메뉴 건너뛰기




Volumn 10, Issue 3, 2014, Pages

Genetic Determinants Influencing Human Serum Metabolome among African Americans

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; TREHALOSE; ACYLTRANSFERASE; NAT8 PROTEIN, HUMAN;

EID: 84897399605     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004212     Document Type: Article
Times cited : (86)

References (43)
  • 1
    • 63449100039 scopus 로고    scopus 로고
    • Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts
    • Psaty BM, O'Donnell CJ, Gudnason V, Lunetta KL, Folsom AR, et al. (2009) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet 2: 73-80.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 73-80
    • Psaty, B.M.1    O'Donnell, C.J.2    Gudnason, V.3    Lunetta, K.L.4    Folsom, A.R.5
  • 2
    • 33747856339 scopus 로고    scopus 로고
    • Metabolomics: building on a century of biochemistry to guide human health
    • German JB, Hammock BD, Watkins SM, (2005) Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 1: 3-9.
    • (2005) Metabolomics , vol.1 , pp. 3-9
    • German, J.B.1    Hammock, B.D.2    Watkins, S.M.3
  • 3
    • 84867744660 scopus 로고    scopus 로고
    • Genetic variation in metabolic phenotypes: study designs and applications
    • Suhre K, Gieger C, (2012) Genetic variation in metabolic phenotypes: study designs and applications. Nat Rev Genet 13: 759-769.
    • (2012) Nat Rev Genet , vol.13 , pp. 759-769
    • Suhre, K.1    Gieger, C.2
  • 4
  • 5
    • 84873855068 scopus 로고    scopus 로고
    • A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol
    • Surakka I, Whitfield JB, Perola M, Visscher PM, Montgomery GW, et al. (2012) A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Res Hum Genet 15: 691-699.
    • (2012) Twin Res Hum Genet , vol.15 , pp. 691-699
    • Surakka, I.1    Whitfield, J.B.2    Perola, M.3    Visscher, P.M.4    Montgomery, G.W.5
  • 6
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42: 105-116.
    • (2010) Nat Genet , vol.42 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3    Saxena, R.4    Soranzo, N.5
  • 7
    • 84947899575 scopus 로고    scopus 로고
    • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
    • Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, et al. (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 45: 145-154.
    • (2013) Nat Genet , vol.45 , pp. 145-154
    • Kottgen, A.1    Albrecht, E.2    Teumer, A.3    Vitart, V.4    Krumsiek, J.5
  • 8
    • 57149114936 scopus 로고    scopus 로고
    • Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    • Gieger C, Geistlinger L, Altmaier E, Hrabe de Angelis M, Kronenberg F, et al. (2008) Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet 4: e1000282.
    • (2008) PLoS Genet , vol.4
    • Gieger, C.1    Geistlinger, L.2    Altmaier, E.3    Hrabe de Angelis, M.4    Kronenberg, F.5
  • 9
    • 79957604338 scopus 로고    scopus 로고
    • A genome-wide association study of metabolic traits in human urine
    • Suhre K, Wallaschofski H, Raffler J, Friedrich N, Haring R, et al. (2011) A genome-wide association study of metabolic traits in human urine. Nat Genet 43: 565-569.
    • (2011) Nat Genet , vol.43 , pp. 565-569
    • Suhre, K.1    Wallaschofski, H.2    Raffler, J.3    Friedrich, N.4    Haring, R.5
  • 10
    • 80052398214 scopus 로고    scopus 로고
    • Human metabolic individuality in biomedical and pharmaceutical research
    • Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, et al. (2011) Human metabolic individuality in biomedical and pharmaceutical research. Nature 477: 54-60.
    • (2011) Nature , vol.477 , pp. 54-60
    • Suhre, K.1    Shin, S.Y.2    Petersen, A.K.3    Mohney, R.P.4    Meredith, D.5
  • 11
    • 84857648463 scopus 로고    scopus 로고
    • Genome-wide association study identifies multiple loci influencing human serum metabolite levels
    • Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, et al. (2012) Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 44: 269-276.
    • (2012) Nat Genet , vol.44 , pp. 269-276
    • Kettunen, J.1    Tukiainen, T.2    Sarin, A.P.3    Ortega-Alonso, A.4    Tikkanen, E.5
  • 12
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, et al. (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449: 851-861.
    • (2007) Nature , vol.449 , pp. 851-861
    • Frazer, K.A.1    Ballinger, D.G.2    Cox, D.R.3    Hinds, D.A.4    Stuve, L.L.5
  • 13
    • 52949093871 scopus 로고    scopus 로고
