-
2
-
-
66749174867
-
The inflammasomes: Guardians of the body
-
Martinon F, Mayor A, Tschopp J (2009) The inflammasomes: guardians of the body. Annu Rev Immunol 27:229-265. doi:10.1146/annurev.immunol.021908.132715
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 229-265
-
-
Martinon, F.1
Mayor, A.2
Tschopp, J.3
-
4
-
-
2542457495
-
Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
-
Martinon F, Tschopp J (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561-574. doi:10.1016/j.cell.2004.05.004
-
(2004)
Cell
, vol.117
, pp. 561-574
-
-
Martinon, F.1
Tschopp, J.2
-
6
-
-
0002928890
-
Identification of a monocyte specific pre-interleukin 1 beta convertase activity
-
Kostura MJ, Tocci MJ, Limjuco G et al (1989) Identification of a monocyte specific pre-interleukin 1 beta convertase activity. Proc Natl Acad Sci U S A 86:5227-5231
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 5227-5231
-
-
Kostura, M.J.1
Tocci, M.J.2
Limjuco, G.3
-
7
-
-
0024551325
-
A pre-aspartatespecific protease from human leukocytes that cleaves prointerleukin- 1 beta
-
Black RA, Kronheim SR, Merriam JE et al (1989) A pre-aspartatespecific protease from human leukocytes that cleaves prointerleukin- 1 beta. J Biol Chem 264:5323-5326
-
(1989)
J Biol Chem
, vol.264
, pp. 5323-5326
-
-
Black, R.A.1
Kronheim, S.R.2
Merriam, J.E.3
-
8
-
-
0026507126
-
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
-
Thornberry NA, Bull HG, Calaycay JR et al (1992) A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:768-774. doi:10.1038/356768a0
-
(1992)
Nature
, vol.356
, pp. 768-774
-
-
Thornberry, N.A.1
Bull, H.G.2
Calaycay, J.R.3
-
9
-
-
0026517239
-
Molecular cloning of the interleukin-1 beta converting enzyme
-
Cerretti DP, Kozlosky CJ, Mosley B et al (1992) Molecular cloning of the interleukin-1 beta converting enzyme. Science 256:97-100
-
(1992)
Science
, vol.256
, pp. 97-100
-
-
Cerretti, D.P.1
Kozlosky, C.J.2
Mosley, B.3
-
10
-
-
0028107827
-
Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: A (p20/p10)2 homodimer
-
Walker NP, Talanian RV, Brady KD et al (1994) Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. Cell 78:343-352
-
(1994)
Cell
, vol.78
, pp. 343-352
-
-
Walker, N.P.1
Talanian, R.V.2
Brady, K.D.3
-
11
-
-
4143096903
-
Crystal structures of a ligand-free and malonate-bound human caspase- 1: Implications for the mechanism of substrate binding
-
Romanowski MJ, Scheer JM, O’Brien T, McDowell RS (2004) Crystal structures of a ligand-free and malonate-bound human caspase- 1: implications for the mechanism of substrate binding. Structure 12:1361-1371. doi:10.1016/j.str.2004.05.010
-
(2004)
Structure
, vol.12
, pp. 1361-1371
-
-
Romanowski, M.J.1
Scheer, J.M.2
O’Brien, T.3
McDowell, R.S.4
-
12
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
-
Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417-426
-
(2002)
Mol Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
13
-
-
84869504451
-
Inflammasomes and their roles in health and disease
-
Lamkanfi M, Dixit VM (2012) Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol 28:137-161. doi:10.1146/annurev-cellbio-101011-155745
-
(2012)
Annu Rev Cell Dev Biol
, vol.28
, pp. 137-161
-
-
Lamkanfi, M.1
Dixit, V.M.2
-
14
-
-
33847376042
-
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation
-
Faustin B, Lartigue L, Bruey J-M et al (2007) Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell 25:713-724. doi:10.1016/j.molcel.2007.01. 032
-
(2007)
Mol Cell
, vol.25
, pp. 713-724
-
-
Faustin, B.1
Lartigue, L.2
Bruey, J.-M.3
