Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs

FEBS Journal

Volumn 281, Issue 14, 2014, Pages 3177-3192

  Fujita, Yoshihisa ^a   Komatsu, Naoki ^a   Matsuda, Michiyuki ^a   Aoki, Kazuhiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Akt; EGFR; ERK; FRET; simulation

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; N [3 (5 CHLORO 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONYL) 2,4 DIFLUOROPHENYL]PROPANESULFONAMIDE; PEPTIDES AND PROTEINS; PHOSPHATIDYLINOSITOL 3 KINASE; RAF PROTEIN; RAS PROTEIN; RHEB PROTEIN; S6 KINASE; SELUMETINIB; TUBEROUS SCLEROSIS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOSENSOR; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; FEEDBACK SYSTEM; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IMAGE PROCESSING; POSITIVE FEEDBACK; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SIMULATION; TIME LAPSE IMAGING;

AKT; EGFR; ERK; FRET; SIMULATION;

DRUG DELIVERY SYSTEMS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELLS; HOMEOSTASIS; HUMANS; MAP KINASE SIGNALING SYSTEM; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TOR SERINE-THREONINE KINASES;

EID: 84904739888     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12852     Document Type: Article

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