    • African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping
    • Campbell MC, Tishkoff SA, (2008) African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet 9: 403-433.
    • (2008) Annu Rev Genomics Hum Genet , vol.9 , pp. 403-433
    • Campbell, M.C.1    Tishkoff, S.A.2
  • 15
    • 84872091789 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2013 update: a report from the American Heart Association
    • Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, et al. (2013) Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation 127: e6-e245.
    • (2013) Circulation , vol.127
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3    Benjamin, E.J.4    Berry, J.D.5
  • 16
    • 0036707889 scopus 로고    scopus 로고
    • Excess risk of chronic kidney disease among African-American versus white subjects in the United States: a population-based study of potential explanatory factors
    • Tarver-Carr ME, Powe NR, Eberhardt MS, LaVeist TA, Kington RS, et al. (2002) Excess risk of chronic kidney disease among African-American versus white subjects in the United States: a population-based study of potential explanatory factors. J Am Soc Nephrol 13: 2363-2370.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2363-2370
    • Tarver-Carr, M.E.1    Powe, N.R.2    Eberhardt, M.S.3    LaVeist, T.A.4    Kington, R.S.5
  • 18
    • 84878256943 scopus 로고    scopus 로고
    • Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes
    • Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, et al. (2013) Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes 62: 2141-2150.
    • (2013) Diabetes , vol.62 , pp. 2141-2150
    • Xie, W.1    Wood, A.R.2    Lyssenko, V.3    Weedon, M.N.4    Knowles, J.W.5
  • 19
    • 77953300281 scopus 로고    scopus 로고
    • Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids
    • Veiga-da-Cunha M, Tyteca D, Stroobant V, Courtoy PJ, Opperdoes FR, et al. (2010) Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids. J Biol Chem 285: 18888-18898.
    • (2010) J Biol Chem , vol.285 , pp. 18888-18898
    • Veiga-da-Cunha, M.1    Tyteca, D.2    Stroobant, V.3    Courtoy, P.J.4    Opperdoes, F.R.5
  • 20
    • 84881600364 scopus 로고    scopus 로고
    • Associations between metabolomic compounds and incident heart failure among African Americans: the ARIC Study
    • Zheng Y, Yu B, Alexander D, Manolio TA, Aguilar D, et al. (2013) Associations between metabolomic compounds and incident heart failure among African Americans: the ARIC Study. Am J Epidemiol 178: 534-542.
    • (2013) Am J Epidemiol , vol.178 , pp. 534-542
    • Zheng, Y.1    Yu, B.2    Alexander, D.3    Manolio, T.A.4    Aguilar, D.5
  • 21
    • 77951766263 scopus 로고    scopus 로고
    • New loci associated with kidney function and chronic kidney disease
    • Kottgen A, Pattaro C, Boger CA, Fuchsberger C, Olden M, et al. (2010) New loci associated with kidney function and chronic kidney disease. Nat Genet 42: 376-384.
    • (2010) Nat Genet , vol.42 , pp. 376-384
    • Kottgen, A.1    Pattaro, C.2    Boger, C.A.3    Fuchsberger, C.4    Olden, M.5
  • 22
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, et al. (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 106: 9362-9367.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5
  • 23
    • 81055145433 scopus 로고    scopus 로고
    • Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants
    • Park JH, Gail MH, Weinberg CR, Carroll RJ, Chung CC, et al. (2011) Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants. Proc Natl Acad Sci U S A 108: 18026-18031.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 18026-18031
    • Park, J.H.1    Gail, M.H.2    Weinberg, C.R.3    Carroll, R.J.4    Chung, C.C.5
  • 24
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
    • Nature , vol.447 , pp. 661-678
  • 26
  • 27
    • 75749134031 scopus 로고    scopus 로고
    • A genome-wide perspective of genetic variation in human metabolism
    • Illig T, Gieger C, Zhai G, Romisch-Margl W, Wang-Sattler R, et al. (2010) A genome-wide perspective of genetic variation in human metabolism. Nat Genet 42: 137-141.
    • (2010) Nat Genet , vol.42 , pp. 137-141
    • Illig, T.1    Gieger, C.2    Zhai, G.3    Romisch-Margl, W.4    Wang-Sattler, R.5
  • 28
    • 0031647972 scopus 로고    scopus 로고
    • Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases
    • Ozaki K, Fujiwara T, Nakamura Y, Takahashi E, (1998) Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases. J Hum Genet 43: 255-258.