-
15
-
-
31744441475
-
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
-
Boyden ED, Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38:240-244. doi:10.1038/ng1724
-
(2006)
Nat Genet
, vol.38
, pp. 240-244
-
-
Boyden, E.D.1
Dietrich, W.F.2
-
16
-
-
34250835251
-
The inflammasome mediates UVB-induced activation and secretion of interleukin- 1beta by keratinocytes
-
Feldmeyer L, Keller M, Niklaus G et al (2007) The inflammasome mediates UVB-induced activation and secretion of interleukin- 1beta by keratinocytes. Curr Biol 17:1140-1145. doi:10.1016/j. cub.2007.05.074
-
(2007)
Curr Biol
, vol.17
, pp. 1140-1145
-
-
Feldmeyer, L.1
Keller, M.2
Niklaus, G.3
-
17
-
-
84921909014
-
The inflammasome and autoinflammatory syndromes
-
141125121526004
-
Broderick L, De Nardo D, Franklin BS et al (2014) The inflammasome and autoinflammatory syndromes. Annu Rev Pathol 10:141125121526004. doi:10.1146/annurev-pathol- 012414-040431
-
(2014)
Annu Rev Pathol
, vol.10
-
-
Broderick, L.1
De Nardo, D.2
Franklin, B.S.3
-
18
-
-
84878237993
-
Activation and regulation of the inflammasomes
-
Latz E, Xiao TS, Stutz A (2013) Activation and regulation of the inflammasomes. Nat Publ Group 13:397-411. doi:10.1038/nri3452
-
(2013)
Nat Publ Group
, vol.13
, pp. 397-411
-
-
Latz, E.1
Xiao, T.S.2
Stutz, A.3
-
19
-
-
84861474688
-
Signaling in innate immunity and inflammation
-
pii: a006049
-
Newton, K, & Dixit, VM (2012) Signaling in innate immunity and inflammation. Cold Spring Harbor Perspectives in Biology, 4(3), pii: a006049. doi:10.1101/cshperspect.a006049
-
(2012)
Cold Spring Harbor Perspectives in Biology
, vol.4
, Issue.3
-
-
Newton, K.1
Dixit, V.M.2
-
20
-
-
70249138036
-
Cutting edge: NF- κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulatingNLRP3 expression
-
Bauernfeind FG, Horvath G, Stutz A et al (2009) Cutting edge: NF- κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulatingNLRP3 expression. J Immunol 183:787-791. doi:10.4049/jimmunol.0901363
-
(2009)
J Immunol
, vol.183
, pp. 787-791
-
-
Bauernfeind, F.G.1
Horvath, G.2
Stutz, A.3
-
21
-
-
84885459019
-
Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome
-
Fernandes-Alnemri T, Kang S, Anderson C et al (2013) Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol 191:3995-3999. doi:10.4049/jimmunol.1301681
-
(2013)
J Immunol
, vol.191
, pp. 3995-3999
-
-
Fernandes-Alnemri, T.1
Kang, S.2
Erson, C.3
-
22
-
-
84869088114
-
Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction
-
Schroder K, Sagulenko V, Zamoshnikova A et al (2012) Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology. doi: 10.1016/j.imbio.2012.07.020
-
(2012)
Immunobiology
-
-
Schroder, K.1
Sagulenko, V.2
Zamoshnikova, A.3
-
23
-
-
84872782298
-
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
-
Py BF, Kim M-S, Vakifahmetoglu-Norberg H, Yuan J (2013) Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell 49:331-338. doi:10.1016/j. molcel.2012.11.009
-
(2013)
Mol Cell
, vol.49
, pp. 331-338
-
-
Py, B.F.1
Kim, M.-S.2
Vakifahmetoglu-Norberg, H.3
Yuan, J.4
-
24
-
-
84867770402
-
Nontranscriptional priming and deubiquitination regulate NLRP3 inflammasome activation
-
Juliana C, Fernandes-Alnemri T, Kang S et al (2012) Nontranscriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 287:36617-36622. doi: 10.1074/jbc.M112.407130
-
(2012)
J Biol Chem
, vol.287
, pp. 36617-36622
-
-
Juliana, C.1
Fernandes-Alnemri, T.2
Kang, S.3
-
26
-
-
0033515520
-
Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
-
