-
1
-
-
30944447568
-
The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
-
Yoon, S., and Seger, R. (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24, 21-44
-
(2006)
Growth Factors
, vol.24
, pp. 21-44
-
-
Yoon, S.1
Seger, R.2
-
2
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall, C. J. (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
3
-
-
0345732643
-
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration
-
Murphy, L. O., MacKeigan, J. P., and Blenis, J. (2004) A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Mol. Cell Biol. 24, 144-153
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 144-153
-
-
Murphy, L.O.1
MacKeigan, J.P.2
Blenis, J.3
-
4
-
-
0036051342
-
Molecular interpretation of ERK signal duration by immediate early gene products
-
Murphy, L. O., Smith, S., Chen, R. H., Fingar, D. C., and Blenis, J. (2002) Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 4, 556-564
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 556-564
-
-
Murphy, L.O.1
Smith, S.2
Chen, R.H.3
Fingar, D.C.4
Blenis, J.5
-
5
-
-
0035150990
-
Growth-factor-dependent mitogenesis requires two distinct phases of signalling
-
Jones, S. M., and Kazlauskas, A. (2001) Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat. Cell Biol. 3, 165-172
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 165-172
-
-
Jones, S.M.1
Kazlauskas, A.2
-
6
-
-
79955971134
-
Two phasesof mitogenic signaling unveil roles for p53 and EGR1 inelimination of inconsistent growth signals
-
Zwang, Y., Sas-Chen, A., Drier, Y., Shay, T., Avraham, R., Lauriola, M., Shema, E., Lidor-Nili, E., Jacob-Hirsch, J., Amariglio, N., Lu, Y., Mills, G. B., Rechavi, G., Oren, M., Domany, E., and Yarden, Y. (2011) Two phasesof mitogenic signaling unveil roles for p53 and EGR1 inelimination of inconsistent growth signals. Mol. Cell 42, 524-535
-
(2011)
Mol. Cell
, vol.42
, pp. 524-535
-
-
Zwang, Y.1
Sas-Chen, A.2
Drier, Y.3
Shay, T.4
Avraham, R.5
Lauriola, M.6
Shema, E.7
Lidor-Nili, E.8
Jacob-Hirsch, J.9
Amariglio, N.10
Lu, Y.11
Mills, G.B.12
Rechavi, G.13
Oren, M.14
Domany, E.15
Yarden, Y.16
-
7
-
-
84870289371
-
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
-
Kwong, L. N., Costello, J. C., Liu, H., Jiang, S., Helms, T. L., Langsdorf, A. E., Jakubosky, D., Genovese, G., Muller, F. L., Jeong, J. H., Bender, R. P., Chu, G. C., Flaherty, K. T., Wargo, J. A., Collins, J. J., and Chin, L. (2012) Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat. Med. 18, 1503-1510
-
(2012)
Nat. Med.
, vol.18
, pp. 1503-1510
-
-
Kwong, L.N.1
Costello, J.C.2
Liu, H.3
Jiang, S.4
Helms, T.L.5
Langsdorf, A.E.6
Jakubosky, D.7
Genovese, G.8
Muller, F.L.9
Jeong, J.H.10
Bender, R.P.11
Chu, G.C.12
Flaherty, K.T.13
Wargo, J.A.14
Collins, J.J.15
Chin, L.16
-
8
-
-
84874765320
-
Encoding and decoding cellular information through signaling dynamics
-
Purvis, J. E., and Lahav, G. (2013) Encoding and decoding cellular information through signaling dynamics. Cell 152, 945-956
-
(2013)
Cell
, vol.152
, pp. 945-956
-
-
Purvis, J.E.1
Lahav, G.2
-
9
-
-
84865298239
-
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst
-
Birtwistle, M. R., Rauch, J., Kiyatkin, A., Aksamitiene, E., Dobrzyński, M., Hoek, J. B., Kolch, W., Ogunnaike, B. A., and Kholodenko, B. N. (2012) Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst. Biol. 6, 109
-
(2012)
Biol.
