Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

BMC Systems Biology

Volumn 6, Issue , 2012, Pages

  Birtwistle, Marc R ^a,b,c,d   Rauch, Jens ^b   Kiyatkin, Anatoly ^c   Aksamitiene, Edita ^c   Dobrzyński, Maciej ^b   Hoek, Jan B ^c   Kolch, Walter ^b   Ogunnaike, Babatunde A ^d   Kholodenko, Boris N ^b,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

ARTICLE; BIOLOGICAL MODEL; CELL STRAIN HEK293; DRUG EFFECT; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; STATISTICS;

ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MODELS, BIOLOGICAL; RAS PROTEINS; SIGNAL TRANSDUCTION; STOCHASTIC PROCESSES;

EID: 84865298239     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-6-109     Document Type: Article

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