McDermott MF, Aksentijevich I, Galon J et al (1999) Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97:133-144
-
(1999)
Cell
, vol.97
, pp. 133-144
-
-
McDermott, M.F.1
Aksentijevich, I.2
Galon, J.3
-
27
-
-
84882284037
-
Monogenic autoinflammatory diseases: Concept and clinical manifestations
-
Almeida de Jesus A, Goldbach-Mansky R (2013) Monogenic autoinflammatory diseases: concept and clinical manifestations. Clin Immunol 147:155-174. doi:10.1016/j.clim.2013.03.016
-
(2013)
Clin Immunol
, vol.147
, pp. 155-174
-
-
De Almeida Jesus, A.1
Goldbach-Mansky, R.2
-
28
-
-
0035179970
-
Mutation of a newgene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
-
Hoffman HM, Mueller JL, Broide DH et al (2001) Mutation of a newgene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29:301-305. doi:10.1038/ng756
-
(2001)
Nat Genet
, vol.29
, pp. 301-305
-
-
Hoffman, H.M.1
Mueller, J.L.2
Broide, D.H.3
-
29
-
-
0036899758
-
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrinassociated autoinflammatory diseases
-
Aksentijevich I, Nowak M, Mallah M et al (2002) De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrinassociated autoinflammatory diseases. Arthritis Rheum 46:3340- 3348. doi:10.1002/art.10688
-
(2002)
Arthritis Rheum
, vol.46
-
-
Aksentijevich, I.1
Nowak, M.2
Mallah, M.3
-
30
-
-
0036302235
-
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes
-
Feldmann J, Prieur A-M, Quartier P et al (2002) Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet 71:198-203
-
(2002)
Am J Hum Genet
, vol.71
, pp. 198-203
-
-
Feldmann, J.1
Prieur, A.-M.2
Quartier, P.3
-
31
-
-
67650736238
-
Horror autoinflammaticus: The Molecular pathophysiology of autoinflammatory disease
-
Masters SL, Simon A, Aksentijevich I, Kastner DL (2009) Horror autoinflammaticus: the Molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol 27:621-668. doi: 10.1146/annurev.immunol.25.022106.141627
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 621-668
-
-
Masters, S.L.1
Simon, A.2
Aksentijevich, I.3
Kastner, D.L.4
-
32
-
-
77950363011
-
Autoinflammatory disease reloaded: A clinical perspective
-
Kastner DL, Aksentijevich I, Goldbach-Mansky R (2010) Autoinflammatory disease reloaded: a clinical perspective. Cell 140:784-790. doi:10.1016/j.cell.2010.03.002
-
(2010)
Cell
, vol.140
, pp. 784-790
-
-
Kastner, D.L.1
Aksentijevich, I.2
Goldbach-Mansky, R.3
-
33
-
-
39749084641
-
Active caspase-1 is a regulator of unconventional protein secretion
-
Keller M, Rüegg A, Werner S, Beer H-D (2008) Active caspase-1 is a regulator of unconventional protein secretion. Cell 132:818-831. doi:10.1016/j.cell.2007.12.040
-
(2008)
Cell
, vol.132
, pp. 818-831
-
-
Keller, M.1
Rüegg, A.2
Werner, S.3
Beer, H.-D.4
-
34
-
-
84894344719
-
Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses
-
Bulau A-M, Nold MF, Li S et al (2014) Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1324140111
-
(2014)
Proc Natl Acad Sci U S A
-
-
Bulau, A.-M.1
Nold, M.F.2
Li, S.3
-
35
-
-
33748598700
-
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
-
Gurcel L, Abrami L, Girardin S et al (2006) Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 126:1135-1145. doi:10.1016/j. cell.2006.07.033
-
(2006)
Cell
, vol.126
, pp. 1135-1145
-
-
Gurcel, L.1
Abrami, L.2
Girardin, S.3
-
36
-
-
84893947749
-
Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection
-
Jabir MS, Ritchie ND, Li D et al (2014) Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection. Cell Host Microbe 15: 214-227. doi:10.1016/j.chom.2014.01.010
-
(2014)
Cell Host Microbe
, vol.15
, pp. 214-227
-
