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Volumn 19, Issue 10, 2010, Pages 2050-2058

Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CARBAMOYL PHOSPHATE SYNTHASE; HOMOCYSTEINE; THREONINE;

EID: 77952469251     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddq062     Document Type: Article
Times cited : (63)

References (34)
  • 1
    • 34547518713 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: a review of the evidence
    • Wierzbicki, A.S. (2007) Homocysteine and cardiovascular disease: a review of the evidence. Diab. Vasc. Dis. Res., 4, 143-150.
    • (2007) Diab. Vasc. Dis. Res. , vol.4 , pp. 143-150
    • Wierzbicki, A.S.1
  • 2
    • 0034533298 scopus 로고    scopus 로고
    • Coronary artery disease - free radical damage, antioxidant protection and the role of homocysteine
    • Maxwell, S.R. (2000) Coronary artery disease - free radical damage, antioxidant protection and the role of homocysteine. Basic Res. Cardiol., 95 (Suppl. 1), I65-I71.
    • (2000) Basic Res. Cardiol. , vol.95 , Issue.SUPPL. 1
    • Maxwell, S.R.1
  • 3
    • 0030698745 scopus 로고    scopus 로고
    • Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: the Rotterdam Study
    • Bots, M.L., Launer, L.J., Lindemans, J., Hofman, A. and Grobbee, D.E. (1997) Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: the Rotterdam Study. J. Intern. Med., 242, 339-347.
    • (1997) J. Intern. Med. , vol.242 , pp. 339-347
    • Bots, M.L.1    Launer, L.J.2    Lindemans, J.3    Hofman, A.4    Grobbee, D.E.5
  • 4
    • 0028926633 scopus 로고
    • Measurement of homocyst(e)ine in the prediction of arteriosclerosis
    • Fortin, L.J. and Genest, J. Jr (1995) Measurement of homocyst(e)ine in the prediction of arteriosclerosis. Clin. Biochem., 28, 155-162.
    • (1995) Clin. Biochem. , vol.28 , pp. 155-162
    • Fortin, L.J.1    Genest J., Jr.2
  • 6
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry, I.J., Refsum, H., Morris, R.W., Ebrahim, S.B., Ueland, P.M. and Shaper, A.G. (1995) Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet, 346, 1395-1398.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 7
    • 0034723761 scopus 로고    scopus 로고
    • Blood levels of homocysteine and increased risks of cardiovascular disease: causal or casual?
    • Christen, W.G., Ajani, U.A., Glynn, R.J. and Hennekens, C.H. (2000) Blood levels of homocysteine and increased risks of cardiovascular disease: causal or casual? Arch. Intern. Med., 160, 422-434.
    • (2000) Arch. Intern. Med. , vol.160 , pp. 422-434
    • Christen, W.G.1    Ajani, U.A.2    Glynn, R.J.3    Hennekens, C.H.4
  • 8
    • 3042728564 scopus 로고    scopus 로고
    • The dose-response relation between serum homocysteine and cardiovascular disease: implications for treatment and screening
    • Wald, D.S., Law, M. and Morris, J.K. (2004) The dose-response relation between serum homocysteine and cardiovascular disease: implications for treatment and screening. Eur. J. Cardiovasc. Prev. Rehabil., 11, 250-253.
    • (2004) Eur. J. Cardiovasc. Prev. Rehabil. , vol.11 , pp. 250-253
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 9
    • 34547850403 scopus 로고    scopus 로고
    • The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway
    • Siva, A., De Lange, M., Clayton, D., Monteith, S., Spector, T. and Brown, M.J. (2007) The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. Q. J. Med., 100, 495-499.
    • (2007) Q. J. Med. , vol.100 , pp. 495-499
    • Siva, A.1    De Lange, M.2    Clayton, D.3    Monteith, S.4    Spector, T.5    Brown, M.J.6
  • 10
    • 0036705558 scopus 로고    scopus 로고
    • Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriography
    • Jee, S.H., Song, K.S., Shim, W.H., Kim, H.K., Suh, I., Park, J.Y., Won, S.Y. and Beaty, T.H. (2002) Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriography. Hum. Genet., 111, 128-135.