, vol.6
, pp. 109
-
-
Birtwistle, M.R.1
Rauch, J.2
Kiyatkin, A.3
Aksamitiene, E.4
Dobrzyński, M.5
Hoek, J.B.6
Kolch, W.7
Ogunnaike, B.A.8
Kholodenko, B.N.9
-
10
-
-
82655181489
-
Development of an optimized backbone of FRET biosensors for kinases and GTPases
-
Komatsu, N., Aoki, K., Yamada, M., Yukinaga, H., Fujita, Y., Kamioka, Y., and Matsuda, M. (2011) Development of an optimized backbone of FRET biosensors for kinases and GTPases. Mol. Biol. Cell 22, 4647-4656
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 4647-4656
-
-
Komatsu, N.1
Aoki, K.2
Yamada, M.3
Yukinaga, H.4
Fujita, Y.5
Kamioka, Y.6
Matsuda, M.7
-
11
-
-
58049221116
-
A genetically encoded fluorescent sensor of ERK activity
-
Harvey, C. D., Ehrhardt, A. G., Cellurale, C., Zhong, H., Yasuda, R., Davis, R. J., and Svoboda, K. (2008) A genetically encoded fluorescent sensor of ERK activity. Proc. Natl. Acad. Sci. U. S. A. 105, 19264-19269
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 19264-19269
-
-
Harvey, C.D.1
Ehrhardt, A.G.2
Cellurale, C.3
Zhong, H.4
Yasuda, R.5
Davis, R.J.6
Svoboda, K.7
-
12
-
-
84903217674
-
High-sensitivity measurements of multiple kinase activities in live single cells
-
Regot, S., Hughey, J. J., Bajar, B. T., Carrasco, S., and Covert, M. W. (2014) High-sensitivity measurements of multiple kinase activities in live single cells. Cell 157, 1724-1734
-
(2014)
Cell
, vol.157
, pp. 1724-1734
-
-
Regot, S.1
Hughey, J.J.2
Bajar, B.T.3
Carrasco, S.4
Covert, M.W.5
-
13
-
-
84872796463
-
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals
-
Albeck, J. G., Mills, G. B., and Brugge, J. S. (2013) Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol. Cell 49, 249-261
-
(2013)
Mol. Cell
, vol.49
, pp. 249-261
-
-
Albeck, J.G.1
Mills, G.B.2
Brugge, J.S.3
-
14
-
-
84888202081
-
Stochastic ERK activation induced by noise and cellto-cell propagation regulates cell density-dependent proliferation
-
Aoki, K., Kumagai, Y., Sakurai, A., Komatsu, N., Fujita, Y., Shionyu, C., and Matsuda, M. (2013) Stochastic ERK activation induced by noise and cellto-cell propagation regulates cell density-dependent proliferation. Mol. Cell 52, 529-540
-
(2013)
Mol. Cell
, vol.52
, pp. 529-540
-
-
Aoki, K.1
Kumagai, Y.2
Sakurai, A.3
Komatsu, N.4
Fujita, Y.5
Shionyu, C.6
Matsuda, M.7
-
15
-
-
84922896900
-
Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin
-
Hiratsuka, T., Fujita, Y., Naoki, H., Aoki, K., Kamioka, Y., and Matsuda, M. (2015) Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. Elife 4, e05178
-
(2015)
Elife
, vol.4
, pp. e05178
-
-
Hiratsuka, T.1
Fujita, Y.2
Naoki, H.3
Aoki, K.4
Kamioka, Y.5
Matsuda, M.6
-
16
-
-
52949098296
-
Frequency-modulated nuclear localization bursts coordinate gene regulation
-
Cai, L., Dalal, C. K., and Elowitz, M. B. (2008) Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature 455, 485-490
-
(2008)
Nature
, vol.455
, pp. 485-490
-
-
Cai, L.1
Dalal, C.K.2
Elowitz, M.B.3
-
17
-
-
84872813837
-
Tunable signal processing through modular control of transcription factor translocation
-
Hao, N., Budnik, B. A., Gunawardena, J., and O'Shea, E. K. (2013) Tunable signal processing through modular control of transcription factor translocation. Science 339, 460-464
-
(2013)
Science
, vol.339
, pp. 460-464
-
-
Hao, N.1
Budnik, B.A.2
Gunawardena, J.3
O'Shea, E.K.4
-
18
-
-
78449248996
-
Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network
-
Cirit, M., Wang, C. C., and Haugh, J. M. (2010) Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network. J. Biol. Chem. 285, 36736-36744
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 36736-36744
-
-
Cirit, M.1
Wang, C.C.2
Haugh, J.M.3
-
19
-
-
33751102674
-
Regulationofras signaling dynamics by Sos-mediated positive feedback
-
Boykevisch, S., Zhao, C., Sondermann, H., Philippidou, P., Halegoua, S., Kuriyan, J., and Bar-Sagi, D. (2006) Regulationofras signaling dynamics by Sos-mediated positive feedback. Curr. Biol. 16, 2173-2179
-
(2006)
Curr. Biol.