-
Jabir, M.S.1
Ritchie, N.D.2
Li, D.3
-
37
-
-
84939631887
-
Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation
-
Madouri F, Guillou N, Fauconnier L et al (2015) Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation. J Mol Cell Biol. doi:10.1093/jmcb/mjv012
-
(2015)
J Mol Cell Biol
-
-
Madouri, F.1
Guillou, N.2
Fauconnier, L.3
-
38
-
-
83655191976
-
A protective role for inflammasome activation following injury
-
Osuka A, Hanschen M, Stoecklein V, Lederer JA (2012) A protective role for inflammasome activation following injury. Shock 37: 47-55. doi:10.1097/SHK.0b013e318234f7ff
-
(2012)
Shock
, vol.37
, pp. 47-55
-
-
Osuka, A.1
Hanschen, M.2
Stoecklein, V.3
Lederer, J.A.4
-
39
-
-
84858786676
-
Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation
-
Menzel CL, Sun Q, Loughran PA et al (2011) Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation. Mol Med 17:1031-1038. doi:10.2119/molmed.2011.00015
-
(2011)
Mol Med
, vol.17
, pp. 1031-1038
-
-
Menzel, C.L.1
Sun, Q.2
Loughran, P.A.3
-
40
-
-
84871608014
-
Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β
-
Luksch H, Romanowski MJ, Chara O et al (2013) Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β. Hum Mutat 34: 122-131. doi:10.1002/humu.22169
-
(2013)
Hum Mutat
, vol.34
, pp. 122-131
-
-
Luksch, H.1
Romanowski, M.J.2
Chara, O.3
-
41
-
-
84899560815
-
Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling
-
Heymann MC, Winkler S, Luksch H et al (2014) Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling. J Immunol 192:4379-4385. doi:10.4049/jimmunol.1203524
-
(2014)
J Immunol
, vol.192
, pp. 4379-4385
-
-
Heymann, M.C.1
Winkler, S.2
Luksch, H.3
-
42
-
-
0028984948
-
Mice deficient in IL-1b-converting enzyme are defective in production of mature IL-1b and resistant to endotoxic shock
-
Li P (1995) Mice deficient in IL-1b-converting enzyme are defective in production of mature IL-1b and resistant to endotoxic shock. Cell 80:401-411. doi:10.1016/0092-8674(95)90490-5
-
(1995)
Cell
, vol.80
, pp. 401-411
-
-
Li, P.1
-
43
-
-
0028920863
-
Altered cytokine export and apoptosis inmice deficient in interleukin-1 beta converting enzyme
-
Kuida K, Lippke JA, Ku G et al (1995) Altered cytokine export and apoptosis inmice deficient in interleukin-1 beta converting enzyme. Science 267:2000-2003
-
(1995)
Science
, vol.267
, pp. 2000-2003
-
-
Kuida, K.1
Lippke, J.A.2
Ku, G.3
-
44
-
-
0026635783
-
Shigella flexneri induces apoptosis in infected macrophages
-
Zychlinsky A, Prevost MC, Sansonetti PJ (1992) Shigella flexneri induces apoptosis in infected macrophages. Nature 358:167-169. doi:10.1038/358167a0
-
(1992)
Nature
, vol.358
, pp. 167-169
-
-
Zychlinsky, A.1
Prevost, M.C.2
Sansonetti, P.J.3
-
45
-
-
80052179138
-
Caspase-1-induced pyroptotic cell death
-
Miao EA, Rajan JV, Aderem A (2011) Caspase-1-induced pyroptotic cell death. Immunol Rev 243:206-214. doi:10.1111/j. 1600-065X.2011.01044.x
-
(2011)
Immunol Rev
, vol.243
, pp. 206-214
-
-
Miao, E.A.1
Rajan, J.V.2
Aderem, A.3
-
47
-
-
62649139025
-
Immunological and inflammatory functions of the interleukin-1 family
-
Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27:519-550. doi:10.1146/annurev.immunol.021908.132612
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 519-550
-
-
Dinarello, C.A.1
-
48
-
-
33847672241
-
NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
-
Miggin SM, Palsson-McDermott E, Dunne A et al (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A 104:3372-3377. doi:10.1073/pnas.0608100104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3372-3377