    • (2002) Hum. Genet. , vol.111 , pp. 128-135
    • Jee, S.H.1    Song, K.S.2    Shim, W.H.3    Kim, H.K.4    Suh, I.5    Park, J.Y.6    Won, S.Y.7    Beaty, T.H.8
  • 12
    • 0030845376 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) mutation, homocyst(e)ine, and coronary artery disease
    • Wilcken, D.E., Wang, X.L. and Wilcken, B. (1997) Methylenetetrahydrofolate reductase (MTHFR) mutation, homocyst(e)ine, and coronary artery disease. Circulation, 96, 2738-2740.
    • (1997) Circulation , vol.96 , pp. 2738-2740
    • Wilcken, D.E.1    Wang, X.L.2    Wilcken, B.3
  • 15
    • 12144291030 scopus 로고    scopus 로고
    • Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I
    • Summar, M.L., Hall, L., Christman, B., Barr, F., Smith, H., Kallianpur, A., Brown, N., Yadav, M., Willis, A., Eeds, A. et al. (2004) Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Mol. Genet. Metab., 81 (Suppl. 1), S12-S19.
    • (2004) Mol. Genet. Metab. , vol.81 , Issue.SUPPL. 1
    • Summar, M.L.1    Hall, L.2    Christman, B.3    Barr, F.4    Smith, H.5    Kallianpur, A.6    Brown, N.7    Yadav, M.8    Willis, A.9    Eeds, A.10
  • 17
    • 33947182032 scopus 로고    scopus 로고
    • Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study
    • Canter, J.A., Summar, M.L., Smith, H.B., Rice, G.D., Hall, L.D., Ritchie, M.D., Motsinger, A.A., Christian, K.G., Drinkwater, D.C. Jr, Scholl, F.G. et al. (2007) Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study. Mitochondrion, 7, 204-210.
    • (2007) Mitochondrion , vol.7 , pp. 204-210
    • Canter, J.A.1    Summar, M.L.2    Smith, H.B.3    Rice, G.D.4    Hall, L.D.5    Ritchie, M.D.6    Motsinger, A.A.7    Christian, K.G.8    Drinkwater D.C., Jr.9    Scholl, F.G.10
  • 18
    • 77649222029 scopus 로고    scopus 로고
    • Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association of fibrinogen in 17,686 women
    • Danik, J.S., Pare, G., Chasman, D.I., Zee, R.Y.L., Kwiatkowski, D.J., Parker, A., Miletich, J.P. and Ridker, P.M. (2009) Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association of fibrinogen in 17,686 women. Circ. Cardiovasc. Genet., 2, 134-141.
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 134-141
    • Danik, J.S.1    Pare, G.2    Chasman, D.I.3    Zee, R.Y.L.4    Kwiatkowski, D.J.5    Parker, A.6    Miletich, J.P.7    Ridker, P.M.8
  • 19
    • 0034489473 scopus 로고    scopus 로고
    • 5,10-methylenetetrahydrofolate reductase common mutations, folate status and plasma homocysteine in healthy French adults of the Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) cohort
    • Chango, A., Potier De Courcy, G., Boisson, F., Guilland, J.C., Barbe, F., Perrin, M.O., Christides, J.P., Rabhi, K., Pfister, M., Galan, P. et al. (2000) 5,10-methylenetetrahydrofolate reductase common mutations, folate status and plasma homocysteine in healthy French adults of the Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) cohort. Br. J. Nutr., 84, 891-896.
    • (2000) Br. J. Nutr. , vol.84 , pp. 891-896
    • Chango, A.1    Potier De Courcy, G.2    Boisson, F.3    Guilland, J.C.4    Barbe, F.5    Perrin, M.O.6    Christides, J.P.7    Rabhi, K.8    Pfister, M.9    Galan, P.10
  • 20
    • 0035864690 scopus 로고    scopus 로고
    • The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study
    • Dekou, V., Whincup, P., Papacosta, O., Ebrahim, S., Lennon, L., Ueland, P.M., Refsum, H., Humphries, S.E. and Gudnason, V. (2001) The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study. Atherosclerosis, 154, 659-666.