, vol.16
, pp. 2173-2179
-
-
Boykevisch, S.1
Zhao, C.2
Sondermann, H.3
Philippidou, P.4
Halegoua, S.5
Kuriyan, J.6
Bar-Sagi, D.7
-
20
-
-
0344885558
-
Structural evidence for feedback activation by Ras. GTP of the Ras-specific nucleotide exchange factor SOS
-
Margarit, S. M., Sondermann, H., Hall, B. E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D., and Kuriyan, J. (2003) Structural evidence for feedback activation by Ras. GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112, 685-695
-
(2003)
Cell
, vol.112
, pp. 685-695
-
-
Margarit, S.M.1
Sondermann, H.2
Hall, B.E.3
Nagar, B.4
Hoelz, A.5
Pirruccello, M.6
Bar-Sagi, D.7
Kuriyan, J.8
-
21
-
-
33644856401
-
Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase
-
Balan, V., Leicht, D. T., Zhu, J., Balan, K., Kaplun, A., Singh-Gupta, V., Qin, J., Ruan, H., Comb, M. J., and Tzivion, G. (2006) Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase. Mol. Biol. Cell 17, 1141-1153
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 1141-1153
-
-
Balan, V.1
Leicht, D.T.2
Zhu, J.3
Balan, K.4
Kaplun, A.5
Singh-Gupta, V.6
Qin, J.7
Ruan, H.8
Comb, M.J.9
Tzivion, G.10
-
22
-
-
11844294679
-
Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation
-
Marchetti, S., Gimond, C., Chambard, J. C., Touboul, T., Roux, D., Pouysségur, J., and Pagès, G. (2005) Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol. Cell Biol. 25, 854-864
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 854-864
-
-
Marchetti, S.1
Gimond, C.2
Chambard, J.C.3
Touboul, T.4
Roux, D.5
Pouysségur, J.6
Pagès, G.7
-
23
-
-
65249103982
-
Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway
-
Shin, S. Y., Rath, O., Choo, S. M., Fee, F., McFerran, B., Kolch, W., and Cho, K. H. (2009) Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. J. Cell Sci. 122, 425-435
-
(2009)
J. Cell Sci.
, vol.122
, pp. 425-435
-
-
Shin, S.Y.1
Rath, O.2
Choo, S.M.3
Fee, F.4
McFerran, B.5
Kolch, W.6
Cho, K.H.7
-
24
-
-
77956272475
-
Functional roles of multiple feedback loops in extracellular signalregulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition
-
Shin, S. Y., Rath, O., Zebisch, A., Choo, S. M., Kolch, W., and Cho, K. H. (2010) Functional roles of multiple feedback loops in extracellular signalregulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition. Cancer Res. 70, 6715-6724
-
(2010)
Cancer Res.