-
-
Miggin, S.M.1
Palsson-McDermott, E.2
Dunne, A.3
-
49
-
-
84860325913
-
Inflammasomeactivated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes
-
Erener S, Pétrilli V, Kassner I et al (2012) Inflammasomeactivated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. Mol Cell. doi:10.1016/j. molcel.2012.02.016
-
(2012)
Mol Cell
-
-
Erener, S.1
Pétrilli, V.2
Kassner, I.3
-
50
-
-
2642517305
-
Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity
-
Lamkanfi M, Kalai M, Saelens X et al (2004) Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity. J Biol Chem 279:24785-24793. doi:10.1074/jbc.M400985200
-
(2004)
J Biol Chem
, vol.279
, pp. 24785-24793
-
-
Lamkanfi, M.1
Kalai, M.2
Saelens, X.3
-
51
-
-
80053894653
-
Interaction patches of procaspase-1 caspase recruitment domains (CARDs) Are differently involved in procaspase-1 activation and receptorinteracting protein 2 (RIP2)-dependent nuclear factor B signaling
-
Kersse K, Lamkanfi M, Bertrand MJM et al (2011) Interaction patches of procaspase-1 caspase recruitment domains (CARDs) Are differently involved in procaspase-1 activation and receptorinteracting protein 2 (RIP2)-dependent nuclear factor B signaling. J Biol Chem 286:35874-35882. doi:10.1074/jbc.M111.242321
-
(2011)
J Biol Chem
, vol.286
, pp. 35874-35882
-
-
Kersse, K.1
Lamkanfi, M.2
Bertrand, M.3
-
52
-
-
33645757512
-
ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions
-
Sarkar A, Duncan M, Hart J et al (2006) ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol 176:4979-4986
-
(2006)
J Immunol
, vol.176
, pp. 4979-4986
-
-
Sarkar, A.1
Duncan, M.2
Hart, J.3
-
53
-
-
0024369393
-
Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair
-
Broadley KN, Aquino AM, Woodward SC et al (1989) Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair. Lab Investig 61:571-575
-
(1989)
Lab Investig
, vol.61
, pp. 571-575
-
-
Broadley, K.N.1
Aquino, A.M.2
Woodward, S.C.3
-
54
-
-
0036020218
-
Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production
-
Kumar S, Hanning CR, Brigham-Burke MR et al (2002) Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine 18:61-71. doi:10.1006/cyto. 2002.0873
-
(2002)
Cytokine
, vol.18
, pp. 61-71
-
-
Kumar, S.1
Hanning, C.R.2
Brigham-Burke, M.R.3
-
55
-
-
45949111754
-
The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines
-
Sharma S, Kulk N, Nold MF et al (2008) The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol 180:5477-5482
-
(2008)
J Immunol
, vol.180
, pp. 5477-5482
-
-
Sharma, S.1
Kulk, N.2
Nold, M.F.3
-
56
-
-
77958149102
-
IL-37 is a fundamental inhibitor of innate immunity
-
Nold MF, Nold-Petry CA, Zepp JA et al (2010) IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 11:1014-1022. doi:10.1038/ni.1944
-
(2010)
Nat Immunol
, vol.11
, pp. 1014-1022
-
-
Nold, M.F.1
Nold-Petry, C.A.2
Zepp, J.A.3
-
57
-
-
84912106429
-
IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis
-
Moretti S, Bozza S, Oikonomou V et al (2014) IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis. PLoS Pathog 10:e1004462. doi:10.1371/journal.ppat. 1004462
-
(2014)
Plos Pathog
, vol.10
-
-
Moretti, S.1
Bozza, S.2
Oikonomou, V.3
-
58
-
-
84873710963
-
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPSinduced septic shock
-
Mao K, Chen S, Chen M et al (2013) Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPSinduced septic shock. Cell Res 23:201-212. doi:10.1038/cr. 2013.6
-
(2013)
Cell Res
, vol.23
, pp. 201-212
-
-
Mao, K.1
Chen, S.2
Chen, M.3
-
59
-
-
84856024206
-
