Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 7, 2014, Pages 2650-2655

  Bulau, Ana Maria ^a   Nold, Marcel F ^b   Li, Suzhao ^c   Nold Petry, Claudia A ^b   Fink, Michaela ^a   Mansell, Ashley ^d   Schwerd, Tobias ^a   Hong, Jaewoo ^e   Rubartelli, Anna ^f   Dinarello, Charles A ^c,g   Bufler, Philip ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Ritchie Centre   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d MONASH UNIVERSITY   (Australia)

^e Konkuk University   (South Korea)

^f UNIVERSITY OF GENOA   (Italy)

^g RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; CYTOKINE; CYTOKINE ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 37; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NEUTRALIZING ANTIBODY; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR PYRIN DOMAIN CONTAINING 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENDOTOXEMIA; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; INNATE IMMUNITY; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIBODIES, NEUTRALIZING; BLOTTING, WESTERN; CASPASE 1; CELL LINE; CELL NUCLEUS; ESCHERICHIA COLI; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MUTAGENESIS, SITE-DIRECTED;

EID: 84894344719     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1324140111     Document Type: Article

References (29)

1. Boraschi D, et al. (2011) IL-37: A new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw 22(3):127-147.
2. Keller M, Rüegg A, Werner S, Beer HD (2008) Active caspase-1 is a regulator of unconventional protein secretion. Cell 132(5):818-831.
3. Sutterwala FS, et al. (2006) Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24(3):317-327.
4. Kumar S, et al. (2002) Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine 18(2):61-71.
5. Sharma S, et al. (2008) The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol 180(8):5477-5482.
6. Pan G, et al. (2001) IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. Cytokine 13(1):1-7.
7. McNamee EN, et al. (2011) Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci USA 108(40):16711-16716.
8. Nold MF, et al. (2010) IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 11(11):1014-1022.
9. Hornung V, et al. (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9(8):847-856.
10. Perregaux D, Gabel CA (1994) Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 269(21):15195-15203.
11. Rajamäki K, et al. (2010) Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: A novel link between cholesterol metabolism and inflammation. PLoS ONE 5(7):e11765.
12. Semino C, Angelini G, Poggi A, Rubartelli A (2005) NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1. Blood 106(2):609-616.
13. Sakai N, et al. (2012) Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J Gastroenterol Hepatol 27(10):1609-1616.
14. Dinarello CA, Novick D, Kim S, Kaplanski G (2013) Interleukin-18 and IL-18 Binding Protein. Front Immunol 4:289.
15. Towne JE, et al. (2011) Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36a, IL-36ß, and IL-36?) or antagonist (IL-36Ra) activity. J Biol Chem 286(49): 42594-42602.
16. Agostini L, et al. (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20(3):319-325.
17. Strowig T, Henao-Mejia J, Elinav E, Flavell R (2012) Inflammasomes in health and disease. Nature 481(7381):278-286.
18. He M, et al. (2012) Asian sand dust enhances murine lung inflammation caused by Klebsiella pneumoniae. Toxicol Appl Pharmacol 258(2):237-247.
19. Rotta Detto Loria J, et al. (2013) Nontypeable haemophilus influenzae infection upregulates the NLRP3 inflammasome and leads to caspase-1-dependent secretion of interleukin-1ß-A possible pathway of exacerbations in COPD. PLoS ONE 8(6):e66818.
20. Sandberg WJ, et al. (2012) Comparison of non-crystalline silica nanoparticles in IL-1ß release from macrophages. Part Fibre Toxicol 9:32.
21. Duncan JA, et al. (2007) Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling. Proc Natl Acad Sci USA 104(19): 8041-8046.
22. Levandowski CB, et al. (2013) NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1ß processing via the NLRP1 inflammasome. Proc Natl Acad Sci USA 110(8):2952-2956.
23. Netea MG, et al. (2009) Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113(10):2324-2335.
24. Chijioke O, Munz C (2013) Dendritic cell derived cytokines in human natural killer cell differentiation and activation. Front Immunol 4:365.
25. Li S, et al. (2013) Recombinant IL-37 inhibits LPS induced inflammation in a SIGIRRand MAPK-dependent manner. Cytokine 63(3):281.
26. Nold MF, et al. (2013) Interleukin-37 employs the IL-1 family inhibitory receptor SIGIRR and the alpha chain of the IL-18 receptor to suppress innate immunity. Cytokine 63(3):287.
27. Bufler P, et al. (2002) A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci USA 99(21):13723-13728.
28. Bufler P, Gamboni-Robertson F, Azam T, Kim SH, Dinarello CA (2004) Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide. Biochem J 381(Pt 2):503-510.
29. Halle A, et al. (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9(8):857-865.