, vol.70
, pp. 6715-6724
-
-
Shin, S.Y.1
Rath, O.2
Zebisch, A.3
Choo, S.M.4
Kolch, W.5
Cho, K.H.6
-
25
-
-
77951643590
-
Identifying single-cell molecular programs by stochastic profiling
-
Janes, K. A., Wang, C. C., Holmberg, K. J., Cabral, K., and Brugge, J. S. (2010) Identifying single-cell molecular programs by stochastic profiling. Nat. Methods 7, 311-317
-
(2010)
Nat. Methods
, vol.7
, pp. 311-317
-
-
Janes, K.A.1
Wang, C.C.2
Holmberg, K.J.3
Cabral, K.4
Brugge, J.S.5
-
26
-
-
48449087576
-
Robust single-particle tracking in live-cell time-lapse sequences
-
Jaqaman, K., Loerke, D., Mettlen, M., Kuwata, H., Grinstein, S., Schmid, S. L., and Danuser, G. (2008) Robust single-particle tracking in live-cell time-lapse sequences. Nat. Methods 5, 695-702
-
(2008)
Nat. Methods
, vol.5
, pp. 695-702
-
-
Jaqaman, K.1
Loerke, D.2
Mettlen, M.3
Kuwata, H.4
Grinstein, S.5
Schmid, S.L.6
Danuser, G.7
-
27
-
-
81155137325
-
Linear approaches to intramolecular Forster resonance energy transfer probe measurements for quantitative modeling
-
Birtwistle, M. R., Von Kriegsheim, A., Kida, K., Schwarz, J. P., Anderson, K. I., and Kolch, W. (2011) Linear approaches to intramolecular Forster resonance energy transfer probe measurements for quantitative modeling. PLoS One 6, e27823
-
(2011)
PLoS One
, vol.6
, pp. e27823
-
-
Birtwistle, M.R.1
Von Kriegsheim, A.2
Kida, K.3
Schwarz, J.P.4
Anderson, K.I.5
Kolch, W.6
-
28
-
-
84859173050
-
Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%
-
Goedhart, J., Von Stetten, D., Noirclerc-Savoye, M., Lelimousin, M., Joosen, L., Hink, M. A., Van Weeren, L., Gadella, T. W., Jr., and Royant, A. (2012) Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%. Nat. Commun. 3, 751
-
(2012)
Nat. Commun.
, vol.3
, pp. 751
-
-
Goedhart, J.1
Von Stetten, D.2
Noirclerc-Savoye, M.3
Lelimousin, M.4
Joosen, L.5
Hink, M.A.6
Van Weeren, L.7
Gadella, T.W.8
Royant, A.9
-
29
-
-
84912114619
-
Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor
-
Bessman, N. J., Bagchi, A., Ferguson, K. M., and Lemmon, M. A. (2014) Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor. Cell Rep. 9, 1306-1317
-
(2014)
Cell Rep.
, vol.9
, pp. 1306-1317
-
-
Bessman, N.J.1
Bagchi, A.2
Ferguson, K.M.3
Lemmon, M.A.4
-
30
-
-
32044469862
-
A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity
-
Blinov, M. L., Faeder, J. R., Goldstein, B., and Hlavacek, W. S. (2006) A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity. Biosystems 83, 136-151
-
(2006)
Biosystems
, vol.83
, pp. 136-151
-
-
Blinov, M.L.1
Faeder, J.R.2
Goldstein, B.3
Hlavacek, W.S.4
-
31
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon, M. A., and Schlessinger, J. (2010) Cell signaling by receptor tyrosine kinases. Cell 141, 1117-1134
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
32
-
-
79953300722
-
Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival
-
Vanhecke, E., Adriaenssens, E., Verbeke, S., Meignan, S., Germain, E., Berteaux, N., Nurcombe, V., Le Bourhis, X., and Hondermarck, H. (2011) Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival. Clin. Cancer Res. 17, 1741-1752
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 1741-1752
-
-
Vanhecke, E.1
Adriaenssens, E.2
Verbeke, S.3
Meignan, S.4
Germain, E.5
Berteaux, N.6
Nurcombe, V.7
Le Bourhis, X.8
Hondermarck, H.9
-
33
-
-
84884151405
-
Simultaneous profiling of 194 distinct receptor transcripts in human cells
-
Kang, B. H., Jensen, K. J., Hatch, J. A., and Janes, K. A. (2013) Simultaneous profiling of 194 distinct receptor transcripts in human cells. Sci. Signal. 6, rs13
-
(2013)