Inflammasome activation via intracellular NLRs triggered by bacterial infection
-
Koizumi Y, Toma C, Higa N et al (2011) Inflammasome activation via intracellular NLRs triggered by bacterial infection. Cell Microbiol 14:149-154. doi:10.1111/j.1462-5822.2011.01707.x
-
(2011)
Cell Microbiol
, vol.14
, pp. 149-154
-
-
Koizumi, Y.1
Toma, C.2
Higa, N.3
-
60
-
-
30344473341
-
Brown MS(2006) Protein sensors for membrane sterols
-
Goldstein JL, DeBose-Boyd RA, Brown MS(2006) Protein sensors for membrane sterols. Cell 124:35-46. doi:10.1016/j.cell.2005.12. 022
-
Cell
, vol.124
, pp. 35-46
-
-
Goldstein, J.L.1
Debose-Boyd, R.A.2
-
61
-
-
84927922772
-
Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate
-
Aries A, Whitcomb J, Shao Wet al (2014) Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate. Cell Death Dis 5:e1566. doi:10.1038/cddis.2014.524
-
(2014)
Cell Death Dis
, vol.5
-
-
Aries, A.1
Whitcomb, J.2
Al, S.W.3
-
62
-
-
67649607465
-
Autophagy, immunity, and microbial adaptations
-
Deretic V, Levine B (2009) Autophagy, immunity, and microbial adaptations. Cell Host Microbe 5:527-549. doi:10.1016/j.chom. 2009.05.016
-
(2009)
Cell Host Microbe
, vol.5
, pp. 527-549
-
-
Deretic, V.1
Levine, B.2
-
63
-
-
20344387475
-
Autophagy: Dual roles in life and death?
-
Baehrecke EH (2005) Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 6:505. doi:10.1038/nrm1666
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 505
-
-
Baehrecke, E.H.1
-
64
-
-
54049126870
-
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases
-
Rebsamen M, Meylan E, Curran J, Tschopp J (2008) The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. Cell Death Differ 15:1804-1811. doi:10.1038/cdd.2008. 119
-
(2008)
Cell Death Differ
, vol.15
, pp. 1804-1811
-
-
Rebsamen, M.1
Meylan, E.2
Curran, J.3
Tschopp, J.4
-
65
-
-
80455176839
-
Non-canonical inflammasome activation targets caspase-11
-
Kayagaki N, Warming S, Lamkanfi M et al (2011) Non-canonical inflammasome activation targets caspase-11. Nature 479:117-121. doi:10.1038/nature10558
-
(2011)
Nature
, vol.479
, pp. 117-121
-
-
Kayagaki, N.1
Warming, S.2
Lamkanfi, M.3
-
66
-
-
84864600268
-
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gramnegative bacteria
-
Rathinam VAK, Vanaja SK, Waggoner L et al (2012) TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gramnegative bacteria. Cell 150:606-619. doi:10.1016/j.cell.2012.07. 007
-
(2012)
Cell
, vol.150
, pp. 606-619
-
-
Rathinam, V.1
Vanaja, S.K.2
Waggoner, L.3
-
67
-
-
84867241369
-
Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens
-
Gurung P, Malireddi RKS, Anand PK et al (2012) Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens. J Biol Chem 287:34474-34483. doi:10.1074/jbc.M112.401406
-
(2012)
J Biol Chem
, vol.287
, pp. 34474-34483
-
-
Gurung, P.1
Malireddi, R.2
Anand, P.K.3
-
68
-
-
34249044447
-
Type I interferon signaling is required for activation of the inflammasome during Francisella infection
-
Henry T, Brotcke A, Weiss DS et al (2007) Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J Exp Med 204:987-994. doi:10.1084/jem. 20062665
-
(2007)
J Exp Med
, vol.204
, pp. 987-994
-
-
Henry, T.1
Brotcke, A.2
Weiss, D.S.3
-
69
-
-
84895807942
-
Role of interleukin 33 in respiratory allergy and asthma
-
Makrinioti H, Toussaint M, Jackson DJ et al (2014) Role of interleukin 33 in respiratory allergy and asthma. Lancet Respir Med 2: 226-237. doi:10.1016/S2213-2600(13)70261-3
-
(2014)
Lancet Respir Med
, vol.2
, pp. 226-237
-
-
Makrinioti, H.1
Toussaint, M.2
Jackson, D.J.3
-