    • (1998) J Hum Genet , vol.43 , pp. 255-258
    • Ozaki, K.1    Fujiwara, T.2    Nakamura, Y.3    Takahashi, E.4
  • 30
    • 84880872926 scopus 로고    scopus 로고
    • Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate
    • Tin A, Colantuoni E, Boerwinkle E, Kottgen A, Franceschini N, et al. (2013) Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate. J Hum Genet 58: 461-6.
    • (2013) J Hum Genet , vol.58 , pp. 461-466
    • Tin, A.1    Colantuoni, E.2    Boerwinkle, E.3    Kottgen, A.4    Franceschini, N.5
  • 31
    • 58149477054 scopus 로고    scopus 로고
    • Effect of trehalose on protein structure
    • Jain NK, Roy I, (2009) Effect of trehalose on protein structure. Protein Sci 18: 24-36.
    • (2009) Protein Sci , vol.18 , pp. 24-36
    • Jain, N.K.1    Roy, I.2
  • 32
    • 1642633757 scopus 로고    scopus 로고
    • Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
    • Tanaka M, Machida Y, Niu S, Ikeda T, Jana NR, et al. (2004) Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat Med 10: 148-154.
    • (2004) Nat Med , vol.10 , pp. 148-154
    • Tanaka, M.1    Machida, Y.2    Niu, S.3    Ikeda, T.4    Jana, N.R.5
  • 33
    • 29644437591 scopus 로고    scopus 로고
    • Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy
    • Davies JE, Sarkar S, Rubinsztein DC, (2006) Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Hum Mol Genet 15: 23-31.
    • (2006) Hum Mol Genet , vol.15 , pp. 23-31
    • Davies, J.E.1    Sarkar, S.2    Rubinsztein, D.C.3
  • 34
    • 0036282324 scopus 로고    scopus 로고
    • Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies
    • Richards AB, Krakowka S, Dexter LB, Schmid H, Wolterbeek AP, et al. (2002) Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies. Food Chem Toxicol 40: 871-898.
    • (2002) Food Chem Toxicol , vol.40 , pp. 871-898
    • Richards, A.B.1    Krakowka, S.2    Dexter, L.B.3    Schmid, H.4    Wolterbeek, A.P.5
  • 35
    • 84866919001 scopus 로고    scopus 로고
    • Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions
    • Wu C, Kraft P, Zhai K, Chang J, Wang Z, et al. (2012) Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet 44: 1090-1097.
    • (2012) Nat Genet , vol.44 , pp. 1090-1097
    • Wu, C.1    Kraft, P.2    Zhai, K.3    Chang, J.4    Wang, Z.5
  • 36
    • 1342281649 scopus 로고    scopus 로고
    • Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity
    • You YJ, Kim Y, Nam NH, Bang SC, Ahn BZ, (2004) Alkyl and carboxylalkyl esters of 4′-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity. Eur J Med Chem 39: 189-193.
    • (2004) Eur J Med Chem , vol.39 , pp. 189-193
    • You, Y.J.1    Kim, Y.2    Nam, N.H.3    Bang, S.C.4    Ahn, B.Z.5
  • 38
    • 84868112190 scopus 로고    scopus 로고
    • Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
    • Krumsiek J, Suhre K, Evans AM, Mitchell MW, Mohney RP, et al. (2012) Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information. PLoS Genet 8: e1003005.
    • (2012) PLoS Genet , vol.8
    • Krumsiek, J.1    Suhre, K.2    Evans, A.M.3    Mitchell, M.W.4    Mohney, R.P.5
  • 39
    • 0024591825 scopus 로고    scopus 로고
    • The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators
    • The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol 129: 687-702.
    • Am J Epidemiol , vol.129 , pp. 687-702
  • 40
    • 68649113524 scopus 로고    scopus 로고
    • Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats
    • Ohta T, Masutomi N, Tsutsui N, Sakairi T, Mitchell M, et al. (2009) Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats. Toxicol Pathol 37: 521-535.
    • (2009) Toxicol Pathol , vol.37 , pp. 521-535
    • Ohta, T.1    Masutomi, N.2    Tsutsui, N.3    Sakairi, T.4    Mitchell, M.5
  • 41
    • 68849083050 scopus 로고    scopus 로고
    • Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems
    • Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E, (2009) Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 81: 6656-6667.
    • (2009) Anal Chem , vol.81 , pp. 6656-6667
    • Evans, A.M.1    DeHaven, C.D.2    Barrett, T.3    Mitchell, M.4    Milgram, E.5
  • 42
    • 70449647008 scopus 로고
    • Proportional hazards tests and diagnostics based on weighted residuals
    • Grambsch PM, Therneau TM, (1994) Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81: 515-526.
    • (1994) Biometrika , vol.81 , pp. 515-526
    • Grambsch, P.M.1    Therneau, T.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.