Sci. Signal
, vol.6
, pp. rs13
-
-
Kang, B.H.1
Jensen, K.J.2
Hatch, J.A.3
Janes, K.A.4
-
34
-
-
0027996869
-
Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor
-
Basu, T., Warne, P. H., and Downward, J. (1994) Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor. Oncogene 9, 3483-3491
-
(1994)
Oncogene
, vol.9
, pp. 3483-3491
-
-
Basu, T.1
Warne, P.H.2
Downward, J.3
-
35
-
-
0035947724
-
Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells
-
Kao, S., Jaiswal, R. K., Kolch, W., and Landreth, G. E. (2001) Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. J. Biol. Chem. 276, 18169-18177
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18169-18177
-
-
Kao, S.1
Jaiswal, R.K.2
Kolch, W.3
Landreth, G.E.4
-
36
-
-
0034019315
-
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
-
Kholodenko, B. N. (2000) Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur. J. Biochem. 267, 1583-1588
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 1583-1588
-
-
Kholodenko, B.N.1
-
37
-
-
0842288229
-
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
-
Markevich, N. I., Hoek, J. B., and Kholodenko, B. N. (2004) Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J. Cell Biol. 164, 353-359
-
(2004)
J. Cell Biol.
, vol.164
, pp. 353-359
-
-
Markevich, N.I.1
Hoek, J.B.2
Kholodenko, B.N.3
-
38
-
-
33750989365
-
Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation
-
Chickarmane, V., Kholodenko, B. N., and Sauro, H. M. (2007) Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation. J. Theor. Biol. 244, 68-76
-
(2007)
J. Theor. Biol.
, vol.244
, pp. 68-76
-
-
Chickarmane, V.1
Kholodenko, B.N.2
Sauro, H.M.3
-
39
-
-
33644966561
-
Effects of sequestration on signal transduction cascades
-
Blüthgen, N., Bruggeman, F. J., Legewie, S., Herzel, H., Westerhoff, H. V., and Kholodenko, B. N. (2006) Effects of sequestration on signal transduction cascades. FEBS J. 273, 895-906
-
(2006)
FEBS J.
, vol.273
, pp. 895-906
-
-
Blüthgen, N.1
Bruggeman, F.J.2
Legewie, S.3
Herzel, H.4
Westerhoff, H.V.5
Kholodenko, B.N.6
-
40
-
-
58249092059
-
Digital signaling and hysteresis characterize ras activation in lymphoid cells
-
Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A. K., and Roose, J. P. (2009) Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 136, 337-351
-
(2009)
Cell
, vol.136
, pp. 337-351
-
-
Das, J.1
Ho, M.2
Zikherman, J.3
Govern, C.4
Yang, M.5
Weiss, A.6
Chakraborty, A.K.7
Roose, J.P.8
-
41
-
-
84863482471
-
Biophysical mechanism of T-cell receptor triggering in a reconstituted system
-
James, J. R., and Vale, R. D. (2012) Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature 487, 64-69
-
(2012)
Nature
, vol.487
, pp. 64-69
-
-
James, J.R.1
Vale, R.D.2
-
42
-
-
77955289201
-
Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation
-
Ariotti, N., Liang, H., Xu, Y., Zhang, Y., Yonekubo, Y., Inder, K., Du, G., Parton, R. G., Hancock, J. F., and Plowman, S. J. (2010) Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation. Mol. Cell Biol. 30, 3795-3804
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 3795-3804
-
-
Ariotti, N.1
Liang, H.2
Xu, Y.3
Zhang, Y.4
Yonekubo, Y.5
Inder, K.6
Du, G.7
Parton, R.G.8
Hancock, J.F.9
Plowman, S.J.10
-
43
-
-
0036080555
-
Autocrine loops with positive feedback enable context-dependent cell signaling
-
Shvartsman, S. Y., Hagan, M. P., Yacoub, A., Dent, P., Wiley, H. S., and Lauffenburger, D. A. (2002) Autocrine loops with positive feedback enable context-dependent cell signaling. Am. J. Physiol. Cell Physiol. 282, C545-C559
-
(2002)
Am. J. Physiol. Cell Physiol.
