Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

Molecular Cancer Therapeutics

Volumn 6, Issue 2, 2007, Pages 712-722

  Senkal, Can E ^a   Ponnusamy, Suriyan ^a   Rossi, Michael J ^a   Bialewski, Jacek ^a,b   Sinha, Debijyati ^b   Jiang, James C ^c   Jazwinski, S Michal ^c   Hannun, Yusuf A ^a,b   Ogretmen, Besim ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C18 CERAMIDE; CASPASE 3; CASPASE 8; CASPASE 9; CERAMIDE; DOXORUBICIN; GEMCITABINE; GENE PRODUCT; LONGEVITY ASSURANCE PROTEIN 1; MESSENGER RNA; SMALL INTERFERING RNA; SYNTHETASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; SQUAMOUS CELL CARCINOMA; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CASPASES; CELL LINE, TUMOR; CERAMIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DEOXYCYTIDINE; DOXORUBICIN; FLUORESCENT ANTIBODY TECHNIQUE; HEAD AND NECK NEOPLASMS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, SCID; OXIDOREDUCTASES; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SURVIVAL RATE;

EID: 33847376437     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0558     Document Type: Article

References (42)

1. Her C. Nasopharyngeal cancer and the Southeast Asian patient. Am Fam Physician 2001;63:1776-82.
2. Jemal A, Murray T, Ward E, et al. Cancer statistics. CA Cancer J Clin 2005;55:10-30.
3. Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science 1996;274:1855-9.
4. Hannun YA, Obeid LM. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 2002;277: 25847-50.
5. 16-ceramide and involves mitochondria. J Biol Chem 2001; 276:13606-14.
6. Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem 2000;275:9078-84.
7. Santana P, Pena LA, Haimovitz-Friedman A, et al. Acid sphingomye-linase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 1996;86:189-99.
8. Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004;4:604-16.
9. Mehta S, Blackinton D, Omar I, et al. Combined cytotoxic action of paclitaxel and ceramide against the human Tu 138 head and neck squamous carcinoma cell line. Cancer Chemother Pharmacol 2000;46: 85-92.
10. Rossi MJ, Sundararaj K, Koybasi S, et al. Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg 2005;132:55-62.
11. Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick R. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 1995;82: 405-14.
12. Chalfant CE, Ogretmen B, Galadari S, Kroesen BJ, Pettus BJ, Hannun YA. FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J Biol Chem 2001;276:44848-55.
13. Zhang Y, Mattjus P, Schmid PC, et al. Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis. J Biol Chem 2001; 276:11775-82.
14. D'Mello NP, Childress AM, Franklin DS, Kale SP, Pinswasdi C, Jazwinski SM. Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J Biol Chem 1994;269:15451-9.
15. Schorling S, Vallee B, Barz WP, Riezman H, Oesterhelt D. Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction inSaccharomyces cerevisae. Mol Biol Cell 2001;12:3417-27.
16. Guillas I, Kirchman PA, Chuard R, et al. C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J 2001;20:2655-65.
17. 18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. J Biol Chem 2002;277:35642-9.
18. Riebeling C, Allegood JC, Wang E, Merrill AH, Jr., Futerman AH. Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem 2003;278:43452-9.
19. Jiang JC, Kirchman PA, Zagulski M, Hunt J, Jazwinski SM. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res 1998;8:1259-72.
20. 18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 2004; 279:44311-9.
21. Steel GG, Peckham MJ. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Biol Phys 1979;5: 85-91.
22. Ogretmen B, Schady D, Usta J, et al. Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem 2001;276:24901-10.
23. Schulz A, Mousallem T, Venkataramani M, et al. The CLN9 protein, a regulator of dihydroceramide synthase. J Biol Chem 2006;281:2784-94.
24. Kraveka JM, Li L, Bielawski J, Obeid LM, Ogretmen B. Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Arch Biochem Biophys 2003;419:110-9.
25. Stover TC, Sharma A, Robertson GP, Kester M. Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma. Clin Cancer Res 2005;11:3465-74.
26. Senkal CE, Ponnusamy S, Rossi MJ, et al. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther 2006;317:1188-99.
27. Braakhuis BJ, van Dongen GA, Vermorken JB, Snow GB. Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (gemcitabine) against human head and neck cancer. Cancer Res 1991;51:211-4.
28. Braakhuis BJ, van Dongen GA, Bagnay M, van Walsum M, Snow GB. Preclinical chemotherapy on human head and neck cancer xenografts grown in athymic nude mice. Head Neck 1989;11:511-5.
29. Chalfant CE, Rathman K, Pinkerman RL, et al. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem 2002;277:12587-95.
30. Mizutani Y, Kihara A, Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J 2005;390:263-71.
31. Lahiri S, Futerman AH. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem 2005;280:33735-8.
32. Sultan I, Senkal CE, Ponnusamy S, et al. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J 2006; 393:513-21.
33. Obeid LM, Hannun YA. Ceramide, stress, and a "LAG" in aging. Sci Aging Knowledge Environ 2003; PE27.
34. Vallee B, Riezman H. Lip1p: a novel subunit of acyl-CoA ceramide synthase. EMBO J 2005;24:730-41.
35. Novgorodov SA, Szulc ZM, Luberto C, et al. Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem 2005;280:16096-105.
36. Dindo D, Dahm F, Szulc ZM, et al. Cationic long chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther 2006;5:1520-9.
37. Modica-Napolitano JS, Aprille JR. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv Drug Deliv Rev 2001;49:63-70.
38. Modrak DE, Cardillo TM, Newsome GA, et al. Synergistic interaction between sphingomyelin and gemcitabine potentiates ceramide-mediated apoptosis in pancreatic cancer. Cancer Res 2004;64:8405-10.
39. Veldman RJ, Zerp S, van Blitterswijk WJ, et al. N-Hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx. Br J Cancer 2004;90:917-25.
40. Massiello A, Chalfant CE, SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness. J Lipid Res 2006;47:892-7.
41. Pewzner-Jung Y, Ben-Dor S, Futerman AH. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: insights into the regulation of ceramide synthesis. J Biol Chem 2006; 281:25001-5.
42. Marchesini N, Osta W, Bielawski J, et al. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF-7 cells. J Biol Chem 2004;279:25101-11.