A genome-wide metabolic QTL analysis in europeans implicates two Loci shaped by recent positive selection

PLoS Genetics

Volumn 7, Issue 9, 2011, Pages

  Nicholson, George ^a   Rantalainen, Mattias ^a   Li, Jia V ^b   Maher, Anthony D ^b,c   Malmodin, Daniel ^d   Ahmadi, Kourosh R ^e   Faber, Johan H ^d   Barrett, Amy ^f   Min, Josine L ^g   Rayner, N William ^f,g   Toft, Henrik ^d   Krestyaninova, Maria ^h   Viksna, Juris ⁱ   Neogi, Sudeshna Guha ^j   Dumas, Marc Emmanuel ^b   Sarkans, Ugis ^h   Donnelly, Peter ^a,g   Illig, Thomas ^k   Adamski, Jerzy ^k,l   Suhre, Karsten ^k,m,o   Allen, Maxine ^f   Zondervan, Krina T ^g   Spector, Tim D ^e   Nicholson, Jeremy K ^b   Lindon, John C ^b   Baunsgaard, Dorrit ^d   Holmes, Elaine ^b   McCarthy, Mark I ^f,g,n   Holmes, Chris C ^a   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c Biosciences Research Division   (Australia)

^d NOVO NORDISK A S   (Denmark)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

ⁱ UNIVERSITY OF LATVIA   (Latvia)

^j ADDENBROOKE S HOSPITAL   (United Kingdom)

^k INSTITUTE OF EPIDEMIOLOGY   (Germany)

^l TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^m UNIVERSITY OF MUNICH   (Germany)

ⁿ CHURCHILL HOSPITAL   (United Kingdom)

^o WEILL CORNELL MEDICAL COLLEGE   (Qatar)

more..

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO ISOBUTYRATE; DIMETHYLAMINE; ISOBUTYRIC ACID DERIVATIVE; TRIMETHYLAMINE; UNCLASSIFIED DRUG; ACYLTRANSFERASE; METHYLAMINE; NAT8 PROTEIN, HUMAN;

ACETYLATION; ADULT; AGED; AGXT2 GENE; ALMS1 GENE; ARTICLE; BLOOD SAMPLING; CHROMOSOME 10Q; CHROMOSOME 2P; COHORT ANALYSIS; CONTROLLED STUDY; DUSP11 GENE; EFFECT SIZE; EUROPEAN AMERICAN; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC SELECTION; GENOME ANALYSIS; HAPLOTYPE; HUMAN; LONGITUDINAL STUDY; METABOLIC REGULATION; METABOLITE; METABOLOME; METABOLOMICS; NAT8 GENE; POPULATION GENETICS; POSITIVE SELECTION; PROTON NUCLEAR MAGNETIC RESONANCE; PYROXD2 GENE; QUANTITATIVE TRAIT LOCUS MAPPING; SINGLE NUCLEOTIDE POLYMORPHISM; TPRKB GENE; TWINS; URINALYSIS; URINE LEVEL; BLOOD; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTITATIVE TRAIT LOCUS; URINE;

ACETYLTRANSFERASES; DIMETHYLAMINES; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HUMANS; ISOBUTYRIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; METHYLAMINES; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; SELECTION, GENETIC;

EID: 80053456207     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002270     Document Type: Article

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