, vol.282
, pp. C545-C559
-
-
Shvartsman, S.Y.1
Hagan, M.P.2
Yacoub, A.3
Dent, P.4
Wiley, H.S.5
Lauffenburger, D.A.6
-
44
-
-
84890036078
-
Using optogenetics to interrogate the dynamic control of signal transmission by the ras/erk module
-
Toettcher, J. E., Weiner, O. D., and Lim, W. A. (2013) Using optogenetics to interrogate the dynamic control of signal transmission by the ras/erk module. Cell 155, 1422-1434
-
(2013)
Cell
, vol.155
, pp. 1422-1434
-
-
Toettcher, J.E.1
Weiner, O.D.2
Lim, W.A.3
-
45
-
-
17344362384
-
Prediction and validation of the distinct dynamics of transient and sustained ERK activation
-
Sasagawa, S., Ozaki, Y., Fujita, K., and Kuroda, S. (2005) Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat. Cell Biol. 7, 365-373
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 365-373
-
-
Sasagawa, S.1
Ozaki, Y.2
Fujita, K.3
Kuroda, S.4
-
46
-
-
84923141003
-
Ras nanoclusters: Versatile lipid-based signaling platforms
-
Zhou, Y., and Hancock, J. F. (2015) Ras nanoclusters: versatile lipid-based signaling platforms. Biochim. Biophys. Acta 1853, 841-849
-
(2015)
Biochim. Biophys. Acta
, vol.1853
, pp. 841-849
-
-
Zhou, Y.1
Hancock, J.F.2
-
47
-
-
58549083142
-
Input-output behavior of ERBB signaling pathways as revealed by a mass action model trained against dynamic data
-
Chen, W. W., Schoeberl, B., Jasper, P. J., Niepel, M., Nielsen, U. B., Lauffenburger, D. A., and Sorger, P. K. (2009) Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. Mol. Syst. Biol. 5, 239
-
(2009)
Mol. Syst. Biol.
, vol.5
, pp. 239
-
-
Chen, W.W.1
Schoeberl, B.2
Jasper, P.J.3
Niepel, M.4
Nielsen, U.B.5
Lauffenburger, D.A.6
Sorger, P.K.7
-
48
-
-
84885722700
-
Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines
-
Niepel, M., Hafner, M., Pace, E. A., Chung, M., Chai, D. H., Zhou, L., Schoeberl, B., and Sorger, P. K. (2013) Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines. Sci. Signal. 6, ra84
-
(2013)
Sci. Signal
, vol.6
, pp. ra84
-
-
Niepel, M.1
Hafner, M.2
Pace, E.A.3
Chung, M.4
Chai, D.H.5
Zhou, L.6
Schoeberl, B.7
Sorger, P.K.8
-
49
-
-
84904739888
-
Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs
-
Fujita, Y., Komatsu, N., Matsuda, M., and Aoki, K. (2014) Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. FEBS J. 281, 3177-3192
-
(2014)
FEBS J.