70
-
-
84889653647
-
Emerging role of interleukin-33 in autoimmune diseases
-
Pei C, Barbour M, Fairlie-Clarke KJ et al (2013) Emerging role of interleukin-33 in autoimmune diseases. Immunology 141:9-17. doi:10.1111/imm.12174
-
(2013)
Immunology
, vol.141
, pp. 9-17
-
-
Pei, C.1
Barbour, M.2
Fairlie-Clarke, K.J.3
-
71
-
-
53249113212
-
The IL-33/ST2 pathway: Therapeutic target and novel biomarker
-
Kakkar R, Lee RT (2008) The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov 7:827-840. doi:10.1038/nrd2660
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 827-840
-
-
Kakkar, R.1
Lee, R.T.2
-
72
-
-
67049158193
-
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
-
Cayrol C, Girard J-P (2009) The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci U S A 106:9021-9026. doi:10.1073/pnas.0812690106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 9021-9026
-
-
Cayrol, C.1
Girard, J.-P.2
-
73
-
-
79954597670
-
An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma
-
Kool M, Willart MAM, van Nimwegen M et al (2011) An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 34:527-540. doi:10.1016/j.immuni.2011.03.015
-
(2011)
Immunity
, vol.34
, pp. 527-540
-
-
Kool, M.1
Willart, M.2
Van Nimwegen, M.3
-
74
-
-
33645312379
-
Circuitry of nuclear factor kappaB signaling
-
Hoffmann A, Baltimore D (2006) Circuitry of nuclear factor kappaB signaling. Immunol Rev 210:171-186. doi:10.1111/j. 0105-2896.2006.00375.x
-
(2006)
Immunol Rev
, vol.210
, pp. 171-186
-
-
Hoffmann, A.1
Baltimore, D.2
-
75
-
-
0035895992
-
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NFkappaB
-
Ogura Y, Inohara N, Benito A et al (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NFkappaB. J Biol Chem 276:4812-4818. doi:10.1074/jbc. M008072200
-
(2001)
J Biol Chem
, vol.276
, pp. 4812-4818
-
-
Ogura, Y.1
Inohara, N.2
Benito, A.3
-
76
-
-
3142654767
-
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
-
Mariathasan S, Newton K, Monack DM et al (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-218. doi:10.1038/nature02664
-
(2004)
Nature
, vol.430
, pp. 213-218
-
-
Mariathasan, S.1
Newton, K.2
Monack, D.M.3
-
77
-
-
84858761335
-
Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
-
Groß O, Yazdi AS, Thomas CJ et al (2012) Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36:388-400. doi:10.1016/j.immuni.2012.01.018
-
(2012)
Immunity
, vol.36
, pp. 388-400
-
-
Groß, O.1
Yazdi, A.S.2
Thomas, C.J.3
-
78
-
-
78650210802
-
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
-
Broz P, von Moltke J, Jones JW et al (2010) Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 8:471-483. doi:10.1016/j.chom.2010.11.007
-
(2010)
Cell Host Microbe
, vol.8
, pp. 471-483
-
-
Broz, P.1
Von Moltke, J.2
Jones, J.W.3
-
79
-
-
84914132432
-
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
-
Guey B, Bodnar M, Manié SN et al (2014) Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function. Proc Natl Acad Sci U S A 111:17254- 17259. doi:10.1073/pnas.1415756111
-
(2014)
Proc Natl Acad Sci U S a 111:17254-
, pp. 17259
-
-
Guey, B.1
Bodnar, M.2
Manié, S.N.3
-
80
-
-
84893835896
-
Activation of the NLRP1b inflammasome independently of ASCmediated caspase-1 autoproteolysis and speck formation
-
Van Opdenbosch N, Gurung P, Vande Walle L et al (2014) Activation of the NLRP1b inflammasome independently of ASCmediated caspase-1 autoproteolysis and speck formation. Nat Commun 5:3209. doi:10.1038/ncomms4209
-
(2014)
Nat Commun
, vol.5
, pp. 3209
-
-
Van Opdenbosch, N.1
Gurung, P.2
Vande Walle, L.3
|