De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation

Prostaglandins and Other Lipid Mediators

Volumn 86, Issue 1-4, 2008, Pages 41-48

  Panjarian, Shoghag ^a   Kozhaya, Lina ^a   Arayssi, Sawsan ^a   Yehia, Maisaa ^a   Bielawski, Jacek ^b   Bielawska, Alicja ^b   Usta, Julnar ^a   Hannun, Yusuf A ^b   Obeid, Lina M ^b,c   Dbaibo, Ghassan S ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Ceramide; Ceramide synthase; Lass5; N Palmitoylsphingosine; p53; Sphingomyelinase

Indexed keywords

CERAMIDE; CERAMIDE SYNTHASE; FUMONISIN B1; PROTEIN P53; SERINE PALMITOYLTRANSFERASE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; SPHINGOSINE DERIVATIVE; ZINC CHLORIDE;

ARTICLE; CANCER CELL; CELL DEATH; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GAMMA IRRADIATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIPID STORAGE; LIPOGENESIS; PROTEIN EXPRESSION; UPREGULATION;

CELL LINE, TUMOR; CERAMIDES; CHLORIDES; ENZYME ACTIVATION; GAMMA RAYS; HUMANS; OXIDOREDUCTASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERINE C-PALMITOYLTRANSFERASE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPHINGOMYELIN PHOSPHODIESTERASE; TANDEM MASS SPECTROMETRY; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; ZINC COMPOUNDS;

EID: 43049156529     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2008.02.004     Document Type: Article

References (49)

1. Lane D.P. p53, guardian of the genome. Nature 358 (1992) 15-16
2. Mummenbrauer T., Janus F., Muller B., Wiesmuller L., Deppert W., and Grosse F. p53 Protein exhibits 3′-to-5′ exonuclease activity. Cell 85 (1996) 1089-1099
3. Lowe S.W., Ruley H.E., Jacks T., and Housman D.E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74 (1993) 957-967
4. Vousden K.H., and Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2 (2002) 594-604
5. Miyashita T., and Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 (1995) 293-299
6. Nakano K., and Vousden K.H. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7 (2001) 683-694
7. Oda E., Ohki R., Murasawa H., et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288 (2000) 1053-1058
8. Hoffman W.H., Biade S., Zilfou J.T., Chen J., and Murphy M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem 277 (2002) 3247-3257
9. Shen Y., and Shenk T. Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein. Proc Natl Acad Sci USA 91 (1994) 8940-8944
10. Arima Y., Nitta M., Kuninaka S., et al. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem 280 (2005) 19166-19176
11. Erster S., Mihara M., Kim R.H., Petrenko O., and Moll U.M. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol 24 (2004) 6728-6741
12. Mihara M., Erster S., Zaika A., et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11 (2003) 577-590
13. Hannun Y.A., and Linardic C.M. Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim Biophys Acta 1154 (1993) 223-236
14. Jayadev S., Liu B., Bielawska A.E., et al. Role for ceramide in cell cycle arrest. J Biol Chem 270 (1995) 2047-2052
15. Obeid L.M., Linardic C.M., Karolak L.A., and Hannun Y.A. Programmed cell death induced by ceramide. Science 259 (1993) 1769-1771
16. Venable M.E., Lee J.Y., Smyth M.J., Bielawska A., and Obeid L.M. Role of ceramide in cellular senescence. J Biol Chem 270 (1995) 30701-30708
17. Ogretmen B., and Hannun Y.A. Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance. Drug Resist Updat 4 (2001) 368-377
18. Haimovitz-Friedman A., Kan C.C., Ehleiter D., et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 180 (1994) 525-535
19. Jaffrezou J.P., Bruno A.P., Moisand A., Levade T., and Laurent G. Activation of a nuclear sphingomyelinase in radiation-induced apoptosis. FASEB J 15 (2001) 123-133
20. Andrieu-Abadie N., and Levade T. Sphingomyelin hydrolysis during apoptosis. Biochim Biophys Acta 1585 (2002) 126-134
21. Hanada K. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta 1632 (2003) 16-30
22. Merill Jr. A.H. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J Biol Chem 277 (2002) 25843-25846
23. Dolgachev V., Farooqui M.S., Kulaeva O.I., et al. De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells. J Biol Chem 279 (2004) 23238-23249
24. Dbaibo G.S., Pushkareva M.Y., Rachid R.A., et al. p53-dependent ceramide response to genotoxic stress. J Clin Invest 102 (1998) 329-339
25. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37 (1959) 911-917
26. Bielawska A., Perry D.K., and Hannun Y.A. Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem 298 (2001) 141-150
27. Andrieu N., Salvayre R., and Levade T. Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts. Biochem J 303 (1994) 341-345
28. Dickson R.C., Lester R.L., and Nagiec M.M. Serine palmitoyltransferase. Methods Enzymol 311 (2000) 3-9
29. Darwiche N., Abou-Lteif G., Najdi T., et al. Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide. Biochem J 392 (2005) 231-239
30. Bielawski J., Szulc Z.M., Hannun Y.A., and Bielawska A. Simultaneous quantitative analysis of bioactive sphingolipids by high performance liquid chromatography-tandem mass spectrometry. Methods 39 (2006) 82-91
31. Zhao R., Gish K., Murphy M., et al. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev 14 (2000) 981-993
32. El-Assaad W., Kozhaya L., Araysi S., et al. Ceramide and glutathione define two independently regulated pathways of cell death initiated by p53 in Molt-4 leukaemia cells. Biochem J 376 (2003) 725-732
33. Hannun Y.A., and Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol 10 (2000) 73-80
34. Pettus B.J., Chalfant C.E., and Hannun Y.A. Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 1585 (2002) 114-125
35. Farrell A.M., Uchida Y., Nagiec M.M., et al. UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes. J Lipid Res 39 (1998) 2031-2038
36. Mizutani Y., Kihara A., and Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J 390 (2005) 263-271
37. Lahiri S., and Futerman A.H. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem 280 (2005) 33735-33738
38. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T., and Kawasaki T. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem Biophys Res Commun 211 (1995) 396-403
39. Merrill Jr. A.H., Sullards M.C., Wang E., Voss K.A., and Riley R.T. Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. Environ Health Perspect 109 Suppl. 2 (2001) 283-289
40. Riebeling C., Allegood J.C., Wang E., Merrill Jr. A.H., and Futerman A.H. Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem 278 (2003) 43452-43459
41. Jenkins G.M., Cowart L.A., Signorelli P., Pettus B.J., Chalfant C.E., and Hannun Y.A. Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. J Biol Chem 277 (2002) 42572-42578
42. Perry D.K., Carton J., Shah A.K., Meredith F., Uhlinger D.J., and Hannun Y.A. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem 275 (2000) 9078-9084
43. Gomez del Pulgar T., Velasco G., Sanchez C., Haro A., and Guzman M. De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem J 363 (2002) 183-188
44. Magnoni C., Euclidi E., Benassi L., et al. Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes. Toxicol In Vitro 16 (2002) 349-355
45. 2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. Blood 91 (1998) 4350-4360
46. Santana P., Pena L.A., Haimovitz-Friedman A., et al. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86 (1996) 189-199
47. Hara S., Nakashima S., Kiyono T., et al. p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis. Cell Death Differ 11 (2004) 853-861
48. Maceyka M., Payne S.G., Milstien S., and Spiegel S. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta 1585 (2002) 193-201
49. Taha T.A., Osta W., Kozhaya L., et al. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem 279 (2004) 20546-20554