL LINE; CELL ACTIVATION; CELL MEMBRANE PERMEABILITY; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPOGENESIS; PRIORITY JOURNAL; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; GENE SILENCING; GENETICS; MCF-7 CELL LINE; METABOLISM; PHYSIOLOGY;

APOPTOSIS; CASPASES; CERAMIDES; ENZYME ACTIVATION; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FUMONISINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MCF-7 CELLS; OXIDOREDUCTASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84944407529     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.658658     Document Type: Article

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