, vol.281
, pp. 3177-3192
-
-
Fujita, Y.1
Komatsu, N.2
Matsuda, M.3
Aoki, K.4
-
50
-
-
71149092283
-
Dynamics and variability of ERK2 response to EGF in individual living cells
-
Cohen-Saidon, C., Cohen, A. A., Sigal, A., Liron, Y., and Alon, U. (2009) Dynamics and variability of ERK2 response to EGF in individual living cells. Mol. Cell 36, 885-893
-
(2009)
Mol. Cell
, vol.36
, pp. 885-893
-
-
Cohen-Saidon, C.1
Cohen, A.A.2
Sigal, A.3
Liron, Y.4
Alon, U.5
-
51
-
-
33644850529
-
Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein
-
Brummer, T., Schramek, D., Hayes, V. M., Bennett, H. L., Caldon, C. E., Musgrove, E. A., and Daly, R. J. (2006) Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J. Biol. Chem. 281, 626-637
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 626-637
-
-
Brummer, T.1
Schramek, D.2
Hayes, V.M.3
Bennett, H.L.4
Caldon, C.E.5
Musgrove, E.A.6
Daly, R.J.7
-
52
-
-
84907392675
-
Plasticity of mammary cell boundaries governed by EGF and actin remodeling
-
Tang, W. Y., Beckett, A. J., Prior, I. A., Coulson, J. M., Urbé, S., and Clague, M. J. (2014) Plasticity of mammary cell boundaries governed by EGF and actin remodeling. Cell Rep. 8, 1722-1730
-
(2014)
Cell Rep.
, vol.8
, pp. 1722-1730
-
-
Tang, W.Y.1
Beckett, A.J.2
Prior, I.A.3
Coulson, J.M.4
Urbé, S.5
Clague, M.J.6
-
53
-
-
2542452082
-
Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells
-
Graham, N. A., and Asthagiri, A. R. (2004) Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells. J. Biol. Chem. 279, 23517-23524
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 23517-23524
-
-
Graham, N.A.1
Asthagiri, A.R.2
-
54
-
-
0021333875
-
Relationship between epidermal growth factor receptor occupancy and mitogenic response: Quantitative analysis using a steady state model system
-
Knauer, D. J., Wiley, H. S., and Cunningham, D. D. (1984) Relationship between epidermal growth factor receptor occupancy and mitogenic response: quantitative analysis using a steady state model system. J. Biol. Chem. 259, 5623-5631
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 5623-5631
-
-
Knauer, D.J.1
Wiley, H.S.2
Cunningham, D.D.3
-
55
-
-
80052211582
-
Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding
-
Kleiman, L. B., Maiwald, T., Conzelmann, H., Lauffenburger, D. A., and Sorger, P. K. (2011) Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Mol. Cell 43, 723-737
-
(2011)
Mol. Cell
, vol.43
, pp. 723-737
-
-
Kleiman, L.B.1
Maiwald, T.2
Conzelmann, H.3
Lauffenburger, D.A.4
Sorger, P.K.5
-
56
-
-
33847355217
-
Growth factorinduced MAPK network topology shapes Erk response determining PC-12 cell fate
-
Santos, S. D., Verveer, P. J., and Bastiaens, P. I. (2007) Growth factorinduced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat. Cell Biol. 9, 324-330
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 324-330
-
-
Santos, S.D.1
Verveer, P.J.2
Bastiaens, P.I.3
-
57
-
-
78650635354
-
The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier
-
Sturm, O. E., Orton, R., Grindlay, J., Birtwistle, M., Vyshemirsky, V., Gilbert, D., Calder, M., Pitt, A., Kholodenko, B., and Kolch, W. (2010) The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier. Sci. Signal. 3, ra90
-
(2010)
Sci. Signal
, vol.3
, pp. ra90
-
-
Sturm, O.E.1
Orton, R.2
Grindlay, J.3
Birtwistle, M.4
Vyshemirsky, V.5
Gilbert, D.6
Calder, M.7
Pitt, A.8
Kholodenko, B.9
Kolch, W.10
-
58
-
-
84898662770
-
Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states
-
Ahmed, S., Grant, K. G., Edwards, L. E., Rahman, A., Cirit, M., Goshe, M. B., and Haugh, J. M. (2014) Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states. Mol. Syst. Biol. 10, 718
-
(2014)
Mol. Syst. Biol.
, vol.10
, pp. 718
-
-
Ahmed, S.1
Grant, K.G.2
Edwards, L.E.3
Rahman, A.4
Cirit, M.5
Goshe, M.B.6
Haugh, J.M.7
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