Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB Signaling

Journal of Immunology

Volumn 192, Issue 9, 2014, Pages 4379-4385

  Heymann, Michael C ^a   Winkler, Stefan ^a   Luksch, Hella ^a   Flecks, Silvana ^a   Franke, Marcus ^a   Ru, Susanne ^a   Özen, Seza ^b   Yilmaz, Engin ^b   Klein, Christoph ^c   Kallinich, Tilmann ^d   Lindemann, Dirk ^a   Brenner, Sebastian ^a   Ganser, Gerd ^e   Roesler, Joachim ^a   Rösen Wolff, Angela ^a   Hofmann, Sigrun R ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b HACETTEPE UNIVERSITY   (Turkey)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e Abt Kinder und Jugendrheumatologie   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; ENZYME VARIANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROCASPASE 1; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 2; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME RELEASE; FEVER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INFLAMMATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

BLOTTING, WESTERN; CASPASE 1; FEVER; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCKDOWN TECHNIQUES; GENETIC VARIATION; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; NF-KAPPA B; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASE 2; SIGNAL TRANSDUCTION; TRANSDUCTION, GENETIC; TRANSFECTION;

EID: 84899560815     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1203524     Document Type: Article

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