Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

Journal of Cell Biology

Volumn 164, Issue 3, 2004, Pages 353-359

  Markevich, Nick I ^a   Hoek, Jan B ^a   Kholodenko, Boris N ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Bistable biological switch; Covalent protein modification; Mitogen activated protein kinase cascades; Multisite phosphorylation

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PROTEIN KINASE;

ARTICLE; BINDING SITE; COVALENT BOND; DEPHOSPHORYLATION; DRUG DISTRIBUTION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; FEEDBACK SYSTEM; HYSTERESIS; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANIMALS; ENZYME ACTIVATION; FEEDBACK, BIOCHEMICAL; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, THEORETICAL; PHOSPHORYLATION;

EID: 0842288229     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200308060     Document Type: Article

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