    • (2001) Atherosclerosis , vol.154 , pp. 659-666
    • Dekou, V.1    Whincup, P.2    Papacosta, O.3    Ebrahim, S.4    Lennon, L.5    Ueland, P.M.6    Refsum, H.7    Humphries, S.E.8    Gudnason, V.9
  • 22
    • 0038754110 scopus 로고    scopus 로고
    • Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2)
    • Husemoen, L.L., Thomsen, T.F., Fenger, M., Jorgensen, H.L. and Jorgensen, T. (2003) Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2). Genet. Epidemiol., 24, 322-330.
    • (2003) Genet. Epidemiol. , vol.24 , pp. 322-330
    • Husemoen, L.L.1    Thomsen, T.F.2    Fenger, M.3    Jorgensen, H.L.4    Jorgensen, T.5
  • 23
    • 0033533505 scopus 로고    scopus 로고
    • Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations
    • Selhub, J., Jacques, P.F., Rosenberg, I.H., Rogers, G., Bowman, B.A., Gunter, E.W., Wright, J.D. and Johnson, C.L. (1999) Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann. Intern. Med., 131, 331-339.
    • (1999) Ann. Intern. Med. , vol.131 , pp. 331-339
    • Selhub, J.1    Jacques, P.F.2    Rosenberg, I.H.3    Rogers, G.4    Bowman, B.A.5    Gunter, E.W.6    Wright, J.D.7    Johnson, C.L.8
  • 24
    • 0038168733 scopus 로고    scopus 로고
    • Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence
    • Bjorke Monsen, A.L. and Ueland, P.M. (2003) Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence. Am. J. Clin. Nutr., 78, 7-21.
    • (2003) Am. J. Clin. Nutr. , vol.78 , pp. 7-21
    • Bjorke Monsen, A.L.1    Ueland, P.M.2
  • 25
    • 0034661530 scopus 로고    scopus 로고
    • Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey
    • Morris, M.S., Jacques, P.F., Selhub, J. and Rosenberg, I.H. (2000) Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey. Am. J. Epidemiol., 152, 140-148.
    • (2000) Am. J. Epidemiol. , vol.152 , pp. 140-148
    • Morris, M.S.1    Jacques, P.F.2    Selhub, J.3    Rosenberg, I.H.4
  • 26
    • 0035964389 scopus 로고    scopus 로고
    • Maternal energy stores and diet composition during pregnancy program adolescent blood pressure
    • Adair, L.S., Kuzawa, C.W. and Borja, J. (2001) Maternal energy stores and diet composition during pregnancy program adolescent blood pressure. Circulation, 104, 1034-1039.
    • (2001) Circulation , vol.104 , pp. 1034-1039
    • Adair, L.S.1    Kuzawa, C.W.2    Borja, J.3
  • 27
    • 1542499806 scopus 로고    scopus 로고
    • Analytical and clinical evaluation of the Bayer ADVIA Centaur homocysteine assay
    • Tewari, P.C., Zhang, B. and Bluestein, B.I. (2004) Analytical and clinical evaluation of the Bayer ADVIA Centaur homocysteine assay. Clin. Chim. Acta, 342, 171-178.
    • (2004) Clin. Chim. Acta , vol.342 , pp. 171-178
    • Tewari, P.C.1    Zhang, B.2    Bluestein, B.I.3
  • 29
    • 77952516883 scopus 로고    scopus 로고
    • Food and Nutrition Research Institute Food Composition Table and Menu Eval
    • Manila, Philippines
    • Food and Nutrition Research Institute (2000) Food Composition Table and Menu Eval., Department of Science and Technology, Manila, Philippines.
    • (2000) Department of Science and Technology
  • 33
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A. and Reich, D. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet., 38, 904-909.
    • (2006) Nat. Genet. , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 34
    • 0032714352 scopus 로고    scopus 로고
    • Genomic control for association studies
    • Devlin, B. and Roeder, K. (1999) Genomic control for association studies. Biometrics, 55, 997-1004.
    • (1999) Biometrics , vol.55 , pp. 997-1004
    • Devlin, B.1    Roeder, K.2


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